How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

260 results for

Adamantane

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus. Full Text available with Trip Pro

hyperglycemia exacerbates cerebral injury by upregulating sEH and decreasing brain EET levels. Type 1 diabetes mellitus was modeled by streptozotocin (STZ; 50 mg/kg per day intraperitoneally, 5 days) in male mice. At 4 weeks, STZ-treated and control mice underwent 45-minute middle cerebral artery occlusion (MCAO) with or without sEH blockade by trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB; 1 mg/kg intraperitoneally daily for 6 days before MCAO). The STZ-treated mice had increased

2013 Journal of Cerebral Blood Flow and Metabolism

162. Spread of Influenza A(H1N1) oseltamivir-resistant viruses in Africa in 2008 confirmed by multiple introductions in Senegal. Full Text available with Trip Pro

binding to its target. Same phenomenon is reported for adamantanes drugs and mutations in the M2 channel protein gene of Influenza viruses.Reverse-Transcription/Restriction Fragment Length Polymorphism (RT-PCR/RFLP) method, phenotypic testing for oseltamivir resistance, and sequencing of NA, HA and M2 genes were used in this study. Phylogenetic analyses were performed using BioEdit and Mega 5 softwares for alignment of sequences and phylogenetic trees building respectively.Using a simple RT-PCR/RFLP (...) method, we found that the 86 seasonal A(H1N1) isolates from 2008 bear the oseltamivir resistance-associated mutation (H274Y) in the NA gene. In contrast all isolates isolated in Senegal in 2007 were sensitive to oseltamivir. These results were first confirmed by finding high IC50 values using a phenotypic testing for oseltamivir resistance, and secondly by sequencing the whole NA gene. Regarding M2 gene, no mutation associated to adamantanes resistance was characterized of the isolates.The present

2013 BMC Infectious Diseases

163. Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082 Full Text available with Trip Pro

inhibition. Diabetes Care 2012;35:2076-2082. e80 10.2337/dc12-2220 Makdissi Antoine A Chaudhuri Ajay A Kuhadiya Nitesh N Batra Manav M Dandona Paresh P eng Letter Comment United States Diabetes Care 7805975 0149-5992 0 Blood Glucose 0 Dipeptidyl-Peptidase IV Inhibitors 0 Nitriles 0 Pyrazines 0 Pyrrolidines 0 Triazoles PJY633525U Adamantane IM Diabetes Care. 2012 Oct;35(10):2076-82 22688551 Adamantane analogs & derivatives Blood Glucose drug effects Diabetes Mellitus, Type 2 drug therapy Dipeptidyl

2013 Diabetes Care

164. In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. Full Text available with Trip Pro

Ca²⁺-ATPase of Plasmodium falciparum (PfATP6). In the present study the type of interaction between thapsigargin and artemisinin derivatives as well as the ozonide OZ277 (RBx11160 or arterolane) was evaluated in parasite cultures. The latter compound is an adamantane-based peroxide and the first fully synthetic clinical candidate recently registered in India by Ranbaxy Laboratories Ltd. for anti-malarial combination therapy.Drug interaction studies were performed using a previously described

2013 Malaria journal

165. Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME. Full Text available with Trip Pro

-carbinol (I3C) in Cyp1a1-Ren-2 transgenic rats. Blood pressure (BP) was monitored by radiotelemetry and treatment with the sEH inhibitor [cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoic acid (c-AUCB)] was started 48 h before administration of the diet containing I3C. In separate groups of rats, combined administration of the sEH inhibitor and the nonspecific NO synthase inhibitor [Nω-nitro-L-arginine methyl ester (L-NAME)] on the course of BP in I3C-induced and noninduced rats were evaluated

2013 Journal of Hypertension

166. Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082 Full Text available with Trip Pro

inhibition. Diabetes Care 2012;35:2076-2082. e12 10.2337/dc12-1218 Devries J Hans JH eng Letter Comment United States Diabetes Care 7805975 0149-5992 0 Blood Glucose 0 Dipeptidyl-Peptidase IV Inhibitors 0 Nitriles 0 Pyrazines 0 Pyrrolidines 0 Triazoles PJY633525U Adamantane IM Diabetes Care. 2012 Oct;35(10):2076-82 22688551 Diabetes Care. 2013 Jan;36(1):e13 23264296 Adamantane analogs & derivatives Blood Glucose drug effects Diabetes Mellitus, Type 2 drug therapy Dipeptidyl-Peptidase IV Inhibitors

2012 Diabetes Care

167. Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ Full Text available with Trip Pro

-adamantan-1-yl-ureido) dodecanoic acid (AUDA; 10 μM) or trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB, sEH-inhibitors; 10(-5) M), and T0070907 (PPARγ-antagonist; 10(-7) M). In sEH(-/-) mice, ACh response was not different from sEH(+/+) (P > 0.05), and l-NAME blocked ACh-responses in both sEH(-/-) and sEH(+/+) mice (P < 0.05). NECA (10(-6) M)-induced relaxation was higher in sEH(-/-) (+12.94 ± 3.2%) vs. sEH(+/+) mice (-5.35 ± 5.2%); however, it was blocked by ZM-241385 (-22.42

2012 American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

168. Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One

data but these mutations are likely to result in reduced antiviral efficacy of Oseltamivir and the adamantanes against H1N1. Furthermore, amantadine treatment of influenza frequently results in the rapid development of amantadine resistance in both H1N1 and H2N3 viruses, resulting in continued virus replication, thus, making this drug less than ideal for treating influenza. Currently, there is limited adamantane resistant H1N1 but widespread adamantane resistant in H3N2. H3N2 and influenza B remain (...) sensitive to Oseltamivir. The adamantanes have no activity against influenza B. The emergence of resistance poses difficulties for the treatment of influenza in children less than one but oseltamivir represents at present the optimal choice for treating such children. Therefore, this protocol will assess the effect of oral Oseltamivir at doses recommended by the WHO to see if they are applicable to Thai children. Study Design Go to Layout table for study information Study Type : Interventional (Clinical

2012 Clinical Trials

169. Mannose-decorated cyclodextrin vesicles: The interplay of multivalency and surface density in lectin–carbohydrate recognition Full Text available with Trip Pro

Mannose-decorated cyclodextrin vesicles: The interplay of multivalency and surface density in lectin–carbohydrate recognition Cyclodextrin vesicles are versatile models for biological cell membranes since they provide a bilayer membrane that can easily be modified by host-guest interactions with functional guest molecules. In this article, we investigate the multivalent interaction of the lectin concanavalin A (ConA) with cyclodextrin vesicles decorated with mannose-adamantane conjugates (...) with one, two or three adamantane units as well as one or two mannose units. The carbohydrate-lectin interaction in this artificial, self-assembled glycocalyx was monitored in an agglutination assay by the increase of optical density at 400 nm. It was found that there is a close relation between the carbohydrate density at the cyclodextrin vesicle surface and the multivalent interaction with ConA, and the most efficient interaction (i.e., fastest agglutination at lowest concentration) was observed

2012 Beilstein journal of organic chemistry

170. Response to Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082 Full Text available with Trip Pro

of dipeptidyl peptidase-IV inhibition. Diabetes Care 2012;35:2076-2082. e13 10.2337/dc12-1436 Rizzo Maria Rosaria MR Barbieri Michelangela M Marfella Raffaele R Paolisso Giuseppe G eng Letter Comment United States Diabetes Care 7805975 0149-5992 0 Blood Glucose 0 Dipeptidyl-Peptidase IV Inhibitors 0 Nitriles 0 Pyrazines 0 Pyrrolidines 0 Triazoles PJY633525U Adamantane IM Diabetes Care. 2012 Oct;35(10):2076-82 22688551 Diabetes Care. 2013 Jan;36(1):e12 23264295 Adamantane analogs & derivatives Blood Glucose

2012 Diabetes Care

171. Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling Full Text available with Trip Pro

spectroscopy experiments on drug-induced conformational changes of the M2 protein embedded in lipid bilayers. We obtained data in the presence of adamantane drugs for two different M2 constructs (M2TM 22-46 and M2TMC 23-60). M2TM peptides were spin labeled at the N-terminal end of the transmembrane domain. M2TMC peptides were spin labeled site specifically at cysteine residues substituted for amino acids within the transmembrane domain (L36, I39, I42, and L43) and the C-terminal amphipathic helix (L46, F47 (...) , F48, C50, I51, Y52, R53, F54, F55, and E56). Addition of adamantane drugs brought about significant changes in measured electron paramagnetic resonance spectroscopy environmental parameters consistent with narrowing of the transmembrane channel pore and closer packing of the C-terminal amphipathic helices.Copyright © 2012 The Protein Society.

2012 Protein science : a publication of the Protein Society

172. Effects of Trehalose Polycation End-group Functionalization on Plasmid DNA Uptake and Transfection Full Text available with Trip Pro

Effects of Trehalose Polycation End-group Functionalization on Plasmid DNA Uptake and Transfection In this study, we have synthesized six analogs of a trehalose-pentaethylenehexamine glycopolymer (Tr4) that contain (1A) adamantane, (1B) carboxy, (1C) alkynyl-oligoethyleneamine, (1D) azido trehalose, (1E) octyl, or (1F) oligoethyleneamine end groups and evaluated the effects of polymer end group chemistry on the ability of these systems to bind, compact, and deliver pDNA to cultured HeLa cells

2012 Biomacromolecules

173. Development of a Low Toxicity, Effective pDNA Vector Based on Non-covalent Assembly of Bioresponsive Amino-β-Cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes Full Text available with Trip Pro

Development of a Low Toxicity, Effective pDNA Vector Based on Non-covalent Assembly of Bioresponsive Amino-β-Cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes A host:guest-derived gene delivery vector has been developed, based on the self-assembly of cationic β-CD derivatives with a poly(vinyl alcohol) (MW 27 kDa) (PVA) main chain polymer bearing poly(ethylene glycol) (MW 750) (PEG) or MW 2000 PEG and acid-labile adamantane-modified (Ad) grafts through

2012 Bioconjugate chemistry

174. On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1 Full Text available with Trip Pro

On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1 Successfully forming ligand-protein complexes with specific compounds can be a significant challenge in supporting structure-based drug design for a given protein target. In this respect, an on-column ligand- and detergent-exchange method was developed to obtain ligand-protein complexes of an adamantane series of compounds with 11β-hydroxysteroid dehydrogenase type 1 (11β

2012 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

175. Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets Full Text available with Trip Pro

+), the quinuclidine's cationic center interacts with PPi and three Mg(2+), mimicking a transition state involved in diphosphate ionization. With 3, there are again two structures. In one, the geranyl side chain binds to either S1 or S2 and the adamantane headgroup binds to S1. In the second, the side chain binds to S2 while the headgroup binds to S1. These results provide structural clues for the mechanism and inhibition of the head-to-head prenyl transferases and should aid future drug design.

2012 Journal of medicinal chemistry

176. Soluble Epoxide Hydrolase Gene Deficiency or Inhibition Attenuates Chronic Active Inflammatory bowel disease in IL-10(−/−) Mice Full Text available with Trip Pro

of IBD in IL-10(-/-) mice.Either the small molecule sEH inhibitor trans/-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) or sEH knockout mice were used in combination with IL-10(-/-) mice. t-AUCB was administered to mice in drinking fluid. Extensive histopathologic, immunochemical, and biochemical analyses were performed to evaluate effect of sEH inhibition or deficiency on chronic active inflammation and related mechanism in the bowel.Compared to IL-10 (-/-) mice, sEH inhibition

2012 Digestive diseases and sciences

177. The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with Type 2 diabetes. (Abstract)

England Diabet Med 8500858 0742-3071 0 Biomarkers 0 Chylomicron Remnants 0 Dipeptidyl-Peptidase IV Inhibitors 0 Hypolipidemic Agents 0 Lipoproteins, LDL 0 Nitriles 0 Pyrrolidines 0 Triglycerides I6B4B2U96P Vildagliptin PJY633525U Adamantane IM Adamantane analogs & derivatives therapeutic use Biomarkers blood chemistry Chylomicron Remnants blood chemistry Diabetes Mellitus, Type 2 blood drug therapy Diet, High-Fat adverse effects Dipeptidyl-Peptidase IV Inhibitors therapeutic use Humans Hyperglycemia

2012 Diabetic Medicine

178. Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: an open-label, multiple-dose, randomized, crossover study. (Abstract)

Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: an open-label, multiple-dose, randomized, crossover study. Preclinical data suggest increased antiviral activity and less viral resistance when neuraminidase inhibitors and adamantanes are used in combination to harness the complementary effects of their different mechanisms of action. Healthy volunteers were randomized to 5-day oral treatment with oseltamivir 75 mg or rimantadine 100 mg twice daily

2012 Journal of clinical pharmacology Controlled trial quality: uncertain

179. Aminoadamantane-resistant strains of influenza A2 virus Full Text available with Trip Pro

-adamantane methylamine and 2-adamantanamine sulphate. No aminoadamantane-resistant viruses were detected after passage of influenza four times in mice treated with lower (15 or 1.5 mg./kg./day) concentrations of aminoadamantane. Aminoadamantane had no detectable effect on the development of lung lesions in mice infected with the drug-resistant influenza strain, whereas lung lesions were reduced in aminoadamantane treated mice infected with a control strain of influenza A2/Singapore virus. No differences

1973 The Journal of hygiene

180. Influenza

; however, no other data clearly show that treatment of influenza prevents complications. Peramivir is given IV as a single dose and can be used in patients > 2 yr who cannot tolerate oral or inhaled drugs. Studies of its use for influenza B are limited. Adamantanes ( amantadine and rimantadine ) were previously used; however, more than 99% of current and recent circulating influenza viruses are resistant to adamantanes, so these drugs are currently not recommended for treatment. Adamantanes block

2013 Merck Manual (19th Edition)

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>