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Acute Otitis Media Observation

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101. Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined for pain relief in acute otitis media in children [Cochrane Protocol]

Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined for pain relief in acute otitis media in children [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr (...) screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination

2015 PROSPERO

102. Otitis Media Acute Treatment

Otitis Media Acute Treatment Aka: Otitis Media Acute Treatment , Acute Otitis Media Management From Related Chapters II. Pitfalls s and s are not useful Antibiotic dosages are often too low III. Risk factors: Treatment Failure within the last month Antibiotic within the last month Day Care attendance Bilateral Age less than 2 years old Age at first less than 6 months old Over 3 episodes in last 6 months IV. Protocol: Observation Protocol See Strongly consider observation <48 hours of symptoms Age (...) Otitis Media Acute Treatment Otitis Media Acute Treatment Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Otitis Media Acute Treatment

2015 FP Notebook

103. Non-capsulated and capsulated Haemophilus influenzae in children with acute otitis media in Venezuela: a prospective epidemiological study. Full Text available with Trip Pro

Non-capsulated and capsulated Haemophilus influenzae in children with acute otitis media in Venezuela: a prospective epidemiological study. Non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae are major causes of bacterial acute otitis media (AOM). Data regarding AOM are limited in Latin America. This is the first active surveillance in a private setting in Venezuela to characterize the bacterial etiology of AOM in children < 5 years of age.Between December 2008 and December (...) -capsulated (NTHi) and 31.4% (11/35 episodes) were capsulated including types d, a, c and f, across all age groups. Low antibiotic resistance for H. influenzae was observed to amoxicillin/ampicillin (5.7%; 2/35 samples). NTHi was isolated in four of the six H. influenzae positive samples (66.7%) from recurrent episodes.We found H. influenzae and S. pneumoniae to be the main pathogens causing AOM in Venezuela. Pneumococcal conjugate vaccines with efficacy against these bacterial pathogens may have

2012 BMC Infectious Diseases

104. Comparison of the effectiveness and safety of cefpodoxime and ciprofloxacin in acute exacerbation of chronic suppurative otitis media: A randomized, open-labeled, phase IV clinical trial. Full Text available with Trip Pro

Comparison of the effectiveness and safety of cefpodoxime and ciprofloxacin in acute exacerbation of chronic suppurative otitis media: A randomized, open-labeled, phase IV clinical trial. To compare the effectiveness and safety of cefpodoxime and ciprofloxacin for the treatment of mild to moderate cases of acute exacerbation of chronic suppurative otitis media (AECSOM).Adult patients diagnosed with AECSOM were screened and patients fulfilling the inclusion criteria were randomized to receive (...) % in the ciprofloxacin group. These rates are comparable, but no statistically significant difference was observed between the groups. Few mild and self-limiting AEs were observed and the tolerability of both the drugs was also good.The results of this randomized, open-labeled phase IV clinical trial showed that a 7-day course of cefpodoxime is therapeutically comparable to ciprofloxacin in terms of both clinical effectiveness and safety for the treatment of patients with AECSOM.

2012 Journal of pharmacology & pharmacotherapeutics Controlled trial quality: uncertain

105. Pneumococcal Serotypes causing Acute Otitis Media among Children in Barcelona (1992-2011): Emergence of the Multi-Resistant Clone ST320 of Serotype 19A. (Abstract)

Pneumococcal Serotypes causing Acute Otitis Media among Children in Barcelona (1992-2011): Emergence of the Multi-Resistant Clone ST320 of Serotype 19A. There is scarce information about changes in serotypes and clonal types of Streptococcus pneumoniae causing acute otitis media (AOM) in recent years, particularly in European countries.Pneumococcal serotypes and clones from S. pneumoniae strains isolated from children with AOM who were attended at Hospital Sant Joan de Déu, Barcelona (1992 (...) % of nonsusceptible serotype 19A isolates.Among children with AOM, a rapid expansion of the multiresistant clone ST320 expressing serotype 19A has been observed in Barcelona. The implementation of PCV13, which includes this serotype, may decrease the prevalence of AOM and reduce antimicrobial resistance.

2012 Pediatric Infectious Dsease Journal

106. Delayed Versus Immediate Antimicrobial Treatment for Acute Otitis Media. (Abstract)

Delayed Versus Immediate Antimicrobial Treatment for Acute Otitis Media. Watchful waiting with the option of delayed antimicrobial treatment for acute otitis media is recommended in several guidelines. Our aim was to study whether delayed, as compared with immediate, initiation of antimicrobial treatment worsens the recovery from acute otitis media in young children.Children (6-35 months) with acute otitis media received either delayed or immediate antimicrobial treatment with amoxicillin (...) groups.Our results indicate that delayed initiation of antimicrobial treatment does not worsen the recovery from acute otitis media, as measured by improvement during treatment. However, watchful waiting before the initiation of delayed antimicrobial treatment might be associated with transient worsening of a child's condition, prolongation of symptoms and economic losses.

2012 Pediatric Infectious Dsease Journal Controlled trial quality: uncertain

107. Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France. Full Text available with Trip Pro

Nasopharyngeal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France. Several studies have investigated the impact of 7-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal (Sp) and staphylococcal (Sa) nasopharyngeal (NP) carriage. Few have investigated the impact on Haemophilus influenzae (Hi) and Moraxella catarrhalis (Mc) carriage. We aimed to compare the NP carriage rates in young children with acute otitis (...) media (AOM) before and after PCV7 implementation in France.Prior to PCV7 implementation, we performed 4 successive randomized trials with NP samples. These studies compared several antibiotic regimens for treating AOM in young children (6 to 30 months). After PCV7 implementation, to assess the impact of the vaccination program on NP flora, young children with AOM were enrolled in a prospective surveillance study. In each study, we obtained an NP sample to analyze the carriage rates of Sp, Hi, Mc

2012 BMC infectious diseases Controlled trial quality: uncertain

108. The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis

until analysis.DNA will be purified from ear swabs, and amplified by PCR so that a barcoded 16S rRNA library from each subject will be generated. Using correlation analysis, we will compare between microbial compositions in chronic otorrhea patients vs. control groups.An additional ear swab will be collected from patients and cultured to test antibiotic resistance. Condition or disease Suppurative Otitis Media Study Design Go to Layout table for study information Study Type : Observational Estimated (...) Enrollment : 240 participants Observational Model: Ecologic or Community Time Perspective: Prospective Official Title: The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Media in Pediatric Patients in Northern Israel Estimated Study Start Date : April 20, 2018 Estimated Primary Completion Date : April 20, 2019 Estimated Study Completion Date : February 20, 2020 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort

2018 Clinical Trials

109. Cefaclor compared with amoxycillin acute otitis media with effusion: a preliminary report. (Abstract)

Cefaclor compared with amoxycillin acute otitis media with effusion: a preliminary report. A double-blind, randomized clinical trial comparing cefaclor with amoxycillin in the treatment of acute otitis media with effusion (OME) in infants and children is being conducted at Children's Hospital of Pittsburgh. Although the randomization code has not yet been broken, the results of treating the first 55 children are reported, since they appear to be of interest. Of the 62 ears with acute OME (...) subjects observed for the first 2 weeks, the initial symptomatic response was excellent. Six children had persistent signs and symptoms of acute OME and received a second tympanocentesis; however, none of the effusions from the repeat aspiration revealed an organism. An effusion was still present in 97% of the ears after 3 days, in 69% after 2 weeks, and in 48% 6 weeks after initiation of the study. Tympanocentesis did not appear to affect either the initial clinical response or the persistence

1979 Postgraduate medical journal Controlled trial quality: uncertain

110. Antibiotics for Otitis Media Full Text available with Trip Pro

Antibiotics for Otitis Media Antibiotics for Otitis Media – TheNNTTheNNT Antibiotics for Acute Otitis Media No benefit found IMPORTANT! In Summary, for those who took the antibiotics: Benefits in NNT 100% saw no benefit (reduction of serious complications: mastoiditis, meningitis, hearing loss) 100% saw no benefit (reduced late recurrence) 100% saw no benefit (pain reduction after 24 hours) 6% had reduced pain (after 2-7 days) None had fewer serious complications None had less disease (...) recurrence None had less pain after 24 hours 1 in 16 were helped (pain reduction after 2-7 days) Harms in NNT 11% were harmed (diarrhea) 1 in 9 were harmed (diarrhea) View As: NNT % Source: Efficacy Endpoints: Serious complications (mastoiditis, meningitis, hearing loss), disease recurrence, pain Harm Endpoints: Adverse medication effects Narrative: This review included 15 trials (n = 4199 children) of which 10 (n = 2928) compared antibiotics with placebo in patients with acute otitis media. Amoxicillin

2010 theNNT

111. Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction

. Exclusion Criteria: Hospitalised during the diagnosis of otitis media or during treatment. Having an otitis externa, or otitis media with effusion Presence of a transtympanic tubes. Children presenting with a new episode of otitis media but having received antibiotic systemic therapy in the past 3 days for a separate illness. Receiving antimicrobial prophylaxis for recurrent acute otitis media. Received antibiotics for otitis media in the last day (exception: children with otitis media treatment (...) Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2014 Clinical Trials

112. A Novel Objective Diagnostic Test for Otitis Media With Effusion

. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 52 participants Observational Model: Case Control Time Perspective: Prospective Official Title: RGB Measurements as a Novel Objective Diagnostic Test for Otitis Media With Effusion Study Start Date : January 2013 Actual Primary Completion Date : May 2013 Actual Study Completion Date : May 2013 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group (...) totally normal tympanic membranes and type A tympanograms. They had no hearing loss, Eustachian tube dysfunction, or any other ear-related problem, and were included in the study as healthy controls. Excluded from the study were patients presenting with acute otitis media, tympanosclerotic plaques, mental retardation, and children who were difficult to cooperate with. All subjects were examined by 4 mm 0-degree Storz endoscope and light source. The Adobe Photoshop Elements 7.0 program was used for RGB

2014 Clinical Trials

113. Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3. Full Text available with Trip Pro

Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3. Otitis media (OM) is a common childhood disease characterised by middle ear effusion and inflammation. Susceptibility to recurrent acute OM and chronic OM with effusion is 40-70% heritable. Linkage studies provide evidence for multiple putative OM susceptibility loci. This study attempts to replicate these linkages in a Western Australian (WA) population, and to identify the etiological gene(s (...) in paired adenoid and tonsil samples, and in epithelial and macrophage cell lines. Comparative genomics methods were used to identify putative regulatory elements and transcription factor binding sites potentially affected by associated SNPs.Evidence for linkage was observed at 10q26.3 (Zlr = 2.69; P = 0.0036; D10S1770) with borderline evidence for linkage at 10q22.3 (Zlr = 1.64; P = 0.05; D10S206). No evidence for linkage was seen at 3p25.3, 17q12, or 19q13.43. Peak association at 10q26.3

2014 BMC Medical Genetics

114. Epidemiology of Intratemporal Complications of Otitis Media Full Text available with Trip Pro

, observational study. Between February 2010 and January 2011, patients admitted to a tertiary care, university-based otology practice with diagnosis of otitis media and an associated intratemporal complication (ITC) were included in the study. The following data were evaluated: age, sex, type of ITC, treatment, imaging tests findings, type and degree of hearing loss, and clinical outcome. The overall incidence of all complications and of each complication individually was determined. Results A total of 1,816 (...) patients were diagnosed with otitis media. For 592 (33%) individuals, the diagnosis was chronic otitis media; for 1,224 (67%), the diagnosis was acute otitis media. ITCs of otitis media were diagnosed in 15 patients; thus, the annual incidence of intratemporal complications was 0.8%. We identified 19 ITC diagnoses in 15 patients (3 patients had more than one diagnosis). Labyrinthine fistulae were diagnosed in 7 (36.8%) individuals, mastoiditis in 5 (26.3%), facial palsy in 4 (21.1%), and labyrinthitis

2014 International archives of otorhinolaryngology

115. Complications of Otitis Media

of treatment of suppurative labyrinthitis is bed rest, IV antibiotics, and close observation for evidence of intracranial involvement. Surgical drainage of the labyrinth is indicated in cases with suspected intracranial involvement (on the basis of lumbar puncture results, meningismus, and other diagnostics and manifestations). Facial nerve paralysis may present as a complication of acute or chronic middle ear disease. In the setting of acute otitis media (within 7-10 d), facial nerve weakness is due (...) : Jun 27, 2017 Author: Debbie A Eaton, MD; Chief Editor: Arlen D Meyers, MD, MBA Share Email Print Feedback Close Sections Sections Complications of Otitis Media Overview Overview Antibiotics have produced an overall decline in the frequency of complications of relative to the preantibiotic era. However, severe complications still occur and may be associated with high mortality. [ ] Intracranial and extracranial complications of acute and chronic otitis media are possible. A discussion

2014 eMedicine Surgery

116. Pediatrics, Otitis Media (Treatment)

Treatment or Observation in Children With Acute Otitis Media [ ] Age Certain Diagnosis Uncertain Diagnosis < 6 mo Antibacterial therapy Antibacterial therapy 6 mo–2 y Antibacterial therapy Antibacterial therapy if severe illness; observation option* if nonsevere illness ≥2 y Antibacterial therapy if severe illness; observation option* if nonsevere illness Observation option* *Observation is an appropriate option only when follow-up can be ensured and antibacterial agents started if symptoms persist (...) . 2004 Jun 1. 69(11):2713-5. . Chao JH, Kunkov S, Reyes LB, Lichten S, Crain EF. Comparison of two approaches to observation therapy for acute otitis media in the emergency department. Pediatrics . 2008 May. 121(5):e1352-6. . Spiro DM, Tay KY, Arnold DH, Dziura JD, Baker MD, Shapiro ED. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA . 2006 Sep 13. 296(10):1235-41. . Fischer T, Singer AJ, Lee C, Thode HC Jr. National trends in emergency

2014 eMedicine Emergency Medicine

117. Otitis Media (Treatment)

Treatment or Observation in Children With Acute Otitis Media [ ] Age Certain Diagnosis Uncertain Diagnosis < 6 mo Antibacterial therapy Antibacterial therapy 6 mo–2 y Antibacterial therapy Antibacterial therapy if severe illness; observation option* if nonsevere illness ≥2 y Antibacterial therapy if severe illness; observation option* if nonsevere illness Observation option* *Observation is an appropriate option only when follow-up can be ensured and antibacterial agents started if symptoms persist (...) . 2004 Jun 1. 69(11):2713-5. . Chao JH, Kunkov S, Reyes LB, Lichten S, Crain EF. Comparison of two approaches to observation therapy for acute otitis media in the emergency department. Pediatrics . 2008 May. 121(5):e1352-6. . Spiro DM, Tay KY, Arnold DH, Dziura JD, Baker MD, Shapiro ED. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA . 2006 Sep 13. 296(10):1235-41. . Fischer T, Singer AJ, Lee C, Thode HC Jr. National trends in emergency

2014 eMedicine Emergency Medicine

118. Otitis Media (Treatment)

& Management Updated: Mar 19, 2018 Author: Muhammad Waseem, MBBS, MS, FAAP, FACEP, FAHA; Chief Editor: Ravindhra G Elluru, MD, PhD Share Email Print Feedback Close Sections Sections Otitis Media Treatment Medical Care Medical management of otitis media (OM) is actively debated in the medical literature, primarily because of a dramatic increase in acute OM (AOM) prevalence over the past 10 years caused by drug-resistant S pneumoniae (DRSP) and beta-lactamase–producing H influenzae or M catarrhalis . Beta (...) with AOM. Medical therapy for acute otitis media In 1999, the Centers for Disease Control and Prevention (CDC) therapeutic working group on DRSP published consensus recommendations for AOM management. [ ] The recommendations supported the use of amoxicillin as the first-line antimicrobial agent of choice in patients with AOM. The group recommended increasing the dose used for empiric treatment from 40-45 mg/kg/day to 80-90 mg/kg/day because of concerns about increasingly resistant strains of S

2014 eMedicine Pediatrics

119. Otitis Media (Overview)

: Muhammad Waseem, MBBS, MS, FAAP, FACEP, FAHA; Chief Editor: Ravindhra G Elluru, MD, PhD Share Email Print Feedback Close Sections Sections Otitis Media Overview Practice Essentials Otitis media (OM) is any inflammation of the middle ear (see the images below), without reference to etiology or pathogenesis. It is very common in children. Acute otitis media with purulent effusion behind a bulging tympanic membrane. Chronic otitis media with a retraction pocket of the pars flaccida. There are several (...) subtypes of OM, as follows: Acute OM (AOM) OM with effusion (OME) Chronic suppurative OM Adhesive OM Signs and symptoms AOM implies rapid onset of disease associated with one or more of the following symptoms: Otalgia Otorrhea Headache Fever Irritability Loss of appetite Vomiting Diarrhea OME often follows an episode of AOM. Symptoms that may be indicative of OME include the following: Hearing loss Tinnitus Vertigo Otalgia Chronic suppurative otitis media is a persistent ear infection that results

2014 eMedicine Pediatrics

120. Otitis Media (Follow-up)

Treatment or Observation in Children With Acute Otitis Media [ ] Age Certain Diagnosis Uncertain Diagnosis < 6 mo Antibacterial therapy Antibacterial therapy 6 mo–2 y Antibacterial therapy Antibacterial therapy if severe illness; observation option* if nonsevere illness ≥2 y Antibacterial therapy if severe illness; observation option* if nonsevere illness Observation option* *Observation is an appropriate option only when follow-up can be ensured and antibacterial agents started if symptoms persist (...) . 2004 Jun 1. 69(11):2713-5. . Chao JH, Kunkov S, Reyes LB, Lichten S, Crain EF. Comparison of two approaches to observation therapy for acute otitis media in the emergency department. Pediatrics . 2008 May. 121(5):e1352-6. . Spiro DM, Tay KY, Arnold DH, Dziura JD, Baker MD, Shapiro ED. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA . 2006 Sep 13. 296(10):1235-41. . Fischer T, Singer AJ, Lee C, Thode HC Jr. National trends in emergency

2014 eMedicine Emergency Medicine

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