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Acute Vision Loss

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121. Effect of Phenytoin on the Ganglion Cell Inner Plexiform Layer and Visual Field in Patients With an Acute Optic Neuritis

days since onset visual loss Exclusion Criteria: Contraindication or known allergy to Phenytoin Use of a calcium channel or sodium channel blocker in the past 2 months Corticosteroid use in the past 2 months Pregnancy Significant cardiac, renal or liver abnormalities Prior clinical episode of optic neuritis in either eye Bilateral acute optic neuritis Known ocular or neurological conditions or abnormalities other than refractive error that impair visual function Refractive error of greater than +5 (...) Effect of Phenytoin on the Ganglion Cell Inner Plexiform Layer and Visual Field in Patients With an Acute Optic Neuritis Effect of Phenytoin on the Ganglion Cell Inner Plexiform Layer and Visual Field in Patients With an Acute Optic Neuritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2016 Clinical Trials

122. Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. (PubMed)

Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can damage vision through neurodegeneration in the optic nerve and in its fibres in the retina. Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient (...) with acute optic neuritis.We did a randomised, placebo-controlled, double-blind phase 2 trial at two UK academic hospitals in London and Sheffield. Patients with acute optic neuritis aged 18-60 years, presenting within 2 weeks of onset, with visual acuity of 6/9 or worse, were randomly assigned (1:1) by minimisation via a web-based service to oral phenytoin (maintenance dose 4 mg/kg per day if randomised before or on July 16, 2013, and 6 mg/kg per day if randomised on or after July 17, 2013) or placebo

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2016 The Lancet. Neurology

123. Extramedullary Relapse of Acute Myelogenous Leukemia Presenting as a Large Serous Retinal Detachment (PubMed)

transplant, presented with acute vision loss. Ophthalmic workup revealed a large, unilateral, bullous, serous retinal detachment. Ultimately, he underwent subretinal fluid biopsy, which was found to be positive for leukemic blast cells. Cytologic markers matched his initial bone marrow biopsy, and therefore were diagnostic of extramedullary AML relapse.Leukemia can cause various ophthalmic manifestations. Autopsy studies suggest that choroidal infiltration is relatively common, but clinical progression (...) Extramedullary Relapse of Acute Myelogenous Leukemia Presenting as a Large Serous Retinal Detachment To describe the rare presentation of a large, unilateral, serous retinal detachment as an extramedullary manifestation of acute myelogenous leukemia (AML) recurrence without bone marrow or central nervous system involvement after more than 1 year of follow-up.Case report.A teenage patient with AML, previously treated with multiple courses of systemic chemotherapy, radiation, and bone marrow

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2016 Ocular oncology and pathology

124. Acute multifocal hemorrhagic retinal vasculitis in a child: a case report. (PubMed)

Acute multifocal hemorrhagic retinal vasculitis in a child: a case report. Acute Multifocal Hemorrhagic Retinal Vasculitis (AMHRV) is a rare disease with unknown incidence that presents with abrupt onset of visual loss associated with retinal vasculitis, retinal hemorrhage, non-confluent posterior retinal infiltrates, vitreous cellular inflammation and papillitis in, otherwise, healthy adult individuals. The reported treatment options for Acute Multifocal Hemorrhagic Retinal Vasculitis are oral (...) corticosteroids, intravitreal ganciclovir and laser photocoagulation or vitrectomy. We report a child with Acute Multifocal Hemorrhagic Retinal Vasculitis who was treated with aggressive immunosuppressive therapy resulting in a favorable visual outcome.A retrospective case report of a 10-year-old African American girl who developed unilateral Acute Multifocal Hemorrhagic Retinal Vasculitis, which later on progressed bilaterally. We conducted a review of the clinical, laboratory and photographic records

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2016 BMC Ophthalmology

125. Cross-sectional study of the retinal nerve fiber layer thickness at 7 years after an acute episode of unilateral primary acute angle closure. (PubMed)

. The peripapillary RNFL thickness was correlated with age, gender, presenting intraocular pressure (IOP), time to laser iridotomy, time to cataract extraction, follow-up duration, as well as the last IOP, vertical cup-to-disc ratio (CDR), and vision. The fellow uninvolved eye was used as a proxy comparison of RNFL loss in the attack eye. In 40 eligible patients, the mean age was 68.3 ± 8.7 years with a male-to-female ratio of 1:7. The mean presenting IOP was 49.2 ± 14.0 mm Hg and the time from presentation (...) Cross-sectional study of the retinal nerve fiber layer thickness at 7 years after an acute episode of unilateral primary acute angle closure. The purpose of this article is to investigate the long-term retinal nerve fiber layer (RNFL) status and determinants of RNFL thinning after an episode of unilateral primary acute angle closure (AAC). This cross-sectional study analyzed the medical records of consecutive patients with a single episode of unilateral AAC from 1999 to 2009 in Hong Kong

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2015 Medicine

126. Reversal of Severe Visual Loss from Syphilitic Chorioretinitis Following Penicillin Treatment (PubMed)

Reversal of Severe Visual Loss from Syphilitic Chorioretinitis Following Penicillin Treatment A 51-year-old Caucasian male was referred to neuro-ophthalmology clinic for an evaluation of acute onset of painless visual loss in the left eye. The ocular examination revealed subtle retinal changes suspicious for chorioretinitis. Laboratory workup revealed a reactive Treponema pallidum particle agglutination assay (TP-PA), confirming the diagnosis of ocular syphilis. The patient was treated (...) with intravenous infusion of penicillin with complete recovery of vision and resolution of retinal abnormalities.

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2015 Neuro-Ophthalmology

127. RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery

RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02128113 Recruitment Status : Completed First Posted : May 1, 2014

2014 Clinical Trials

128. Light to Maximize Vision, Minimize Insomnia

acuity Greater than 20° visual field with no lower visual field loss Stable health Male or female Normal color vision Normal hearing Exclusion Criteria: Extreme chronotype Sleep disorders Dementia Smoker Depression Alcohol abuse Use of illegal drugs Use of sleep/wake altering drugs on an acute or as needed basis (including nutraceuticals, antihistamines) Use of light sensitizing drugs Self-reported history of nocturia (>3 times per night) Contacts and Locations Go to Information from the National (...) Light to Maximize Vision, Minimize Insomnia Light to Maximize Vision, Minimize Insomnia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Light to Maximize Vision, Minimize Insomnia The safety and scientific

2012 Clinical Trials

129. Acute childhood limp

and potentially life-threatening conditions, such as septic arthritis and malignancy. The underlying cause varies between age-groups because children become susceptible to specific conditions as they progress through childhood. Assessment of a child presenting with acute limp involves: Excluding red flags which may indicate an underlying serious disease or condition, such as nocturnal pain; redness, swelling, or stiffness of the joint or limb; weight loss or anorexia; and fever or night sweats. Identifying (...) that persists for longer than 6 weeks and has no known cause. Systemic symptoms of lethargy and anorexia may be present. Often children with JIA are otherwise well and blood tests and X-rays may be normal. Be aware that there is a high risk of uveitis in children with JIA and this may be asymptomatic initially. If undiagnosed and untreated, uveitis can lead to loss of vision. [ ] Sever's disease Sever's disease Sever's disease or apophysitis of the calcaneus produces heel pain as a result of inflammation

2015 NICE Clinical Knowledge Summaries

130. Sudden Visual Loss (Treatment)

with placebo at 6 months. [ ] There was, however, indication that treating with steroids hastened the rate of return of vision to normal compared with placebo. When choosing this treatment, oral steroids must be preceded by intravenous steroids, as oral steroids alone resulted in fewer patients achieving normal visual acuity compared with controls and may in fact be associated with increased recurrence rates. In cases of acute CRAO, conservative therapy may include the following: [ ] Ocular massage Topical (...) . [ ] Surgical patients experienced both intraoperative and postoperative adverse events, including CRAO during surgery and light perception vision at 6 months. There was also immediate loss of light perception following surgery and loss of vision that persisted to the 12-month visit. Central Retinal Vein Occlusion Surgical options for CRVO include radial optic neurotomy, chorioretinal venous anastomosis, vitrectomy, and retinal vein injection with tPA. None of these surgical treatments has been proven

2014 eMedicine.com

131. Pseudotumor cerebri in a child receiving peritoneal dialysis: recovery of vision after lumbo-pleural shunt (PubMed)

Pseudotumor cerebri in a child receiving peritoneal dialysis: recovery of vision after lumbo-pleural shunt A 9-year-old boy with end-stage renal disease who was receiving continuous ambulatory peritoneal dialysis (CAPD) presented with acute visual loss and was found to have papilledema. Neuroimaging and cerebrospinal fluid (CSF) analysis were normal. The lumbar puncture opening pressure was 290 mm of water so the diagnosis of pseudotumor cerebri (PTC) was entertained. Medical treatment

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2011 Annals of Saudi Medicine

132. Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure

or better [ Time Frame: 6 Months ] Secondary Outcome Measures : The percentage of treated eyes within +/- 1.00D of target refraction [ Time Frame: 6 Months ] The percentage of treated eyes within +/- 0.50D of target refraction [ Time Frame: 6 Months ] The percentage of treated eyes with a monocular uncorrected high contrast distance VA of 20/40 or better [ Time Frame: 6 Months ] Preservation of VA: Loss of more than 2 lines in monocular BCVA for distance vision [ Time Frame: 6 Months ] The percentage (...) Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2011 Clinical Trials

133. Interventions for acute non-arteritic central retinal artery occlusion. (PubMed)

Interventions for acute non-arteritic central retinal artery occlusion. Acute central retinal artery occlusion (CRAO) occurs as a sudden interruption of the blood supply to the retina and results in an almost complete loss of vision in the affected eye. There is no generally agreed treatment regimen although a number of therapeutic interventions have been proposed.The objective of this review was to examine the effects of treatments used for acute non-arteritic CRAO.We searched the Cochrane (...) Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library, Issue 3, 2008), MEDLINE (January 1966 to September 2008), EMBASE (January 1980 to September 2008) and the reference lists of relevant papers.We included randomised controlled trials (RCTs) only in which one treatment aimed to re-establish blood supply to the retina in people with acute CRAO was compared to another treatment.Two authors independently assessed

2009 Cochrane

134. Buscopan Versus Acetaminophen for Acute Abdominal Pain in Children

on quality of life, functional outcomes, and patient satisfaction. It is a major source of school and work absence, loss of sleep, and extracurricular impairment. Despite this, analgesia has traditionally been withheld from patients with acute abdominal pain. The reasons behind this are likely two-fold. First, there is good evidence that clinicians fear that analgesia will mask signs of an underlying surgical pathology such as appendicitis. There is no current published literature that supports (...) Buscopan Versus Acetaminophen for Acute Abdominal Pain in Children Buscopan Versus Acetaminophen for Acute Abdominal Pain in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Buscopan Versus

2015 Clinical Trials

135. Pyelonephritis - acute

Pyelonephritis - acute Pyelonephritis - acute - NICE CKS Clinical Knowledge Summaries Share Pyelonephritis - acute: Summary Acute pyelonephritis is an infection of one or both kidneys usually caused by bacteria travelling up from the bladder – the most common causative pathogen is Escherichia coli, which is responsible for 60-80% of uncomplicated infections. Complications of acute pyelonephritis include: Sepsis. Parenchyma renal scarring. Recurrent urinary tract infections. Renal abscess (...) formation. Preterm labour in pregnancy. Emphysematous pyelonephritis. Acute pyelonephritis should be diagnosed by taking a detailed medical history and conducting a physical examination. Acute pyelonephritis should be suspected in people with signs or symptoms of a urinary tract infection (for example, dysuria, frequency, urgency) accompanied by any new signs or symptoms of pyelonephritis (including fever, nausea, vomiting, or flank pain). A midstream or catheter specimen of urine should be sent

2013 NICE Clinical Knowledge Summaries

136. The Effects of Re-challenge in Patients with a History of Acute Anterior Uveitis Following Intravenous Zoledronate. (PubMed)

= 1000) or zoledronate 5 mg (N = 1001) intravenous infusion. Recruitment occurred over a 2-year period, with the first infusion being administered at recruitment, and subsequent infusions every 18 months. Eight participants developed acute anterior uveitis (AAU) (diagnosed by an ophthalmologist) following the first infusion of zoledronate. Following appropriate ophthalmic treatment, no patients had visual loss or other ocular sequelae. One further participant reported "sore red eyes" but did (...) of the acute phase response. If treated promptly under the care of an ophthalmologist, the visual prognosis is excellent. The results of this study suggest that the development of AAU should not be a contraindication to further infusion. However, in such cases, patients should be warned of the symptoms of AAU (ocular pain, redness, photophobia or blurred vision) and should be promptly referred to an ophthalmologist if symptoms develop.

2015 Calcified tissue international

137. The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure

: ocular massage Device: LenstarLS900 Device: Goldmann tonometer Not Applicable Detailed Description: Background: Primary angle closure glaucoma is still the most common type in Asia. Lowering intraocular pressure remains the mainstay of therapy in the management of glaucoma, since it has been shown to be effective in reducing optic nerve damage and loss of vision. The objective of this study was to evaluate to assess the effect of ocular massage on intraocular pressure in patients with acute primary (...) The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2015 Clinical Trials

138. Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)

concurrently. Condition or disease Intervention/treatment Phase Optic Neuritis Drug: Clemastine Drug: Placebo Phase 2 Detailed Description: Optic neuritis is an inflammatory, demyelinating disease of the optic nerve. It is most often characterized by visual loss or blurred vision along with dyschromatopsiaaccompanied by pain (especially with eye movement) and no demonstrable evidence of an alternate diagnosis such as ischemia or retinal disease. It can also be associated with a swollen optic disc (Optic (...) of California, San Francisco ClinicalTrials.gov Identifier: Other Study ID Numbers: 15-17428 First Posted: August 13, 2015 Last Update Posted: November 14, 2018 Last Verified: November 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Keywords provided by University of California, San Francisco: multiple sclerosis eye pain vision loss Additional relevant MeSH terms: Layout table for MeSH terms Neuritis Optic Neuritis

2015 Clinical Trials

139. Platelet Reactivity in Acute Non-disabling Cerebrovascular Events

[PRBCs]) for bleeding. The PLATO definition of other of major bleed is any one of the following:Significantly disabling (eg. intraocular with permanent vision loss), Clinically overt or apparent bleeding associated with a decrease in Hb of 30 g/L to 50 g/L, Transfusion of 2-3 units (whole blood or PRBCs) for bleeding. Intracranial hemorrhagic events. [ Time Frame: 90 days, 6 months, 1 year ] Intracranial hemorrhagic events is assessed by brain computed tomography (CT) or gradient recalled echo (GRE (...) Platelet Reactivity in Acute Non-disabling Cerebrovascular Events Platelet Reactivity in Acute Non-disabling Cerebrovascular Events - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelet Reactivity

2015 Clinical Trials

140. Neuroprotection for acute optic neuritis-Can it work? (PubMed)

Neuroprotection for acute optic neuritis-Can it work? Optic neuritis is a common manifestation of MS and the acute inflammatory lesion in the optic nerve resembles demyelinating plaques elsewhere in the CNS. As with other MS relapses, treatment with corticosteroids has little or no impact on the extent to which vision eventually recovers after an attack of optic neuritis. Neuroaxonal loss is now recognised as a major cause of permanent disability. Imaging of the retinal nerve fibre layer (...) with optical coherence tomography (OCT) and of the optic nerve with MRI both demonstrate significant volume loss which correlates with impaired visual function. The extent of axonal loss correlates with the magnitude of inflammation and there is robust evidence that excessive accumulation of sodium ions within axons in an inflammatory environment leads to axonal degeneration. Partial blockade of sodium channels protects against axonal loss and improves clinical outcome in experimental models of MS

2015 Multiple sclerosis and related disorders

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