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Adrenal Mass

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3601. Tissue-specific distribution of cross-linked somatostatin receptor proteins in the rat. (PubMed)

ranging from 27 kDa to 200 kDa. In order to resolve this discrepancy, as well as to determine whether SS-14 and SS-28 interact with specific receptor proteins, we have cross-linked radioiodinated derivatives of [125I-Tyr11]SS-14 (T*-SS-14) and [Leu8,D-Trp22,125I-Tyr25]SS-28 (LTT*-SS-28) to membrane SS receptors in rat brain, pituitary, exocrine pancreas and adrenal cortex using a number of chemical and photoaffinity cross-linking agents. The labelled cross-linked receptor proteins were analysed by SDS (...) /PAGE under reducing conditions followed by autoradiography. Our findings indicate that the pattern of specifically labelled cross-linked SS receptor proteins is sensitive to the concentration of chemical cross-linking agents such as disuccinimidyl suberate and dithiobis-(succinimidyl propionate). Labelled high-molecular-mass complexes of cross-linked receptor-ligand proteins were observed only when high concentrations of these cross-linkers were employed. Using optimized low concentrations of cross

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1992 Biochemical Journal

3602. Laparoscopic adrenalectomy: lessons learned from 100 consecutive procedures. (PubMed)

Laparoscopic adrenalectomy: lessons learned from 100 consecutive procedures. One hundred consecutive laparoscopic adrenal procedures for a variety of endocrine disorders were reviewed. There was no mortality, morbidity was 12%, and conversions was 3%. During follow-up, none had recurrence of hormonal excess. Laparoscopic adrenalectomy is the procedure of choice for adrenal removal except in carcinoma or masses > 15 cm.The authors evaluate the effectiveness of laparoscopic adrenalectomy (...) for a variety of endocrine disorders.Since the first laparoscopic adrenalectomy was performed in 1992, this approach quickly has been adopted, and increasing numbers are being reported. However, the follow-up period has been too short to evaluate the completeness of these operations.One hundred consecutive laparoscopic adrenal procedures from January 1992 until November 1996 were reviewed and followed for adequacy of resection.Eighty-eight patients underwent 97 adrenalectomies and biopsies. The mean age

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1997 Annals of Surgery

3603. Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. (PubMed)

with failure to thrive and congenital heart defects was found to have unilateral adrenal masses which, at surgical removal, proved to be an adrenocortical carcinoma and a ganglioneuroblastoma. Further investigation showed a germline p53 mutation and Turner syndrome. It remains to be determined what effect the 45,X chromosomal complement may have on the expression of neoplasms seen in patients with p53 germline mutations.

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1998 Journal of Medical Genetics

3604. Pheochromocytoma manifesting with shock presents a clinical paradox: a case report (PubMed)

Pheochromocytoma manifesting with shock presents a clinical paradox: a case report A 46-year-old man presented with shock and adult respiratory distress syndrome. Investigations revealed an adrenal mass that was diagnosed, by fine-needle aspiration biopsy, as pheochromocytoma. Because biopsy is contraindicated in patients with pheochromocytoma, this confusing presentation underscores the value of excluding this diagnosis by biochemical means before performing fine-needle aspiration of adrenal

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1997 CMAJ: Canadian Medical Association Journal

3605. Regulation of bile-acid synthesis. Role of sterol carrier protein 2 in the biosynthesis of 7 alpha-hydroxycholesterol. (PubMed)

; and enhances mitochondrial utilization of cholesterol for pregnenolone formation in the adrenals. The conversion of cholesterol into 7 alpha-hydroxycholesterol is the rate-limiting step in bile-acid synthesis. We therefore investigated the effect of SCP2 on this physiologically critical reaction by using a gas-chromatography-mass-spectrometry procedure that measures the mass of 7 alpha-hydroxycholesterol formed. The results show that SCP2 enhances 7 alpha-hydroxycholesterol formation by rat liver

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1985 Biochemical Journal

3606. The phosphatidylinositide-Ca2+ hypothesis does not apply to the steroidogenic action of corticotropin. (PubMed)

The phosphatidylinositide-Ca2+ hypothesis does not apply to the steroidogenic action of corticotropin. The hypothesis that ACTH (corticotropin) stimulates steroidogenesis by a mechanism that involves breakdown of polyphosphoinositides and increase in intracellular Ca2+ (called here the 'phosphatidylinositide-Ca2+ mechanism') was tested in Y-1 adrenal-tumour cells and in bovine fasciculata cells, by using incorporation of 32P and myo-[3H]inositol to study phospholipid metabolism, and quin-2 (...) and fura 2 to measure intracellular Ca2+. As a positive control, we repeated experiments showing that angiotensin II stimulates glomerulosa cells by way of the phosphatidylinositide-Ca2+ mechanism, by using the same methods. With Y-1 and fasciculata cells, no change was observed in the incorporation of either of the labelled precursors into any phosphatidylinositide or into any of three major phosphoinositols, i.e. inositol phosphate, bisphosphate and trisphosphate. Moreover, no change in mass of any

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1986 Biochemical Journal

3607. Obscure anaemia and hepatic dysfunction in Castleman's disease. (PubMed)

Obscure anaemia and hepatic dysfunction in Castleman's disease. A case is reported illustrating a rare and puzzling cause of long standing anaemia and abnormal liver function tests. The diagnosis of Castleman's disease came to light only after an adrenal mass was noted during ultrasound examination. Removal of the mass led to a rapid reversal of all the abnormalities.

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1990 Gut

3608. Pituitary Apoplexy Presenting as Addisonian Crisis: after Coronary Artery Bypass Grafting (PubMed)

Pituitary Apoplexy Presenting as Addisonian Crisis: after Coronary Artery Bypass Grafting Addisonian crisis, also commonly referred to as adrenal crisis, occurs when the cortisol produced by the adrenal glands is insufficient to meet the body's acute needs. The symptoms are nonspecific and can mimic other processes, such as sepsis. Hypotension, lethargy, and fever can all be presenting signs. Secondary addisonian crisis can also result from pituitary apoplexy. Pituitary apoplexy usually occurs (...) were overlooked; however, once recognized, they were reduced dramatically with standard stress-dose cortisone. A suprasellar mass with a cystic component was found on magnetic resonance imaging. The hemorrhagic pituitary gland was treated by transsphenoidal decompression, which relieved the patient's bitemporal hemianopia and 6th-nerve palsy.

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2002 Texas Heart Institute Journal

3609. Low-dose dexamethasone challenge in women with atypical major depression: pilot study (PubMed)

Low-dose dexamethasone challenge in women with atypical major depression: pilot study To examine if atypical depression may be associated with hypersuppression of the hypothalamic-pituitary-adrenal (HPA) axis.Eight women with atypical major depression and 11 controls with no history of psychiatric illness, matched on age and body mass index, were challenged with low-dose dexamethasone (0.25 mg and 0.50 mg in random order and 1 week apart). Dexamethasone was self administered at 11 pm

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2002 Journal of Psychiatry and Neuroscience

3610. Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats. (PubMed)

of approximately 5 kb as well as several smaller transcripts. To elucidate the nature of the large LRAT transcript, a high-molecular-mass adrenal gland cDNA library was screened. Two similar clones of 3962 and 3187 nt were identified which appeared to be part of the 3'-untranslated region (UTR) of a 5358 nt LRAT mRNA. The 5.3 kb cDNA was then amplified from liver by reverse transcriptase PCR (RT-PCR) and demonstrated to encode functional LRAT activity. The 3'-UTR of the 5.3 kb cDNA contains several AAUAAA

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2002 Biochemical Journal

3611. The screening of congenital adrenal hyperplasia. Applicability in Galicia

by CRD MeSH Adrenal Hyperplasia, Congenital; Costs and Cost Analysis; Mass Screening; Neonatal Screening Language Published Spanish Country of organisation Spain Address for correspondence Subdireccion Xeral de Aseguramento e Planificacion Sanitaria, Conselleria de Sanidade, Xunta de Galicia, San Lazaro s/n 15781 Santiago de Compostela, Spain. Tel: 34 981 541831; Fax: 34 981 542854; Email: avalia-t@sergas.es AccessionNumber 32005000346 Date bibliographic record published 18/07/2005 Date abstract (...) The screening of congenital adrenal hyperplasia. Applicability in Galicia Cribado neonatal de la hiperplasia suprarrenal congenita. Aplicabilidad en Galicia [The screening of congenital adrenal hyperplasia. Applicability in Galicia] Cribado neonatal de la hiperplasia suprarrenal congenita. Aplicabilidad en Galicia [The screening of congenital adrenal hyperplasia. Applicability in Galicia] Rey-Liste T, Garcia-Caeiro A Record Status This is a bibliographic record of a published health technology

2004 Health Technology Assessment (HTA) Database.

3612. Diagnosis and treatment of adrenal incidentaloma: a cost-effectiveness analysis

assessment on the reliability of the study and the conclusions drawn. Health technology Several health technologies were considered for the diagnosis and the treatment of adrenal incidentaloma, an adrenal mass incidentally detected during the course of abdominal diagnostic imaging, performed for another reason. The eight diagnostic tests were grouped in three sets: imaging techniques, namely I-iodomethyl-norcholesterol (NP59), magnetic resonance imaging, I-meta-iodobenzylguanidine, and computed (...) Diagnosis and treatment of adrenal incidentaloma: a cost-effectiveness analysis Diagnosis and treatment of adrenal incidentaloma: a cost-effectiveness analysis Diagnosis and treatment of adrenal incidentaloma: a cost-effectiveness analysis Kievit J, Haak H R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical

2000 NHS Economic Evaluation Database.

3613. Diagnostic evaluation of the adrenal incidentaloma: decision and cost-effectiveness analyses

contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Comparison of different diagnostic strategies to discriminate benign from malignant adrenal incidentalomas. Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population Hypothetical cohort ofpatients with incidentally discovered unilateral, non-hypersecretory adrenal masses (...) masses. Outcomes assessed in the review The outcomes assessed were prevalence of non-hypersecretory adenomas, adrenocortical carcinomas, and adrenal metastases in adrenal incidentaloma. Additionally the diagnostic performance of biopsy and imaging procedures, and the morbidity of invasive modalities were considered. Study designs and other criteria for inclusion in the review No specific study design criteria were identified by the authors. Only articles published in English were included

1998 NHS Economic Evaluation Database.

3614. Adrenal insufficiency. (PubMed)

Adrenal insufficiency. A 44-year-old woman reported several weeks of fatigue, somnolence, pain in the large joints, nausea, and decreased appetite. She had also noted an unintentional 11-kg weight loss over a period of 6 months. She had a remote history of amenorrhea, but she was presently menstruating regularly. She was taking no medications, with the exception of acetaminophen as needed for knee pain. The diagnosis of adrenal insufficiency (AI) was considered. Serum cortisol level after (...) adrenocorticotropin hormone (ACTH) stimulation was abnormal. Because her plasma ACTH level was not increased, a diagnosis of secondary AI (due to deficiency in ACTH) was made. Magnetic resonance imaging of the brain performed to exclude the presence of a sellar or suprasellar mass showed reduction in size of the pituitary gland and an increased cerebrospinal fluid content within the sella, consistent with a partially empty sella. The patient's symptoms improved rapidly with hydrocortisone therapy but during

2005 JAMA

3615. Cortisol production rates in preterm infants in relation to growth and illness: a noninvasive prospective study using gas chromatography-mass spectrometry. (PubMed)

Cortisol production rates in preterm infants in relation to growth and illness: a noninvasive prospective study using gas chromatography-mass spectrometry. Whereas intrauterine growth and maturation depend on low cortisol levels, an adrenal stress response postnatally is thought to be mandatory in preterm infants.The goal of this study was to determine cortisol production rates (CPRs) in preterm infants during early life with extreme illness and, thereafter, during extrauterine growth (...) and maturation.We describe a longitudinal observational study.The study was conducted at a university neonatal intensive care unit.Seventeen well (27.9 +/- 1.8 wk) and 44 ill (27.3 +/- 1.6 wk) preterm infants were classified by the Score for Neonatal Acute Physiology. Glucocorticoid metabolites were profiled by gas chromatography-mass spectrometry in 24-h urinary samples. Urine was collected noninvasively using cellulose nappies and extracted by hydraulic press.Medians of CPRs (microg kg(-1) d(-1) mg creatinine

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2005 Journal of Clinical Endocrinology and Metabolism

3616. Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. (PubMed)

Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. Melanocortin-4 receptors (MC4Rs) are involved in the regulation of food intake, sympathetic nervous activity, and adrenal and thyroid function by leptin. The role of MC4Rs in regulating energy balance by leptin was investigated using double heterozygote or homozygous leptin (Lep(ob)) and Mc4r gene mutant mice. Double (...) heterozygous or homozygous mutants were generated by crossing MC4R knockout (Mc4r-/-) mice, backcrossed onto C57BL/6J, with B6.V-Lep(ob) mice. Energy expenditure was measured using indirect calorimetry. The effect of leptin on food intake, weight loss, insulin, and corticosterone was compared for Lep(ob)/Lep(ob)Mc4r-/- mice and Lep(ob)/Lep(ob) mice. Double heterozygous and homozygous mutants exhibited an additive effect on fat mass. The 2-fold increase in body weight associated with severe obesity of Lep

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2005 Endocrinology

3617. Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. (PubMed)

+/- 1.1%; p = 0.004). This trend was confirmed by linear regression, suggesting a "major gene" behavior for the T allele. Multiple regression analysis showed that this effect was independent of anthropometric and clinical factors, including adrenal aldosterone.Our data suggest that -344C/T polymorphism affects LV mass and thickness in essential hypertension, independent of adrenal aldosterone. A role for intracardiac aldosterone synthesis is hypothesized. (...) Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. The aim of our study was to evaluate the relationship between aldosterone synthase gene polymorphism and cardiac dimensions in essential hypertension.Higher aldosterone synthase messenger ribonucleic acid levels in the human heart are accompanied by increased intracardiac aldosterone production, a phenomenon that is associated with cardiac fibrosis and hypertrophy. Recent

2004 Journal of the American College of Cardiology

3618. The Circadian Variation of Cortisol Secretion in Patients with Anorexia Nervosa in Childhood and Adolescence after Recovery of Body Weight by Treatment Using Gas Chromatography/Mass Spectrometry in Selected Ion Monitoring (PubMed)

The Circadian Variation of Cortisol Secretion in Patients with Anorexia Nervosa in Childhood and Adolescence after Recovery of Body Weight by Treatment Using Gas Chromatography/Mass Spectrometry in Selected Ion Monitoring Anorexia nervosa (AN) is a chronic psychiatric disorder which is characterized by patient-induced weight loss. Complications in many organ systems can be seen in AN such as cardiovascular, gastrointestinal, and endocrine system including hypothalamic-pituitary-adrenal axis (...) , even after recovery of body weight by treatment. Urinary steroid profile analysis using gas chromatography/mass spectrometry (GC/MS) in selected ion monitoring (SIM) has been reported to be useful for the diagnosis of abnormal steroidogenesis in newborn infants, childhood, and adults. The aim of this study was to analyze the circadian variation of cortisol secretion in patients with anorexia nervosa (AN) in childhood and adolescence after recovery of body weight by treatment using GC/MS in SIM

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2007 Clinical Pediatric Endocrinology

3619. Quantitative, highly sensitive liquid chromatography-tandem mass spectrometry method for detection of synthetic corticosteroids. (PubMed)

Quantitative, highly sensitive liquid chromatography-tandem mass spectrometry method for detection of synthetic corticosteroids. Measurements of serum or urine concentrations of synthetic glucocorticoids are useful for assessing suspected iatrogenic hypothalamic-pituitary-adrenal axis suppression and Cushing syndrome. We have developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for the simultaneous quantitative analysis of beclomethasone dipropionate, betamethasone

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2004 Clinical Chemistry

3620. Pulmonary Paraganglioma Manifesting as an Endobronchial Mass (PubMed)

Pulmonary Paraganglioma Manifesting as an Endobronchial Mass Thoracic paragangliomas comprise only 1-2% of all paragangliomas, including the adrenal pheochromocytomas, and these tumors are mostly found in the mediastinal compartments (1). To the best of our knowledge, there is only one case report in the pathology literature of endobronchial involvement by a primary pulmonary paraganglioma (2). We report here on the CT and bronchoscopic findings of a case of pathologically proven endobronchial (...) paraganglioma in a 37-year-old woman. In our case, bronchoscopy and CT demonstrated an endobronchial hypervascular mass, which indicated the presence of carcinoid or hypervascular metastasis based on the known incidence of such tumors.

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2008 Korean Journal of Radiology

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