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Acute Otitis Media Observation

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181. Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwan

for study information Study Type : Observational Actual Enrollment : 10 participants Observational Model: Case-Only Time Perspective: Prospective Official Title: Identification and Characterization of the Bacteria Causing Acute Otitis Media (AOM) Episodes in Young Children in Taiwan Study Start Date : July 2010 Actual Primary Completion Date : April 2011 Actual Study Completion Date : April 2011 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go (...) Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwan Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwan - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2010 Clinical Trials

182. [Preliminary study on diplopore puncture of tympanum and intratympanic administration for management of acute secretory otitis media]. (Abstract)

[Preliminary study on diplopore puncture of tympanum and intratympanic administration for management of acute secretory otitis media]. To evaluate the therapeutical effects of diplopore puncture of tympanum and intratympanic administration (DPTIA) on patients with acute secretory otitis media (ASOM).One hundred and forty-one cases with ASOM were divided into two groups randomly, with 69 cases (80 ears) in group A (experimental group) and 72 cases (84 ears) in group B (control group). Group (...) A was treated with DPTIA combined with medication, group B was treated with haplopore puncture of tympanum combined with medication. All patients accepted 1 to 3 courses of treatment, and were observed during the period of treatment and 3 months after treatment.The factors (including gender, age, side of ailing ear, course of disease, air-bone gap in the pure tone average, and acoustic immittance type in ailing ear) which may impact the prognosis were matched in two groups prior treatment (P>0.05). While

2010 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Controlled trial quality: uncertain

183. Implantable Devices for Single-Sided Deafness and Conductive or Mixed Hearing Loss

March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 1, pp. 1–165, March 2020 126 Table A2: GRADE Evidence Profile for Comparison of Cochlear Implantation and No Intervention in Adults and Children With Single-Sided Deafness Number of Studies (Designs) Risk of Bias Inconsistency Indirectness Imprecision Publication Bias Upgrade Considerations Quality Speech audiometry 4 (systematic reviews of observational studies) 38-41 No serious limitations a No serious limitations b No serious (...) limitations c No serious limitations d Undetected e Other considerations (+1) f ? ? ? Moderate Sound localization 4 (systematic reviews of observational studies) 38-41 No serious limitations a No serious limitations g No serious limitations c No serious limitations d Undetected e Other considerations (+1) f ? ? ? Moderate Tinnitus 2 (systematic reviews of observational studies) 39,40 No serious limitations a No serious limitations g No serious limitations c No serious limitations d Undetected e Other

2020 Health Quality Ontario

184. Covid-19: National supporting guidance for Scottish General Practice

a few too many antibiotics at this time it's not a concern, but equally don’t give them out too easily. • 99% will not need to come to surgery during COVID-19. Prescribe by phone. NATIONAL COVID-19 SUPPORTING GUIDANCE FOR SCOTTISH GENERAL PRACTICE • If they can't swallow fluids then bring in for examination. OTALGIA: • We do not need to see/treat any ear pain under 2/7 unless they have facial nerve weakness, severely unwell (despite analgesia), under 2 years of age. • Otitis Media - do not treat (...) , China. Clinical presentations may range from mild to moderate illness to pneumonia or severe acute respiratory infection. As a result, patients with COVID-19 could present to primary care either via telephone or in person 2. As of 12 March 2020 the UK has moved into the ‘delay phase’ of management. This includes significant changes to the identification and management of possible cases. 3. Health Protection Scotland are publishing regular updates to case definitions which are changing rapidly

2020 Covid-19 Ad hoc guidelines

185. Treatment of Depression in Children and Adolescents

that consisted of at least 6 weeks of treatment; and (3) study participants reported outcomes of interest (standardized depression or functional impairment benefit measures or harms outcomes). We included randomized controlled trials (RCTs) for benefits and RCTs or observational studies for harms. We further restricted the studies to those conducted in countries with a very high Human Development Index (HDI; at least one country in multiple-country studies had to be on the very high HDI list) and those (...) or effectiveness between subgroups of interest. Assessment of Methodological Risk of Bias of Individual Studies The criteria set forth by AHRQ’s Methods Guide for Effectiveness and Comparative Effectiveness Reviews guided our assessment of methodological risk of bias. To assess the risk of bias (i.e., internal validity), we used the ROBINS-1 9 tool for observational studies and the Cochrane RCT tool 10 for RCTs. Two independent reviewers assigned risk-of-bias ratings for each study with disagreements resolved

2020 Effective Health Care Program (AHRQ)

186. Ménière’s Disease (Meniere) Full Text available with Trip Pro

, and Erin M. Buchanan, MPH Otolaryngology–Head and Neck Surgery 2020 162 : 2_suppl , S1-S55 Share Share this article via social media. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Recommend to a friend Email a link to the following content: * Recipient's Email Address: * Your Email: Your Name: * Subject: Send me a copy of this email Retype the code from the picture: The e-mail addresses that you supply to use this service (...) , and aural fullness. Diseases such otosyphilis, vestibular neuritis, acute labyrinthitis, and others respond to different treatments. Due to the variability in clinical presentation in patients with definite and probable MD, it is important to acknowledge that a full and accurate diagnosis may take many months to attain. This is an important consideration since this speaks to the natural history and variable clinical presentation of MD that the panelists on this clinical practice guideline (CPG) felt

2020 American Academy of Otolaryngology - Head and Neck Surgery

187. Vomiting in Infants

etiologies include neonatal appendicitis, intussusception, gastric ulcer disease, gastric volvulus, and lactobezoar. Medical causes to consider include sepsis, enteritis, pneumonia, otitis media, meningitis, raised intracranial pressure (from tumor, trauma, or hydrocephalus), kernicterus, metabolic disorders (phenylketonuria, hyperammonemia, maple syrup urine disease, galactosemia, diabetes, adrenocortical hyperplasia, methylmalonic acidemia), diencephalic syndrome, and rarely drugs or toxic agents [2-4 (...) vomiting may be demonstrated by barium enema [3,19]. The use of barium enema for analyzing malrotation is less direct than analysis by UGI series. Approximately 20% of barium enemas may be falsely negative, whereas up to 15% of infants have a high mobile cecum that may cause false-positive interpretations of the study [7]. Nuclear Medicine Nuclear medicine studies, which can be highly effective in analyzing gastric emptying and GER, have no significant role in the evaluation of the neonate with acute

2020 American College of Radiology

188. National Trends in Otitis Media in Children Under 5 Years of Age

to Brief Summary: The rationale for this study is to assess the change in ambulatory care visit rates for acute otitis media between the period before (2001-2009) and after the introduction of the 13-valent pneumococcal conjugate vaccine (13vPnC) (2011-2013) among children less than 5 years old in the United States. Condition or disease Intervention/treatment Otitis Media Myringotomy Tube Insertion Skin Rash Trauma Other: no intervention Detailed Description: NAMCS-The survey utilizes a three stage (...) Observational Model: Ecologic or Community Time Perspective: Retrospective Official Title: National Trends In Ambulatory Care Visits For Otitis Media In Children Under The Age Of Five In The United States Actual Study Start Date : June 9, 2010 Actual Primary Completion Date : June 30, 2017 Actual Study Completion Date : June 30, 2017 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Study population All ambulatory visits

2010 Clinical Trials

189. Cephalexin

intravenous preoperative cephalosporin prophylaxis. Randomization was stratified by intact vs rupture of membranes prior 2017 4. Cephalexin compared to ampicillin treatment of otitis media. 787913 1976 12 03 1976 12 03 2013 11 21 0031-4005 58 4 1976 Oct Pediatrics Pediatrics Cephalexin compared to ampicillin treatment of otitis media. 532-6 Cephalexin was compared to ampicillin for the treatment of otitis media in a randomized study. Bacteriologic diagnosis was sought by needle tympanocentesis in 179 (...) children. No overall statistically significant differences were noted between the two groups; however, 20 patients who (...) received cephalexin had a poor response to therapy whereas only five recipients of ampicillin responded poorly. A significant difference (P less than .05) between the two regimens was noted when Hemophilus influenzae was recovered. Fifty per cent of the children with H. influenzae otitis media who were treated with cephalexin responded poorly; no patients receiving ampicillin had

2018 Trip Latest and Greatest

190. Azithromycin

was made of the clinical effectiveness of azithromycin (once daily for three days at a dose of 10 mg/kg in children or 500 mg (...) /day in adults) and amoxicillin/clavulanic acid and cefaclor (standard doses for 7 to 14 days) in acute ear, nose and throat infections in an open randomized study. The group with azithromycin included 37 otitis media, 24 pharyngotonsillitis and 6 maxillary sinusitis (n = 67). The amoxicillin/clavulanic acid group, 22 otitis media, 19 pharyngotonsillitis and 6 maxillary (...) symptoms? Methods: Exhaustive search of available medical literature was performed using MEDLINE-Ovid, Web of Science, and CINAHL. The search terms azithromycin , respiratory tract infection, lower 2016 18. Single-dose azithromycin versus seven days of amoxycillin in the treatment of acute otitis media in Aboriginal children (AATAAC): a double blind, randomised controlled trial. 20047544 2010 01 05 2010 02 23 2013 11 21 0025-729X 192 1 2010 Jan 04 The Medical journal of Australia Med. J. Aust. Single

2018 Trip Latest and Greatest

191. Influenza

. Generally, influenza B causes (...) less severe clinical illness, although it can still be responsible for outbreaks. Influenza C usually causes a mild or asymptomatic infection similar to the common cold. Influenza usually occurs in the UK during the winter months, from October to May. Most complications of influenza in adults are respiratory in nature and include: Acute bronchitis. Pneumonia. Exacerbations of asthma and chronic obstructive pulmonary disease. Otitis media. Sinusitis. Influenza presents (...) vaccines for preventing acute otitis media in infants and children. BACKGROUND: Acute otitis media (AOM) is one of the most common infectious diseases in children. It has been reported that 64% of infants have an episode of AOM by the age of six months and 86% by one year. Although most cases of AOM are due to bacterial infection, it is commonly triggered by a viral infection. In most children AOM is self limiting, but it does carry a risk of complications. Since antibiotic treatment (...) increases

2018 Trip Latest and Greatest

192. Ciprofloxacin

salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing 2018 2. Ciprofloxacin 3mg/mL + dexamethasone 1mg/mL ear drops (Cilodex) - Acute otitis media in patients with tympanostomy tubes (AOMT) and Acute otitis externa Published 10 July 2017 Product Update: ciprofloxacin 3mg/mL + dexamethasone 1mg/mL ear drops (Cilodex ® ) SMC No (1256/17) Novartis Pharmaceuticals UK Ltd 09 June 2017 The Scottish Medicines Consortium (SMC) has completed its (...) assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use (...) in NHS Scotland. The advice is summarised as follows: ADVICE: following an abbreviated submission ciprofloxacin +dexamethasone (Cilodex ® ) is accepted for restricted use within NHS Scotland. Indication under review: Treatment of the following infections in adults and children: Acute otitis media in patients with tympanostomy tubes (AOMT) Acute otitis externa SMC restriction: Treatment

2018 Trip Latest and Greatest

193. Amoxicillin

. Combination of Potassium Clavulanate (CVA) and Amoxicillin (AMPC) produces higher antibiotic activity against beta-lactamase-producing 2013 6. Comparison of cefuroxime axetil, cefaclor, and amoxicillin -clavulanate potassium suspensions in acute otitis media in infants and children. 2218657 1990 11 07 1990 11 07 2016 11 23 0038-4348 83 10 1990 Oct Southern medical journal South. Med. J. Comparison of cefuroxime axetil, cefaclor, and amoxicillin -clavulanate potassium suspensions in acute otitis media (...) in infants and children. 1174-7 In this randomized, blinded, multicenter comparison study, 377 infants and children with acute otitis (...) media (AOM) received a 10-day course of an oral suspension of one of the following: cefuroxime axetil (CAE), 30 mg/kg/day; cefaclor (CEC), 40 mg/kg/day; or amoxicillin -clavulanate potassium (AMX-CL), 40 mg/kg/day. Clinical efficacy was determined by pneumatic otoscopy and tympanometric testing 3 to 5, 11 to 14, and 22 to 26 days after the initiation of therapy

2018 Trip Latest and Greatest

194. Measles

, but once infected lifelong immunity develops. Although endemic in the UK in the past, measles (...) has become relatively rare since the introduction of measles immunization. However, in recent years, the infection has become more prevalent due to a failure of uptake of vaccination. The main complications of measles are of the respiratory tract or central nervous system and include: Otitis media (7–9% of children). Pneumonia (1–6% of children. Febrile convulsions (about 1 in 200 children). Encephalitis (...) and the Netherlands, and measles remains endemic in some countries. Health care professionals play an important role in diagnosing and managing acute cases of measles , preventing spread during outbreaks, and vaccination uptake (...) . Objective: To provide an overview of measles and vaccination for health care professionals. Evidence Review: MEDLINE and PubMed were searched from January 1, 1980, to April 30, 2016, in addition to the data repositories of the Centers for Disease Control and Prevention and World

2018 Trip Latest and Greatest

195. Probiotics to Prevent Antibiotic Associated Diarrhea in Children

and find that the eardrum has limited mobility, especially compared to the other side. with a diagnosis of acute otitis media in hand, you decide to prescribe high-dose amoxicillin for the child, based on the . However, as you start to explain this to the parents, they sound very hesitant because they have had other children who "always" get diarrhea when given antibiotics. They also recently had an elderly relative who was ill due to C. diff and they are scared to give their daughter antibiotics (...) of approximately 11. For the outcome of antibiotic associated diarrhea, defined as diarrhea with etiher a positive culture for Clostridium difficile or negative cultures for other pathogens, the reduction observed with probiotics did not achieve statistical significance (RR 0.33, 95% CI 0.1 to 1.06). The PGY-1 paper was a systematic review and meta-anaylysis from the Cochrane Collaboration. The pooled results of 23 studies, comprising 3938 patients, demonstrated a significant reduction in th eincidence

2018 Washington University Emergency Medicine Journal Club

196. Review of effective strategies to promote breastfeeding

that when in-person nutrition education was combined with mass media, participants generally reported greater improvements in breast and complementary feeding practices, whereas in three studies where mass media was the only approach, there were no significant improvements in IYCF practices. More efficient use of economic resources, and stronger incentives Economic studies show there can be substantial cost savings from improving suboptimal breastfeeding practices. This points to the potential (...) feasibility and benefits of financing ANBS-E from anticipated health cost savings. For example, the 2009–2010 value of the lifetime cost of treating maternal breast cancer attributable to low breastfeeding rates in Britain has been estimated at £959 million 14 , while in Australia the hospitalisation costs of treating acute infectious illness associated with premature cessation of exclusive breastfeeding were previously estimated at $60 million to $100 million annually. 15, 16 On the other hand

2018 Sax Institute Evidence Check

197. Peramivir (Alpivab) - Influenza, Human

. In the rabbit, at IV doses =200 mg/kg/day, following dosing from 1-9 days duration, the kidney was identified as the target organ for toxicity, with increased BUN and creatinine and increased ratios of excreted sodium and chloride compared to creatinine. Microscopically, mild to marked acute tubular necrosis was observed (in some studies “nephrosis”) which generally occurred at exposure (AUC) values of > 1,130,000 nghr/mL. Several additional nephrotoxicity studies were conducted to more thoroughly evaluate (...) the renal changes and all such studies were consistent in the identification of a no- observed adverse-effect-level (NOAEL) of 100 mg/kg/day in the rabbit with respect to acute tubular necrosis (3.4x (Cmax) and 2.1x (AUC) exposure safety margin). This renal toxicity noted only in the rabbit may be related to the formation of the acyl glucuronide (DM98405; 14% – 33% of radioactivity) or other unidentified metabolite, which was not observed in other species or in humans (S-021812-PF- 062-C). The applicant

2018 European Medicines Agency - EPARs

198. Velmanase alfa (Lamzede) - alpha-Mannosidosis

of motor proficiency CEV Comprehensive Evaluation Visit CHAQ childhood health assessment questionnaire CHO Chinese hamster ovary CI Confidence interval Cmax The maximum observed plasma concentration CNS Central nervous system CRF case report form CSF Cerebrospinal fluid CSR Clinical study report CTR clinical trial report CV curriculum vitae ECG Electrocardiogram ECHO echocardiogram EIA Enzyme immuno assay Assessment report EMA/205473/2018 Page 4/109 ELISA Enzyme-linked immunosorbent assay EOW every (...) of the protein was dimer. Monomer was present, while low amounts of the multimer form was detected. Aggregation properties have been intensively investigated with UV-Vis absorbance, 90° light- scattering, intrinsic fluorescence spectroscopy, Nile Red fluorescence spectroscopy, 1,8-ANS fluorescence spectroscopy, Nile Red fluorescence microscopy, SEC-MALS, mFF-MALS and FFF-MALS. Low levels of aggregates have been observed. Purity has also been studied with RP-HPLC. Co-elution of peaks has been observed

2018 European Medicines Agency - EPARs

199. Diagnosis and management of gonorrhoea and syphilis

, Belgium, 2016 19 Table 4 – Number of reported cases and reported cases / 100 000 inhabitants for chlamydia by age and gender, Belgium, 2016 21 Table 5 – Project structure 23 Table 6 – Research questions and PICO 28 Table 7 – Diagnostic tests for gonorrhoea - Included observational studies 37 Table 8 – Treatment for gonorrhoea - Included systematic reviews 39 Table 9 – Treatment for gonorrhoea - Included RCTs 39 Table 10 – Diagnostic tests for syphilis - Included observational studies 40 Table 11 (...) and epidemiological trends 1.1.1.1 Gonorrhoea Gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae (N. gonorrhoea) with infection of the columnar epithelium of the urethra, endocervix, rectum, pharynx and conjunctivae. 2 Symptoms and physical signs of gonorrhoea constitute of a localised in?ammation of the infected mucosal surfaces. In men, the presentation is mostly of acute urethritis with symptoms of mucopurulent urethral discharge (80%) and dysuria (50%), usually starting within 2–8 days

2019 Belgian Health Care Knowledge Centre

200. Proposals for a more effective antibiotic policy in Belgium

The availability of antibiotics in Belgium 235 8.2 MISMATCH BETWEEN ANTIBIOTIC PACKAGE SIZE AND GUIDELINES FOR THEIR USE LEADING TO SELF-MEDICATION 238 8.3 ETHICAL CHALLENGE: INDIVIDUAL VS. COLLECTIVE RESPONSIBILITY 241 9 JOINT EC – ECDC ONE HEALTH COUNTRY VISIT TO BELGIUM – KEY ISSUES WITH REGARD TO ANTIBIOTIC USE 242 9.1 HUMAN HEALTH – ECDC 242 9.1.1 Observations made by ECDC 242 9.1.2 Key recommendations made by ECDC 245 9.2 ANIMAL HEALTH - DG HEALTH AND FOOD SAFETY 247 9.2.1 Observations made by DG Health (...) and Food Safety 247 9.2.2 Considerations for possible future actions 250 10 DISCUSSION 251 11 HOW CAN THE SITUATION BE IMPROVED? 253 11.1 DEVELOP A NATIONAL ONE HEALTH AMR ACTION PLAN 253 11.2 STRENGTHEN ANTIBIOTIC STEWARDSHIP IN ACUTE CARE HOSPITALS 254 11.3 ROLL OUT LOCAL ANTIBIOTIC STEWARDSHIP TEAMS IN THE AMBULATORY SECTOR 255 6 Antibiotic policy in Belgium KCE Report 311 11.4 DEVELOP ANTIBIOTIC STEWARDSHIP IN NURSING HOMES 255 11.5 IMPROVE THE PROFESSIONAL EDUCATION ON PRUDENT ANTIBIOTIC

2019 Belgian Health Care Knowledge Centre

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