How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

264 results for

Adamantane

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Influenza (Follow-up)

cough suppressants and expectorants to treat the cough. Steam inhalations may also be useful. If dehydration occurs, administration of oral or intravenous fluids is indicated. Previous Next: Antiviral Therapy Antiviral agents available for influenza treatment and/or prevention include neuraminidase inhibitors (oseltamivir, peramivir, zanamivir) and the cap-dependent endonuclease inhibitor (baloxavir marboxil). [ , , , ] The use of adamantanes, such as amantadine, has not been recommended since (...) the 2005-2006 influenza season owing to resistance among influenza A viruses. [ ] The use of adamantanes, such as amantadine, has not been recommended since the 2005-2006 influenza season owing to resistance among influenza A viruses. The Infectious Disease Society of America (IDSA) Guidelines for Antiviral Therapy IDSA latest guidelines for antiviral therapy are as follows: [ ] High risk individuals Clinicians should initiate antivirals as soon as possible for adults and children with documented

2014 eMedicine Pediatrics

162. Pediatrics, Pneumonia (Follow-up)

(oseltamivir [Tamiflu], zanamivir, amantadine, rimantadine) are approved for treatment and chemoprophylaxis of influenza. Influenza A pneumonia that is particularly severe or when it occurs in a high-risk patient may be treated with zanamivir or oseltamivir. The neuraminidase inhibitors have activity against influenza A and B viruses, whereas the adamantanes have activity against only influenza A viruses. Check for resistance patterns for other antiviral agents indicated for treatment or chemoprophylaxis (...) of influenza. Since January 2006, the neuraminidase inhibitors (oseltamivir, zanamivir) have been the only recommended influenza antiviral drugs because of widespread resistance to the adamantanes (amantadine, rimantadine) among influenza A (H3N2) virus strains. In 2007-08, a significant increase in the prevalence of oseltamivir resistance was reported among influenza A (H1N1) viruses worldwide. During the 2007-08 influenza season, 10.9% of H1N1 viruses tested in the United States were resistant

2014 eMedicine Emergency Medicine

163. Point-of-Care influenza diagnostic tests

recovery (Harper et al 2002). There are currently four drugs available to treat influenza. These include the adamantanes (amantadine and rimantadine) and the neuraminidase inhibitors (oseltamivir and zanamivir). Adamantanes are active against influenza A but not influenza B. Adamantanes are no longer recommended for use in the United States due to the recent emergence of resistance to these drugs, which has rendered them ineffective. The neuraminidase inhibitors are effective in treating influenza

2008 Australia and New Zealand Horizon Scanning Network

164. A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated MiTF and tyrosinase expression. (PubMed)

A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated MiTF and tyrosinase expression. Melanogenesis is essential for the protection of skin against UV, but excessive production of melanin causes unaesthetic hyperpigmentation. Much effort is being made to develop effective depigmenting agents. Here, we found that a tyrosinase inhibitor, AP736 (5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide) potently

Full Text available with Trip Pro

2013 Experimental Dermatology

165. Outbreak of Variant Influenza A (H3N2v) Virus in the United States. (PubMed)

to illness. We identified 15 cases of possible person-to-person transmission of H3N2v. Viruses recovered from patients were 93%-100% identical and similar to viruses recovered from previous cases of H3N2v. All H3N2v viruses examined were susceptible to oseltamivir and zanamivir and resistant to adamantane antiviral medications.In a large outbreak of variant influenza, the majority of infected persons reported exposures, suggesting that swine contact at an agricultural fair was a risk for H3N2v infection

Full Text available with Trip Pro

2013 Clinical Infectious Diseases

166. Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus. (PubMed)

hyperglycemia exacerbates cerebral injury by upregulating sEH and decreasing brain EET levels. Type 1 diabetes mellitus was modeled by streptozotocin (STZ; 50 mg/kg per day intraperitoneally, 5 days) in male mice. At 4 weeks, STZ-treated and control mice underwent 45-minute middle cerebral artery occlusion (MCAO) with or without sEH blockade by trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB; 1 mg/kg intraperitoneally daily for 6 days before MCAO). The STZ-treated mice had increased

Full Text available with Trip Pro

2013 Journal of Cerebral Blood Flow and Metabolism

167. Spread of Influenza A(H1N1) oseltamivir-resistant viruses in Africa in 2008 confirmed by multiple introductions in Senegal. (PubMed)

binding to its target. Same phenomenon is reported for adamantanes drugs and mutations in the M2 channel protein gene of Influenza viruses.Reverse-Transcription/Restriction Fragment Length Polymorphism (RT-PCR/RFLP) method, phenotypic testing for oseltamivir resistance, and sequencing of NA, HA and M2 genes were used in this study. Phylogenetic analyses were performed using BioEdit and Mega 5 softwares for alignment of sequences and phylogenetic trees building respectively.Using a simple RT-PCR/RFLP (...) method, we found that the 86 seasonal A(H1N1) isolates from 2008 bear the oseltamivir resistance-associated mutation (H274Y) in the NA gene. In contrast all isolates isolated in Senegal in 2007 were sensitive to oseltamivir. These results were first confirmed by finding high IC50 values using a phenotypic testing for oseltamivir resistance, and secondly by sequencing the whole NA gene. Regarding M2 gene, no mutation associated to adamantanes resistance was characterized of the isolates.The present

Full Text available with Trip Pro

2013 BMC Infectious Diseases

168. In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. (PubMed)

Ca²⁺-ATPase of Plasmodium falciparum (PfATP6). In the present study the type of interaction between thapsigargin and artemisinin derivatives as well as the ozonide OZ277 (RBx11160 or arterolane) was evaluated in parasite cultures. The latter compound is an adamantane-based peroxide and the first fully synthetic clinical candidate recently registered in India by Ranbaxy Laboratories Ltd. for anti-malarial combination therapy.Drug interaction studies were performed using a previously described

Full Text available with Trip Pro

2013 Malaria journal

169. Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME. (PubMed)

-carbinol (I3C) in Cyp1a1-Ren-2 transgenic rats. Blood pressure (BP) was monitored by radiotelemetry and treatment with the sEH inhibitor [cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoic acid (c-AUCB)] was started 48 h before administration of the diet containing I3C. In separate groups of rats, combined administration of the sEH inhibitor and the nonspecific NO synthase inhibitor [Nω-nitro-L-arginine methyl ester (L-NAME)] on the course of BP in I3C-induced and noninduced rats were evaluated

Full Text available with Trip Pro

2013 Journal of Hypertension

170. Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082 (PubMed)

inhibition. Diabetes Care 2012;35:2076-2082. e80 10.2337/dc12-2220 Makdissi Antoine A Chaudhuri Ajay A Kuhadiya Nitesh N Batra Manav M Dandona Paresh P eng Letter Comment United States Diabetes Care 7805975 0149-5992 0 Blood Glucose 0 Dipeptidyl-Peptidase IV Inhibitors 0 Nitriles 0 Pyrazines 0 Pyrrolidines 0 Triazoles PJY633525U Adamantane IM Diabetes Care. 2012 Oct;35(10):2076-82 22688551 Adamantane analogs & derivatives Blood Glucose drug effects Diabetes Mellitus, Type 2 drug therapy Dipeptidyl

Full Text available with Trip Pro

2013 Diabetes Care

171. Influenza outbreak control practices and the effectiveness of interventions in long-term care facilities: a systematic review. (PubMed)

on ILI attack rates.Of 654 articles identified in the literature review, 37 articles describing 60 influenza outbreaks met the inclusion criteria. Individuals in facilities where chemoprophylaxis was used were significantly less likely to develop influenza A or B than those in facilities with no interventions [odds ratio (OR) 0·48, 95% CI: 0·28, 0·84]. Considered by drug class, adamantanes significantly reduced infection risk (OR 0·22, 95% CI: 0·12, 0·42), while neuraminidase inhibitors did not show

Full Text available with Trip Pro

2013 Influenza and other respiratory viruses

172. Effects of Trehalose Polycation End-group Functionalization on Plasmid DNA Uptake and Transfection (PubMed)

Effects of Trehalose Polycation End-group Functionalization on Plasmid DNA Uptake and Transfection In this study, we have synthesized six analogs of a trehalose-pentaethylenehexamine glycopolymer (Tr4) that contain (1A) adamantane, (1B) carboxy, (1C) alkynyl-oligoethyleneamine, (1D) azido trehalose, (1E) octyl, or (1F) oligoethyleneamine end groups and evaluated the effects of polymer end group chemistry on the ability of these systems to bind, compact, and deliver pDNA to cultured HeLa cells

Full Text available with Trip Pro

2012 Biomacromolecules

173. Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets (PubMed)

+), the quinuclidine's cationic center interacts with PPi and three Mg(2+), mimicking a transition state involved in diphosphate ionization. With 3, there are again two structures. In one, the geranyl side chain binds to either S1 or S2 and the adamantane headgroup binds to S1. In the second, the side chain binds to S2 while the headgroup binds to S1. These results provide structural clues for the mechanism and inhibition of the head-to-head prenyl transferases and should aid future drug design.

Full Text available with Trip Pro

2012 Journal of medicinal chemistry

174. Soluble Epoxide Hydrolase Gene Deficiency or Inhibition Attenuates Chronic Active Inflammatory bowel disease in IL-10(−/−) Mice (PubMed)

of IBD in IL-10(-/-) mice.Either the small molecule sEH inhibitor trans/-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) or sEH knockout mice were used in combination with IL-10(-/-) mice. t-AUCB was administered to mice in drinking fluid. Extensive histopathologic, immunochemical, and biochemical analyses were performed to evaluate effect of sEH inhibition or deficiency on chronic active inflammation and related mechanism in the bowel.Compared to IL-10 (-/-) mice, sEH inhibition

Full Text available with Trip Pro

2012 Digestive diseases and sciences

175. Development of a Low Toxicity, Effective pDNA Vector Based on Non-covalent Assembly of Bioresponsive Amino-β-Cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes (PubMed)

Development of a Low Toxicity, Effective pDNA Vector Based on Non-covalent Assembly of Bioresponsive Amino-β-Cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes A host:guest-derived gene delivery vector has been developed, based on the self-assembly of cationic β-CD derivatives with a poly(vinyl alcohol) (MW 27 kDa) (PVA) main chain polymer bearing poly(ethylene glycol) (MW 750) (PEG) or MW 2000 PEG and acid-labile adamantane-modified (Ad) grafts through

Full Text available with Trip Pro

2012 Bioconjugate chemistry

176. On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1 (PubMed)

On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1 Successfully forming ligand-protein complexes with specific compounds can be a significant challenge in supporting structure-based drug design for a given protein target. In this respect, an on-column ligand- and detergent-exchange method was developed to obtain ligand-protein complexes of an adamantane series of compounds with 11β-hydroxysteroid dehydrogenase type 1 (11β

Full Text available with Trip Pro

2012 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

177. Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling (PubMed)

spectroscopy experiments on drug-induced conformational changes of the M2 protein embedded in lipid bilayers. We obtained data in the presence of adamantane drugs for two different M2 constructs (M2TM 22-46 and M2TMC 23-60). M2TM peptides were spin labeled at the N-terminal end of the transmembrane domain. M2TMC peptides were spin labeled site specifically at cysteine residues substituted for amino acids within the transmembrane domain (L36, I39, I42, and L43) and the C-terminal amphipathic helix (L46, F47 (...) , F48, C50, I51, Y52, R53, F54, F55, and E56). Addition of adamantane drugs brought about significant changes in measured electron paramagnetic resonance spectroscopy environmental parameters consistent with narrowing of the transmembrane channel pore and closer packing of the C-terminal amphipathic helices.Copyright © 2012 The Protein Society.

Full Text available with Trip Pro

2012 Protein science : a publication of the Protein Society

178. Mannose-decorated cyclodextrin vesicles: The interplay of multivalency and surface density in lectin–carbohydrate recognition (PubMed)

Mannose-decorated cyclodextrin vesicles: The interplay of multivalency and surface density in lectin–carbohydrate recognition Cyclodextrin vesicles are versatile models for biological cell membranes since they provide a bilayer membrane that can easily be modified by host-guest interactions with functional guest molecules. In this article, we investigate the multivalent interaction of the lectin concanavalin A (ConA) with cyclodextrin vesicles decorated with mannose-adamantane conjugates (...) with one, two or three adamantane units as well as one or two mannose units. The carbohydrate-lectin interaction in this artificial, self-assembled glycocalyx was monitored in an agglutination assay by the increase of optical density at 400 nm. It was found that there is a close relation between the carbohydrate density at the cyclodextrin vesicle surface and the multivalent interaction with ConA, and the most efficient interaction (i.e., fastest agglutination at lowest concentration) was observed

Full Text available with Trip Pro

2012 Beilstein journal of organic chemistry

179. Response to Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082 (PubMed)

of dipeptidyl peptidase-IV inhibition. Diabetes Care 2012;35:2076-2082. e13 10.2337/dc12-1436 Rizzo Maria Rosaria MR Barbieri Michelangela M Marfella Raffaele R Paolisso Giuseppe G eng Letter Comment United States Diabetes Care 7805975 0149-5992 0 Blood Glucose 0 Dipeptidyl-Peptidase IV Inhibitors 0 Nitriles 0 Pyrazines 0 Pyrrolidines 0 Triazoles PJY633525U Adamantane IM Diabetes Care. 2012 Oct;35(10):2076-82 22688551 Diabetes Care. 2013 Jan;36(1):e12 23264295 Adamantane analogs & derivatives Blood Glucose

Full Text available with Trip Pro

2012 Diabetes Care

180. The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with Type 2 diabetes. (PubMed)

England Diabet Med 8500858 0742-3071 0 Biomarkers 0 Chylomicron Remnants 0 Dipeptidyl-Peptidase IV Inhibitors 0 Hypolipidemic Agents 0 Lipoproteins, LDL 0 Nitriles 0 Pyrrolidines 0 Triglycerides I6B4B2U96P Vildagliptin PJY633525U Adamantane IM Adamantane analogs & derivatives therapeutic use Biomarkers blood chemistry Chylomicron Remnants blood chemistry Diabetes Mellitus, Type 2 blood drug therapy Diet, High-Fat adverse effects Dipeptidyl-Peptidase IV Inhibitors therapeutic use Humans Hyperglycemia

2012 Diabetic Medicine

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>