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Adenomyosis

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1. Recommendations for surgical treatment of endometriosis. Part 1: Ovarian Endometrioma Full Text available with Trip Pro

. The endoscopic localization of endometrial implants in the ovarian chocolate cyst . Fertil Steril 1994 ; 61 : 1034 – 1038 . Burney RO , Giudice LC . Pathogenesis and pathophysiology of endometriosis . Fertil Steril 2012 ; 98 : 511 – 519 . Busacca M , Vignali M . Ovarian endometriosis: from pathogenesis to surgical treatment . Curr Opin Obstet Gynecol 2003 ; 15 : 321 – 326 . Chapron C , Pietin-Vialle C , Borghese B , Davy C , Foulot H , Chopin N . Associated ovarian endometrioma is a marker for greater (...) Recommendations for surgical treatment of endometriosis. Part 1: Ovarian Endometrioma We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Recommendations for the Surgical Treatment of Endometriosis. Part 1: Ovarian Endometrioma†‡¶ | Human Reproduction Open | Oxford Academic Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter

2018 European Society of Human Reproduction and Embryology

2. Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. (Abstract)

Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. What is the physiological role of transforming growth factor-beta (TGF-β1) and syndecans (SDC1, SDC4) in endometriotic cells in women with endometriosis?We observed an abnormal, pro-invasive phenotype in a subgroup of samples with ovarian endometriosis, which was reversed by combining gene silencing of SDC1 with the TGF-β1 treatment.Women with endometriosis express high (...) levels of TGF-β1 and the proteoglycan co-receptors SDC1 and SDC4 within endometriotic cysts. However, how SDC1 and SDC4 expression is regulated by TGF-β1 and the physiological significance of the high expression in endometriotic cysts remains unknown as does the potential role in disease severity.We utilized a pre-validated panel of stem- and cancer cell-associated markers on endometriotic tissue (n = 15) to stratify subgroups of women with endometriosis. Furthermore, CD90+CD73+CD105+ (SC

2020 Human Reproduction

3. Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: an observational clinical study. Full Text available with Trip Pro

Lesion distribution characteristics of deep infiltrating endometriosis with ovarian endometrioma: an observational clinical study. To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM).The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal (...) of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Clinical data were recorded for each patient from medical, operative and pathological reports. Patients were then divided into two groups according to unilateral or bilateral OEM. Patients with unilateral OEM were subsequently divided into two subgroups according to OEM location (left- or right-hand side) and the diameter of the OEM (≤50 and > 50 mm). The distribution

2020 BMC Women's Health

4. Focal adenomyosis of the outer myometrium and deep infiltrating endometriosis severity. (Abstract)

Focal adenomyosis of the outer myometrium and deep infiltrating endometriosis severity. To determine whether the presence of focal adenomyosis of the outer myometrium (FAOM) at preoperative magnetic resonance imaging is associated with the severity of deep infiltrating endometriosis.Observational cross-sectional study involving 255 symptomatic deep infiltrating endometriosis patients. Comparisons were performed according to the presence of FAOM.University hospital.Women with a preoperative (...) magnetic resonance imaging and complete surgical exeresis of endometriotic lesions with histologically documented deep infiltrating endometriosis.Surgical management for deep infiltrating endometriosis.The presence of multiple deep infiltrating endometriosis lesions, the mean number and location of deep infiltrating endometriosis lesions, and the mean total revised American Society for Reproductive Medicine scores.The prevalence of FAOM at preoperative magnetic resonance imaging in the 255 patients

2020 Fertility and Sterility

5. Malignant risk of pelvic mass after hysterectomy for adenomyosis or endometriosis. Full Text available with Trip Pro

Malignant risk of pelvic mass after hysterectomy for adenomyosis or endometriosis. Pelvic mass onset following a hysterectomy due to benign disease is not rarely seen. Appropriate diagnosis and treatment are of great importance.This study aims to analyze the clinicopathological features of patients who have received surgery for pelvic mass following hysterectomy due to gynecological benign disease, especially endometriosis or adenomyosis.This study retrospectively analyzed the patients (...) undergone reoperation for pelvic mass subsequently to hysterectomy from January 2012 to December 2016 in a tertiary teaching hospital.A total of 247 patients were enrolled in this study. There is a significant difference between the patients with or without a history of endometriosis/adenomyosis. Multivariate analysis showed that the pelvic mass had a higher risk of being ovarian endometrioid carcinoma, ovarian clear cell carcinoma, ovarian endometriosis, and ovarian physiological cysts in patients

2020 Medicine

6. Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. Full Text available with Trip Pro

Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female (...) patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1

2018 PLoS ONE

7. Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study. Full Text available with Trip Pro

Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study. To compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China.A subgroup analysis of factors associated with DIE versus OMA was performed in Chinese women from the FEELING study. This study included 156 OMA patients and 78 DIE patients. Retrospective information (...) stress were major factors that are associated with the diagnosis of OMA.The findings provide additional information on the potential risk factors that are associated with DIE, compared with OMA among Chinese endometriosis patients. The results may help to better understand DIE versus OMA, and aid in earlier risk stratification and diagnosis of the patients.NCT01351051 . Registered 10 May 2011.

2018 BMC Women's Health

8. Endometriosis, endometrioma, and ART results: Current understanding and recommended practices. (Abstract)

Endometriosis, endometrioma, and ART results: Current understanding and recommended practices. Endometriosis and infertility are linked in a complex relationship, and a number of different pathogenetic mechanisms may associate the two. Endometriosis is diagnosed in 6-8% of women undergoing ART. Women with endometriosis appear to have similar ART outcomes compared to controls in terms of live birth rates, despite a lower oocyte quality. Laparoscopy should not be routinely performed before ART (...) with the only aim to diagnose mild or moderate endometriosis, but if the latter is found, surgical removal can be considered, as it might improve pregnancy rates. In case of more severe forms of the disease (endometrioma and deep infiltrating endometriosis), the benefits of surgery before ART are uncertain and must be balanced against risks. Management decisions should be individualized based on patient choice, age, associated symptoms, and the risk of repeat surgery.Copyright © 2018. Published by Elsevier

2018 Best practice & research. Clinical obstetrics & gynaecology

9. Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report Full Text available with Trip Pro

Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report Dienogest (DNG) is considered to be effective against ovarian endometrioma (OMA). We report a rare case of OMA transformation to ovarian cancer during long-term endometriosis treatment with a periodic administration of a gonadotropin-releasing hormone agonist (Gn-RH agonist) and DNG. The patient was a 41-year-old Japanese woman. OMA and adenomyosis of the uterus were revealed via computed

2018 Case reports in obstetrics and gynecology

10. Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis. Full Text available with Trip Pro

in paired-endometrium and -endometrioma tissue samples from another cohort (Tissue cohort, n = 19) of endometriosis patients.Paired-endometrial and -endometriotic biopsies were obtained from women with endometriosis (ASRM stage III-IV) undergoing laparoscopic surgery. Control endometria were obtained from healthy volunteers. Isolated CD73+CD90+CD105+ SC were evaluated for the presence of known endometrial surface markers, colony forming efficiency, multi-lineage differentiation, cell cycle distribution (...) Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis. Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)?We identified aberrant gene expression signatures associated with malignant transformation in a small subgroup of women with ovarian endometriosis.Epidemiological studies have shown an increased risk of EAOC in women with ovarian endometriosis

2018 Human Reproduction

11. Miscarriage risk on Endometriosis and Adenomyosis in Women With Spontaneous Conception or Using Assisted Reproductive Technology: A Systematic Review and Meta-Analysis

Miscarriage risk on Endometriosis and Adenomyosis in Women With Spontaneous Conception or Using Assisted Reproductive Technology: A Systematic Review and Meta-Analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2020 PROSPERO

12. Ultrasound diagnosis of endometriosis and adenomyosis: State of the art. (Abstract)

Ultrasound diagnosis of endometriosis and adenomyosis: State of the art. Transvaginal ultrasonography has become the primary test in the diagnosis of pelvic endometriosis and adenomyosis. A review of the literature on the diagnostic accuracy of ultrasonography in pelvic endometriosis and adenomyosis, as well as a comparison with magnetic resonance imaging, will be presented. Criteria for diagnosis of an endometrioma according to robust prospective data together with guidelines as to adequate (...) reporting of the location of deep infiltrating endometriosis will be given. The sonographic features of adenomyosis including the differential diagnosis between focal adenomyosis and a uterine fibroid are reviewed. The available data in the literature on ultrasound diagnosis of pelvic endometriosis and adenomyosis, their clinical relevance, and their limitations are discussed.Copyright © 2018. Published by Elsevier Ltd.

2018 Best practice & research. Clinical obstetrics & gynaecology

14. Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? Full Text available with Trip Pro

Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did report how they foundered, the reasons why they failed are often completely unclear. Surprisingly, there has been no open discussion on why these trials failed. If the causes (...) their publication status using trial identifiers. For trials that were completed at least 2 years ago and have, or have not, published their results, a PubMed search was performed using the name of the therapeutic that has been tested and 'endometriosis' or 'adenomyosis' to identify published preclinical studies prior to the launch of the trial. For those published trials, the cited preclinical studies were also retrieved and scrutinized.Despite repeated calls for more transparency, only a small fraction

2018 Human Reproduction Update

15. Effects of pelvic endometriosis and adenomyosis on ciliary beat frequency and muscular contractions in the human fallopian tube Full Text available with Trip Pro

Effects of pelvic endometriosis and adenomyosis on ciliary beat frequency and muscular contractions in the human fallopian tube Pelvic endometriosis (EM) and adenomyosis (AM) have different effects on the fallopian tube. This study aimed to assess the transport capability of the fallopian tube in women with pelvic EM or AM.Twenty women with uterine leiomyoma (control group), 20 with adenomyosis without pelvic EM (AM group) and 35 with pelvic EM without AM (EM group) were included. EM cases were

2018 Reproductive biology and endocrinology : RB&E

16. Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis

in women with endometrioma, deep infiltrating endometriosis, and/or adenomyosis. Condition or disease Intervention/treatment Phase Endometriosis Drug: Quinagolide 1080 µg Drug: Placebo Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 72 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Randomised, Double-blind (...) , Placebo-controlled, Proof-of-mechanism Phase 2 Trial Investigating the Effect of Quinagolide Extended-release Vaginal Ring on Reduction of Lesions Assessed by High-resolution Magnetic Resonance Imaging in Women With Endometrioma, Deep Infiltrating Endometriosis, and/or Adenomyosis Estimated Study Start Date : May 2019 Estimated Primary Completion Date : November 2020 Estimated Study Completion Date : December 2020 Resource links provided by the National Library of Medicine related topics: Arms

2018 Clinical Trials

17. Spontaneous fertility after expectant or surgical management of rectovaginal endometriosis in women with or without ovarian endometrioma: a retrospective analysis. Full Text available with Trip Pro

Spontaneous fertility after expectant or surgical management of rectovaginal endometriosis in women with or without ovarian endometrioma: a retrospective analysis. To investigate spontaneous pregnancy rate (SPRs) of women with rectovaginal endometriosis (RV) with/without ovarian endometrioma (OMA) and treated with the use of expectant or surgical management.Retrospective study.University hospital.The study included patients with RV with or without OMA who tried to conceive spontaneously for 1

2017 Fertility and Sterility

18. The impact of endometriosis on early pregnancy and that of pregnancy on endometriomas. A systemic review and meta-analysis.

The impact of endometriosis on early pregnancy and that of pregnancy on endometriomas. A systemic review and meta-analysis. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

19. Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis

Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

20. Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Full Text available with Trip Pro

Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. What is the relationship between endometriosis phenotypes superficial peritoneal endometriosis (SUP), ovarian endometrioma (OMA), deep infiltrating endometriosis (DIE) and the adenomyosis appearance by magnetic resonance imaging (MRI)?Focal adenomyosis located in the outer myometrium (FAOM) was observed more frequently in women with endometriosis, and was significantly associated (...) with the DIE phenotype.An association between endometriosis and adenomyosis has been reported previously, although data regarding the association between MRI appearance of adenomyosis and the endometriosis phenotype are currently still lacking.This was an observational, cross-sectional study using data prospectively collected from non-pregnant patients who were between 18 and 42 years of age, and who underwent surgery for symptomatic benign gynecological conditions between January 2011 and December 2014

2017 Human Reproduction

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