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Actinic Keratoses

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141. Actinic Keratoses

Actinic Keratoses Actinic Keratoses Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Actinic Keratoses Actinic Keratoses Aka: Actinic (...) Keratoses , Actinic Keratosis From Related Chapters II. Epidemiology Most common premalignant skin lesion Responsible for 60% of involving the skin : White skin (increases with age) Age 20-29: 10% Age 80-89: 75% III. Pathophysiology Superficial keratotic tumor Previously considered distinct premalignant changes Now thought to be very early s IV. Risk Factors Fair-skinned, blue-eyed persons Living in sunny climate Cummulative extensive Older persons V. Symptoms Typically asymptomatic May be pruritic

2015 FP Notebook

142. Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp

Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01600014 Recruitment Status : Completed First Posted : May 16, 2012 Results First Posted : May 9, 2016 Last Update Posted : May 9, 2016 Sponsor

2012 Clinical Trials

143. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. Full Text available with Trip Pro

Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. 22297641 2012 06 18 2013 11 21 1523-1747 132 5 2012 May The Journal of investigative dermatology J. Invest. Dermatol. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. 1497-500 10.1038/jid.2011.459 Surjana Devita D Halliday Gary M GM Martin Andrew J AJ Moloney Fergal J FJ Damian Diona L DL eng Clinical Trial, Phase II Letter Randomized (...) Controlled Trial Research Support, Non-U.S. Gov't 2012 02 02 United States J Invest Dermatol 0426720 0022-202X 12001-76-2 Vitamin B Complex 25X51I8RD4 Niacinamide IM Aged Aged, 80 and over Carcinoma, Basal Cell pathology Carcinoma, Squamous Cell pathology Cell Transformation, Neoplastic Confidence Intervals Double-Blind Method Female Humans Keratosis, Actinic drug therapy prevention & control Logistic Models Male Medication Adherence Middle Aged Niacinamide administration & dosage therapeutic use Odds

2012 The Journal of investigative dermatology Controlled trial quality: predicted high

144. Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients

Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients (AKtransplant) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01538901 Recruitment Status : Terminated (prolonged recruitment phase) First Posted : February 24, 2012 Last Update Posted

2012 Clinical Trials

145. Photodynamic Therapy of Actinic Keratoses With Alacare®

Photodynamic Therapy of Actinic Keratoses With Alacare® Photodynamic Therapy of Actinic Keratoses With Alacare® - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Photodynamic Therapy of Actinic Keratoses (...) Go to Brief Summary: This study aims to collect data on the frequency of SCCs in the Alacare®-treated area during an interval of two years after Alacare®-PDT. Condition or disease Actinic Keratosis Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 388 participants Observational Model: Case-Only Time Perspective: Prospective Official Title: Non-interventional Observational Study on Photodynamic Therapy of Actinic Keratoses With Alacare® Study

2012 Clinical Trials

146. Photodynamic Treatment of Actinic Keratoses With Different Light Doses

Photodynamic Treatment of Actinic Keratoses With Different Light Doses Photodynamic Treatment of Actinic Keratoses With Different Light Doses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Photodynamic (...) Treatment of Actinic Keratoses With Different Light Doses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01541228 Recruitment Status : Completed First Posted : February 29, 2012 Last Update Posted : September 4, 2013 Sponsor: Lithuanian University of Health Sciences Information provided by (Responsible

2012 Clinical Trials

147. A multicenter, randomized, vehicle-controlled phase 2 study of blue light photodynamic therapy with aminolevulinic acid HCl 20% topical solution for the treatment of actinic keratoses on the upper extremities: the effect of occlusion during the drug incub (Abstract)

A multicenter, randomized, vehicle-controlled phase 2 study of blue light photodynamic therapy with aminolevulinic acid HCl 20% topical solution for the treatment of actinic keratoses on the upper extremities: the effect of occlusion during the drug incub Photodynamic therapy (PDT) with aminolevulinic acid (ALA) has been shown to be safe and effective in the treatment of actinic keratoses (AKs) of the face and scalp. A recent small study has suggested that ALA-PDT can be effective for AKs

2012 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

148. A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO(2) laser ablation in immunocompetent patients with multiple actinic keratoses. (Abstract)

A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO(2) laser ablation in immunocompetent patients with multiple actinic keratoses. Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head.To compare PDT and carbon dioxide (CO(2) ) LA in the management of multiple AK using objective and subjective outcome measures.A single-centre, randomized, two

2012 The British journal of dermatology Controlled trial quality: uncertain

149. Recurrence rates and patient assessed outcomes of 0.5% 5-fluorouracil in combination with salicylic acid treating actinic keratoses. Full Text available with Trip Pro

Recurrence rates and patient assessed outcomes of 0.5% 5-fluorouracil in combination with salicylic acid treating actinic keratoses. Actinic keratoses (AK) have been classified as early in situ squamous cell carcinomas and should be treated.To evaluate the clinical benefit of 5-fluorouracil 0.5%/salicylic acid 10.0% (5-FU/SA) versus 3% diclofenac/hyaluronic acid (HA) for the treatment of AK and report patients' assessments of efficacy, tolerability and practicability.Randomised, placebo

2012 European journal of dermatology : EJD Controlled trial quality: predicted high

150. Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography: A Pilot Study. (Abstract)

Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography: A Pilot Study. Optical coherence tomography (OCT) is a non-invasive optical imaging technique providing high-resolution images. OCT may be useful as a monitoring tool during treatment of actinic keratoses (AK) and skin cancer.To examine and describe how OCT skin morphology changes when the tissue is exposed to the effects of cryotherapy.Normal ex vivo skin and in vivo AK lesions were examined. Cryotherapy

2012 Dermatology

151. Effective photodynamic therapy of actinic keratoses and Bowen's disease using microneedle perforation. (Abstract)

Effective photodynamic therapy of actinic keratoses and Bowen's disease using microneedle perforation. 22804095 2013 07 18 2013 11 21 1365-2133 168 2 2013 Feb The British journal of dermatology Br. J. Dermatol. Effective photodynamic therapy of actinic keratoses and Bowen's disease using microneedle perforation. 450-2 10.1111/j.1365-2133.2012.11153.x Kolde G G Rowe E E Meffert H H eng Case Reports Letter England Br J Dermatol 0004041 0007-0963 0 Photosensitizing Agents 88755TAZ87 Aminolevulinic (...) Acid IM Aged Aminolevulinic Acid therapeutic use Bowen's Disease drug therapy Female Humans Keratosis, Actinic drug therapy Male Middle Aged Needles Photochemotherapy instrumentation methods Photosensitizing Agents therapeutic use Punctures methods Skin Neoplasms drug therapy 2012 7 19 6 0 2012 7 19 6 0 2013 7 19 6 0 ppublish 22804095 10.1111/j.1365-2133.2012.11153.x

2012 British Journal of Dermatology

152. Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp: a randomized multicentre study. (Abstract)

Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp: a randomized multicentre study. Photodynamic therapy (PDT) is an attractive therapy for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight-mediated PDT is a simple and tolerable treatment procedure for PDT. Methyl aminolaevulinate (MAL)-PDT is approved for the treatment of thin or nonhyperkeratotic AKs on the face and scalp. However, thick AK lesions are often treated as well when

2012 The British journal of dermatology Controlled trial quality: uncertain

153. Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial. (Abstract)

Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial. Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is effective for thin actinic keratoses (AKs) in field-cancerized skin. Ablative fractional laser resurfacing (AFXL) creates vertical channels that facilitate MAL uptake and may improve PDT efficacy.To evaluate efficacy and safety of AFXL-assisted PDT (AFXL-PDT) compared with conventional PDT in field-directed treatment

2012 The British journal of dermatology Controlled trial quality: uncertain

154. Results of an investigator-initiated single-blind split-face comparison of photodynamic therapy and 5% imiquimod cream for the treatment of actinic keratoses. (Abstract)

Results of an investigator-initiated single-blind split-face comparison of photodynamic therapy and 5% imiquimod cream for the treatment of actinic keratoses. Topical photodynamic therapy (PDT) with aminolevulinic acid (ALA) and 5% imiquimod cream are effective therapies for the treatment of actinic keratoses (AKs), but no split-face studies directly comparing these treatment options are available in the literature.To compare the efficacy and tolerability of ALA-PDT and imiquimod 5% cream

2012 Dermatologic Surgery Controlled trial quality: uncertain

155. Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group. (Abstract)

Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group. Actinic keratoses (AK) are carcinomata in situ with the potential to develop into invasive carcinoma. Several studies have demonstrated that 3% diclofenac in 2.5% hyaluronic acid gel (HA) is effective and well tolerated in the treatment of AK. To date there are no large randomized multicentre

2012 Journal of the European Academy of Dermatology and Venereology : JEADV Controlled trial quality: uncertain

156. Single vs. fractionated photodynamic therapy for face and scalp actinic keratoses: a randomized, intraindividual comparison trial with 12-month follow-up. (Abstract)

Single vs. fractionated photodynamic therapy for face and scalp actinic keratoses: a randomized, intraindividual comparison trial with 12-month follow-up. To compare the efficacy and tolerability of a single ALA-PDT illumination scheme with that of a fractionated ALA-PDT illumination scheme in face and scalp actinic keratoses (AKs).Eligible patients received either a single ALA-PDT illumination or a fractionated illumination scheme randomly allocated to alternate sides of face/scalp. The side

2012 Journal of the European Academy of Dermatology and Venereology : JEADV Controlled trial quality: uncertain

157. The use of topical 5-fluorouracil in actinic keratoses. Full Text available with Trip Pro

The use of topical 5-fluorouracil in actinic keratoses. 5150335 1972 08 17 2018 11 13 0008-4409 105 12 1971 Dec 18 Canadian Medical Association journal Can Med Assoc J The use of topical 5-fluorouracil in actinic keratoses. 1314-5 Richards R N RN eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 U3P01618RT Fluorouracil AIM IM Adult Aged Aging Biopsy Carcinoma, Squamous Cell etiology Fluorouracil therapeutic use Humans Keratosis complications drug therapy etiology Middle Aged Skin

1971 Canadian Medical Association Journal

158. Spanish Version of Actinic Keratosis Quality of Life Questionnaire (AKQoL). (Abstract)

Spanish Version of Actinic Keratosis Quality of Life Questionnaire (AKQoL). Patient-reported outcome measures are very important outcomes. For specific diseases, health-related quality of life-instruments (HRQoL) are increasingly used to provide data on patients' overall perceptions of the course of a given disease. Actinic keratoses (AKs) are common keratotic lesions that occur on chronically sunlight-exposed skin. Only few studies regarding HRQoL in AKs have been made.In order to be able (...) to compare HRQoL among different countries and cultures, we aimed to translate and validate the Actinic Keratosis Quality of Life (AKQoL) questionnaire into Spanish and quantify the impairment caused by AKs in Spanish patients.The AKQoL was translated. Then, 15 patients with AKs were interviewed to ensure cultural adaption before it was tested in one hundred patients with AK lesions at the Melanoma Unit of Hospital Clinic in Barcelona.Validation showed high interitem correlations, as well as a high

2017 Journal of the European Academy of Dermatology and Venereology

159. Daylight Photodynamic Therapy for Actinic Keratosis

Francisco Study Details Study Description Go to Brief Summary: This is a randomized, single-blind controlled trial with parallel group design to determine whether daylight photodynamic therapy (PDT) affords a reduction in treatment symptoms of pain, burning, and pruritus as measured by 1) symptom level during the treatment period and 2) pain at the end of treatment exposure. Condition or disease Intervention/treatment Phase Actinic Keratoses Drug: Aminolevulinic Acid Topical 20% Topical Solution Device (...) : BLU-U blue light phototherapy illuminator Phase 1 Detailed Description: Actinic keratoses (AK) are common precancerous skin lesions that arise on sun-damaged skin. Treatment is aimed at preventing progression to cutaneous squamous cell carcinoma (SCC). First-line therapy for clinically apparent lesions includes cryotherapy and curettage; and field therapy options are topical 5-fluorouracil, imiquimod, ingenol mebutate, and photodynamic therapy (PDT). PDT involves the topical application

2017 Clinical Trials

160. Conventional vs. Daylight Photodynamic Therapy for patients with actinic keratosis on face and scalp: 12-month follow-up results of a randomized, intraindividual comparative analysis. (Abstract)

Conventional vs. Daylight Photodynamic Therapy for patients with actinic keratosis on face and scalp: 12-month follow-up results of a randomized, intraindividual comparative analysis. Daylight PDT (DLPDT) is a new PDT procedure. Several trials demonstrate that DLPDT achieves similar response rates with conventional PDT (CPDT) in the treatment of non-hyperkeratotic actinic keratoses (AKs) in a nearly painless way. It seems that DLPDT represents a more convenient and equally effective treatment

2017 Journal of the European Academy of Dermatology and Venereology Controlled trial quality: uncertain

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