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Adenomyosis

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41. Adenomyosis incidence, prevalence and treatment: United States population-based study 2006-2015. (Abstract)

calculations. Associated symptom-related codes (menorrhagia or abnormal uterine bleeding, dysmenorrhea or pelvic pain, dyspareunia, and infertility) were observed in 90.8%; 18.0% had co-occurrent endometriosis codes and 47.6% had co-occurrent uterine fibroid codes. The overall adenomyosis incidence was 1.03% or 28.9 per 10,000 woman-years, with a high of 30.6 in 2007 and a low of 24.4 in 2014. Overall age-adjusted estimated incidence rates declined during the 10-year study interval (linear trend P < .05 (...) Adenomyosis incidence, prevalence and treatment: United States population-based study 2006-2015. Adenomyosis symptoms are disabling. Population-based data on incidence and prevalence of adenomyosis are lacking that could guide future evidence-based treatments and clinical management.To evaluate the incidence, 10-year secular trends, and prevalence of adenomyosis diagnoses and to describe symptoms and treatment patterns in a large U.S. cohort.We performed a retrospective population-based cohort

2020 American Journal of Obstetrics and Gynecology

42. Dysmenorrhea and Endometriosis in the Adolescent

for endometriosis in adolescents is conservative surgical therapy for diagnosis and treatment combined with ongoing suppressive medical therapies to prevent endometrial proliferation. Patients with endometriosis who have pain refractory to conservative surgical therapy and suppressive hormonal therapy often benefit from at least 6 months of gonadotropin-releasing hormone (GnRH) agonist therapy with add-back medicine. Nonsteroidal antiinflammatory drugs should be the mainstay of pain relief for adolescents (...) in adolescents requiring the presence of endometrial glands and stroma in the biopsy specimen from a location outside of the endometrial cavity. Patients with persistent dysmenorrhea despite treatment and no other identified etiologies should be counseled about the high likelihood of endometriosis and the risks and benefits of diagnostic laparoscopy. The benefits of laparoscopy include confirmation of the presence or absence of endometriosis or other causes of chronic pain such as adhesive disease

2019 American College of Obstetricians and Gynecologists

43. Ultrasound-guided high-intensity focused ultrasound for endometriosis of the uterus? Assessment according to §137h Social Code Book V

Ultrasound-guided high-intensity focused ultrasound for endometriosis of the uterus? Assessment according to §137h Social Code Book V 1 Translation of the executive summary of the assessment according to §137h Social Code Book (SGB) V Sonografiegesteuerte hochfokussierte Ultraschalltherapie bei der Endometriose des Uterus (Version 1.0; Status: 30 January 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text (...) is absolutely authoritative and legally binding. Executive Summary IQWiG Reports – Commission No. H16-02A Ultrasound-guided high- intensity focused ultrasound therapy for uterine endometriosis 1 Executive summary of assessment H16-02A according to §137h SGB V Version 1.0 USgHIFU for uterine endometriosis 30 January 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Ultrasound-guided high-intensity

2017 Institute for Quality and Efficiency in Healthcare (IQWiG)

44. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Full Text available with Trip Pro

Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Endometriosis is a common gynaecological condition that affects women and can lead to painful symptoms and infertility. It greatly affects women's quality of life, impacting their careers, everyday activities, sexual and nonsexual relationships and fertility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are most commonly used as first-line treatment for women with pain associated with endometriosis.To assess effects (...) of NSAIDs used for management of pain in women with endometriosis compared with placebo, other NSAIDs, other pain management drugs or no treatment.We searched the Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials (October 2016), published in the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, as well as MEDLINE (January 2008 to October 2016), Embase (date limited from 1 January 2016 to 19 October 2016, as all earlier references

2017 Cochrane

45. The benefit of adenomyomectomy on fertility outcomes in women with rectovaginal endometriosis with coexisting adenomyosis Full Text available with Trip Pro

The benefit of adenomyomectomy on fertility outcomes in women with rectovaginal endometriosis with coexisting adenomyosis To evaluate the effect of removal of coexisting adenomyosis on fertility outcomes in women with rectovaginal endometriosis.A retrospective cohort study.A general hospital.A total of 190 women who underwent laparoscopic nodule excision surgery for rectovaginal endometriosis between April 2007 and December 2012.Surgical excision of the rectovaginal endometriosis and coexisting (...) that surgical removal of coexisting adenomyosis positively effects fertility outcomes in women with rectovaginal endometriosis. However, it is also important to note that the age at surgery was a critical factor for successful pregnancy.

2016 Gynecology and Minimally Invasive Therapy

46. Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study Full Text available with Trip Pro

Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study Despite being quite frequent and having serious implications in terms of symptomatology and fertility, data on incidence and prevalence of endometriosis and adenomyosis following gold standard definitions are dramatically lacking. The average time from onset of symptoms to diagnosis in industrialized countries still ranges from five to ten years. Using the regional centralized data (...) linkage system, we calculated incidence and prevalence of endometriosis and adenomyosis in the female population of Friuli Venezia Giulia region, Italy, for the years 2011-2013. Cases were defined as new diagnoses from hospital discharge records, following procedures allowing direct visualization for endometriosis and hysterectomy for adenomyosis, with or without histological confirmation. Diagnoses were considered "new" after verifying women had not been diagnosed in the previous ten years. Incidence

2016 PloS one

47. Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. Full Text available with Trip Pro

Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. Both adenomyosis and endometriosis are characterized by the presence of ectopic endometrial glands and stroma and have been suggested to share some characteristics with malignant tumors. Although accumulating evidence indicates that endometriosis is associated with some cancer types, the cancer risks in patients with adenomyosis have been rarely examined. In this study, we (...) endometriosis-free women.Compared with adenomyosis-free women, patients with adenomyosis had higher risks of endometrial and thyroid cancers, with estimated hazard ratios (HRs) (95% confidence interval) of 2.19 (1.51-3.16) and 1.70 (1.29-2.24), respectively. For both cancers, distributions of CFS were not significantly different between the early- and late-diagnosed adenomyosis groups. Furthermore, compared with endometriosis-free women, patients with endometriosis had higher risks of endometrial

2018 PLoS ONE

48. Abdominal Wall Endometrioma after Laparoscopic Operation of Uterine Endometriosis Full Text available with Trip Pro

Abdominal Wall Endometrioma after Laparoscopic Operation of Uterine Endometriosis Endometriosis is presence of functional endometrium outside of uterine cavum. As a pluripotent tissue, endometrium has the possibility of implanting itself almost everywhere; even implantation in abdominal wall was described, but it is not common site. This case report presents implantation of functional endometrium in abdominal wall, inside scar tissue, and after insertion of a laparoscopic trocar port. Final

2016 Case reports in surgery

49. Cystic Endometriosis in a Huge Degenerated Subserous Leiomyoma Mimicking Bilateral Multicystic Endometriomas in an Infertile Woman with Diminished Ovarian Reserve: A Rare Endometriotic Implantation Full Text available with Trip Pro

Cystic Endometriosis in a Huge Degenerated Subserous Leiomyoma Mimicking Bilateral Multicystic Endometriomas in an Infertile Woman with Diminished Ovarian Reserve: A Rare Endometriotic Implantation Uterine leiomyomas are the most common pelvic tumor in women. Leiomyoma can show atypical locations and degenerations and may not be easily differentiated from adnexal masses. Uterine leiomyoma can undergo cystic degeneration and is said to be found in 4% of all types of degenerations. The commonest (...) type of degeneration is hyaline seen in 60% of patients. Usually uterine leiomyoma does not present as clinical and radiological diagnostic challenge. However, when leiomyoma undergoes massive cystic degeneration they may become clinical and radiological diagnostic dilemmas. The MRI showed a huge cystic mass protruding up to the pelvis not differentiated from bilateral endometriomas and accompanying subserous myomas. Surgery revealed that the mass is not bilateral endometriomas but a huge

2016 Case reports in obstetrics and gynecology

50. Endometriomas and deep infiltrating endometriosis in adulthood are strongly associated with anogenital distance, a biomarker for prenatal hormonal environment. Full Text available with Trip Pro

Endometriomas and deep infiltrating endometriosis in adulthood are strongly associated with anogenital distance, a biomarker for prenatal hormonal environment. Is the length of the anogenital distance (AGD), a biomarker of the in-utero prenatal hormonal environment, associated with the presence of endometriomas and deep infiltrating endometriosis (DIE)?Shorter AGD is associated with presence of endometriomas and DIE.It is debated whether hormonal exposure to estrogens in utero may be a risk (...) factor for endometriosis in adulthood. AGD is a biomarker of prenatal hormonal environment and observational studies have shown an association between AGD and reproductive parameters in both sexes.This case-control study of 114 women with endometriosis (endometriomas and/or DIE) and 105 controls was conducted between September 2014 and May 2015.Cases were attending the Endometriosis Unit of the Hospital. Prevalent as well as incident cases, diagnosed by transvaginal ultrasound (TVUS), were included

2016 Human Reproduction

51. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. (Abstract)

Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Many women who experience endometriosis and endometriomas also encounter problems with fertility.The purpose of this study was to determine the impact of surgical excision of endometriosis and endometriomas compared with control subjects on ovarian reserve.This was a prospective cohort study of 116 women aged 18-43 years with pelvic pain and/or infertility who underwent surgical treatment of suspected (...) endometriosis (n=58) or endometriomas (n=58). Based on surgical findings, the suspected endometriosis group was further separated into those with evidence of peritoneal disease (n=29) and those with no evidence of endometriosis (n=29). Ovarian reserve was measured by anti-Müllerian hormone and compared before surgery and at 1 month and 6 months after surgery.Baseline anti-Müllerian hormone values were significantly lower in the endometrioma vs negative laparoscopy group (1.8 ng/mL [95% confidence interval

2016 American Journal of Obstetrics and Gynecology

52. Management of endometriosis

guidelines was developed by the French National Authority for Health (HAS) and the French College of Gynaecologists and Obstetricians (CNGOF) to update the 2006 CNGOF guideline on the management of endometriosis. The purpose of this guide is to help hospital and community based healthcare professionals offer patients the best possible information and management. This guideline deals with the diagnosis and management of peritoneal, ovarian and deep endometriosis. The management of adenomyosis (...) Management of endometriosis Haute Autorité de Santé - Management of endometriosis Fermer Choose language Accessibility Change contrast : Standards Reinforced icone Chercher icone plus Chercher My account My account Please fill in your email address to retrieve your email alerts subscriptions. Please fill in your email address to retrieve your newsletter subscriptions. You do not have a saved search Sélection No element in selection Services Services Déclarer un événement indésirable grave

2018 HAS Guidelines

53. Elagolix for Treating Endometriosis

for Treating Endometriosis Return to Table of Contents Executive Summary Background Endometriosis is a chronic gynecological condition characterized by the attachment and proliferation of endometrial-like tissue outside of the uterus. 1 Endometriosis affects 6-10% of women of reproductive age, with peak prevalence between 25 to 35 years of age, and is estimated to affect four to 10 million women in the United States. 2-4 Common symptoms of endometriosis include painful menstrual periods, nonmenstrual (...) they should be in removing observed endometrial-like tissue. • Studies have shown that adding hormonal therapy after surgery results in better pain control than surgery alone, but have included newer, more aggressive approaches. 21 Elagolix is a novel agent, but enthusiasm is muted because it still works by lowering hormone levels. • Elagolix is the first new FDA approved drug for endometriosis in over 20 years, but it highlights a lack of research focused on a basic understanding of what causes

2018 California Technology Assessment Forum

54. Elagolix for Treating Endometriosis

adverse event SRDR Systematic Review Data Repository VAS Visual Analogue Scale ©Institute for Clinical and Economic Review, 2018 Page ES 1 Evidence Report – Elagolix for Treating Endometriosis Return to Table of Contents Executive Summary Background Endometriosis is a chronic gynecological condition characterized by the attachment and proliferation of endometrial-like tissue outside of the uterus. 1 Endometriosis affects 6-10% of women of reproductive age, with peak prevalence between 25 to 35 years (...) uncertainty about the optimal surgical procedures, especially how aggressive they should be in removing observed endometrial-like tissue. • Studies have shown that adding hormonal therapy after surgery results in better pain control than surgery alone, but have included newer, more aggressive approaches. 20 Elagolix is a novel agent, but enthusiasm is muted because it still works by lowering hormone levels. • Elagolix may be the first new FDA approved drug for endometriosis in over 20 years

2018 California Technology Assessment Forum

55. The Endometriosis Impact Questionnaire (EIQ): a tool to measure the long-term impact of endometriosis on different aspects of women's lives. Full Text available with Trip Pro

The Endometriosis Impact Questionnaire (EIQ): a tool to measure the long-term impact of endometriosis on different aspects of women's lives. Endometriosis is a chronic disease impacting on many aspects of a woman's life. Because of the chronic and recurring nature, many of the impacts of endometriosis could be missed using existing questionnaires which focus on recent events. Therefore, a questionnaire with a long-term perspective is necessary. This study aimed to develop and evaluate (...) a questionnaire to measure the long-term impact of endometriosis on different aspects of women's lives.Through a methodological design, phase 1 was qualitative and phase 2 was a cross-sectional study. The original 100 EIQ items were developed based on results from an earlier qualitative study and literature review. Through a process of assessing face and content validity this was reduced to 66 items. The psychometric properties of the final 63 item EIQ were evaluated through a web-based survey with data from

2019 BMC Women's Health

56. Fertility performance and the predictive value of the endometriosis fertility index staging system in women with recurrent endometriosis: A retrospective study. Full Text available with Trip Pro

Fertility performance and the predictive value of the endometriosis fertility index staging system in women with recurrent endometriosis: A retrospective study. This study presents the postoperative pregnancy rate of women with recurrent endometriosis and evaluates the predictive value of the endometriosis fertility index (EFI) for the pregnancy.A total of 107 women who wished to conceive after surgery for recurrent endometriosis from January 2007 to December 2016 were included. The EFI score (...) % and 66.38%, respectively, and increased to 71.98% within the first 5 years postoperatively in patients with EFI scores ≥5. However, the CPR was 26.00% during the first 2 years after surgery in individuals with EFI scores <5, and there was no increase in the CRP thereafter.Women suffering from recurrent endometriosis still experienced a probability of natural pregnancy, especially patients with EFI scores ≥5. The EFI score had good predictive power for postoperative pregnancy in these patients.

2019 Medicine

57. A Randomised, Single-Blind Clinical Trial to Investigate the Effectiveness of Bipolar Versus Monopolar Diathermy Treatment on Pain Symptoms for Women With Newly Diagnosed Superficial Endometriosis: The Set Study (Superficial Endometriosis Treatment). (Abstract)

A Randomised, Single-Blind Clinical Trial to Investigate the Effectiveness of Bipolar Versus Monopolar Diathermy Treatment on Pain Symptoms for Women With Newly Diagnosed Superficial Endometriosis: The Set Study (Superficial Endometriosis Treatment). 27678954 2019 11 20 1553-4669 22 6S 2015 Nov-Dec Journal of minimally invasive gynecology J Minim Invasive Gynecol A Randomised, Single-Blind Clinical Trial to Investigate the Effectiveness of Bipolar Versus Monopolar Diathermy Treatment on Pain (...) Symptoms for Women With Newly Diagnosed Superficial Endometriosis: The Set Study (Superficial Endometriosis Treatment). S176-S177 S1553-4650(15)01259-5 10.1016/j.jmig.2015.08.651 Hardcastle R J RJ Portsmouth Hospital, Portsmouth, Hampshire, United Kingdom. eng Journal Article 2015 10 15 United States J Minim Invasive Gynecol 101235322 1553-4650 2016 9 29 6 0 2016 9 30 6 0 2016 9 30 6 0 ppublish 27678954 S1553-4650(15)01259-5 10.1016/j.jmig.2015.08.651

2019 Journal of minimally invasive gynecology Controlled trial quality: uncertain

58. Deep endometriosis transvaginal ultrasound in the workup of patients with signs and symptoms of endometriosis: a cost analysis. (Abstract)

Deep endometriosis transvaginal ultrasound in the workup of patients with signs and symptoms of endometriosis: a cost analysis. Deep endometriosis transvaginal ultrasound (DE TVS) is accurate in the detection of ovarian endometriosis and DE; however, realisation of its full potential and utilisation remains variable. As such, patients may require a two-step surgical approach (diagnostic followed by therapeutic laparoscopy) or experience incomplete surgical treatment. Besides the clinical (...) implications, the economic impact of a two-step approach to diagnosis and treatment on the healthcare system is likely to be significant. We aim to compare the economic costs of two diagnostic models of care for patients with potential endometriosis.Cost analysis using Markov model with 12-month time horizon comparing the economic costs of two diagnostic models.The study used a hypothetical population of 1000 women visiting a public tertiary gynaecology clinic.Women with potential endometriosis. Estimates

2019 BJOG

59. [Effect of GnRHa therapy following conservative laparoscopic surgery for endometriosis on clinical pregnant rate in patients with endometriosis-associated infertility]. (Abstract)

[Effect of GnRHa therapy following conservative laparoscopic surgery for endometriosis on clinical pregnant rate in patients with endometriosis-associated infertility]. To investigate the impact of conservative laparoscopic surgery for endometriosis with postoperative gonadotropin-releasing hormone agonist (GnRHa) therapy on the pregnancy outcomes in patients with endometriosis-associated infertility.The clinical data were collected from the patients with endometriosis-associated infertility (...) undergoing conservative laparoscopic surgery in our department between January, 2011 and December, 2016. The patients were divided into laparoscopic surgery only group (without any other treatments) and postoperative GnRha therapy group, and the pregnancy outcomes were compared between the two groups at different time points during the follow-up.In cases with moderate or severe endometriosis, laparoscopic surgery with postoperative GnRha therapy was associated with a significantly higher clinical

2019 Nan fang yi ke da xue xue bao = Journal of Southern Medical University

60. Beyond infertility: obstetrical and postpartum complications associated with endometriosis and adenomyosis. Full Text available with Trip Pro

Beyond infertility: obstetrical and postpartum complications associated with endometriosis and adenomyosis. The risk of pregnancy and neonatal complications in women with endometriosis and adenomyosis is debatable. A literature review looking at rates, presentation, and management of spontaneous hemoperitoneum, enlargement, abscess, and rupture of an endometrioma, uterine rupture, and bowel perforation in pregnant women with endometriosis was conducted. Moreover, studies addressing differences (...) in early pregnancy (miscarriage), late pregnancy (gestational diabetes mellitus, preeclampsia, prematurity, placenta previa, placental abruption, cesarean section, hemorrhages) and neonatal outcomes (weight at birth) between endometriosis and adenomyosis patients versus control subjects were reviewed. The overall prevalence of endometriosis-related spontaneous hemoperitoneum in pregnancy is estimated to be ∼0.4%. Only four cases of endometrioma rupture in pregnancy have been reported. Although during

2015 Fertility and Sterility

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