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Acute Pancreatitis

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1. Actim Pancreatitis for diagnosing acute pancreatitis

Actim Pancreatitis for diagnosing acute pancreatitis Actim Pancreatitis for diagnosing acute pancreatitis Medtech innovation briefing Published: 18 June 2020 www.nice.org.uk/guidance/mib218 pathways Summary Summary • The technology technology described in this briefing is the Actim Pancreatitis rapid test. It is to diagnose acute pancreatitis in people presenting to emergency departments with acute abdominal pain or in people who have had endoscopic retrograde cholangiopancreatography (ERCP (...) ). • The innovative aspects innovative aspects are that it is a urine dipstick test which means the likelihood of pancreatitis can be rapidly assessed. It does not need processing in a laboratory. • The intended place in therapy place in therapy would be instead of amylase or lipase blood tests to diagnose acute pancreatitis. • The main points from the evidence main points from the evidence summarised in this briefing are from 6 studies including 3,134 patients in a meta-analysis and 5 observational studies

2020 National Institute for Health and Clinical Excellence - Advice

2. Acute pancreatitis

Acute pancreatitis Acute pancreatitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acute pancreatitis Last reviewed: February 2019 Last updated: January 2019 Summary The most common presenting symptom is mid-epigastric or left upper quadrant pain that radiates to the back. Epigastric tenderness is typical. Associated with nausea and vomiting. A history of cholelithiasis or alcohol intake is often present. Signs (...) of hypovolaemia (including decreased skin turgor, dry mucous membranes, hypotension, and sweating) are common. In more severe cases, the patient may be tachycardic and/or tachypnoeic. Elevated serum lipase or amylase concentration supports, but is not pathognomonic for, the diagnosis of acute pancreatitis. Initial treatment includes resuscitation with intravenous fluids and correction of electrolyte abnormalities, analgesia, and tight glucose control. Treatment of severe acute pancreatitis includes support

2019 BMJ Best Practice

3. Acute pancreatitis

Acute pancreatitis Evidence Maps - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading

2018 Trip Evidence Maps

4. Clinico-radiological comparison and short-term prognosis of single acute pancreatitis and recurrent acute pancreatitis including pancreatic volumetry. Full Text available with Trip Pro

Clinico-radiological comparison and short-term prognosis of single acute pancreatitis and recurrent acute pancreatitis including pancreatic volumetry. The necrosis-fibrosis hypothesis describes a continuum between single attacks of acute pancreatitis (SAP), recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) with endocrine and exocrine pancreatic insufficiency. For prevention purposes we evaluated clinico-radiological parameters and pancreatic volumetry to compare SAP and RAP (...) and provide prognostic relevance on short-term mortality, need for intervention and the hospitalization duration.We retrospectively investigated 225 consecutive patients (150 males, range 19-97years) with acute pancreatitis (74%SAP, 26%RAP) according to the revised Atlanta classification. All patients received an intravenous contrast-enhanced CT after a median time of 5 (IQR 5-7) days after onset of symptoms. Two experienced observers rated the severity of AP by 3 CT scores (CTSI, mCTSI, EPIC). Moreover

2018 PLoS ONE

5. Acute pancreatitis

Acute pancreatitis Acute pancreatitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acute pancreatitis Last reviewed: February 2019 Last updated: January 2019 Summary The most common presenting symptom is mid-epigastric or left upper quadrant pain that radiates to the back. Epigastric tenderness is typical. Associated with nausea and vomiting. A history of cholelithiasis or alcohol intake is often present. Signs (...) of hypovolaemia (including decreased skin turgor, dry mucous membranes, hypotension, and sweating) are common. In more severe cases, the patient may be tachycardic and/or tachypnoeic. Elevated serum lipase or amylase concentration supports, but is not pathognomonic for, the diagnosis of acute pancreatitis. Initial treatment includes resuscitation with intravenous fluids and correction of electrolyte abnormalities, analgesia, and tight glucose control. Treatment of severe acute pancreatitis includes support

2018 BMJ Best Practice

6. Clinical analysis of patients with acute pancreatitis complicated with hemorrhagic fever with renal syndrome and acute biliary pancreatitis. Full Text available with Trip Pro

Clinical analysis of patients with acute pancreatitis complicated with hemorrhagic fever with renal syndrome and acute biliary pancreatitis. Acute pancreatitis (AP) is a rare complication of hemorrhagic fever with renal syndrome (HFRS), and is difficult to diagnose. In this study, we retrospectively analyzed the clinical characteristics of 7 cases of HFRS complicated with AP and 105 cases of acute biliary pancreatitis (ABP).Medical records of 83 hospitalized patients with HFRS and 105 (...) discharged from the hospital after conservative treatment, 53 patients were treated by endoscopic invasive treatment after stabilization, and 31 patients were treated by surgery after stabilization.AP is not a frequent complication in patients with HFRS. There are differences in clinical manifestations and laboratory findings between the HFRS complicated with AP group and the ABP group; these differences may help in the differential diagnosis and treatment of these 2 types of pancreatitis.

2020 Medicine

7. Prolonged hyperamylasemia in patients with acute pancreatitis is associated with recurrence of acute pancreatitis. Full Text available with Trip Pro

Prolonged hyperamylasemia in patients with acute pancreatitis is associated with recurrence of acute pancreatitis. Serum amylase levels in patients with acute pancreatitis often remain or fluctuate above the upper normal limit for over a week. This study investigated the clinical characteristics of patients with prolonged hyperamylasemia and their prognoses, including recurrence.We retrospectively analyzed patients with first attacks of acute pancreatitis in a single center between March 2010 (...) hyperamylasemia over a week is associated with recurrence of acute pancreatitis.

2020 Medicine

11. Carbimazole: risk of acute pancreatitis

Carbimazole: risk of acute pancreatitis Carbimazole: risk of acute pancreatitis - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Carbimazole: risk of acute pancreatitis If acute pancreatitis occurs during treatment with carbimazole, immediately and permanently stop treatment. Re-exposure (...) to carbimazole may result in life-threatening acute pancreatitis with a decreased time to onset. Published 18 February 2019 From: Therapeutic area: , Contents Advice for healthcare professionals: cases of acute pancreatitis have been reported very infrequently during treatment with carbimazole if acute pancreatitis occurs, stop carbimazole treatment immediately do not use carbimazole in patients with a history of acute pancreatitis in association with previous treatment re-exposure may result in life

2019 MHRA Drug Safety Update

12. Acute Pancreatitis

Acute Pancreatitis Date of origin: 1998 Last review date: 2013 ACR Appropriateness Criteria ® 1 Acute Pancreatitis American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Acute Pancreatitis Variant 1: First time presentation, typical abdominal pain, and increased amylase and lipase with high clinical certainty of diagnosis; 48–72 hours after onset of symptoms. Radiologic Procedure Rating Comments RRL* CT abdomen with IV contrast 8 This is the single best, most practical (...) is contraindicated. ??? CT abdomen without and with IV contrast 4 Without contrast portion of examination, this is generally not necessary. ???? Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Acute Pancreatitis Clinical Condition: Acute Pancreatitis Variant 3: Continued SIRS, severe clinical scores, leukocytosis, and fever; >7–21 days after onset of symptoms. Radiologic Procedure Rating Comments RRL* CT

2019 American College of Radiology

13. Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Full Text available with Trip Pro

Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. The treatment of people with acute abdominal pain differs if they have acute pancreatitis. It is important to know the diagnostic accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis, so that an informed decision can be made as to whether the person with abdominal pain has acute pancreatitis. There is currently no Cochrane (...) review of the diagnostic test accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis.To compare the diagnostic accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase, either alone or in combination, in the diagnosis of acute pancreatitis in people with acute onset of a persistent, severe epigastric pain or diffuse abdominal pain.We searched MEDLINE, Embase, Science Citation Index Expanded, National

2017 Cochrane

14. Endoscopic management of acute necrotizing pancreatitis

Endoscopic management of acute necrotizing pancreatitis Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guideline – European Society of Gastrointestinal Endoscopy (ESGE) +49-89-9077936-11 Menu https://doi.org/10.1055/a-0588-5365 Published online: 9.4.2018 | Endoscopy 2018; 50: 524–546 © Georg Thieme Verlag KG Stuttgart· New York Explore the ESGE website Menu Contact us +49-89-9077936-0 Follow us ©

2018 European Society of Gastrointestinal Endoscopy

15. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee

Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee Copyright © ESPGHAN and NASPGHAN. All rights reserved. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee Maisam Abu-El-Haija, y Soma Kumar, z Jose Antonio Quiros (...) , § Keshawadhana Balakrishnan, jj Bradley Barth, Samuel Bitton, # John F. Eisses, Elsie Jazmin Foglio, yy Victor Fox, zz Denease Francis, §§ Alvin Jay Freeman, jjjj Tanja Gonska, yy Amit S. Grover, # Sohail Z. Husain, Rakesh Kumar, ## Sameer Lapsia, Tom Lin, Quin Y. Liu, yyy Asim Maqbool, zzz Zachary M. Sellers, §§§ Flora Szabo, jjjjjj Aliye Uc, Steven L. Werlin, and ### Veronique D. Morinville ABSTRACT Background: Although the incidence of acute pancreatitis (AP) in children is increasing, management

2018 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

16. Initial Management of Acute Pancreatitis Full Text available with Trip Pro

Initial Management of Acute Pancreatitis American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis - Gastroenterology Email/Username: Password: Remember me Search AGA Journals Search Terms Search within Search Access provided by Volume 154, Issue 4, Pages 1096–1101 American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis x Seth D. Crockett Affiliations Division of Gastroenterology and Hepatology (...) Sachin B. Wani x Sachin B. Wani , x David Weinberg x David Weinberg DOI: | Publication History Published online: February 04, 2018 Expand all Collapse all Article Outline Abbreviations used in this paper: ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ) This document presents the official recommendations of the American Gastroenterological Association (AGA) on the initial management of acute pancreatitis (AP). The guideline was developed by the AGA’s Clinical Practice Guideline Committee and approved

2018 American Gastroenterological Association Institute

17. Acute Pancreatitis Task Force on Quality: Development of Quality Indicators for Acute Pancreatitis Management. (Abstract)

Acute Pancreatitis Task Force on Quality: Development of Quality Indicators for Acute Pancreatitis Management. Detailed recommendations and guidelines for acute pancreatitis (AP) management currently exist. However, quality indicators (QIs) are required to measure performance in health care. The goal of the Acute Pancreatitis Task Force on Quality was to formally develop QIs for the management of patients with known or suspected AP using a modified version of the RAND/UCLA Appropriateness

2019 American Journal of Gastroenterology

18. Evaluation of Opioid Use in Acute Pancreatitis in Absence of Chronic Pancreatitis: Absence of Opioid Dependence an Important Feature. (Abstract)

Evaluation of Opioid Use in Acute Pancreatitis in Absence of Chronic Pancreatitis: Absence of Opioid Dependence an Important Feature. Chronic opioid use and dependence is common in patients with chronic pancreatitis. Patients with acute pancreatitis are frequently treated with opioids, but their risk for ongoing use is not well known. The aim of our study is to characterize opioid use in patients after an episode of acute pancreatitis and to assess persistent, chronic, and daily opioid use (...) in such patients in the absence of chronic pancreatitis.This is a single-center review of prospectively enrolled patients with acute pancreatitis. Using the Massachusetts Prescription Awareness Tool, we recorded all opioid prescriptions (ie, frequency, duration, and amount) for patients from December 2016 to September 2019, after index hospitalization for acute pancreatitis. Patients with chronic pancreatitis were excluded. We used univariate and multivariate analysis to determine predictors of opioid use

2020 American Journal of Medicine

19. Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial Full Text available with Trip Pro

Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Randomized Controlled Trial Am J Gastroenterol Actions . 2020 Mar;115(3):473-480. doi: 10.14309/ajg.0000000000000529. Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial , , , , , , , , Affiliations Expand Affiliations 1 Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China. 2 Laboratory of Gastroenterology

2020 EvidenceUpdates

20. Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children. Full Text available with Trip Pro

Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children. Research is lacking on the natural history of acute pancreatitis (AP) progression to acute recurrent pancreatitis (ARP). The aim of this project was to study the progression from AP to ARP among pediatric patients with pancreatitis to better understand the presentation and natural history of pancreatitis.Patients presenting with AP were included in a prospective database in Research Electronic Data Capture. We (...) with ARP progressed from AP to ARP within 5 months from first diagnosis. A comparison of patients who rapidly progressed to ARP within 3 months (n = 12) to those followed for >3 months without progression in 3 months (n = 97) revealed associations with a higher weight percentile for age (P = 0.045), male sex (P = 0.03), and presence of pancreatic necrosis during first AP attack (P = 0.004). Progression to ARP significantly differed by etiology group with genetics having the highest risk for ARP

2018 Journal of Pediatric Gastroenterology and Nutrition

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