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141. European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults Full Text available with Trip Pro

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors in: European Journal of Endocrinology Volume 179 Issue 4 Year 2018 This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing (...) experience. If you don't change your settings, we'll assume you're happy with this. Google Translate to save searches and organize your favorite content. Not registered? Search Recently viewed (1) European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors in Authors: , , , , , , , , , , , , , , , , , , and View More View Less 1 Division of Endocrinology and Diabetes

2018 European Society of Endocrinology

142. European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas Full Text available with Trip Pro

determining potential side effects, an experienced radiation oncologist is required ( ). For SRS, the tumour target should be at least 3–5 mm distant from the optic chiasm and less than 3 cm in diameter. Otherwise, fractionated EBRT may be the only option. Furthermore, EBRT should be preferred for tumours with irregular anatomy, including diffuse local infiltration and suprasellar or brainstem extension, to avoid high dose radiation of healthy tissue ( ). SRS may be more convenient for the patient (...) ( ). Standard medical treatments do not arrest growth of aggressive gonadotroph/NFPA tumours. Morbidity and mortality in patients with aggressive corticotroph tumours are mostly related to cortisol excess. Drugs reducing adrenal glucocorticoid synthesis should be given in doses aiming at achieving eucortisolism. There is little experience with pasireotide in aggressive corticotroph tumours. A single patient with a large corticotroph tumour following bilateral adrenalectomy had a lowering of ACTH

2018 European Society of Endocrinology

143. CUA-PUC Canadian guideline for the diagnosis, management and followup of cryptorchidism

during intercourse or sports and provides psychological benefits by attempting to recre - ate normal anatomy. Long-term implications Reduced fertility Any correlation of infertility with undescended testis (UDT) must be tempered by the fact that 15?20% of couples in the general Canadian population have difficulty conceiving, 5 and there is often more than one factor involved. Paternity rates are largely unchanged for men with unilateral cryptorchidism compared to the general population (around 90 (...) in an abnormal location (most important intra-abdominal), as it could lead to delayed diagnosis of testicular neoplasm – Locate testicle(s) in a position amenable to self-exam (or caretaker/healthcare provider regular assessment in patients unable to reliably conduct self-examination) – Relocate all viable gonad(s) in scrotum to maximize psychological benefits of normal anatomy – Consider surgical morbidity, comorbidities, life expectancy, and fertility expectations in special situationsCUAJ • July 2017

2017 Canadian Urological Association

148. Renal Mass and Localized Renal Cancer

should perform adrenalectomy if imaging and/or intraoperative findings suggest metastasis or direct invasion of the adrenal gland. (Clinical Principle) In patients undergoing surgical excision of a renal mass, a minimally invasive approach should be considered when it would not compromise oncologic, functional and perioperative outcomes. (Expert Opinion) Pathologic evaluation of the adjacent renal parenchyma should be performed after PN or RN to assess for possible intrinsic renal disease (...) and aggressive tumor biology. Contrast-enhanced abdominal imaging (CT or MRI) best characterizes the mass, provides information regarding renal morphology (of the affected and unaffected kidney), assesses extrarenal tumor spread (venous invasion or regional lymphadenopathy) and evaluates the adrenal glands and other abdominal organs for visceral metastases. Patients with CKD and GFR less than 45 ml/min/1.73m 2 should receive contrast with caution as iodinated contrast agents can transiently or permanently

2017 American Urological Association

149. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

(on a calibrated machine that has been validated for use in the pediatric population) or auscultatory (by using a mercury or aneroid sphygmomanometer , ). (Validation status for oscillometric BP devices, including whether they are validated in the pediatric age group, can be checked at .) BP should be measured in the right arm by using standard measurement practices unless the child has atypical aortic arch anatomy, such as right aortic arch and aortic coarctation or left aortic arch with aberrant right

2017 American Academy of Pediatrics

151. The 2017 hormone therapy position statement of The North American Menopause Society

therapy has been shown in RCTs to effectively restore genitourinary tract anatomy, increase superficial vag- inal cells, reduce vaginal pH, and treat symptoms of vulvo- vaginal atrophy (VVA). 32 Key point HormonetherapyisapprovedbyFDAforfourindications: bothersome VMS; prevention of bone loss; hypoestrogen- ism caused by hypogonadism, castration, or POI; and genitourinary symptoms. NAMS POSITION STATEMENT Menopause, Vol. 24, No. 7, 2017 731Copyright @ 2017 The North American Menopause Society

2017 The North American Menopause Society

152. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline Full Text available with Trip Pro

, and personality traits that a society (in a given culture and historical period) designates as masculine or feminine and/or that society associates with or considers typical of the social role of men or women. Sex designated at birth: This refers to sex assigned at birth, usually based on genital anatomy. Sex: This refers to attributes that characterize biological maleness or femaleness. The best known attributes include the sex-determining genes, the sex chromosomes, the H-Y antigen, the gonads, sex hormones (...) /gender-affirming treatment. Gender role: This refers to behaviors, attitudes, and personality traits that a society (in a given culture and historical period) designates as masculine or feminine and/or that society associates with or considers typical of the social role of men or women. Sex designated at birth: This refers to sex assigned at birth, usually based on genital anatomy. Sex: This refers to attributes that characterize biological maleness or femaleness. The best known attributes include

2017 Pediatric Endocrine Society

153. Diagnosis and management of Silver-Russell syndrome: 1st international consensus statement Full Text available with Trip Pro

)genetic disorders. , , Edith Said is a Consultant Medical Geneticist & Head of Section of Clinical Genetics & Cytogenetics, Mater dei Hospital, Malta, and Resident Academic Senior Lecturer, Department of Anatomy and Cell Biology, University of Malta. Her special interest is in clinical genetics and dysmorphology, cryptic chromosomal rearrangements and imprinting disorders. She is responsible for paediatric genetic clinics with over 750 consultations a year, at least a third of which are related (...) with particular interest in imprinting disorders, and has over 230 publications across these fields. , Madeleine Harbison is Assistant Professor of Pediatrics in the Genetic Endocrinology, Adrenal and Steroid Disorders Group, Mount Sinai School of Medicine, New York, USA, and Assistant Attending Physician at the Department of Pediatrics, Mount Sinai Hospital, New York, USA. She is a pioneer in clinical diagnosis and care of patients with Silver–Russell syndrome. She has 20 PubMed publications. , , I. Karen

2017 Pediatric Endocrine Society

154. The Association of Coloproctology of Great Britain and Ireland Consensus Guidelines in Surgery for Inflammatory Bowel Disease Full Text available with Trip Pro

of its anatomy, drainage of sepsis, nutritional support and determining the underlying cause, whether inflammation or stenosis. For primary enterocutaneous fistula, resectional surgery is generally necessary, although medical treatment may be attempted , . The evidence for medical therapy is minimal and of low quality. Entero‐enteric fistulas are usually asymptomatic and require surgery only if they cause malabsorption or diarrhoea . For entero‐urogenital fistula, surgery is still superior to medical

2018 Association of Coloproctology of Great Britain and Ireland

155. Joint NASPGHAN and ESPGHAN guidelines on Gastro-oesophageal Reflux Disease in Children

Urinary tract infection Intracranial hemorrhage Upper/lower airway infection Intracranial mass Otitis media Hepatitis Metabolic/endocrine Others Galactosemia Pediatric condition falsi?cation (PCF)/factitious disorder by proxy (FDP) Hereditary fructose intolerance Child neglect or abuse Urea cycle defects Self-induced vomiting Amino and organic acidemias Cyclic vomiting syndrome Fatty acid oxidation disorders Rumination syndrome Metabolic acidosis Congenital adrenal hyperplasia/adrenal crisis Toxic

2018 British Society of Paediatric Gastroenterology Hepatology and Nutrition

157. Lymphoma

, kidney, adrenal, or symptoms referable to CNS or nerve roots. Consider for elevated LDH, ECOG 2-4, and >1 ENS. ENT exam Suprahyoid cervical lymph node or stomach UGI & SBFT W a l d e y e r ’ s ring involvement Ophthalmologic (slit lamp) exam Primary brain lymphoma HIV serology If any HIV risk factors. Lymphomas with unusual presentations or aggressiveness including Primary CNS. Cardio-oncology imaging (MR or Echocardiogram) All patients who are planned to receive anthracycline or high dose (...) ) or without (n=120) ASCT (72% vs 64%). Newer methods of identifying poor prognosis DLBCL patients include the use of interim or final PET+ response to RCHOP, as well as cell of origin (COO) GCB vs non-GCB, and MYC/BCL2 expression. Ennishi et al. (2017) reported very poor outcomes (5yr TTP 10%) for relapse in the central nervous system include 4-6 of the following factors: 1) Age >60 years, 2) elevated LDH, 3) ECOG=2-4, 4) Stage 3-4, 5) >1 extranodal site of involvement, and 6) kidney or adrenal

2016 CPG Infobase

158. Lenvima - lenvatinib

). Distribution EMA/250082/2015 Page 26/169 Tissue distribution of radioactivity was investigated after a single oral administration of 14C-lenvatinib mesilate (3 mg/kg) to male SD rats and male cynomolgus monkeys and after a single oral administration of 14C-CB-lenvatinib mesilate (3 mg/kg) to male cynomolgus monkeys. In rats, the highest concentrations of radioactivity were found at 0.5 hours postdose (Tmax) in most tissues (the small intestine, liver, adrenal gland, and stomach showed concentrations 1.19 (...) ), ? activity, soft stool, ? food consumption and body weight ? RBC, Hb, Ht, platelet, reticulocyte, albumin, globulin, ?AST and ALT, cholesterol, BUN, creatinine, proteinuria All doses: Histologic lesions in bone ( ? thickness of epiphysial growth plate and cartilage), kidney (glomerulopathy), ovary (follicular atresia), incisor (dysplasia), testes (hypocellularity of seminiferous epithelium) At MD and HD only: liver (sinusoidal dilatation), adrenal gland (sinusoidal dilatation and cortical necrosis

2015 European Medicines Agency - EPARs

159. Kengrexal - cangrelor

not been observed in clinical studies. Slightly increased weights and/or vacuolation of adrenals in rats and the reduced weights of thymus and the pituitary gland in rats and dogs were observed in the 7-day and 1-month studies in rats. This could mean that cangrelor has some interaction with the hypothalamic-pituitary-adrenocortical axis. This could be a class effect. But it seems not to be clinically relevant, since it was only observed the high-dose groups. For ticagrelor, a Assessment report EMA (...) /137542/2015 Page 25/113 medicinal compound of the same class, inhibition of corticosterone synthesis has been demonstrated at clinical relevant concentrations, but there were no signs of any effects on the adrenal glands in clinical trials. In dogs, target organs of toxicity were essentially the same as those in rats: the kidney, the urinary tract and the liver. Additional findings in dogs included gastritis and inflammatory changes in the gut. These effects are most likely the consequence

2015 European Medicines Agency - EPARs

160. Glaucoma

) but with no signs of glaucoma. [ ; ; ] Anatomy and physiology What is the anatomy and physiology of the eye relevant to glaucoma? The descriptions of the anatomy and physiology of the eye may be more easily understood when read with the aid of a diagram of the eye, such as that on the website of the . Anterior chamber The anterior chamber is the fluid-filled space between the iris and the cornea. The anterior chamber angle is the angle between the iris and the cornea where they join the sclera towards

2019 NICE Clinical Knowledge Summaries

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