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885 results for

Actinic Keratoses

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881. Preventative effect of etretinate therapy on multiple actinic keratoses. (PubMed)

Preventative effect of etretinate therapy on multiple actinic keratoses. Multiple actinic keratoses (MAK) are premalignant lesions that may produce a significant treatment problem not always controllable by destructive therapy. Etretinate therapy has been shown to produce both prophylactic and therapeutic effects on premalignant epithelial tumors of mice. Results are presented on an 8-month double blind crossover trial (4 months placebo/4 months etretinate, randomly assigned) in 15 patients (...) with severe MAK. Fourteen patients improved significantly on etretinate, whereas five of six patients who had placebo in the first 4-month period became worse as measured by the number of lesions and diameter of larger lesions. However, eight of nine patients who had placebo in the second 4-month period (ie, following etretinate therapy) showed no significant increase in the number of actinic keratoses, suggesting that etretinate may prevent the appearance of new lesions during, and for some time after

1986 Cancer detection and prevention

882. Effect of intralesional alpha 2-interferon on actinic keratoses. (PubMed)

Effect of intralesional alpha 2-interferon on actinic keratoses. The effect of intralesional alpha 2-interferon (IFN) on actinic keratoses was examined in this two-part study. In phase I, 11 of 12 lesions cleared following nine injections of IFN (5 X 10(5) IU per dose) compared with none of 12 keratoses injected with placebo. Smaller doses of IFN (1 X 10(5) IU and 1 X 10(4) IU per injection) produced clearing of 42% and 58% of lesions, respectively. The second phase, which was designed (...) to investigate the optimum schedule for treatment with IFN, showed that a minimum of six injections of IFN (5 X 10(5) IU per injection) was necessary to clear 14 of 15 actinic keratoses. Although this mode of delivery is not practical for clinical use, intralesional alpha 2-IFN demonstrates biologic activity against actinic keratoses.

1986 Archives of Dermatology

883. Topical chemotherapy of actinic keratoses of the upper extremity with tretinoin and 5-fluorouracil: a double-blind controlled study. (PubMed)

Topical chemotherapy of actinic keratoses of the upper extremity with tretinoin and 5-fluorouracil: a double-blind controlled study. In a randomized double-blind controlled study, 19 patients applied 5% 5-fluorouracil (5-FU) cream to actinic keratoses (AK) on each arm twice daily, followed by nightly application of 0.05% tretinoin cream to one arm, and a control cream to the other arm until discomfort precluded further applications. After 3 months, the number of residual AK was compared to pre

1987 The British journal of dermatology

884. Imiquimod cream in the treatment of actinic keratoses. (PubMed)

Imiquimod cream in the treatment of actinic keratoses. We studied the usefulness of imiquimod cream in the treatment of 3 patients with actinic keratoses. One patient was treated 3 times per week for 4 weeks and had a marked inflammatory response with nearly complete resolution of actinic keratoses. Two subsequent patients were treated in a bilateral paired comparison study. Both patients had similar numbers of actinic keratoses on symmetric areas and treated only one side with imiquimod cream (...) 2 to 3 times per week with frequent rest periods to avoid inflammation. Both experienced marked reductions in actinic keratoses. After 8 weeks, both patients applied imiquimod cream twice per week for 9 months with continued reduction in actinic keratoses on both sides. Treatments were well tolerated. Imiquimod cream appears to be effective in the treatment of actinic keratoses. The main adverse effect is local inflammation, which can be avoided by reducing the frequency of application.

2002 Journal of American Academy of Dermatology

885. Prevalence of actinic keratoses and associated factors in a representative sample of the Italian adult population: Results from the Prevalence of Actinic Keratoses Italian Study, 2003-2004. (Full text)

Prevalence of actinic keratoses and associated factors in a representative sample of the Italian adult population: Results from the Prevalence of Actinic Keratoses Italian Study, 2003-2004. The Prevalence of Actinic Keratoses Italian Study (PraKtis) was designed to estimate the point prevalence of actinic keratoses (AKs) and associated factors in a representative sample of the Italian adult population.A representative sample of people 45 years or older was selected from the electoral rolls

2006 Archives of Dermatology PubMed

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