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Acute Pancreatitis

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161. Chronic pancreatitis

. Underlying causes and precipitating factors are treated. There is no definitive therapy; treatment is otherwise aimed at symptoms. Common complications include narcotic addiction, pancreatic pseudocysts, pancreatic calcification, diabetes mellitus, and malabsorption. Definition Pancreatitis is a clinical diagnosis defined by pancreatic inflammation. Although not always clinically distinguishable, pancreatitis can be defined as acute or chronic. Acute pancreatitis is a self-limiting and reversible (...) , management decisions, and future. Pancreas. 2016 May-Jun;45(5):641-50. http://www.ncbi.nlm.nih.gov/pubmed/27077713?tool=bestpractice.com (1) Recurrent acute pancreatitis: there is an identifiable cause of acute pancreatitis that does not lead to chronic pancreatitis (e.g., gallstones, drugs, hypercalcaemia, etc.). (2) Idiopathic pancreatitis: exhaustive evaluation identifies no cause. Most commonly this represents chronic relapsing pancreatitis or definite chronic pancreatitis. (3) Chronic relapsing

2018 BMJ Best Practice

162. Chronic pancreatitis

. Underlying causes and precipitating factors are treated. There is no definitive therapy; treatment is otherwise aimed at symptoms. Common complications include narcotic addiction, pancreatic pseudocysts, pancreatic calcification, diabetes mellitus, and malabsorption. Definition Pancreatitis is a clinical diagnosis defined by pancreatic inflammation. Although not always clinically distinguishable, pancreatitis can be defined as acute or chronic. Acute pancreatitis is a self-limiting and reversible (...) , management decisions, and future. Pancreas. 2016 May-Jun;45(5):641-50. http://www.ncbi.nlm.nih.gov/pubmed/27077713?tool=bestpractice.com (1) Recurrent acute pancreatitis: there is an identifiable cause of acute pancreatitis that does not lead to chronic pancreatitis (e.g., gallstones, drugs, hypercalcaemia, etc.). (2) Idiopathic pancreatitis: exhaustive evaluation identifies no cause. Most commonly this represents chronic relapsing pancreatitis or definite chronic pancreatitis. (3) Chronic relapsing

2018 BMJ Best Practice

163. Comparison of normal saline versus Lactated Ringer's solution for fluid resuscitation in patients with mild acute pancreatitis, A randomized controlled trial. (Abstract)

Comparison of normal saline versus Lactated Ringer's solution for fluid resuscitation in patients with mild acute pancreatitis, A randomized controlled trial. Aggressive fluid resuscitation is recommended for initial management of acute pancreatitis. However, there are few studies which focus on types of fluid therapy.We performed a randomized controlled trial in patients with acute pancreatitis. The patients were randomized into two groups. Each group received Normal Saline solution (NSS (...) solution was superior to NSS in SIRS reduction in acute pancreatitis only in the first 24 h. But SIRS at 48 h and mortality were not different between LRS and NSS.Copyright © 2018 IAP and EPC. Published by Elsevier B.V. All rights reserved.

2018 Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Controlled trial quality: uncertain

164. Early Enteral Nutrition Prevent Acute Pancreatitis From Deteriorating in Obese Patients. (Abstract)

Early Enteral Nutrition Prevent Acute Pancreatitis From Deteriorating in Obese Patients. The aim of this study was to determine a potential strategy to prevent acute pancreatitis (AP) from deteriorating in obese patients.Nutritional support plays a critical role in the treatment of AP. Early enteral nutrition (EEN) is considered to be able to protect mucosa of AP patients and alleviate inflammatory reactions. Obesity worsen AP prognosis. However, little is known about the effects of EEN (...) , plasma levels of cytokines, and intestine gut barrier index were measured at different timepoints after admission.VFO was a risk factor for aggravating of AP. EEN prevented the VFO patients from developing pancreatic necrotic infection, the mechanism of which might be related with inhibiting excessive inflammatory reactions, adjusting the imbalance of inflammatory response, and alleviating ischemia of intestine mucosa.The potential strategy, EEN, was able to prevent AP from deteriorating in obese

2018 Journal of clinical gastroenterology Controlled trial quality: uncertain

165. Percutaneous catheter drainage combined with peritoneal dialysis for treating acute severe pancreatitis: a single-center prospective study. (Abstract)

Percutaneous catheter drainage combined with peritoneal dialysis for treating acute severe pancreatitis: a single-center prospective study. To investigate the efficacy of percutaneous catheter drainage (PCD) and peritoneal dialysis (PD) in the treatment of severe acute pancreatitis (SAP) and its underlying mechanism.Totally 64 SAP patients were included in our study and randomly assigned into PCD + PD group (the combination group, N = 32) and convention group (N = 32). SAP patients (...) (amelioration time of abdominal pain and abdominal distension, Balthazar CT scores, acute physiology and chronic health enquiry II score, length of hospital stay, complications and prognosis).The expression levels of inflammatory cytokines were significantly decreased in the combination group in a time-dependent manner in comparison with those of the convention group. In addition, the amelioration time of abdominal pain and abdominal distension, length of hospital stay, Balthazar CT scores and the acute

2018 Minerva chirurgica Controlled trial quality: uncertain

166. [Clinical observation on severe acute pancreatitis treated with electroacupuncture at Dachangshu (BL 25) and Shangjuxu (ST 37) combined with ulinastatin]. (Abstract)

[Clinical observation on severe acute pancreatitis treated with electroacupuncture at Dachangshu (BL 25) and Shangjuxu (ST 37) combined with ulinastatin]. To observe the clinical therapeutic effects on severe acute pancreatitis (SAP) treated with electroacupuncture (EA), sparse-dense wave and 2 Hz/15 Hz, at Dachangshu (BL 25) and Shangjuxu (ST 37) assisting ulinastetin and explore the effective therapeutic method for SAP.A total of 120 patients of SAP were randomized into an observation group (...) and the hospitalization time were recorded in the patients of the two groups. The changes in the tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and amylase, as well as the scores in the acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) were compared in the patients of the two groups before treatment, and on the 3rd, 8th and 14th days of treatment. The therapeutic effects, the cases of surgical transfer or the cases of the transfer of intensive care unit (ICU) were compared between the two

2018 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

167. [Effect of Proton Pump Inhibitors on Severe Acute Pancreatitis--a Prospective Randomized Trial]. (Abstract)

[Effect of Proton Pump Inhibitors on Severe Acute Pancreatitis--a Prospective Randomized Trial]. To evaluate the effect of proton pump inhibitors (PPIs) therapy on severe acute pancreatitis (SAP) patients.Forty five patients with SAP recruited in our center from October 2015 to October 2016,were randomly assigned into two groups: convention group (C group,n=21) and convention+esomeprazole group (C+E group,n=24). C+E group received esomeprazole 40 mg/d intravenously for 1 week,whereas C group (...) only received baseline treatment. Serum C-reactive protein (CRP),interleukin-6 (IL-6) and interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) were detected by ELISA on the first day (baseline) and the seventh day. Acute physiology and chronic health evaluation Ⅱ scores (APACHE Ⅱ),systemic inflammatory response syndrome scores (SIRS) and modified Marshall scoring system (Marshall) were obtained at 1 d (baseline),3 d and 7 d. Upper gastrointestinal manifestation (peptic ulcer

2018 Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Controlled trial quality: uncertain

168. [Electroacupuncture for severe acute pancreatitis accompanied with paralytic ileus:a randomized controlled trial]. (Abstract)

[Electroacupuncture for severe acute pancreatitis accompanied with paralytic ileus:a randomized controlled trial]. To observe the clinical efficacy differences between electroacupuncture (EA) and regular treatment for severe acute pancreatitis accompanied with paralytic ileus.This was a prospective pragmatic randomized controlled trial. A total of 140 cases of severe acute pancreatitis accompanied with paralytic ileus were randomly assigned into an EA group and a regular treatment group, 70 (...) significantly superior to those of the regular treatment group (all P<0.05). (2) The number of patients who transferred to surgery or ICU was not significantly different between the two groups (P>0.05).EA at Zusanli (ST 36) and Zhigou (TE 6) can significantly reduce the abdominal distension and pain severity scales in patients of severe acute pancreatitis accompanied with paralytic ileus, indicating positive clinical significance; in addition, EA is safe and can be recommended to the treatment of severe

2018 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

169. [Comparison of Clinical Effects of Electroacupuncture of Abdominal and Limb Acupoints in the Treatment of Acute Pancreatitis]. (Abstract)

[Comparison of Clinical Effects of Electroacupuncture of Abdominal and Limb Acupoints in the Treatment of Acute Pancreatitis]. To compare the difference of therapeutic efficacy of electroacupuncture (EA) stimulation of abdominal acupoints and limb acupoints in the treatment of acute pancreatitis (AP), so as to provide a reference for EA treatment of AP.A total of 60 patients with AP were equally and randomly divided into abdominal acupoint group and limb acupoint group. On the basis

2018 Zhen ci yan jiu = Acupuncture research Controlled trial quality: uncertain

170. Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report. Full Text available with Trip Pro

Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report. Blood infection with Candida glabrata often occurs in during severe acute pancreatitis (SAP). It complicate severe agranulocytosis has not been reported.We present a case where a SAP patient presenting with a sudden hyperpyrexia was treated for 19 days. We monitored her routine blood panel and CRP levels once or twice daily. The results showed that WBC count decreased gradually

2018 BMC Infectious Diseases

171. The impact of empiric endoscopic biliary sphincterotomy on future gallstone-related complications in patients with non-severe acute biliary pancreatitis whose cholecystectomy was deferred or not performed. (Abstract)

The impact of empiric endoscopic biliary sphincterotomy on future gallstone-related complications in patients with non-severe acute biliary pancreatitis whose cholecystectomy was deferred or not performed. Early cholecystectomy (EC) is recommended in patients with acute biliary pancreatitis (ABP). In real-life practice, cholecystectomy is frequently deferred due to various reasons and delayed cholecystectomy (DC) is performed instead. Endoscopic sphincterotomy (ES) is an alternative to prevent (...) recurrent pancreatitis, however other gallstone-related complications (GCs) may still develop. We aimed to determine the impact of ES on future GCs in patients with non-severe acute biliary pancreatitis whose cholecystectomy was deferred or not performed.During 2006-2016, we included patients with non-severe ABP while those with severe pancreatitis and concurrent cholangitis were excluded. GC events were compared between those who had DC with ES and those who had DC without ES. A similar comparison

2018 Surgical endoscopy

172. Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study. Full Text available with Trip Pro

Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study. Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.Cohort study.Electronic healthcare registries in Scotland.The ccAP cohort included 1471 patients (...) admitted to critical care with AP between 1 January 2008 and 31 December 2010 followed up until 31 December 2014. The population cohort included 3450 individuals from the general population of Scotland frequency-matched for age, sex and social deprivation.Record linkage of routinely collected electronic health data with population matching.Patient demographics, comorbidity (Charlson Comorbidity Index), acute physiology, organ support and other critical care data were linked to records of mortality

2018 BMJ open

173. Body Mass Index and the Risk of Acute Pancreatitis by Etiology: A Prospective Analysis of Korean National Screening Cohort. (Abstract)

Body Mass Index and the Risk of Acute Pancreatitis by Etiology: A Prospective Analysis of Korean National Screening Cohort. It is unclear whether obesity increases the incidence of acute pancreatitis (AP) in the general population. Further, no study has prospectively examined the associations of the risk of AP by etiology with measured body mass index (BMI) values.A total of 512 928 Korean participants in routine health examinations during 2002-2003 were followed up until 2013 via linkage

2018 Journal of gastroenterology and hepatology

174. Validation of Lipase and SIRS as Prognostic Indicators in Pediatric Acute Pancreatitis: A Retrospective Analysis. (Abstract)

Validation of Lipase and SIRS as Prognostic Indicators in Pediatric Acute Pancreatitis: A Retrospective Analysis. Acute pancreatitis (AP) is understudied in the pediatric population despite increasing incidence. Although many cases are mild and resolve with supportive care, severe acute pancreatitis (SAP) can be associated with significant morbidity and mortality. There is a lack of pediatric-specific predictive tools to help stratify risk of SAP in children.A retrospective cohort study (...) ). Patients with comorbidities stayed an average of 5.6 ± 7.6 days NPO, whereas those without comorbidities spent 2.8 ± 2.4 days NPO. Lipase was not predictive of SAP, LOS, or length of time spent NPO.These results support the use of SIRS as a simple screening tool on admission to identify children at risk for the development of SAP. The presence of any comorbidity was predictive of LOS and length of NPO in the multivariate model. This may reflect that comorbidities prolong pancreatitis or influence

2018 Journal of Pediatric Gastroenterology and Nutrition

175. Acute Pancreatitis: Updates for Emergency Clinicians. (Abstract)

Acute Pancreatitis: Updates for Emergency Clinicians. Acute pancreatitis is a frequent reason for patient presentation to the emergency department (ED) and the most common gastrointestinal disease resulting in admission. Emergency clinicians are often responsible for the diagnosis and initial management of acute pancreatitis.This review article provides emergency clinicians with a focused overview of the diagnosis and management of pancreatitis.Pancreatitis is an inflammatory process within (...) ultrasound. The initial management of choice is fluid resuscitation and pain control. Recent data have suggested that more cautious fluid resuscitation in the first 24 h might be more appropriate for some patients. Intravenous opiates are generally safe if used judiciously. Appropriate disposition is a multifactorial decision, which can be facilitated by using Ranson criteria or the Bedside Index of Severity in Acute Pancreatitis score. Complications, though rare, can be severe.Pancreatitis

2018 Journal of Emergency Medicine

176. Classification and Nutrition Management of Acute Pancreatitis in the Pediatric Intensive Care Unit. (Abstract)

Classification and Nutrition Management of Acute Pancreatitis in the Pediatric Intensive Care Unit. The aims of this retrospective cohort study were to classify the severity of patients admitted to the pediatric intensive care unit (PICU) with acute pancreatitis (AP) and to identify how many patients received appropriate nutritional management in accordance with more recent guidelines and the outcomes of those patients. Of the 54 children with AP, 12 (22.2%) had a primary diagnosis of AP (50

2018 Journal of Pediatric Gastroenterology and Nutrition

177. Trypsin encoding PRSS1-PRSS2 variation influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report. Full Text available with Trip Pro

Trypsin encoding PRSS1-PRSS2 variation influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report. Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pancreatitis pathogenesis, ten trial groups contributed remission samples from patients aged 1.0-17.9 years treated (...) for acute lymphoblastic leukemia between 2000 and 2016. Cases (n=244) were defined by the presence of at least two of the following criteria: (i) abdominal pain; (ii) levels of pancreatic enzymes ≥3 × upper normal limit; and (iii) imaging compatible with pancreatitis. Controls (n=1320) completed intended asparaginase therapy, with 78% receiving ≥8 injections of pegylated-asparaginase, without developing asparaginase-associated pancreatitis. rs62228256 on 20q13.2 showed the strongest association

2018 Haematologica

178. Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis

Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

2018 Clinical Trials

179. A PK/PD Study of CM4620-IE in Patients With Acute Pancreatitis

A PK/PD Study of CM4620-IE in Patients With Acute Pancreatitis A PK/PD Study of CM4620-IE in Patients With Acute Pancreatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A PK/PD Study of CM4620-IE (...) in Patients With Acute Pancreatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03709342 Recruitment Status : Active, not recruiting First Posted : October 17, 2018 Last Update Posted : March 14, 2019 Sponsor: CalciMedica, Inc. Information provided by (Responsible Party): CalciMedica, Inc. Study

2018 Clinical Trials

180. Secretin for Acute Pancreatitis

Secretin for Acute Pancreatitis Secretin for Acute Pancreatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Secretin for Acute Pancreatitis (SNAP) The safety and scientific validity of this study (...) Party): ChiRhoClin, Inc. Study Details Study Description Go to Brief Summary: Acute pancreatitis is a frequently devastating pancreatic inflammatory process that results in extensive morbidity, mortality, and hospitalization costs. The incidence of acute pancreatitis has been increasing over the last decade with an overall mortality rate of 5%, although it may be as high as 30% in the most severe cases. It was the most common inpatient gastrointestinal diagnosis in 2009, totaling over 270,000

2018 Clinical Trials

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