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Actinic Keratoses

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141. Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention

First Posted : August 22, 2018 Last Update Posted : March 19, 2019 See Sponsor: Shanghai Dermatology Hospital Collaborators: Huadong Hospital Peking University First Hospital The First Affiliated Hospital of Kunming Medical College General Hospital of Ningxia Medical University Chinese Academy of Medical Sciences Information provided by (Responsible Party): Xiuli Wang, Shanghai Dermatology Hospital Study Details Study Description Go to Brief Summary: Background Actinic keratoses (AKs) are often (...) /treatment Phase Actinic Keratoses Drug: ALA Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 300 participants Allocation: Randomized Intervention Model: Sequential Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Prevention Official Title: Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention: A Long-term (3 Years) Follow-up of Prospective, Randomized, Multicenter

2018 Clinical Trials

142. Conventional versus daylight photodynamic therapy for actinic keratosis: A randomized and prospective study in China. (PubMed)

Conventional versus daylight photodynamic therapy for actinic keratosis: A randomized and prospective study in China. Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT in Europe. However, few studies have been conducted with Asian

2018 Photodiagnosis and Photodynamic Therapy

143. Clinical utility of ingenol mebutate in the management of actinic keratosis: perspectives from clinical practice (Full text)

Clinical utility of ingenol mebutate in the management of actinic keratosis: perspectives from clinical practice Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed surfaces as a result of DNA damage. AKs have historically been characterized as being "precancerous"; however, now it is considered by many authors a carcinoma in situ that can persist or progress to invasive

2018 Therapeutics and clinical risk management PubMed

144. Efficacy and safety of daylight photodynamic therapy after tailored pretreatment with ablative fractional laser or microdermabrasion: a randomized, side-by-side, single-blind trial in patients with actinic keratosis and large area field cancerization. (PubMed)

Efficacy and safety of daylight photodynamic therapy after tailored pretreatment with ablative fractional laser or microdermabrasion: a randomized, side-by-side, single-blind trial in patients with actinic keratosis and large area field cancerization. Physical pretreatments can potentiate the efficacy of daylight photodynamic therapy (dPDT), but clinical comparative studies remain limited.Performed in large skin areas with actinic keratoses (AKs) and photodamage, this blinded, randomized

2018 British Journal of Dermatology

145. Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin. (PubMed)

Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin. Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term

2018 Journal of dermatological science

146. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. (Full text)

Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. 22297641 2012 06 18 2013 11 21 1523-1747 132 5 2012 May The Journal of investigative dermatology J. Invest. Dermatol. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. 1497-500 10.1038/jid.2011.459 Surjana Devita D Halliday Gary M GM Martin Andrew J AJ Moloney Fergal J FJ Damian Diona L DL eng Clinical Trial, Phase II Letter Randomized (...) Controlled Trial Research Support, Non-U.S. Gov't 2012 02 02 United States J Invest Dermatol 0426720 0022-202X 12001-76-2 Vitamin B Complex 25X51I8RD4 Niacinamide IM Aged Aged, 80 and over Carcinoma, Basal Cell pathology Carcinoma, Squamous Cell pathology Cell Transformation, Neoplastic Confidence Intervals Double-Blind Method Female Humans Keratosis, Actinic drug therapy prevention & control Logistic Models Male Medication Adherence Middle Aged Niacinamide administration & dosage therapeutic use Odds

2012 The Journal of investigative dermatology PubMed

147. Interventions for actinic keratoses. (PubMed)

Interventions for actinic keratoses. Actinic keratoses are a skin disease caused by long-term sun exposure, and their lesions have the potential to develop into squamous cell carcinoma. Treatments for actinic keratoses are sought for cosmetic reasons, for the relief of associated symptoms, or for the prevention of skin cancer development. Detectable lesions are often associated with alteration of the surrounding skin (field) where subclinical lesions might be present. The interventions (...) available for the treatment of actinic keratoses include individual lesion-based (e.g. cryotherapy) or field-directed (e.g. topical) treatments. These might vary in terms of efficacy, safety, and cosmetic outcomes.To assess the effects of topical, oral, mechanical, and chemical interventions for actinic keratosis.We searched the following databases up to March 2011: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE (from 2005), EMBASE (from 2010), and LILACS (from

2012 Cochrane database of systematic reviews (Online)

148. Single vs. fractionated photodynamic therapy for face and scalp actinic keratoses: a randomized, intraindividual comparison trial with 12-month follow-up. (PubMed)

Single vs. fractionated photodynamic therapy for face and scalp actinic keratoses: a randomized, intraindividual comparison trial with 12-month follow-up. To compare the efficacy and tolerability of a single ALA-PDT illumination scheme with that of a fractionated ALA-PDT illumination scheme in face and scalp actinic keratoses (AKs).Eligible patients received either a single ALA-PDT illumination or a fractionated illumination scheme randomly allocated to alternate sides of face/scalp. The side

2012 Journal of the European Academy of Dermatology and Venereology : JEADV

149. Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group. (PubMed)

Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group. Actinic keratoses (AK) are carcinomata in situ with the potential to develop into invasive carcinoma. Several studies have demonstrated that 3% diclofenac in 2.5% hyaluronic acid gel (HA) is effective and well tolerated in the treatment of AK. To date there are no large randomized multicentre

2012 Journal of the European Academy of Dermatology and Venereology : JEADV

150. A multicenter, randomized, vehicle-controlled phase 2 study of blue light photodynamic therapy with aminolevulinic acid HCl 20% topical solution for the treatment of actinic keratoses on the upper extremities: the effect of occlusion during the drug incub (PubMed)

A multicenter, randomized, vehicle-controlled phase 2 study of blue light photodynamic therapy with aminolevulinic acid HCl 20% topical solution for the treatment of actinic keratoses on the upper extremities: the effect of occlusion during the drug incub Photodynamic therapy (PDT) with aminolevulinic acid (ALA) has been shown to be safe and effective in the treatment of actinic keratoses (AKs) of the face and scalp. A recent small study has suggested that ALA-PDT can be effective for AKs

2012 Journal of drugs in dermatology : JDD

151. A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO(2) laser ablation in immunocompetent patients with multiple actinic keratoses. (PubMed)

A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO(2) laser ablation in immunocompetent patients with multiple actinic keratoses. Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head.To compare PDT and carbon dioxide (CO(2) ) LA in the management of multiple AK using objective and subjective outcome measures.A single-centre, randomized, two

2012 The British journal of dermatology

152. Effective photodynamic therapy of actinic keratoses and Bowen's disease using microneedle perforation. (PubMed)

Effective photodynamic therapy of actinic keratoses and Bowen's disease using microneedle perforation. 22804095 2013 07 18 2013 11 21 1365-2133 168 2 2013 Feb The British journal of dermatology Br. J. Dermatol. Effective photodynamic therapy of actinic keratoses and Bowen's disease using microneedle perforation. 450-2 10.1111/j.1365-2133.2012.11153.x Kolde G G Rowe E E Meffert H H eng Case Reports Letter England Br J Dermatol 0004041 0007-0963 0 Photosensitizing Agents 88755TAZ87 Aminolevulinic (...) Acid IM Aged Aminolevulinic Acid therapeutic use Bowen's Disease drug therapy Female Humans Keratosis, Actinic drug therapy Male Middle Aged Needles Photochemotherapy instrumentation methods Photosensitizing Agents therapeutic use Punctures methods Skin Neoplasms drug therapy 2012 7 19 6 0 2012 7 19 6 0 2013 7 19 6 0 ppublish 22804095 10.1111/j.1365-2133.2012.11153.x

2012 British Journal of Dermatology

153. Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography: A Pilot Study. (PubMed)

Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography: A Pilot Study. Optical coherence tomography (OCT) is a non-invasive optical imaging technique providing high-resolution images. OCT may be useful as a monitoring tool during treatment of actinic keratoses (AK) and skin cancer.To examine and describe how OCT skin morphology changes when the tissue is exposed to the effects of cryotherapy.Normal ex vivo skin and in vivo AK lesions were examined. Cryotherapy

2012 Dermatology

154. Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp

Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01600014 Recruitment Status : Completed First Posted : May 16, 2012 Results First Posted : May 9, 2016 Last Update Posted : May 9, 2016 Sponsor

2012 Clinical Trials

155. Photodynamic Therapy of Actinic Keratoses With Alacare®

Photodynamic Therapy of Actinic Keratoses With Alacare® Photodynamic Therapy of Actinic Keratoses With Alacare® - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Photodynamic Therapy of Actinic Keratoses (...) Go to Brief Summary: This study aims to collect data on the frequency of SCCs in the Alacare®-treated area during an interval of two years after Alacare®-PDT. Condition or disease Actinic Keratosis Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 388 participants Observational Model: Case-Only Time Perspective: Prospective Official Title: Non-interventional Observational Study on Photodynamic Therapy of Actinic Keratoses With Alacare® Study

2012 Clinical Trials

156. Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients

Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients (AKtransplant) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01538901 Recruitment Status : Terminated (prolonged recruitment phase) First Posted : February 24, 2012 Last Update Posted

2012 Clinical Trials

157. Photodynamic Treatment of Actinic Keratoses With Different Light Doses

Photodynamic Treatment of Actinic Keratoses With Different Light Doses Photodynamic Treatment of Actinic Keratoses With Different Light Doses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Photodynamic (...) Treatment of Actinic Keratoses With Different Light Doses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01541228 Recruitment Status : Completed First Posted : February 29, 2012 Last Update Posted : September 4, 2013 Sponsor: Lithuanian University of Health Sciences Information provided by (Responsible

2012 Clinical Trials

158. Actinic Keratoses

Actinic Keratoses Actinic Keratoses Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Actinic Keratoses Actinic Keratoses Aka: Actinic (...) Keratoses , Actinic Keratosis From Related Chapters II. Epidemiology Most common premalignant skin lesion Responsible for 60% of involving the skin : White skin (increases with age) Age 20-29: 10% Age 80-89: 75% III. Pathophysiology Superficial keratotic tumor Previously considered distinct premalignant changes Now thought to be very early s IV. Risk Factors Fair-skinned, blue-eyed persons Living in sunny climate Cummulative extensive Older persons V. Symptoms Typically asymptomatic May be pruritic

2015 FP Notebook

159. Results of an investigator-initiated single-blind split-face comparison of photodynamic therapy and 5% imiquimod cream for the treatment of actinic keratoses. (PubMed)

Results of an investigator-initiated single-blind split-face comparison of photodynamic therapy and 5% imiquimod cream for the treatment of actinic keratoses. Topical photodynamic therapy (PDT) with aminolevulinic acid (ALA) and 5% imiquimod cream are effective therapies for the treatment of actinic keratoses (AKs), but no split-face studies directly comparing these treatment options are available in the literature.To compare the efficacy and tolerability of ALA-PDT and imiquimod 5% cream

2012 Dermatologic Surgery

160. Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp: a randomized multicentre study. (PubMed)

Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp: a randomized multicentre study. Photodynamic therapy (PDT) is an attractive therapy for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight-mediated PDT is a simple and tolerable treatment procedure for PDT. Methyl aminolaevulinate (MAL)-PDT is approved for the treatment of thin or nonhyperkeratotic AKs on the face and scalp. However, thick AK lesions are often treated as well when

2012 The British journal of dermatology

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