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Acute Vision Loss

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61. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis

Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis Comparative Effectiveness Review Number 157 Comparative Effectiveness Review Number 157 Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2012-00012-I Prepared (...) . Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis. Comparative Effectiveness Review No. 157. (Prepared by the Brown Evidence-based Practice Center under Contract No. 290-2012-00012-I.) AHRQ Publication No. 15(16)-EHC025-EF. Rockville, MD: Agency for Healthcare Research and Quality; December 2015. www.effectivehealthcare.ahrq.gov/reports/final.cfm .iii Preface The Agency for Healthcare Research and Quality (AHRQ), through its Evidence-based Practice Centers (EPCs), sponsors

2016 Effective Health Care Program (AHRQ)

62. IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. (PubMed)

IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. To report acute/subacute vision loss and paracentral scotomata in patients with idiopathic multifocal choroiditis/punctate inner choroidopathy due to large zones of acute photoreceptor attenuation surrounding the chorioretinal lesions.Multimodal imaging case series.Six women and 2 men were included (mean age, 31.5 ± 5.8 years). Vision (...) cases, associated with decrease in hyperautofluorescence on fundus autofluorescence.Multifocal choroiditis/punctate inner choroidopathy can present with transient or permanent central photoreceptor attenuation/loss. This presentation is likely a variant of multifocal choroiditis/punctate inner choroidopathy with chorioretinal atrophy. Associated changes are best evaluated using multimodal imaging.

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2014 Retina

63. High incidence and prevalence of visual problems after acute stroke: An epidemiology study with implications for service delivery. (PubMed)

survivors. Three quarters 752/1033 (73%) had visual problems (point prevalence): 56% with impaired central vision, 40% eye movement abnormalities, 28% visual field loss, 27% visual inattention, 5% visual perceptual disorders. 281/1033 (27%) had normal eye exams.Incidence and point prevalence of visual problems in acute stroke is alarmingly high, affecting over half the survivors. For most, visual screening and full visual assessment was achieved within about 5 days of stroke onset. Crucial information (...) High incidence and prevalence of visual problems after acute stroke: An epidemiology study with implications for service delivery. Visual problems are an under-reported sequela following stroke. The aim of this study is to report annual incidence and point prevalence of visual problems in an acute adult stroke population and to explore feasibility of early timing of visual assessment.Multi-centre acute stroke unit, prospective, epidemiology study (1st July 2014 to 30th June 2015). Orthoptists

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2019 PLoS ONE

64. Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients

Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Effect of Intravenous Tranexamic Acid on Reduction of Blood Losses in Hip Fracture Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03211286 Recruitment Status : Recruiting First Posted

2017 Clinical Trials

65. Visual Loss Induced by Adalimumab Used for Plaque Psoriasis (PubMed)

Visual Loss Induced by Adalimumab Used for Plaque Psoriasis A 61-year-old Caucasian male with severe plaque psoriasis without joint involvement was initiated on adalimumab therapy. Shortly thereafter he presented to the emergency room with acute loss of vision in the right eye. A comprehensive systemic workup was instituted which included magnetic resonance imaging (MRI) with and without gadolinium of the brain and orbits. MRI revealed findings that were consistent with CNS demyelination (...) and retrobulbar optic neuritis. Immediate cessation of adalimumab was instituted without any other systemic therapy. Complete return of vision occurred within 6 weeks. No additional psoriatic or neurologic treatment was instituted, and the patient has remained stable now for 14 months.

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2017 Case reports in dermatology

66. Diffusion MRI quantifies early axonal loss in the presence of nerve swelling (PubMed)

DBSI detected pathologies and corresponding immunohistochemistry markers was quantitatively assessed.In this cohort of EAE mice, monocular vision impairment occurred in all animals. In vivo DBSI detected, differentiated, and quantified optic nerve inflammation, demyelination, and axonal injury/loss, correlating nerve pathologies with visual acuity at different time points of acute optic neuritis. DBSI quantified, in the presence of optic nerve swelling, ~15% axonal loss at the onset of optic (...) Diffusion MRI quantifies early axonal loss in the presence of nerve swelling Magnetic resonance imaging markers have been widely used to detect and quantify white matter pathologies in multiple sclerosis. We have recently developed a diffusion basis spectrum imaging (DBSI) to distinguish and quantify co-existing axonal injury, demyelination, and inflammation in multiple sclerosis patients and animal models. It could serve as a longitudinal marker for axonal loss, a primary cause of permanent

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2017 Journal of neuroinflammation

67. Acute Vision Loss

Acute Vision Loss Acute Vision Loss - Eye Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge Blurred Vision Blurred vision (...) SOCIAL MEDIA Add to Any Platform Loading , MD, Wilmer Eye Institute, Retina Division, Johns Hopkins University School of Medicine Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Loss of vision is usually considered acute if it develops within a few minutes to a couple of days. It may affect one or both eyes and all or part of a visual field. Patients with small visual field defects (eg, caused by a small retinal detachment) may describe

2013 Merck Manual (19th Edition)

68. Outcomes following three-line vision loss during treatment of neovascular age-related macular degeneration: subgroup analyses from MARINA and ANCHOR. (PubMed)

Outcomes following three-line vision loss during treatment of neovascular age-related macular degeneration: subgroup analyses from MARINA and ANCHOR. This study aims to assess the impact of continued ranibizumab treatment for neovascular age-related macular degeneration on patients from the MARINA and ANCHOR randomised clinical studies who lost ≥ 3 lines of best-corrected visual acuity (BCVA) at any time during the first year of treatment.Baseline characteristics, mean BCVA over time and ocular (...) adverse events (AEs) were evaluated both for patients whose BCVA loss occurred at any post-baseline visit and for patients whose BCVA loss was acute. The visit when the ≥ 3-line BCVA loss was detected was defined as the new baseline.Continued monthly ranibizumab treatment led to an improvement in mean BCVA from the new baseline. On average, patients with acute BCVA loss gained 11.9 letters at 3 months after the new baseline, compared with 0.3 letters gained with sham. No strong signals were detected

2011 British Journal of Ophthalmology

69. Stroke and Transient Ischemic Attack ? Acute and Long-Term Management

without evidence of acute infarction. 1 Clinical symptoms typically last minutes to one hour (although they can last up to 24 hours). These symptoms can include motor, sensory, speech/language, vision or cerebellar disturbances. A TIA can be seen along the same pathophysiological process as a stroke. Even with the resolution of symptoms, an infarct may have occurred and should be treated as a continuum of the same disease process as a stroke. A stroke is defined as the sudden onset of focal (...) incidence of cerebrovascular disease (see BCGuidelines.ca – Cardiovascular Disease – Primary Prevention and Hypertension – Diagnosis and Management guidelines). Diagnosis Diagnosis: Stroke or TIA Key features of a stroke/TIA are: 1) sudden onset; and 2) focal neurological deficits associated with a specific cerebral vascular territory. For example: 6 • Weakness - sudden loss of strength or numbness in the face, arm or leg • Difficulty with speech - sudden confusion or trouble speaking • Vision problems

2015 Clinical Practice Guidelines and Protocols in British Columbia

70. Bilateral cataract formation via acute spontaneous fracture of the lens following treatment of hyperglycemic hyperosmolar syndrome (PubMed)

formed by nuclear fracture of the crystalline lens after hyperglycemia correction, an entity that has not yet been described.A 67 year-old Caucasian man presented with sudden bilateral vision loss one week after a week-long hospitalization in the intensive care unit for correction of hyperglycemia in the setting of hyperglycemic hyperosmolar syndrome requiring an insulin drip. This was caused by spontaneous fractures of the lens nuclei causing bilateral irreversible cataracts. The patient underwent (...) Bilateral cataract formation via acute spontaneous fracture of the lens following treatment of hyperglycemic hyperosmolar syndrome Acute development of cataracts that may be transient is known to occur during correction of diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome. Nettleship in 1885 was the first to describe the presence of a transient cataract in three diabetic patients that grew worse and eventually cleared with treatment.1 We present a case of irreversible cataracts

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2017 American journal of ophthalmology case reports

71. Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis (PubMed)

Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear. We used fundus-referenced testing to evaluate visual function in regions of apparent cone loss identified using confocal AOSLO images.A patient diagnosed (...) with acute bilateral foveolitis had spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA + OCT system [Heidelberg Engineering, Vista, CA, USA]) images indicating focal loss of the inner segment-outer segment junction band with an intact, but hyper-reflective, external limiting membrane. Five years after symptom onset, visual acuity had improved from 20/80 to 20/25, but the retinal appearance remained unchanged compared to 3 months after symptoms began. We performed structural assessments

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2017 American journal of ophthalmology case reports

72. A Study Of Implantation Of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium In Subjects With Acute Wet Age Related Macular Degeneration And Recent Rapid Vision Decline

A Study Of Implantation Of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium In Subjects With Acute Wet Age Related Macular Degeneration And Recent Rapid Vision Decline A Study Of Implantation Of Retinal Pigment Epithelium In Subjects With Acute Wet Age Related Macular Degeneration - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies (...) : NCT01691261 Recruitment Status : Active, not recruiting First Posted : September 24, 2012 Last Update Posted : December 11, 2018 Sponsor: Pfizer Collaborator: University College, London Information provided by (Responsible Party): Pfizer Study Details Study Description Go to Brief Summary: Phase 1 trial of retinal pigment epithelium replacement in subjects with wet age-related macular degeneration in whom there is rapidly progressing vision loss Condition or disease Intervention/treatment Phase Age

2012 Clinical Trials

73. Limited efficacy of adalimumab in the acute phase of serpiginous choroiditis refractory to corticosteroid and cyclosporine, a case report. (PubMed)

Limited efficacy of adalimumab in the acute phase of serpiginous choroiditis refractory to corticosteroid and cyclosporine, a case report. The optimal treatment of serpiginous choroiditis is not established. While recent reports indicate the efficacy of adalimumab, there is limited evidence. We present a case of serpiginous choroiditis refractory to steroids, immunosuppressants, and adalimumab.An 18-year-old woman presented with severe vision loss in both eyes. A fundus examination revealed

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2019 BMC Ophthalmology

74. Acute Retinopathy in Pseudoxanthoma Elasticum. (PubMed)

Acute Retinopathy in Pseudoxanthoma Elasticum. Acute retinopathy may partly explain variable disease manifestation and vision loss in patients with pseudoxanthoma elasticum (PXE). The diagnosis of this likely autoimmune process may inform patient counseling and treatment approaches.To characterize acute retinopathy in patients with PXE as a disease manifestation that may be associated with profound visual impairment.This single-center case series was conducted from May 2013 to October 2018 (...) as antiretinal and anti-retinal pigment epithelium (RPE) antibody testing were also used.Acute retinopathy.Clinical presentation and disease course.Nine patients (8 [89%] female; mean [range] age, 43 [19-55] years) with acute retinopathy were identified in a cohort of 167 consecutive patients with PXE (frequency of 5%). Symptoms ranged from light sensations or metamorphopsia or color vision abnormalities to profound vision loss. Visual acuity was reduced in 6 patients (67%), ranging from a best-corrected

2019 JAMA ophthalmology

75. Acute blindness as a presenting sign of left atrial myxoma in a pediatric patient: A case report and literature review. (PubMed)

-old female patient visited our hospital due to sudden onset of vision loss in the left eye, dysarthria, and right-sided hemiplegia.She was diagnosed with CRAO via fundoscopy. Results showed a cherry-red spot, indicating CRAO. Brain magnetic resonance imaging (MRI) revealed multifocal diffusion-restricted foci, particularly in the left frontal lobe. Echocardiography revealed a left atrial mass measuring 4.21 cm × 2.25 cm. The mass was attached to the interseptum and moved along the inflow (...) Acute blindness as a presenting sign of left atrial myxoma in a pediatric patient: A case report and literature review. Central retinal artery occlusion (CRAO) due to cardiac myxoma primarily occurs in elderly individuals. Early detection and surgical resection of myxoma are extremely important because CRAO causes complete blindness in most cases. However, due to the extremely low incidence of CRAO caused by cardiac myxoma in the pediatric age group, such condition is rarely reported.A 16-year

2019 Medicine

76. Practice Advisory for Perioperative Visual Loss Associated with Spine Surgery

and hypotension as contributors to perioperative loss of vision. ANESTHESIOLOGY 1994; 80:222–6 Dunker S, Hsu HY, Sebag J, Sadun AA: Perioperative risk factors for posterior ischemic optic neuropathy. J Am Coll Surg 2002; 194:705–10 Hoff JM, Varhaug P, Midelfart A, Lund-Johansen M: Acute visual loss after spinal surgery. Acta Ophthalmol 2010; 88:490–2 Huber JF, Grob D: Bilateral cortical blindness after lumbar spine surgery. A case report. Spine 1998; 23:1807–9 Lee AG: Ischemic optic neuropathy following (...) from the immediate preoperative assessment through discharge from the acute healthcare facility. Conditions addressed in this Advisory include posterior ischemic optic neuropathy (ION), anterior ION, and central retinal artery occlusion (CRAO). “High-risk patients” are defined as those who undergo spine procedures while positioned prone and who have prolonged procedures, experience substantial blood loss, or both. B. Purpose of the Advisory The purpose of this Advisory is to enhance awareness

2012 American Society of Anesthesiologists

77. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice (PubMed)

of the retinal ganglion cells accompanied Th17-EAE but not Th1.Th17-induced transfer EAE recapitulates pathologies observed in MS-associated optic neuritis, namely, monocular episodes of vision loss, optic nerve inflammation, and geographic retinal ganglion cell (RGC) degeneration. (...) Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice Optic neuritis affects most patients with multiple sclerosis (MS), and current treatments are unreliable. The purpose of this study was to characterize the contribution of Th1 and Th17 cells to the development of optic neuritis.Mice were passively transferred myelin-specific Th1 or Th17 cells to induce experimental autoimmune encephalomyelitis (EAE), a model

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2016 Molecular vision

78. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis (PubMed)

Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis Optic neuritis, inflammation of the optic nerve, is experienced by most patients with multiple sclerosis (MS) and is typically characterized by episodes of acute, monocular vision loss. These episodes of inflammation can lead to damage or degeneration of the retinal ganglion cells (RGCs), the axons of which comprise the optic nerve. Experimental autoimmune encephalomyelitis (EAE

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2016 Molecular vision

79. Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke

Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke | Stroke Search Hello Guest! Login to your account Email Password Keep me logged in Search April 2019 March 2019 February 2019 February 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article (...) Share on Jump to Free Access article Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , MD, MSc, FRCPC, FAHA, Chair , MD, FAHA, Vice-Chair , MD, MS, FAHA , MD , DO , MD , MD, MS, FAHA , MD, MBA, FAHA , PhD , MD, MS, FAHA , MD, MSc, FAHA , and MD, FAHA MD, MPH, FAHAon behalf of the American Heart Association Stroke Council and Council

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2015 American Heart Association

80. Acute Pain Management: Scientific Evidence

Acute Pain Management: Scientific Evidence ACUTE PAIN MANAGEMENT: SCIENTIFIC EVIDENCE Fourth Edition 2015 Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine Edited by: Stephan A Schug Greta M Palmer David A Scott Richard Halliwell Jane T rinca© Australian and New Zealand College of Anaesthetists 2015 ISBN Print: 978-0-9873236-7-5 Online: 978-0-9873236-6-8 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced (...) and Faculty of Pain Medicine (2015), Acute Pain Management: Scientific Evidence (4th edition), ANZCA & FPM, Melbourne. Copyright information for Tables 10.1 and 10.2 The material presented in Table 10.1 and Table 10.2 of this document has been reproduced with permission from Prescribing Medicines in Pregnancy, 2015, Therapeutic Goods Administration. It does not purport to be the official or authorised version. © Commonwealth of Australia 2015 This work is copyright. You may download, display, print

2015 Clinical Practice Guidelines Portal

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