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Adenomyosis

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1. Adenomyosis and Myomata: Risks, Problems, and Complications in Diagnosis and Therapy of Adenomyosis and Myomata (PubMed)

Adenomyosis and Myomata: Risks, Problems, and Complications in Diagnosis and Therapy of Adenomyosis and Myomata 30175136 2018 12 11 2018 12 11 2314-6141 2018 2018 BioMed research international Biomed Res Int Adenomyosis and Myomata: Risks, Problems, and Complications in Diagnosis and Therapy of Adenomyosis and Myomata. 5952460 10.1155/2018/5952460 De Wilde Rudy Leon RL 0000-0001-5759-9745 Department of Gynecology, Obstetrics and Gynecological Oncology, University Hospital for Gynecology, Pius (...) , Frankfurt, Germany. eng Editorial 2018 08 06 United States Biomed Res Int 101600173 0 Receptors, Estrogen IM Adenomyosis classification diagnosis therapy Endometriosis Female Humans Leiomyoma complications diagnosis therapy Myoma complications diagnosis therapy Pregnancy Receptors, Estrogen Uterine Neoplasms complications diagnosis therapy 2018 06 03 2018 06 05 2018 9 4 6 0 2018 9 4 6 0 2018 12 12 6 0 epublish 30175136 10.1155/2018/5952460 PMC6106914

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2018 BioMed research international

2. Short-term effect of acupuncture for adenomyosis: a systematic review and meta-analysis

Short-term effect of acupuncture for adenomyosis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

3. Diagnostic accuracy of non-invasive diagnosis of uterine adenomyosis

Diagnostic accuracy of non-invasive diagnosis of uterine adenomyosis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

4. Chinese herbal medicines for adenomyosis

Chinese herbal medicines for adenomyosis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2019 PROSPERO

5. Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. (PubMed)

Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. Both adenomyosis and endometriosis are characterized by the presence of ectopic endometrial glands and stroma and have been suggested to share some characteristics with malignant tumors. Although accumulating evidence indicates that endometriosis is associated with some cancer types, the cancer risks in patients with adenomyosis have been rarely examined. In this study, we (...) investigated the relationship between adenomyosis and risks of common cancers.This study included a cohort of 12,447 women with adenomyosis but not endometriosis, born in 1951-1984, and a cohort of 124,470 adenomyosis-free women matched by birth year. Their medical records (collected between 1996 and 2011) were obtained from the National Health Insurance Research Database of Taiwan. We first compared the distribution of cancer-free survival (CFS) between cohorts with and without adenomyosis. Subsequently

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2018 PLoS ONE

6. Vaginal Bromocriptine Improves Pain, Menstrual Bleeding and Quality of Life in Women with Adenomyosis; A Pilot study. (PubMed)

Vaginal Bromocriptine Improves Pain, Menstrual Bleeding and Quality of Life in Women with Adenomyosis; A Pilot study. Adenomyosis is a benign uterine disease where endometrial glands and stroma are found within the myometrium surrounded by an area of hypertrophic myometrium. Symptomatology includes heavy menstrual bleeding and pelvic pain. The pathogenesis of adenomyosis is not known; however, animal models have shown increased uterine concentration of prolactin as a risk factor. Prolactin acts (...) as a smooth muscle cell mitogen. If prolactin is central to adenomyosis pathogenesis, reducing uterine prolactin could be a possible medical treatment option. In this pilot study we aim to evaluate the effect of bromocriptine, a prolactin inhibitor, on menstrual bleeding and pain in women with adenomyosis.23 women with diffuse adenomyosis were enrolled from a university hospital in Sweden and a tertiary care center in the United States. 19 patients completed 6 months of treatment with vaginal

2019 Acta Obstetricia et Gynecologica Scandinavica

7. A critical review of recent advances in the diagnosis, classification, and management of uterine adenomyosis. (PubMed)

A critical review of recent advances in the diagnosis, classification, and management of uterine adenomyosis. The purpose of this review is to summarize and highlight recent critical advances in the diagnosis, classification, and management of adenomyosis.Recent studies have clarified the specific mechanism through which adenomyotic lesions invade the underlying myometrium by epithelial-mesenchymal transition. Correlation studies using diagnostic MRI also strongly support the hypothesis (...) of a different pathogenesis between the inner and outer myometrium forms of adenomyosis. Given advances in diagnostic imaging, several international organizations have also highlighted the importance of classification systems for adenomyosis. Finally, selective progesterone receptor modulators and gonadotropin-releasing hormone antagonists have demonstrated significant promise for treating pelvic pain and bleeding associated with adenomyosis, whereas novel fertility-preserving surgical techniques have been

2019 Current Opinion in Obstetrics and Gynecology

8. Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity. (PubMed)

Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity. Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are "innocent bystanders" unrelated to the problem at hand. Although removing an endometrial polyp may be seen as a relatively benign and safe (...) intervention, myomectomy, and in particular adenomyomectomy, can be substantive surgical procedures, associated with their own potential for disrupting fertility. One of the mechanisms thought to be involved when these entities are contributing to infertility is an adverse impact on endometrial receptivity. Indeed polyps, adenomyosis, and leiomyomas have all been associated with an increased likelihood of abnormal endometrial molecular expressions thought to impair implantation and early embryo development

2019 Fertility and Sterility

9. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. (PubMed)

Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. The reproductive impact of adenomyosis and endometriosis is widely researched but the extent of these impacts remains elusive. It has been demonstrated that endometriosis, in particular, is known to result in subfertility but endometriosis and adenomyosis are increasingly linked to late pregnancy complications such as those caused by placental insufficiency (...) . At the molecular level, the presence of ectopic endometrium perturbs the endometrial hormonal, cellular, and immunological milieu, negatively influencing decidualization, placentation, and developmental programming of the embryo. It is unclear if and how such early aberrant reproductive development relates to pregnancy outcomes in endometriosis and adenomyosis.The aims of this systematic review and meta-analysis were to (i) investigate the association of adenomyosis and endometriosis with fertility, obstetric

2019 Human Reproduction Update

10. Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review. (PubMed)

Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review. Adenomyosis commonly occurs with abnormal uterine bleeding (AUB) and is associated with subfertility and a higher miscarriage rate. Recent evidence showed abnormal vascularization in the endometrium in patients with adenomyosis, suggesting a role of angiogenesis in the pathophysiology of AUB and subfertility in adenomyosis and providing a possible treatment target.We hypothesized (...) that the level of abnormal vascularization and expression of angiogenic markers is increased in the ectopic and eutopic endometrium of adenomyosis patients in comparison with the endometrium of control patients. This was investigated through a search of the literature.A systematic search was performed in PubMed and Embase until February 2019. Combinations of terms for angiogenesis and adenomyosis were applied as well as AUB, subfertility or anti-angiogenic therapy. The main search was limited to clinical

2019 Human Reproduction Update

11. Cardiac arrest due to massive hemorrhage from uterine adenomyosis with leiomyoma successfully treated with damage control resuscitation (PubMed)

Cardiac arrest due to massive hemorrhage from uterine adenomyosis with leiomyoma successfully treated with damage control resuscitation A 57-year-old woman was transferred to our emergency department by ambulance with cardiopulmonary arrest caused by massive genital bleeding. Cardiopulmonary resuscitation, including massive transfusion, was carried out and the return of spontaneous circulation was achieved. A giant uterine tumor was considered the source of the bleeding. Although hysterectomy

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2016 Acute medicine & surgery

12. Heavy menstrual bleeding and dysmenorrhea are improved by Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of adenomyosis (PubMed)

Heavy menstrual bleeding and dysmenorrhea are improved by Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of adenomyosis To assess reduction in heavy menstrual bleeding and dysmenorrhea following MRI guided Focused Ultrasound Surgery (MRgFUS) of focal and diffuse adenomyosis up to 12 months post-treatment a retrospective cohort study was done at a tertiary care academic medical center for obstetrics, gynecology and infertility.MRgFUS for adenomyosis uterus was done for thirty (...) -seven patients presenting with symptoms of heavy menstrual bleeding and dysmenorrhea with MRI-suspected adenomyosis. The main outcome measure, was reduction in heavy menstrual bleeding, dysmenorrhea and Symptom Severity Scoring (SSS) over a 3, 6 and 12 month period. Secondary outcome was evidence of fertility preservation post procedure. D'Agostino & Pearson omnibus normality test, one-way Ananova, Pearson's correlation coefficient analysis was performed on the data. Statistical significances, p

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2016 Fertility research and practice

13. Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis. (PubMed)

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis. To explore the expression level of Nrf2 in adenomyosis and study the mechanism of abnormal expression of Nrf2 in the pathogenesis of adenomyosis.Western blot, immunohistochemistry(IHC) and real time PCR were used to measure Nrf2 expression levels in tissue and cell samples. Knockdown and overexpression of Nrf2 were used to investigate the variation of migration ability of endometrial (...) glandular cells as well as the regulatory mechanism.Nrf2 protein levels were significantly higher in the eutopic and ectopic endometrial glands when compared with control cases using IHC and western blot methods. (p< 0.05). However, there was no statistical difference in Nrf2 mRNA expression levels between the adenomyosis and control groups. Using an agonist and Nrf2 siRNA, we regulated the Nrf2 protein levels of primary cultured endometrial glandular cells. With increased expression of Nrf2, cell

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2017 PLoS ONE

14. Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium. (PubMed)

Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium. To estimate the phenotypic characterization of fibrotic process in adenomyosis occurring at the inner or the outer myometrium.Eight cases of adenomyosis occurring at the inner myometrium (Subtype I) and 10 cases of adenomyosis occurring at the outer myometrium (Subtype II), and 10 normal counterparts were used in this study. A immunohistochemical study for smooth muscle cells (SMCs) was performed using (...) , and MHC commonly showed a negative staining at the adjacent area to the glands. A significant staining of Non-muscle myosin IIB, TGF-β, and phosphorylated TGF-β type I receptors were found only at the SMCs of Subtype II adenomyosis. The Smad3/2 ratio of Subtype II adenomyosis was significantly higher than that of Subtype I.The inner myometrium of normal uteri was composed of undifferentiated phenotypes of SMCs, while the outer myometrium was composed of terminally differentiated SMCs. Various fibrotic

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2017 PLoS ONE

15. Eutopic/ectopic endometrial apoptosis initiated by bilateral uterine artery occlusion: A new therapeutic mechanism for uterus-sparing surgery in adenomyosis. (PubMed)

Eutopic/ectopic endometrial apoptosis initiated by bilateral uterine artery occlusion: A new therapeutic mechanism for uterus-sparing surgery in adenomyosis. The objective of the present study was to investigate differences in the expression of apoptosis-related factors in the eutopic and ectopic endometrium (EuE/EE) in women with adenomyosis before and after laparoscopic bilateral uterine artery occlusion (LUAO). Ten patients with uterine adenomyosis who received LUAO were selected (...) as the research subjects, from whom EuE and EE tissues were obtained before and after LUAO and detected for the expression of apoptosis-related molecules in EuE and EE by PT-PCR and Western blot, and changes in the mitochondrial structure by electron microscopy. Normal endometrial stromal cells (NESC), and EuE/EE stromal cells in women with adenomyosis were cultured in a 1% O2, 5% CO2 incubator to establish a physical anoxia state in an in vitro stromal cell model. The expression of apoptosis-related

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2017 PLoS ONE

16. Clinical Usefulness of the Microbubble Contrast Agent SonoVue in Enhancing the Effects of High-Intensity Focused Ultrasound for the Treatment of Adenomyosis. (PubMed)

Clinical Usefulness of the Microbubble Contrast Agent SonoVue in Enhancing the Effects of High-Intensity Focused Ultrasound for the Treatment of Adenomyosis. To evaluate the clinical usefulness of the microbubble contrast agent SonoVue in enhancing high-intensity focused ultrasound (HIFU) for the treatment of adenomyosis.A total of 102 patients with adenomyosis, assessed from August 2015 to April 2017, were randomly divided into 1-minute (A) and 10-minute (B) groups, respectively. In groups

2018 Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

17. Incarceration of early gravid uterus with adenomyosis and myoma: report of two patients managed with uterine reduction (PubMed)

Incarceration of early gravid uterus with adenomyosis and myoma: report of two patients managed with uterine reduction Although gravid uterine incarceration is typically diagnosed during the early second trimester, we encountered two unusual cases in early pregnancy. A 34-year-old multiparous woman with adenomyosis presented at 7 + 2 weeks of gestation with increased urinary frequency and a sensation of incomplete bladder emptying. The uterine incarceration was successfully reduced by manual

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2018 Obstetrics & gynecology science

18. Ultrasound diagnosis of endometriosis and adenomyosis: State of the art. (PubMed)

Ultrasound diagnosis of endometriosis and adenomyosis: State of the art. Transvaginal ultrasonography has become the primary test in the diagnosis of pelvic endometriosis and adenomyosis. A review of the literature on the diagnostic accuracy of ultrasonography in pelvic endometriosis and adenomyosis, as well as a comparison with magnetic resonance imaging, will be presented. Criteria for diagnosis of an endometrioma according to robust prospective data together with guidelines as to adequate (...) reporting of the location of deep infiltrating endometriosis will be given. The sonographic features of adenomyosis including the differential diagnosis between focal adenomyosis and a uterine fibroid are reviewed. The available data in the literature on ultrasound diagnosis of pelvic endometriosis and adenomyosis, their clinical relevance, and their limitations are discussed.Copyright © 2018. Published by Elsevier Ltd.

2018 Best practice & research. Clinical obstetrics & gynaecology

19. Adenomyosis: Genomic Mechanisms and Biological Response

Adenomyosis: Genomic Mechanisms and Biological Response Adenomyosis: Genomic Mechanisms and Biological Response - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Adenomyosis: Genomic Mechanisms and Biological (...) Medical Center Information provided by (Responsible Party): Kinberly Kho, University of Texas Southwestern Medical Center Study Details Study Description Go to Brief Summary: Examination of genomic and biologic responses to LNG-IUS in patients with adenomyosis. Condition or disease Intervention/treatment Adenomyosis Abnormal Uterine Bleeding Drug: LNG-IUS Detailed Description: Examination of genomic and biologic responses to LNG-IUS in patients with adenomyosis. Study Design Go to Layout table

2018 Clinical Trials

20. A Multi-omics Study of Adenomyosis

A Multi-omics Study of Adenomyosis A Multi-omics Study of Adenomyosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Multi-omics Study of Adenomyosis The safety and scientific validity of this study (...) Study Description Go to Brief Summary: This study aims to analyze the multi-omics results between eutopic endometrium, adenomyosis and endometriosis of patients diagnosed of adenomyosis with and without endometriosis. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the pathogenesis of adenomyosis. Condition or disease Intervention/treatment Adenomyosis Endometriosis Ectopic Endometrium Eutopic Endometrium

2018 Clinical Trials

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