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Acute Pancreatitis

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141. Pancreatic Duct Stent for Acute Necrotizing Pancreatitis

Pancreatic Duct Stent for Acute Necrotizing Pancreatitis Pancreatic Duct Stent for Acute Necrotizing Pancreatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pancreatic Duct Stent for Acute Necrotizing (...) by (Responsible Party): Florida Hospital Study Details Study Description Go to Brief Summary: The research design is a randomized prospective clinical study comparing the incidence of Walled Off Necrosis (WON) in patients with acute necrotizing pancreatitis. Condition or disease Intervention/treatment Phase Necrotizing Pancreatitis Walled Off Necrosis Device: Pancreatic Duct Stent Placement Other: No Pancreatic Duct Stent Placement Not Applicable Detailed Description: This is a randomized trial comparing

2017 Clinical Trials

142. A Trial of Early Percutaneous Catheter Drainage of Sterile Pancreatic Fluid Collections in Severe Acute Pancreatitis

A Trial of Early Percutaneous Catheter Drainage of Sterile Pancreatic Fluid Collections in Severe Acute Pancreatitis A Trial of Early Percutaneous Catheter Drainage of Sterile Pancreatic Fluid Collections in Severe Acute Pancreatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. A Trial of Early Percutaneous Catheter Drainage of Sterile Pancreatic Fluid Collections in Severe Acute Pancreatitis (EPCDSAP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

143. Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis

Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acute Necrotizing Pancreatitis (...) University Hospital Information provided by (Responsible Party): Nantes University Hospital Study Details Study Description Go to Brief Summary: Acute necrotizing pancreatitis is a frequent and potentially lethal disease, especially in case of infected pancreatic necrosis (IPN). IPN usually occurs after the first week of evolution. The step up approach is now widely recommended for the management of IPN. In fact, in case of suspicion of IPN, a drainage percutaneous or transgastric is recommended at first

2017 Clinical Trials

144. Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis. (Abstract)

Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis. Opioids such as morphine are widely used for the management of pain associated with acute pancreatitis. Interestingly, opioids are also known to affect the immune system and modulate inflammatory pathways in non-pancreatic diseases. However, the impact of morphine on the progression of acute pancreatitis has never been evaluated. In the current study, we evaluated the impact of morphine (...) on the progression and severity of acute pancreatitis.Effect of morphine treatment on acute pancreatitis in caerulein, L-arginine and ethanol-palmitoleic acid models was evaluated after induction of the disease. Inflammatory response, gut permeability and bacterial translocation were compared. Experiments were repeated in mu (µ) opioid receptor knockout mice (MORKO) and in wild-type mice in the presence of opioid receptor antagonist naltrexone to evaluate the role of µ-opioid receptors in morphine's effect

2017 Gut

145. Early diagnosis of pancreatic necrosis based on perfusion CT to predict the severity of acute pancreatitis. (Abstract)

Early diagnosis of pancreatic necrosis based on perfusion CT to predict the severity of acute pancreatitis. Perfusion CT can diagnose pancreatic necrosis in early stage of severe acute pancreatitis, accurately. However, no study to date has examined whether early diagnosis of pancreatic necrosis is useful in predicting persistent organ failure (POF).We performed a multi-center prospective observational cohort study to investigate whether perfusion CT can predict the development of POF (...) in the early stage of AP, based on early diagnosis of the development of pancreatic necrosis (PN). From 2009 to 2012, we examined patients showing potential early signs of severe AP (n = 78) on admission. Diagnoses for the development of PN were made prospectively by on-site physicians on the admission based on perfusion CT (diagnosis 1). Blinded retrospective reviews were performed by radiologists A and B, having 8 and 13 years of experience as radiologists (diagnosis 2 and 3), respectively. Positive

2017 Journal of gastroenterology

146. Dynamic Measurement of Disease Activity in Acute Pancreatitis: The Pancreatitis Activity Scoring System. Full Text available with Trip Pro

Dynamic Measurement of Disease Activity in Acute Pancreatitis: The Pancreatitis Activity Scoring System. Acute pancreatitis has a highly variable course. Currently there is no widely accepted method to measure disease activity in patients hospitalized for acute pancreatitis. We aimed to develop a clinical activity index that incorporates routine clinical parameters to assist in the measurement, study, and management of acute pancreatitis.We used the UCLA/RAND appropriateness method to identify (...) of illness as well as (iii) early and persistent elevation of disease activity among patients with severe acute pancreatitis defined as persistent organ failure.We present the development and initial validation of a clinical activity score for real-time assessment of disease activity in patients with acute pancreatitis.

2017 American Journal of Gastroenterology

147. Retrospective study of patients with acute pancreatitis: is serum amylase still required? Full Text available with Trip Pro

Retrospective study of patients with acute pancreatitis: is serum amylase still required? Retrospective study of patients with acute pancreatitis: is serum amylase still required? Retrospective study of patients with acute pancreatitis: is serum amylase still required? Gomez D, Addison A, De Rosa A, Brooks A, Cameron IC Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The aim was to explore the cost savings from measuring both serum amylase and lipase enzyme levels, compared with serum lipase alone, in patients with acute pancreatitis. The authors concluded that the measurement of serum lipase concentration alone was sufficient to diagnose patients with pancreatitis, and could produce cost savings. Several aspects of the study

2013 NHS Economic Evaluation Database.

148. Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database Full Text available with Trip Pro

Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database Effect and cost of treatment for acute pancreatitis with or without gabexate mesylate: a propensity score analysis using a nationwide administrative database Yasunaga H, Horiguchi H (...) , Hashimoto H, Matsuda S, Fushimi K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the cost and effectiveness of gabexate mesylate for adult patients with acute pancreatitis. The authors concluded that treatment

2013 NHS Economic Evaluation Database.

149. Chronic Pancreatitis

pancreatic insufficiency and diabetes developing at highly variable rates. CP is most commonly caused by toxins such as alcohol or tobacco use, genetic polymorphisms, and recurrent attacks of acute pancreatitis, although no history of acute pancreatitis is seen in many patients. Diagnosis is made usually on cross-sectional imaging, with modalities such as endoscopic ultrasonography and pancreatic function tests playing a secondary role. Total pancreatectomy represents the only known cure for CP, although (...) Chronic Pancreatitis ACG Clinical Guideline: Chronic Pancreatitis : American Journal of Gastroenterology ')} You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within the USA), 301-223-2300 (outside

2020 American College of Gastroenterology

150. American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis Full Text available with Trip Pro

Division of Gastrointestinal and Laparoscopic Surgery, Medical University of South Carolina, Charleston, South Carolina 4 DOI: | Publication History Published online: August 31, 2019 Accepted: July 31, 2019 ; Received: April 6, 2019 ; | ---- Figure 1 Flow diagram on the suggested nutritional management of patients with severe acute pancreatitis and necrosis. GOO, gastric outlet obstruction; NG, nasogastric; NJ, nasojejunal; PEG, percutaneous endoscopic gastrostomy; PEG-J percutaneous endoscopic (...) outlining the acute- and late-phase management of patients with severe acute pancreatitis and necrosis, including a multidisciplinary approach to drainage and/or debridement when required. ---- | ---- Supplementary Figure 1 Classification of acute pancreatitis and associated fluid collections. Based on international consensus according to the Acute Pancreatitis Classification Working Group (revised Atlanta criteria). x 2 Banks, P.A., Bollen, T.L., Dervenis, C. et al. Classification of acute pancreatitis

2020 American Gastroenterological Association Institute

151. The Roles of Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography in the Evaluation and Treatment of Chronic Pancreatitis in Children:A Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutr

pancreatic imaging findings along with either abdominal pain consistent with pancreatic origin, exocrine pancreatic insuffi- ciency (EPI), or endocrine pancreatic insufficiency (3). This posi- tion paper will not review indications of EUS and ERCP for cases of acute pancreatitis (AP), discussed in a recent NASPGHAN (North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition) clinical report on management of AP in children (4). It will also not consider surgical or medical management (...) of successful use in pediatrics (53,54). LAMS, while having less migration complications, do carry a risk of pseudoaneurysm and bleeding, and are generally removed within 4 to 6 weeks. The indication for intervention in any particular patient must be carefully considered. Acute peripancreatic fluid collections, pseudocysts and pancreatic necrosis often resolve without any intervention, and hence it is important to emphasize that management of these complications of CP should involve a tertiary care center

2020 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

152. Involvement of the PI3K/Akt/NF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract Full Text available with Trip Pro

Involvement of the PI3K/Akt/NF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats (...) and to explore the underlying mechanisms. Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI. During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-κB) p65 in the lungs were upregulated. Meanwhile, a parallel increase in the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the lungs was observed after the induction

2017 BioMed research international

153. Circulating miRNAs as biomarkers for severe acute pancreatitis associated with acute lung injury Full Text available with Trip Pro

Circulating miRNAs as biomarkers for severe acute pancreatitis associated with acute lung injury To identify circulating micro (mi)RNAs as biological markers for prediction of severe acute pancreatitis (SAP) with acute lung injury (ALI).Twenty-four serum samples were respectively collected and classified as SAP associated with ALI and SAP without ALI, and the miRNA expression profiles were determined by microarray analysis. These miRNAs were validated by quantitative reverse transcription

2017 World Journal of Gastroenterology

154. Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis Full Text available with Trip Pro

Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis The present study aimed to evaluate the protective effects of emodin on severe acute pancreatitis (SAP)‑associated acute lung injury (ALI), and investigated the possible mechanism involved. SAP was induced in Sprague‑Dawley rats by retrograde infusion of 5% sodium taurocholate (1 ml/kg), after which, rats were (...) divided into various groups and were administered emodin, FK866 [a competitive inhibitor of pre‑B‑cell colony‑enhancing factor (PBEF)] or dexamethasone (DEX). DEX was used as a positive control. Subsequently, PBEF expression was detected in polymorphonuclear neutrophils (PMNs) isolated from rat peripheral blood by reverse transcription‑quantitative polymerase chain reaction and western blotting. In addition, histological alterations, apoptosis in lung/pancreatic tissues, apoptosis of peripheral blood

2017 Molecular medicine reports

155. Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats Full Text available with Trip Pro

Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats The aim of the present study was to investigate the effect of curcumin on acute renal injury in a rat model of severe acute pancreatitis (SAP). A SAP model with acute kidney injury was established in rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. The serum amylase, creatinine (Cr) and blood urea nitrogen (BUN) levels in rats were measured (...) . Hematoxylin and eosin staining was used to assess pancreatic and renal histological changes. Serum tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured using ELISA kits. Renal protein levels of Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway components were determined by western blot assay. The results showed that curcumin significantly decreased serum amylase, Cr and BUN levels, and alleviated pancreatic and renal histological changes in SAP

2017 Experimental and therapeutic medicine

156. Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis Full Text available with Trip Pro

Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis In health, uromodulin is the main protein of urine. Serum uromodulin concentrations (sUMOD) have been shown to correlate with kidney function. Acute kidney injury (AKI) is among the main complications of severe acute pancreatitis (AP). No reports exist on sUMOD in patients with AP, including the diagnostic usefulness for early prediction of AP severity. We measured sUMOD during first 72 h of AP

2017 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

157. Acute Pancreatitis and Rhabdomyolysis with Acute Kidney Injury following Multiple Wasp Stings Full Text available with Trip Pro

Acute Pancreatitis and Rhabdomyolysis with Acute Kidney Injury following Multiple Wasp Stings Multiple wasp stings can induce multiple organ dysfunction by toxic reactions. However, acute pancreatitis is a rare manifestation in wasp sting injury. A 74-year-old woman visited the emergency department by anaphylactic shock because of multiple wasp stings. Acute kidney injury, rhabdomyolysis, hepatotoxicity, and coagulopathy were developed next day. Serum amylase and lipase were elevated (...) and an abdominal computed tomography revealed an acute pancreatitis. Urine output was recovered after 16 days of oliguria (below 500 ml/day). Her kidney, liver, and pancreas injury gradually improved after sessions of renal replacement therapy.

2017 Case reports in nephrology

158. A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer

A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

159. Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis

Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis Yi F, Ge L, Zhao J, Lei Y, Zhou F, Chen Z, Zhu Y, Xia B CRD summary The authors concluded that total enteral nutrition was associated with decreased mortality (...) , infectious complications, organ failure and surgical intervention rate compared with parenteral nutrition. Given the limited reporting of several aspects of the review and differences between studies, the reliability of the authors' conclusions is unclear. Authors' objectives To compare the effectiveness of total parenteral nutrition with total enteral nutrition in participants with predicted severe acute pancreatitis. Searching PubMed, EMBASE and the Science Citation Index were searched to September

2012 DARE.

160. Pancreatic cancer

cancer other hereditary cancer syndromes chronic sporadic pancreatitis diabetes mellitus obesity dietary factors Diagnostic investigations abdominal ultrasound pancreatic protocol CT LFTs prothrombin time (PT) FBC cancer antigen (CA)19-9 biomarker positron emission tomography endoscopic retrograde cholangiopancreatography (ERCP) magnetic resonance cholangiopancreatography endoscopic ultrasound staging laparoscopy (with laparoscopic ultrasound) biopsy Treatment algorithm ACUTE Contributors Authors (...) Pancreatic cancer Pancreatic cancer - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Pancreatic cancer Last reviewed: February 2019 Last updated: August 2018 Summary Pancreatic cancer is the sixth most common cause of cancer-related death in Europe. Most common presentation is at 65 to 75 years of age with painless obstructive jaundice and weight loss. Generally presents late with advanced disease. Surgical resection

2018 BMJ Best Practice

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