How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

260 results for

Adamantane

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Letter by Muskiet et al Regarding Article, "Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations From the SAVOR-TIMI 53 Randomized Trial". Full Text available with Trip Pro

University Medical Center, Amsterdam, The Netherlands. Tonneijck Lennart L Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. van Raalte Daniël H DH Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. eng Letter Comment United States Circulation 0147763 0009-7322 0 Dipeptides PJY633525U Adamantane AIM IM Circulation. 2014 Oct 28;130(18):1579-88 25189213 Circulation. 2015 Aug 11;132(6):e121-2 (...) 26260506 Adamantane analogs & derivatives Diabetes Mellitus, Type 2 complications drug therapy Dipeptides adverse effects Female Heart Failure chemically induced complications Humans Male 2015 8 12 6 0 2015 8 12 6 0 2015 10 20 6 0 ppublish 26260505 CIRCULATIONAHA.114.013819 10.1161/CIRCULATIONAHA.114.013819

2015 Circulation Controlled trial quality: uncertain

122. Response to Letter Regarding Article, "Heart Failure, Saxagliptin and Diabetes Mellitus: Observations From the SAVOR-TIMI 53 Randomized Trial". Full Text available with Trip Pro

Circulation 0147763 0009-7322 0 Dipeptides PJY633525U Adamantane AIM IM Circulation. 2014 Oct 28;130(18):1579-88 25189213 Circulation. 2015 Aug 11;132(6):e120 26260505 Adamantane analogs & derivatives Diabetes Mellitus, Type 2 complications drug therapy Dipeptides adverse effects Female Heart Failure chemically induced complications Humans Male 2015 8 12 6 0 2015 8 12 6 0 2015 10 20 6 0 ppublish 26260506 CIRCULATIONAHA.115.015511 10.1161/CIRCULATIONAHA.115.015511

2015 Circulation Controlled trial quality: uncertain

123. Study in Healthy Volunteers to Evaluate the Efficacy and Safety of CR6261 in an H1N1 Influenza Healthy Human Challenge Model

by 24-48 hours and reducing shedding in relatively healthy adults, as with vaccination, they have had limited effectiveness in high risk groups and those who have severe or complicated influenza infections. In addition, antiviral resistance has become very common in human influenza A viruses, as currently circulating H1N1 and H3N2 strains are resistant to the adamantane M2 channel blockers and many cases of neuraminidase inhibitor resistance have also been reported with strains of both subtypes

2015 Clinical Trials

124. A Novel Ranking System for Identifying Efficacious Anti-Influenza PB2 Inhibitors. Full Text available with Trip Pro

several neuraminidase inhibitors have been developed for the treatment of influenza virus infections, these have shown a limited window for treatment initiation, and resistant variants have been noted in the population. In addition, an older class of antiviral drugs for influenza, the adamantanes, are no longer recommended for treatment due to widespread resistance. There remains a need for new influenza therapeutic agents with improved efficacy as well as an expanded window for the initiation

2015 Antimicrobial Agents and Chemotherapy

125. Genetic Characterization of H1N1 and H1N2 Influenza A Viruses Circulating in Ontario Pigs in 2012 Full Text available with Trip Pro

of the five Ontario H1N1 viruses had between one and four amino acid (aa) changes within five antigenic sites, while one Ontario H1N2 virus had two aa changes within two antigenic sites. Such aa changes in antigenic sites could have an effect on antibody recognition and ultimately have implications for immunization practices. According to aa sequence analysis of the M2 protein, Ontario H1N1 and H1N2 viruses can be expected to offer resistance to adamantane derivatives, but not to neuraminidase inhibitors.

2015 PloS one

126. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. (Abstract)

, we investigated the involvement of sEH in neuroinflammation, seizure generation and subsequent epileptogenesis using two mouse models of temporal lobe epilepsy. Experimental epileptic seizures were induced by either pilocarpine or electrical amygdala kindling in both wild-type (WT) C57BL/6 mice and sEH knockout (sEH KO) mice. The sEH expression in the hippocampus was detected by immunohistochemistry and Western blot analysis. The effects of the sEH hydrolase inhibitors, 12-(3-adamantan-1-yl

2015 Brain, behavior, and immunity

127. Primary Care Corner with Geoffrey Modest MD: Immunization Updates

….. But at least it looks good so far. By the way, the breakdown for the first 1698 cases of influenza so far in the US is 54% influenza A (of which 5% were pH1N1, 93% H3N2), 46% influenza B. There have been a handful of variant viruses but of the H3N2 and H1N1 strains. All of the tested viruses were susceptible to neuraminidase inhibitors, but adamantanes (e.g. amanadine) does not work/lots of resistance.​ (Visited 21 times, 1 visits today) Post navigation 27 March 2019 Original EBM Research 23 March 2019

2015 Evidence-Based Medicine blog

128. Grand Rounds: Influenza Pandemic

reported a high proportion of patients placed on ECMO for adequate oxygenation. There were 39 documented cases of pulmonary hemorrhage. Pregnant women merit special commentary—five percent of them died from pandemic H1N1 (as compared to making up 1% of the general population), and the relative risk of hospitalization for a pregnant woman was 4.3 (versus those not pregnant). Initial strains of pandemic H1N1 were susceptible to NA inhibitors like oseltamivir but almost 100% resistant to adamantanes (...) -2011 circulating influenza viruses are susceptible to oseltamivir and zanamivir and resistant to the adamantanes. The ACIP (Advisory Committee on Immunization Practices) antiviral use guidelines recommend early empiric therapy with a neuramindase inhibitor for all patients with suspected/confirmed influenza who are hospitalized or severely ill, and for those with a chronic underlying medical condition as previously detailed which puts them at high risk for complications, no matter what

2010 Clinical Correlations

129. [The SAVOR-TIMI 53 study]. (Abstract)

[The SAVOR-TIMI 53 study]. 25072417 2014 10 10 2014 07 30 1827-6806 15 6 2014 Jun Giornale italiano di cardiologia (2006) G Ital Cardiol (Rome) [The SAVOR-TIMI 53 study]. 335-9 10.1714/1582.17270 Di Lenarda Andrea A Candido Riccardo R Cioffi Giovanni G Bossi Antonio C AC ita Journal Article Randomized Controlled Trial Lo studio SAVOR-TIMI 53. Italy G Ital Cardiol (Rome) 101263411 1827-6806 0 Dipeptides 0 Hypoglycemic Agents 9GB927LAJW saxagliptin PJY633525U Adamantane IM Adamantane analogs

2014 Giornale italiano di cardiologia (2006) Controlled trial quality: uncertain

130. Increases in Levels of Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids (EETs and DHETs) in Liver and Heart in Vivo by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and in Hepatic EET:DHET Ratios by Cotreatment with TCDD and the Soluble Epoxide Hydrolas Full Text available with Trip Pro

heart lacks arachidonic acid-metabolizing activity, the latter findings suggest that arachidonic acid metabolites may travel from their site of production to a distal organ, i.e., heart. To determine if the TCDD-arachidonic acid-metabolite profile could be altered pharmacologically, chick embryos were treated with TCDD and the soluble epoxide hydrolase inhibitor 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA). Cotreatment with AUDA increased hepatic EET-to-DHET ratios, indicating

2014 Drug Metabolism and Disposition

131. Diabetes Medications and Heart Failure: Recognizing the Risk. Full Text available with Trip Pro

-7322 0 Dipeptides 9GB927LAJW saxagliptin PJY633525U Adamantane AIM IM Circulation. 2014 Oct 28;130(18):1579-88 25189213 Adamantane adverse effects analogs & derivatives Diabetes Mellitus, Type 2 complications drug therapy Dipeptides adverse effects Female Heart Failure chemically induced complications Humans Male Editorials diabetes mellitus heart failure hospitalization treatment outcome 2014 9 6 6 0 2014 9 6 6 0 2014 12 30 6 0 ppublish 25189212 CIRCULATIONAHA.114.012883 10.1161/CIRCULATIONAHA

2014 Circulation

132. Full-Genome Analysis of Avian Influenza A(H5N1) Virus from a Human, North America, 2013. Full Text available with Trip Pro

Full-Genome Analysis of Avian Influenza A(H5N1) Virus from a Human, North America, 2013. Full-genome analysis was conducted on the first isolate of a highly pathogenic avian influenza A(H5N1) virus from a human in North America. The virus has a hemagglutinin gene of clade 2.3.2.1c and is a reassortant with an H9N2 subtype lineage polymerase basic 2 gene. No mutations conferring resistance to adamantanes or neuraminidase inhibitors were found.

2014 Emerging Infectious Diseases

133. Synthetically Modified l-Histidine-Rich Peptidomimetics Exhibit Potent Activity Against Cryptococcus neoformans Full Text available with Trip Pro

Synthetically Modified l-Histidine-Rich Peptidomimetics Exhibit Potent Activity Against Cryptococcus neoformans We describe the synthesis and antimicrobial evaluation of structurally new peptidomimetics, rich in synthetically modified L-histidine. Two series of tripeptidomimetics were synthesized by varying lipophilicity at the C-2 position of L-histidine and at the N- and C-terminus. The data indicates that peptides (5f, 6f, 9f and 10f) possessing highly lipophilic adamantan-1-yl group

2014 Bioorganic & medicinal chemistry letters

134. Pharmacological Targeting of the Pseudokinase Her3 Full Text available with Trip Pro

that covalent modification of Her3 inhibits Her3 signaling but not proliferation in some Her3-dependent cancer cell lines. Subsequent derivatization with a hydrophobic adamantane moiety demonstrates that the resultant bivalent ligand (TX2-121-1) enhances inhibition of Her3-dependent signaling. Treatment of cells with TX2-121-1 results in partial degradation of Her3 and serendipitously interferes with productive heterodimerization between Her3 with either Her2 or c-Met. These results suggest that small

2014 Nature chemical biology

135. Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus Full Text available with Trip Pro

Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus Amantadine inhibits the M2 proton channel of influenza A virus, yet most of the currently circulating strains of the virus carry mutations in the M2 protein that render the virus amantadine-resistant. While most of the research on novel amantadine analogues has revolved around the synthesis of novel adamantane derivatives, we have recently found that other

2014 Journal of medicinal chemistry

136. Ordered, adherent layers of nanofibers enabled by supramolecular interactions Full Text available with Trip Pro

Ordered, adherent layers of nanofibers enabled by supramolecular interactions Aligned nanofibrous substrates can be created by electrospinning, but methods for creating multilamellar structures of aligned fibers are limited. Here, apposed nanofibrous scaffolds with pendant β-cyclodextrin (CD) were adhered together by adamantane (Ad) modified hyaluronic acid, exploiting the guest-host interactions of CD and Ad for macroscopic assembly. Stable user-defined multi-layered scaffolds were formed

2014 Journal of materials chemistry. B, Materials for biology and medicine

137. Avian Influenza (Follow-up)

and IDSA have issue guidelines regarding antiviral treatment and prophylaxis. [ , ] The neuraminidase inhibitors (oseltamivir, peramivir, and zanamivir) and cap-dependent endonuclease inhibitors (baloxavir marboxil) have activity against influenza A and B viruses (including H1N1), whereas the adamantanes (amantadine and rimantadine) have activity against influenza A viruses only. Since 2006, only the neuraminidase inhibitors have been recommended, because of widespread resistance to the adamantanes

2014 eMedicine.com

138. Pulmonary Rehabilitation (Diagnosis)

and chemoprophylaxis of influenza. Since January 2006, the neuraminidase inhibitors (oseltamivir, zanamivir) have been the only recommended influenza antiviral drugs because of widespread resistance to the adamantanes (amantadine, rimantadine) among influenza A (H3N2) virus strains. The neuraminidase inhibitors have activity against influenza A and B viruses, while the adamantanes have activity against only influenza A viruses. In 2007-2008, a significant increase in the prevalence of oseltamivir resistance

2014 eMedicine.com

139. Pulmonary Rehabilitation (Overview)

and chemoprophylaxis of influenza. Since January 2006, the neuraminidase inhibitors (oseltamivir, zanamivir) have been the only recommended influenza antiviral drugs because of widespread resistance to the adamantanes (amantadine, rimantadine) among influenza A (H3N2) virus strains. The neuraminidase inhibitors have activity against influenza A and B viruses, while the adamantanes have activity against only influenza A viruses. In 2007-2008, a significant increase in the prevalence of oseltamivir resistance

2014 eMedicine.com

140. Avian Influenza (Treatment)

and IDSA have issue guidelines regarding antiviral treatment and prophylaxis. [ , ] The neuraminidase inhibitors (oseltamivir, peramivir, and zanamivir) and cap-dependent endonuclease inhibitors (baloxavir marboxil) have activity against influenza A and B viruses (including H1N1), whereas the adamantanes (amantadine and rimantadine) have activity against influenza A viruses only. Since 2006, only the neuraminidase inhibitors have been recommended, because of widespread resistance to the adamantanes

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>