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Adamantane

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181. [Ladasten in the management of non-motor symptoms of Parkinson's disease]. (Abstract)

-bromophenylamine PJY633525U Adamantane IM Adamantane analogs & derivatives therapeutic use Aged Female Humans Male Middle Aged Parkinson Disease drug therapy physiopathology Treatment Outcome 2011 3 26 6 0 2011 3 26 6 0 2011 4 6 6 0 ppublish 21434470

2011 Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Controlled trial quality: uncertain

182. Effect of a high-fat meal on the pharmacokinetics of saxagliptin in healthy subjects. (Abstract)

eng Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't 2010 02 11 England J Clin Pharmacol 0366372 0091-2700 0 Dietary Fats 0 Dipeptides 0 Dipeptidyl-Peptidase IV Inhibitors 9GB927LAJW saxagliptin PJY633525U Adamantane IM Adamantane analogs & derivatives blood pharmacokinetics Adult Area Under Curve Cross-Over Studies Dietary Fats Dipeptides blood pharmacokinetics Dipeptidyl-Peptidase IV Inhibitors blood pharmacokinetics Female Food-Drug Interactions Humans Male 2010 2 13

2011 Journal of clinical pharmacology Controlled trial quality: uncertain

183. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats Full Text available with Trip Pro

-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (c-AUCB) and HET-0016, the inhibitor of 20-HETE production, to study the role of EETs and 20-HETE in the regulation of renal function. Chronic c-AUCB treatment significantly decreased systolic blood pressure (SBP) (133 ± 1 vs. 163 ± 3 mmHg) and increased sodium excretion (1.23 ± 0.10 vs. 0.59 ± 0.03 mmol/day) in 2K1C rats. HET-0016 did not affect SBP and sodium excretion. In acute experiments, renal blood flow (RBF) was decreased in 2K1C rats

2011 American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

184. Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats Full Text available with Trip Pro

activity, a deficiency of trans-EETs in the SHR was hypothesized to increase blood pressure (BP). This prediction was fulfilled, since sEH inhibition with cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid (AUCB; 2 mg·kg(-1)·day(-1) for 7 days) in the SHR reduced mean BP from 176 ± 8 to 153 ± 5 mmHg (P < 0.05), whereas BP in the control Wistar-Kyoto rat (WKY) was unaffected. Plasma levels of EETs in the SHR were lower than in the age-matched control WKY (16.4 ± 1.6 vs. 26.1 ± 1.8 ng/ml; P

2011 American Journal of Physiology - Heart and Circulatory Physiology

185. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats Full Text available with Trip Pro

Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats We hypothesized that perinatal inhibition of soluble epoxide hydrolase (SEH), which metabolizes epoxyeicosatrienoic acids in the arachidonic acid (AA) cascade, with an orally active SEH inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), would persistently reduce blood pressure (BP) in adult SHR despite discontinuation of AUDA at 4 wk of age. Renal cytoplasmic

2011 American Journal of Physiology - Endocrinology And Metabolism

186. DPP-4 Inhibitors: Impact on glycemic control and cardiovascular risk factors Full Text available with Trip Pro

Dipeptides 0 Dipeptidyl-Peptidase IV Inhibitors 0 Nitriles 0 Pyrrolidines 9GB927LAJW saxagliptin I6B4B2U96P Vildagliptin PJY633525U Adamantane IM Adamantane analogs & derivatives therapeutic use Cardiovascular Diseases prevention & control Dipeptides therapeutic use Dipeptidyl-Peptidase IV Inhibitors therapeutic use Humans Nitriles therapeutic use Pyrrolidines therapeutic use Risk Factors Vildagliptin 2011 4 29 6 0 2011 5 6 6 0 2011 7 2 6 0 ppublish 21525468 34/Supplement_2/S276 10.2337/dc11-s229

2011 Diabetes Care

187. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes Full Text available with Trip Pro

trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (tAUCB) also reduced renal inflammation and injury in diabetic WT mice. Furthermore, inhibition of HO with stannous mesoporphyrin negated the reno-protective effects of tAUCB or Ephx2 KO during diabetes. These data demonstrate that Ephx2 KO improves endothelial function and reduces renal injury during diabetes. Additionally, our data also suggest that activation of HO-1 contributes to improved renal injury in diabetic Ephx2 KO mice.

2011 American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

188. Zanamivir, at 600 mg Twice Daily, Inhibits Oseltamivir-Resistant 2009 pandemic H1N1 Influenza Virus in an in vitro Hollow Fiber Infection Model System. Full Text available with Trip Pro

Zanamivir, at 600 mg Twice Daily, Inhibits Oseltamivir-Resistant 2009 pandemic H1N1 Influenza Virus in an in vitro Hollow Fiber Infection Model System. In 2009, a novel H1N1 influenza A virus emerged and spread worldwide, initiating a pandemic. Various isolates obtained from disparate parts of the world were shown to be uniformly resistant to the adamantanes but sensitive to the neuraminidase inhibitors oseltamivir and zanamivir. Over time, resistance to oseltamivir became more prevalent among

2011 Antimicrobial Agents and Chemotherapy

189. Soluble epoxide hydrolase inhibition prevents coronary endothelial dysfunction in mice with renovascular hypertension. (Abstract)

of the EET-synthesizing enzymes cytochrome P450 epoxygenases, fluconazole and N-methylsulfonyl-6-(2-propargyloxyphenyl)-hexanamide (MSPPOH), reduced the coronary relaxations to acetylcholine in control but not in 2K1C mice. The sEH expression was increased in 2K1C mice. The sEH inhibitor 12-(3-adamantan-1-yl-ureido)dodecanoic acid administered for 2 weeks starting 5 weeks after surgery in 2K1C mice (25 mg/l in drinking water) reduced aortic pressures and cardiac hypertrophy, improved the coronary

2011 Journal of Hypertension

190. MultiDrug-Resistant 2009 Pandemic Influenza A(H1N1) Viruses Maintain Fitness and Transmissibility in Ferrets. Full Text available with Trip Pro

appeared containing resistance to neuraminidase inhibitors and the adamantanes, but the ability of these viruses to replicate, transmit, and cause disease in mammalian hosts has not been fully characterized.Two pretreatment wild-type viruses and 2 posttreatment multidrug-resistant viruses containing the neuraminidase H275Y mutation collected from immunocompromised patients infected with pandemic influenza H1N1 were tested for viral fitness, pathogenicity, and transmissibility in ferrets.The

2011 Journal of Infectious Diseases

191. Safety Study of Single Administration Intravenous Treatment for Influenza

) the increased frequency of resistance to approved forms of therapy for influenza (eg, the adamantane derivatives and, more recently, the NA inhibitor, oseltamivir). AVI-7100 is an experimental phosphorodiamidate morpholino antisense oligomers with positive charges on selected subunits (PMOplus™). AVI-7100 specifically targets viral messenger RNA sequences. The present study is designed to characterize the safety, tolerability and pharmacokinetics of escalating single-administration doses of AVI-7100

2011 Clinical Trials

192. Amitriptyline

., , , , ) (e.g., , , , ) Agonists: Antagonists: Agonists Benzazepines : Ergolines : Dihydrexidine derivatives : Phenethylamines : Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : (+ ) Others : Agonists Adamantanes : Aminotetralins : Ergolines : Dihydrexidine derivatives : Phenethylamines : Atypical antipsychotics : ( ) Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : ( ) Antiemetics/gastroprokinetics/sedatives : Antidepressants : Others

2012 Wikipedia

193. Influenza pandemic Full Text available with Trip Pro

. Relevant learning from the in the UK was published in . Anti-viral drugs [ ] There are two groups of antiviral drugs available for the treatment and prophylaxis of influenza neuraminidase inhibitors such as (trade name Tamiflu) and (trade name Relenza) as well as adamantanes such as amantadine and rimantadine. Due to the high rate of side effects and risk of antiviral resistance, use of adamantanes to fight influenza is limited. Many nations, as well as the World Health Organization, are working

2012 Wikipedia

195. Imipramine

., , , , , ) (e.g., , , , ) (e.g., , , , ) (e.g., , , ) (e.g., , , , , ) (e.g., , , , ) Agonists: Antagonists: (e.g., , , , , , , , ) (e.g., , , , ) (e.g., , , , ) Agonists: Antagonists: Agonists Benzazepines : Ergolines : Dihydrexidine derivatives : Phenethylamines : Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : (+ ) Others : Agonists Adamantanes : Aminotetralins : Ergolines : Dihydrexidine derivatives : Phenethylamines : Atypical antipsychotics : ( ) Others : Antagonists

2012 Wikipedia

196. Doxepin

: Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : (+ ) Others : Agonists Adamantanes : Aminotetralins : Ergolines : Dihydrexidine derivatives : Phenethylamines : Atypical antipsychotics : ( ) Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : ( ) Antiemetics/gastroprokinetics/sedatives : Antidepressants : Others : See also: Agonists: Antagonists: First-generation: Second/third-generation: Others: (e.g., , , , , , , , , , , , ) (e.g

2012 Wikipedia

198. Tricyclic antidepressant

., , , , ) (e.g., , , ) (e.g., , , , , ) (e.g., , , , ) Agonists: Antagonists: (e.g., , , , , , , , ) (e.g., , , , ) (e.g., , , , ) Agonists: Antagonists: Agonists Benzazepines : Ergolines : Dihydrexidine derivatives : Phenethylamines : Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : (+ ) Others : Agonists Adamantanes : Aminotetralins : Ergolines : Dihydrexidine derivatives : Phenethylamines : Atypical antipsychotics : ( ) Others : Antagonists Typical antipsychotics

2012 Wikipedia

199. Quetiapine

( , , , , , ) ( , ) Agonists: Antagonists: (e.g., , , , , ) (e.g., , , , ) (e.g., , , , ) (e.g., , , ) (e.g., , , , , ) (e.g., , , , ) Agonists: Antagonists: (e.g., , , , , , , , ) (e.g., , , , ) (e.g., , , , ) Agonists: Antagonists: Agonists Benzazepines : Ergolines : Dihydrexidine derivatives : Phenethylamines : Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : (+ ) Others : Agonists Adamantanes : Aminotetralins : Ergolines : Dihydrexidine derivatives : Phenethylamines : Atypical

2012 Wikipedia

200. Atypical antipsychotic

). . September 19, 2005. Archived from on September 2, 2013 . Retrieved August 18, 2013 . ( ) : # : : ‡ : Disputed : ‡ ‡ : : Others: / : # : † / : † : # Others: Others # ‡ from market : † § Never to phase III Agonists Benzazepines : Ergolines : Dihydrexidine derivatives : Phenethylamines : Others : Antagonists Typical antipsychotics : ( ) ( ) ( ) Atypical antipsychotics : (+ ) Others : Agonists Adamantanes : Aminotetralins : Ergolines : Dihydrexidine derivatives : Phenethylamines : Atypical antipsychotics

2012 Wikipedia

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