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Actinic Keratoses

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81. Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomised, investigator-blinded, controlled, phase III study throughout Europe. (PubMed)

Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomised, investigator-blinded, controlled, phase III study throughout Europe. Unmet needs exist in actinic keratosis (AK) treatment. Daylight photodynamic therapy (DL-PDT) has shown good efficacy and safety results compared to conventional PDT (c-PDT) in a recent Phase III multi-centre randomised controlled trial in Australia among 100 subjects

2015 Journal of the European Academy of Dermatology and Venereology : JEADV

82. Retrospective analysis evaluating the effect of a keratolytic and physical pretreatment with salicylic acid, urea and curettage on the efficacy and safety of photodynamic therapy of actinic keratoses with methylaminolaevulinate. (PubMed)

Retrospective analysis evaluating the effect of a keratolytic and physical pretreatment with salicylic acid, urea and curettage on the efficacy and safety of photodynamic therapy of actinic keratoses with methylaminolaevulinate. Photodynamic therapy (PDT) is a highly effective treatment option for actinic keratosis (AK). Hyperkeratosis of the AK impairs penetration of the photosensitizer and light and leads to a reduced efficacy of PDT. Therefore, it is commonly recommended to perform curettage

2015 Journal of the European Academy of Dermatology and Venereology

83. Rapidly-growing squamous cell carcinoma shortly after treatment with ingenol mebutate for actinic keratoses: report of 2 cases. (PubMed)

Rapidly-growing squamous cell carcinoma shortly after treatment with ingenol mebutate for actinic keratoses: report of 2 cases. Actinic keratoses (AKs) are defined as cutaneous areas of atypical squamous transformation that are regarded as an early step in the continuum of alterations leading from normal skin to invasive and metastatic squamous cell carcinoma (SCC). AKs are classified as precancerous lesions by some authors and in situ SCC by others. The rate of evolution of a given AK

2015 British Journal of Dermatology

84. Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp

Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2015 Clinical Trials

85. Treatment of Actinic Keratoses (AK) on the Face

Treatment of Actinic Keratoses (AK) on the Face Treatment of Actinic Keratoses (AK) on the Face - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment of Actinic Keratoses (AK) on the Face The safety (...) Sinai Study Details Study Description Go to Brief Summary: Actinic keratoses (AK) are common cutaneous lesions associate with chronic ultraviolet radiation exposure. While most authorities consider AK as a pre-malignant lesion, some consider it as an incipient squamous cell carcinoma (SCC). Ingenol mebutate is the active compound in the sap from Euphorbia peplus L. (E. peplus). Topical ingenol mebutate treatment has been approved for the treatment of AKs. Ingenol mebutate gel 0.015% has shown

2015 Clinical Trials

86. Treatment monitoring of 0.5% 5-fluorouracil and 10% salicylic acid in clinical and subclinical actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy. (PubMed)

Treatment monitoring of 0.5% 5-fluorouracil and 10% salicylic acid in clinical and subclinical actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy. Reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT) allow the observation in vivo of dynamic changes in response to non-surgical treatment of actinic keratosis and field of cancerisation.To non-invasively assess the pharmacodynamic changes induced (...) by treatment with low dose 5-fluorouracil and 10% salicylic acid by means of RCM and high-definition OCT in field cancerization and actinic keratosis.Twenty patients aged >50 years with diagnosis of actinic keratosis on the head and face and indication for treatment with 0.5% 5-fluorouracil and 10% salicylic acid were enrolled. An area of 25 cm² including visible type I and II AK and subclinical AK was treated once daily during 6 weeks and examination was performed with RCM and HD-OCT before treatment

2015 Journal of the European Academy of Dermatology and Venereology

87. Actinic Keratoses Treatment With Metvix® in Combination With Light

Actinic Keratoses Treatment With Metvix® in Combination With Light Actinic Keratoses Treatment With Metvix® in Combination With Light - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Actinic Keratoses (...) : University Hospital, Limoges Collaborator: Galderma Information provided by (Responsible Party): University Hospital, Limoges Study Details Study Description Go to Brief Summary: The main objective of this study is to compare efficacy and safety of Metvix® natural daylight photodynamic therapy with those of Metvix® conventional photodynamic therapy in subjects with mild actinic keratoses (intra-individual comparison) Condition or disease Intervention/treatment Phase Actinic Keratoses Drug: Metvix®

2015 Clinical Trials

88. Dermoscopy and reflectance confocal microscopy of pigmented actinic keratoses: a morphological study. (PubMed)

Dermoscopy and reflectance confocal microscopy of pigmented actinic keratoses: a morphological study. Actinic keratoses (AKs) are very common lesions on sun damaged skin and, when pigmented, represent a challenge in the differential diagnosis with early melanoma. Non-invasive diagnostic methods, such as dermoscopy and reflectance confocal microscopy (RCM) have been shown to improve the diagnostic accuracy of melanoma and non-melanoma skin cancer, however, only one case report described confocal

2015 Journal of the European Academy of Dermatology and Venereology

89. Guidelines for care of patients with actinic keratosis

of this set of recommendations is scheduled for 2021; where necessary, important interim changes will be updated on the BAD website. 6.0 Background Actinic keratoses (synonymous with solar keratoses) are kera- totic lesions occurring on chronically light-exposed adult skin. They represent focal areas of abnormal keratinocyte prolifera- tion and differentiation that carry a low risk of progression to invasive SCC. A spectrum of histology is seen, but the cardinal feature of an AK is epithelial dysplasia (...) . This may be restricted to the basal layer or may extend to full-thickness atypia, at which point the lesion is known as SCC in situ (Bowen dis- ease). There is disorderly arrangement and maturation of epithelial cells. Multiple buds of epithelial cells may occur at the membrane zone, but no invasion is seen. Histological vari- ants of AK have been described, including hypertrophic, bowenoid, lichenoid, acantholytic and pigmented. Actinic keratoses are generally considered to be premalig- nant lesions

2017 British Association of Dermatologists

90. Efficacy of photodynamic therapy vs other interventions in randomized clinical trials for the treatment of actinic keratoses: a systematic review and meta-analysis. (PubMed)

Efficacy of photodynamic therapy vs other interventions in randomized clinical trials for the treatment of actinic keratoses: a systematic review and meta-analysis. IMPORTANCE Photodynamic therapy (PDT) is used extensively to treat actinic keratoses(AKs). An analysis of the effectiveness of PDT compared with other treatments may help physicians decide what role it should play in their own clinical practices.OBJECTIVE To determine the effectiveness of PDT for the treatment of AKs relative (...) to other methods.DATA SOURCES MEDLINE, EMBASE,Web of Knowledge, and Cochrane Central Register. No restrictions on years were placed, and all searches extended to the year of each data base inception. Our search was conducted on March 20, 2013, and included the search terms solar keratosis, actinic keratosis, photodynamic therapy, and photochemotherapy. No restrictions were used for the search string.STUDY SELECTION Only randomized PDT trials that used aminolevulinic acid hydrochloride ormethyl

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2014 JAMA dermatology (Chicago, Ill.)

91. Fractional erbium: YAG laser-assisted photodynamic therapy for facial actinic keratoses: a randomized, comparative, prospective study. (PubMed)

Fractional erbium: YAG laser-assisted photodynamic therapy for facial actinic keratoses: a randomized, comparative, prospective study. Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is effective for treating multiple actinic keratoses (AKs). Ablative fractional laser (FL) creates vertical channels that may facilitate MAL delivery and improve PDT response.To evaluate the efficacy of FL-assisted PDT (FL-PDT) in treating facial AKs in Korean patients.A prospective randomized non

2014 Journal of the European Academy of Dermatology and Venereology

92. A randomized clinical trial of photodynamic therapy with methyl aminolaevulinate vs. diclofenac 3% plus hyaluronic acid gel for the treatment of multiple actinic keratoses of the face and scalp. (PubMed)

A randomized clinical trial of photodynamic therapy with methyl aminolaevulinate vs. diclofenac 3% plus hyaluronic acid gel for the treatment of multiple actinic keratoses of the face and scalp. A gel containing diclofenac and hyaluronic acid (DHA) and photodynamic therapy with methyl aminolaevulinate (MAL-PDT) are widely used treatments for actinic keratoses (AKs).The aim of this single-centre, open-label, prospective, nonsponsored, randomized controlled clinical trial was to compare

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2014 British Journal of Dermatology

93. A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol(®) cream for the treatment of actinic keratoses. (PubMed)

A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol(®) cream for the treatment of actinic keratoses. Actinic keratosis lesions (AKs) have the potential to develop into squamous cell carcinoma (SCC) and thus therapies to prevent SCC development from AKs are warranted. The aim of this study was to assess the effects of a 3 month application of a canola phenolic acid-based cream (CPA) on AK lesions.This was a randomized, double-blind, placebo-controlled, 12 week

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2014 Clinical, cosmetic and investigational dermatology

94. Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: two phase 3,multicenter, randomized, double-blind, placebo-controlled studies. (PubMed)

Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: two phase 3,multicenter, randomized, double-blind, placebo-controlled studies. Imiquimod 3.75% and 2.5% creams were studied for the treatment of actinic keratosis (AK) of the full face or balding scalp, to determine comparable efficacy and tolerability to imiquimod 5% cream.In two identical multicenter, randomized, double-blind, placebo controlled studies. Adult subjects with 5 to 20 visible lesions, or palpable AKs in an area

2014 Journal of drugs in dermatology : JDD

95. A randomized clinical trial of photodynamic therapy with methylaminolevulinate versus 3% diclofenac plus hyaluronic acid gel for the treatment of multiple actinic keratoses of the face and scalp. (PubMed)

A randomized clinical trial of photodynamic therapy with methylaminolevulinate versus 3% diclofenac plus hyaluronic acid gel for the treatment of multiple actinic keratoses of the face and scalp. A gel containing diclofenac and hyaluronic acid (DHA) and photodynamic therapy with methyl aminolaevulinate (MAL-PDT) are widely used treatments for actinic keratoses (AKs).The aim of this single-centre, open-label, prospective, nonsponsored, randomized controlled clinical trial was to compare

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2014 The British journal of dermatology

96. Cryotherapy is preferable to ablative CO<sub>2</sub> laser for the treatment of isolated actinic keratoses of the face and scalp: a randomised clinical trial. (PubMed)

Cryotherapy is preferable to ablative CO2 laser for the treatment of isolated actinic keratoses of the face and scalp: a randomised clinical trial. Actinic keratosis (AK) may progress to squamous cell carcinoma. In the case of normal or mildly photodamaged skin, lesion-directed treatments are considered valuable options despite poor published evidence of their therapeutic activity.The aim of this single-centre, open-label, prospective, nonsponsored, randomized, controlled clinical

2014 British Journal of Dermatology

97. Topical corticosteroid reduces inflammation without compromising efficacy of photodynamic therapy for actinic keratoses a randomised clinical trial. (PubMed)

Topical corticosteroid reduces inflammation without compromising efficacy of photodynamic therapy for actinic keratoses a randomised clinical trial. Photodynamic therapy (PDT) is an effective and established treatment for actinic keratoses (AK) and nonmelanoma skin cancer. The main side-effects of PDT are post-treatment erythema and oedema, and pain during illumination. Severe erythema after PDT enhances the down time associated with the treatment.To evaluate in a randomized intraindividual

2014 The British journal of dermatology

98. Daylight photodynamic therapy for actinic keratoses: A randomized double-blinded non-sponsored prospective study comparing BF-200 aminolevulinic acid with methyl-5-aminolaevulinate. (PubMed)

Daylight photodynamic therapy for actinic keratoses: A randomized double-blinded non-sponsored prospective study comparing BF-200 aminolevulinic acid with methyl-5-aminolaevulinate. Daylight-mediated photodynamic therapy (DL-PDT) using methyl-5-aminolaevulinate (MAL) is effective for thin, grade I, actinic keratoses (AK). There are no published studies of other photosensitizers used in DL-PDT.To compare the efficacy and adverse effects of 5-aminolaevulinic acid nanoemulsion (BF-200 ALA

2014 The British journal of dermatology

99. Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series. (PubMed)

Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series. 25070046 2015 12 18 2015 03 17 1365-2133 172 3 2015 Mar The British journal of dermatology Br. J. Dermatol. Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series. 816-8 10.1111/bjd.13304 Maier T T (...) Department of Dermatology and Allergology, University Hospital of Munich, Frauenlobstraße 9-11, D-80337, Munich, Germany. Cekovic D D Ruzicka T T Sattler E C EC Berking C C eng Letter 2015 01 22 England Br J Dermatol 0004041 0007-0963 0 3-ingenyl angelate 0 Dermatologic Agents 0 Diterpenes IM Administration, Cutaneous Dermatologic Agents administration & dosage Diterpenes administration & dosage Female Humans Keratosis, Actinic drug therapy Male Microscopy, Confocal Tomography, Optical Coherence 2014 7

2014 British Journal of Dermatology

100. Lack of activity of betulin-based Oleogel-S10 in treatment of actinic keratoses: A randomized, multicenter, placebo controlled double-blind phase II trial. (PubMed)

Lack of activity of betulin-based Oleogel-S10 in treatment of actinic keratoses: A randomized, multicenter, placebo controlled double-blind phase II trial. Betulinic acid and other triterpenes have shown strong antitumour activity in vitro and in vivo. A triterpene extract of birch bark formed the base of Oleogel-S10 and allowed topical application. Two previous trials have shown efficacy and tolerability in the treatment of actinic keratoses (AKs) with betulin-based Oleogel-S10.To confirm

2014 The British journal of dermatology

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