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Acute Otitis Media Observation

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61. Acute Otitis Media and the Crying Child. (Abstract)

Acute Otitis Media and the Crying Child. Acute otitis media (AOM) can be difficult to diagnose in a crying child. The vessels of the ear canal and tympanic membrane (TM) can engorge simulating AOM. We observed the pattern of vascular congestion during modified Valsalva maneuver. Sparing of the pars tensa, lack of TM bulging help to differentiate a crying child's red TM from that seen in AOM.

2016 Pediatric Infectious Dsease Journal

62. Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media. (Abstract)

decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group.Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media. (...) Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media. To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media.Twenty-five guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid

2016 Journal of Laryngology & Otology

63. Management of acute otitis media: update

and large observational studies that compared the effectiveness of different treatments for uncomplicated acute otitis media (as defined in the review) in average risk children and children with recurrent or persistent acute otitis media (as defined in the review) were eligible for inclusion. Treatment comparisons could include antibiotics versus wait and see approach, analgesics or placebo, comparisons of various antibiotics, high- versus low-dose treatment and short- versus long-term treatment (...) Management of acute otitis media: update Management of acute otitis media: update Management of acute otitis media: update Shekelle PG, Takata G, Newberry SJ, Coker T, Limbos MA, Chan LS, Timmer MM, Suttorp MJ, Carter J, Motala A, Valentine D, Johnsen B, Shanman R CRD summary The authors concluded that immediate antibiotic therapy was more effective than placebo for treating uncomplicated acute otitis media. Comparison of different antibiotic treatments was inconclusive for recurrent otitis

2010 DARE.

64. Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment Full Text available with Trip Pro

Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment A thorough understanding of the molecular details of the interactions between bacteria and host are critical to ultimately prevent disease. Recent technological advances allow simultaneous analysis of host and bacterial protein and metabolic profiles from a single small tissue sample to provide insight (...) proteomic and metabolomic signature of otitis media. Our studies indicate that establishment of disease coincides with actin morphogenesis, suppression of inflammatory mediators, and bacterial aerobic respiration. We validated the observed increase in the actin-remodeling complex, Arp2/3, and experimentally showed a role for Arp2/3 in nontypeable Haemophilus influenzae invasion. Direct inhibition of actin branch morphology altered bacterial invasion into host epithelial cells, and is supportive of our

2015 Molecular & cellular proteomics : MCP

65. Acute Otitis Media and Nasopharyngeal Colonization Caused by Vaccine Serotypes of Strep Pneumoniae in Healthy Children

. pneumoniae will undergo antibiotic susceptibility testing. All samples that are culture negative will be evaluated with a multi-locus PCR test to examine for presence of the 5 potential otopathogens. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 240 participants Observational Model: Cohort Time Perspective: Prospective Official Title: A Study Evaluating Acute Otitis Media and Nasopharyngeal Colonization Caused by Vaccine Serotypes of Streptococcus (...) and meets recurrent acute otitis media criteria Child has received full ( 3 dose ) infant series of Prevnar 13 Parent/guardian willing to bring to all study visits Exclusion Criteria: Any major illness/condition that in investigator opinion would put subject at risk during study. Participation in another investigational/interventional trial within 28 days prior or during study. ( Observational study is permitted ) Direct descendant of study site personnel. Contacts and Locations Go to Information from

2015 Clinical Trials

66. Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media

Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02567825 Recruitment Status : Active, not recruiting First Posted : October 5, 2015 Last Update Posted : March 8, 2019 Sponsor: University of Pittsburgh Collaborators: George

2015 Clinical Trials

67. Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of Age

Vaccination (UMV) in Colombia. Condition or disease Intervention/treatment Acute Otitis Media Pneumonia Other: Data collection Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 1 participants Observational Model: Other Time Perspective: Retrospective Official Title: Impact of Vaccination Against Pneumococcal Disease on the Morbidity of Acute Otitis Media in Colombian Children < 5 Years of Age Actual Study Start Date : October 1, 2015 Actual Primary (...) Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of Age Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of Age - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2015 Clinical Trials

68. Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media

Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02630992 Recruitment Status : Completed First Posted : December 15, 2015 Results First Posted

2015 Clinical Trials

69. Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence

Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence (OTV_PRE_01) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02345447 Recruitment Status : Completed First Posted : January 26

2015 Clinical Trials

70. Decline in antibiotic resistance and changes in the serotype distribution of Streptococcus pneumoniae isolates from children with acute otitis media; a 2001-2011 survey by the French Pneumococcal Network. Full Text available with Trip Pro

Decline in antibiotic resistance and changes in the serotype distribution of Streptococcus pneumoniae isolates from children with acute otitis media; a 2001-2011 survey by the French Pneumococcal Network. Streptococcus pneumoniae is an important cause of acute otitis media (AOM). The aim of this study was to evaluate trends in antibiotic resistance and circulating serotypes of pneumococci isolated from middle ear fluid of French children with AOM during the period 2001-2011, before and after (...) the introduction of the PCV-7 (2003) and PCV-13 (2010) vaccines. Between 2001 and 2011 the French pneumococcal surveillance network analysed the antibiotic susceptibility of 6683 S. pneumoniae isolated from children with AOM, of which 1569 were serotyped. We observed a significant overall increase in antibiotic susceptibility. Respective resistance (I+R) rates in 2001 and 2011 were 76.9% and 57.3% for penicillin, 43.0% and 29.8% for amoxicillin, and 28.6% and 13.0% for cefotaxime. We also found a marked

2015 Clinical Microbiology and Infection

71. Bacterial and Respiratory Viral Interactions in the Etiology of Acute Otitis Media in HIV-Infected and -Uninfected South African Children. Full Text available with Trip Pro

Bacterial and Respiratory Viral Interactions in the Etiology of Acute Otitis Media in HIV-Infected and -Uninfected South African Children. Bacteria and respiratory viruses are implicated in the pathogenesis of acute otitis media (AOM); however, data from low-middle income countries are sparse. We investigated the etiology of AOM in HIV-infected (HIV+), HIV-uninfected (HIV-) and HIV-exposed clinically asymptomatic for HIV-infection (HEU) South African children.Children ≥3 months to <5 years (...) , H. influenzae, M. catarrhalis (76.9-78.8%) and Staphylococcus aureus (63.4%) cultured from middle ear fluid, as well as in 72.0% of episodes negative for any bacteria.The study suggests that respiratory viruses and pathogenic bacteria play an important role in the development of AOM in children. A similar spectrum of pathogens was observed independently of HIV status. Vaccines targeting both nontypeable Haemophilus influenzae and S. pneumoniae may have a broad impact on AOM in South Africa.

2015 Pediatric Infectious Dsease Journal

72. Impact of the 7-Valent Pneumococcal Conjugate Vaccine on Acute Otitis Media in Japanese Children: Emergence of Serotype 15A Multi-Drug Resistant Streptococcus Pneumoniae in Middle Ear Fluid Isolates. (Abstract)

Impact of the 7-Valent Pneumococcal Conjugate Vaccine on Acute Otitis Media in Japanese Children: Emergence of Serotype 15A Multi-Drug Resistant Streptococcus Pneumoniae in Middle Ear Fluid Isolates. Streptococcus pneumoniae is one of the most common bacteria causing acute otitis media (AOM). In Japan, a 7-valent pneumococcal conjugate vaccine (PCV7) was introduced for voluntary vaccination of children in 2010, and it became a recommended vaccination in April 2013. We surveyed the serotypes (...) and antimicrobial susceptibility profile of S. pneumoniae isolates obtained from the middle ear fluid of Japanese children with AOM.Between April and September 2013, a total of 176 S. pneumoniae isolates were obtained from the middle ear fluid of children aged 0-3 years with AOM. Isolates were collected from various regions of Japan. Minimum inhibitory concentrations were measured by the broth microdilution method. Serotyping was performed by observing the Quellung reaction.Although 45.5% of the strains were

2015 Pediatric Infectious Dsease Journal

73. Effect of pH and oxygen on biofilm formation in acute otitis media associated NTHi clinical isolates. Full Text available with Trip Pro

Effect of pH and oxygen on biofilm formation in acute otitis media associated NTHi clinical isolates. Biofilms occur in animal models of acute otitis media (AOM) and in children with recurrent AOM (rAOM) and chronic otitis media with effusion (OME). We therefore studied the ability of nontypeable Haemophilus influenzae (NTHi) strains from children to form biofilms in vitro under conditions we presumed occurred in the middle ear during AOM, rAOM, and OME.Evaluate NTHi isolates for biofilm (...) ; age range, 9-60 months) subjects tested immediately after withdrawal was similar (mean = 8.0;range 7.0-9.0); 3) biofilms formed optimally at pH 8.0, a finding that is consistent with previous studies by other investigators; 4) biofilms did not form under aerobic conditions as likely occurs in AOM, whereas under microaerophilic and anaerobic conditions biofilm formation was observed as likely occurs during rAOM and OME.We concluded that biofilm formation by NTHi does not occur in all strains

2015 Laryngoscope

74. Comparison of eardrum mobility in acute otitis media and otitis media with effusion models. Full Text available with Trip Pro

Comparison of eardrum mobility in acute otitis media and otitis media with effusion models. To investigate the eardrum mobility difference between acute otitis media (AOM) and experimental otitis media with effusion (OME).Thirty-three Hartley guinea pigs were included in this study. The AOM and OME were created by transbullar injection of Streptococcus pneumoniae and lipopolysaccharide into the middle ear, respectively.Three days after inoculation, the morphologic changes of the middle ear were (...) assessed with otoscopy and histologic sections. Vibrations of the tympanic membrane (TM) at umbo in response to pure tone sound were measured using laser Doppler vibrometry.The purulent effusion, ossicular adhesion, and thickened TM and middle ear mucosa were observed in the AOM ears, and the OME ears had serous effusion and less thickened TM and mucosa in the middle ear. The displacement of TM in AOM was lower than that in OME ears, especially at 0.2 to 4 kHz.The TM mobility difference between the AOM

2013 Otology and Neurotology

75. Persistence of middle-ear effusion after acute otitis media in children. (Abstract)

Persistence of middle-ear effusion after acute otitis media in children. We observed the frequent occurrence of persistent middle-ear effusion in children with acute otitis media and followed them according to standard procedures for otologic diagnosis. We performed a life-table analysis to identify risk factors for such persistent disease. Sixty-two patients were free of middle-ear effusion at one or more clinic visits two to 13 weeks after presentation and were considered cured; 45 had (...) may be associated with impaired hearing and appears to be the most important sequela of otitis media.

1979 NEJM Controlled trial quality: uncertain

76. Acute Otitis Media Observation

Acute Otitis Media Observation Acute Otitis Media Observation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Acute Otitis Media (...) Observation Acute Otitis Media Observation Aka: Acute Otitis Media Observation , Observation Protocol for Acute Otitis Media Management From Related Chapters II. Background Most cases resolve without antibiotics Consider symptomatic treatment Antibiotics are more likely to cause side effects than speed symptomatic improvement for one not to have at 2-7 days: 20 for one to have adverse antibiotic effects ( , , rash): 14 (2013) Presc Lett 20(4): 20-21 III. Indications (with Informed Consent of parents) Age

2015 FP Notebook

77. Some Clinical Observations on Acute Catarrhal Otitis Media Full Text available with Trip Pro

Some Clinical Observations on Acute Catarrhal Otitis Media 19992825 2010 06 24 2010 06 24 0035-9157 37 6 1944 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Some Clinical Observations on Acute Catarrhal Otitis Media. 270-4 Hoople G D GD Blaisdell I H IH eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1944 4 1 0 0 1944 4 1 0 1 ppublish 19992825 PMC2180989

1944 Proceedings of the Royal Society of Medicine

78. Shared decision making and antibiotic benefit-harm conversations: an observational study of consultations between general practitioners and patients with acute respiratory infections. Full Text available with Trip Pro

communication with and without the use of patient decision aids.This was an observational study in Australian general practices, nested within a cluster randomised trial of decision aids (for acute otitis media [AOM], sore throat, acute bronchitis) designed for general practitioners (GPs) to use with patients, compared with usual care (no decision aids). Audio-recordings of consultations of a convenience sample of consenting patients seeing a GP for an ARI were independently analysed by two raters using (...) Shared decision making and antibiotic benefit-harm conversations: an observational study of consultations between general practitioners and patients with acute respiratory infections. Little research has examined whether shared decision making (SDM) occurs in consultations for acute respiratory infections (ARIs), including what, and how, antibiotic benefits and harms are discussed. We aimed to analyse the extent and nature of SDM in consultations between GPs and patients with ARIs, and explore

2018 BMC Family Practice Controlled trial quality: uncertain

79. Effect of Antimicrobial Treatment of Acute Otitis Media on the Daily Disappearance of Middle Ear Effusion: A Placebo-Controlled Trial. Full Text available with Trip Pro

Effect of Antimicrobial Treatment of Acute Otitis Media on the Daily Disappearance of Middle Ear Effusion: A Placebo-Controlled Trial. Antimicrobial treatment reduces the symptoms of acute otitis media (AOM). The effect of antimicrobial treatment on the duration of middle ear effusion (MEE) and concomitant hearing impairment is not known.To determine whether the antimicrobial treatment of AOM reduces the duration of MEE.This randomized, double-blind, placebo-controlled trial involved a total (...) days) earlier (P = .02) in the antimicrobial group (mean time, 2.7 weeks; 95% CI, 1.7-3.7) than in the placebo group (4.7 weeks; 95% CI, 3.6-5.7). Normal otoscopy findings were observed 1.4 weeks sooner in the antimicrobial group than in the placebo group (P = .02). On day 14, 69% of children in the antimicrobial group and 38% in the placebo group had normal tympanometry findings (number needed to treat, 3.2; 95% CI, 2.0-10.5). On day 60, 2 children (5%) in the antimicrobial group and 10 children

2014 JAMA pediatrics Controlled trial quality: predicted high

80. Effects of recurrent acute otitis media on cortical speech-sound processing in 2-year old children. Full Text available with Trip Pro

Effects of recurrent acute otitis media on cortical speech-sound processing in 2-year old children. To investigate at the age of 2 years the effects of childhood recurrent acute otitis media (RAOM) on central auditory processing by using cortical event-related potentials elicited by syllable stimuli.During a 1-year period, 22- to 26-month-old children fulfilling the criteria for tympanostomy tube insertion in Oulu University Hospital, Oulu, Finland, were recruited to the RAOM group (N = 20 (...) was shorter and the frequency MMN amplitude lateralized to the left hemisphere in the RAOM group instead of an adult-like right-hemispheric lateralization observed in the controls. The children with RAOM had a more anterior MMN amplitude scalp distribution for the intensity change than control children. In addition, the MMN amplitude elicited by consonant change was evenly distributed unlike in controls, who had a left-side preponderant lateralization. Taken together, these results suggest an elevated

2014 Ear and hearing

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