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Acute Otitis Media Observation

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41. Global prevalence of antibiotic resistance of bacteria in the nasopharynx and middle ear from children with acute otitis media and the resistance impact of oral and topical antibiotics: a systematic review

Global prevalence of antibiotic resistance of bacteria in the nasopharynx and middle ear from children with acute otitis media and the resistance impact of oral and topical antibiotics: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary

2018 PROSPERO

42. Otitis Media Acute Treatment

Otitis Media Acute Treatment Aka: Otitis Media Acute Treatment , Acute Otitis Media Management From Related Chapters II. Pitfalls s and s are not useful Antibiotic dosages are often too low III. Risk factors: Treatment Failure within the last month Antibiotic within the last month Day Care attendance Bilateral Age less than 2 years old Age at first less than 6 months old Over 3 episodes in last 6 months IV. Protocol: Observation Protocol See Strongly consider observation <48 hours of symptoms Age (...) Otitis Media Acute Treatment Otitis Media Acute Treatment Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Otitis Media Acute Treatment

2018 FP Notebook

43. Extended high-frequency hearing loss following the first episode of otitis media. (Abstract)

Extended high-frequency hearing loss following the first episode of otitis media. Otitis media has been associated with several auditory and developmental sequelae. Here, the results of auditory tests were evaluated in patients who had a first episode of unilateral otitis media and compared with the contralateral healthy ear.Cohort study.This study was undertaken from 2015 to 2016, with a follow-up period of 6 months.A total of 41 patients who had been diagnosed with unilateral acute otitis (...) . A significant elevation of the mean extended high-frequency thresholds in the ears affected by otitis media was observed at the first and subsequent appointments within the 6-month follow-up period. Diseased ears from patients who experienced tinnitus during the 6-month follow-up period had significantly higher thresholds in the extended high frequencies than diseased ears from patients without residual tinnitus.These results suggest that the first episode of otitis media may lead to persistent elevation

2018 Laryngoscope

44. Efficacy of a non-invasive middle ear aeration device in children with recurrent otitis media: A randomized controlled trial protocol Full Text available with Trip Pro

the reduction of episodes AOM in children with recurrent otitis media. The control arm will be observational. The intervention arm will have the EP used. The primary endpoint is incidence of AOM. The secondary endpoints are hazard ratio of time to AOM, proportion without AOM and antibiotics use, quality of life (OMO-22 Form), and adherence to treatment. Sample size is a minimum of 150 patients. The inclusion criteria is ages 4-11, with history of recurrent Acute Otitis Media (AOM). (...) Efficacy of a non-invasive middle ear aeration device in children with recurrent otitis media: A randomized controlled trial protocol Acute otitis media (AOM) represents a significant disease burden in the pediatric population. Besides vaccinations, there are no robust measures of reducing incidence of AOM in this age-group. This is a randomized controlled clinical trial evaluating the efficacy of a non-invasive middle ear aeration device, the EarPopper device (EP). We aim to investigate

2018 Contemporary clinical trials communications Controlled trial quality: uncertain

45. Efficacy of the EarPopper Device in Children With Recurrent Otitis Media

: Northwell Health Information provided by (Responsible Party): Tristan Tham, Northwell Health Study Details Study Description Go to Brief Summary: This is a randomized controlled clinical trial evaluating the efficacy of the EarPopper device (EP) in the reduction of episodes of acute otitis media (AOM) in children with recurrent otitis media. The control arm will be observational. The intervention arm will have the EP used. Condition or disease Intervention/treatment Phase Recurrent Acute Otitis Media (...) Acute Otitis Media Device: EarPopper Not Applicable Detailed Description: The hypothesis of this randomized controlled trial is that the EP device will be able to prophylactically decrease incidence of AOM in children with recurrent AOM. The secondary hypothesis is that the EP device will be able to decrease morbidity of AOM and severity of AOM in children with recurrent AOM (by measuring quality of life and associated endpoints). The EP device is 510(K) regulated (510(K) Number K073401) as a non

2018 Clinical Trials

46. Otitis Media

subjects and 84% of subjects on placebo. Marcetti, F et al. (2005) Delayed prescription may reduce the use of antibiotics for acute otitis media. Arch Pediatr Adol Med 159: 679-684 Observational trial of children with symptomatic AOM followed without antibiotics. Of the 933 initially followed with analgesics alone, only 24% ended up taking antibiotics. Clinical failure was associated with high fever and a red bulging ear drum. 50% of subjects had fever > 38 degrees at enrollment. Recurrent AOM (...) procedure or treatment must be made by the physician in light of the circumstances presented by the patient. Otitis Media Patient population: Pediatric patients (>2 months old) and adults Objectives: (1) Limit acute symptoms and suppurative complications caused by acute otitis media. (2) Maximize language development and minimize long term damage to middle ear structure associated with otitis media with effusion. (3) Limit complications of antibiotic therapy including the development of antibiotic

2014 University of Michigan Health System

47. Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children. (Abstract)

Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children. This paper reports the results of the first study in which Streptococcus salivarius 24SMB, a safe α-haemolytic strain capable of producing bacteriocin-like substances with significant activity against acute otitis media (AOM) pathogens, was intranasally administered in an attempt to reduce the risk of new episodes of AOM in otitis-prone children. In this prospective (...) than among those in the placebo group (30.0 vs 14.9%; p = 0.076). Moreover, the number of children who received antibiotics during the study period was lower among the children treated with S. salivarius 24 SMB than among those who received placebo (70 vs 83.0%; p = 0.13). Compared with the children who were not colonized by S. salivarius 24SMB after treatment, the number of colonized children who experienced any AOM was significantly lower (42.8 vs 13.6%; p = 0.03). Similar results were observed

2015 European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Controlled trial quality: predicted high

48. Impact and effectiveness of PCV7, PCV10, PCV13, and PPSV23 on the reduction of ambulatory care and hospitalization of bacterial acute otitis media in children under 5 years old: systematic review

Impact and effectiveness of PCV7, PCV10, PCV13, and PPSV23 on the reduction of ambulatory care and hospitalization of bacterial acute otitis media in children under 5 years old: systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external (...) will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary

2017 PROSPERO

49. Efficacy of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol

Efficacy of amoxicillin alone in the treatment of uncomplicated acute otitis media: a systematic review protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about

2017 PROSPERO

50. Impact of pneumococcal conjugate vaccines on otitis media: A review of measurement and interpretation challenges. Full Text available with Trip Pro

Impact of pneumococcal conjugate vaccines on otitis media: A review of measurement and interpretation challenges. Acute otitis media (AOM) is among the most frequent childhood diseases and is caused by various bacterial and viral etiological agents. In this article, we provide an overview of published studies assessing the impact of higher-valent pneumococcal conjugate vaccines (PCVs) on AOM. In some instances, reports of PCV impact on complications of AOM have been included. While randomized (...) controlled trials (RCTs) allow for the most precise assessment of vaccine efficacy against AOM, observational studies provide answers to questions regarding the public health value of these vaccines in real-life settings. We discuss the challenges that arise when measuring PCV impact on AOM in observational studies: the local variability of viral and bacterial etiology, differences in case ascertainment, care-seeking behavior, standards of care and diagnosis of AOM (e.g. use of incisions), as well

2017 International Journal of Pediatric Otorhinolaryngology

51. Early signs and symptoms of intracranial complications of otitis media in pediatric and adult patients: A different presentation? (Abstract)

and outcomes were reviewed and analyzed.We included 47 patients with OIC: 21 children (range 1-13 years) and 26 adults (range 22-71 years). We included more patients with acute otitis media than with chronic otitis media (children 5% adults 19%, all with cholesteatoma). In children; the most common OIC was central cerebral venous thrombosis. In both children and adults; otogenic symptoms such as otalgia and otorrhea were present. Children presented more frequently with headache and nausea. Adults presented (...) Early signs and symptoms of intracranial complications of otitis media in pediatric and adult patients: A different presentation? The aim of this study was to review the clinical presentation and early signs and symptoms of otogenic intracranial complications (OIC) in children and adults.retrospective chart review. The medical records of all children and adults admitted in our center with OIC during the period 2008-2017 were reviewed. Data concerning clinical presentation, treatment

2017 International Journal of Pediatric Otorhinolaryngology

52. OTO-201 for the Treatment of Acute Otitis Externa: Results from a Phase 3 Randomized Clinical Study. Full Text available with Trip Pro

OTO-201 for the Treatment of Acute Otitis Externa: Results from a Phase 3 Randomized Clinical Study. OTO-201 is a ciprofloxacin otic suspension previously approved by the US Food and Drug Administration to treat children with bilateral otitis media with effusion requiring tympanostomy tube placement. In this phase 3, double-blind, randomized, prospective, sham-controlled, multicenter study, a single dose of OTO-201 was administered to the external auditory canal in subjects with unilateral (...) with sham at day 8 (69.2% vs 46.1%, P < .001). Higher CC was also noted on day 4 ( P = .028), day 15 ( P < .001), and day 29 ( P < .001). A similar effect was observed in the pathogen-positive population. Single OTO-201 administration in the office setting was well tolerated by subjects.In this study in subjects with acute otitis externa, a single administration of 12 mg OTO-201 to the external auditory canal demonstrated a significantly higher proportion of subjects with CC and bacterial eradication

2019 Rhinology and Laryngology Controlled trial quality: uncertain

53. Severe Acute Mastoiditis Admission is Not Related to Delayed Antibiotic Treatment for Antecedent Acute Otitis Media. (Abstract)

Severe Acute Mastoiditis Admission is Not Related to Delayed Antibiotic Treatment for Antecedent Acute Otitis Media. Delayed antibiotic treatment for acute otitis media (AOM) is recommended for children >6 months with nonsevere illness, no risk factors for complications or history of recurrent AOM. This study evaluates relationship between delayed antibiotic treatment for antecedent AOM and severity of subsequent acute mastoiditis admission.A prospective observational study of children aged 0 (...) -14 years admitted with acute mastoiditis to 8 hospitals between 2007 and 2012 calculates rates of severe acute mastoiditis admission [defined by ≥1 of the following: complication (mastoid subperiosteal abscess, brain abscess and sagittal vein thrombosis), need for surgical procedure and duration of admission >6 days].Severe acute mastoiditis admissions in children with antecedent AOM treated with immediate antibiotics were compared with those with delayed antibiotic treatment.Antecedent AOM

2015 Pediatric Infectious Dsease Journal

54. Effectiveness of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media-A Double-Blind Randomized Clinical Trial in Finland. Full Text available with Trip Pro

Effectiveness of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media-A Double-Blind Randomized Clinical Trial in Finland. After administering the 10-valent pneumococcal polysaccharide nontypeable Haemophilus influenzae protein D-conjugated vaccine (PHiD-CV) to children aged 2-18 months, we observed a reduction in vaccine-type nasopharyngeal carriage, resulting in a reduction of overall pneumococcal (...) bacterial nasopharyngeal carriage and acute otitis media (AOM).Infants (aged 6 weeks to 6 months) received the PHiD-CV or a control vaccine (hepatitis B) (schedule 3+1 or 2+1). Nasopharyngeal swabs were collected at 4 time points post-vaccination from all of the infants and at pre-vaccination from a subset. Parent-reported physician-diagnosed AOM was assessed from first vaccination until last contact (mean follow-up, 18 months). Vaccine effectiveness (VE) was derived as (1 - relative risk)*100

2016 Journal of the Pediatric Infectious Diseases Society Controlled trial quality: predicted high

55. Use of symptoms and risk factors to predict acute otitis media in infants. Full Text available with Trip Pro

Use of symptoms and risk factors to predict acute otitis media in infants. Infants and children with upper respiratory tract infection (URI) often have concurrent acute otitis media (AOM). Young infants have fewer specific symptoms than older children. The purpose of this study was to evaluate the usefulness of symptoms and other risk factors in predicting the presence of AOM in infants.Healthy infants, age less than four weeks, were enrolled and followed prospectively for up to age one year (...) and cough added to better correlation. These observations may have clinical application in identification of infants at risk for AOM.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

2016 International Journal of Pediatric Otorhinolaryngology

56. Comparison of Axillary and Tympanic Temperature Measurements in Children Diagnosed with Acute Otitis Media Full Text available with Trip Pro

Comparison of Axillary and Tympanic Temperature Measurements in Children Diagnosed with Acute Otitis Media Background. Acute otitis media [AOM] may affect the accuracy of tympanic temperature measurements. We aimed to compare tympanic temperature measurements in patients with AOM against control groups, as well as compare the tympanic temperatures with axillary thermometry. Methods. This is a prospective, observational study. Patients from pediatric outpatient and emergency clinics who were

2016 International journal of pediatrics

57. Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers

Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02888457 Recruitment Status : Unknown Verified August 2016 by Pierre Van

2016 Clinical Trials

58. Incidence of acute otitis media in children below 6 years of age seen in medical practices in five East European countries. Full Text available with Trip Pro

Incidence of acute otitis media in children below 6 years of age seen in medical practices in five East European countries. Although acute otitis media (AOM) remains a major public health problem worldwide and brings economic burden on health care system and caregivers, little information is available about its epidemiology in Eastern Europe.We conducted an epidemiological, prospective, observational, multi-centre cohort study (NCT01365390) in five East European countries (Estonia, Lithuania

2016 BMC Pediatrics

59. Morphological changes in the round window membrane associated with Haemophilus influenzae-induced acute otitis media in the chinchilla. Full Text available with Trip Pro

Morphological changes in the round window membrane associated with Haemophilus influenzae-induced acute otitis media in the chinchilla. The round window membrane (RWM) encloses the round window, the opening into the scala tympani (ST) from the middle ear. During the course of acute otitis media (AOM), structural changes of the RWM can occur that potentially affect sound transmission into and out of the cochlea. The relationship between such structural changes and conductive hearing loss during (...) the primary contributors to these thickness increases. No significant further increases in RWM thickness were observed when RWMs from chinchillas ears infected for 4 and 8 days were compared. Thickness and structural changes at the RWM lateral and medial areas were less visually obvious and not statistically significant among the three treatment groups. These latter RWM regions clearly were less affected during AOM than the central areas.This histological study establishes that H. influenzae-induced AOM

2016 International Journal of Pediatric Otorhinolaryngology

60. Reduction of Streptococcus pneumoniae in upper respiratory tract cultures and a decreased incidence of related acute otitis media following introduction of childhood pneumococcal conjugate vaccines in a Swedish county. Full Text available with Trip Pro

Reduction of Streptococcus pneumoniae in upper respiratory tract cultures and a decreased incidence of related acute otitis media following introduction of childhood pneumococcal conjugate vaccines in a Swedish county. The effect of pneumococcal conjugate vaccines (PCV) on invasive pneumococcal disease is frequently reported, but the impact on upper respiratory tract infections in a clinical setting is less documented. Our aim in this 5-year observational study was to investigate serotype (...) -2013; n = 1707) were prospectively collected. Microbiological findings were compared between the two periods, and information from clinical referrals was recorded in order to explore changes in incidence of pneumococcal acute otitis media (AOM).Pneumococcal serotypes covered by PHiD-CV10 decreased from 45 to 12 % prior to and after immunization (p < 0.001), respectively. Despite non-PHiD-CV10 serotypes increased from 49 to 80 %, a significant decline of 35 % in the absolute incidence

2016 BMC Infectious Diseases

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