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Actinic Keratoses

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21. Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment. (PubMed)

Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment. The treatment of actinic keratosis (AK) is a potentially effective strategy for the prevention of cutaneous squamous cell carcinoma (cSCC). However, the patient perspective on potential benefits of AK treatment in terms of skin cancer reduction has received little attention to date.(i) To investigate patient preferences for topical treatments for AK using a discrete-choice experiment (DCE); (ii

2018 British Journal of Dermatology

22. A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses. (PubMed)

A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses. Overexpression of hexokinase 2, and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to aerobic glycolysis, which enables them to proliferate. We describe Comp-1, an allosteric small molecule that selectively detaches hexokinase 2 from the mitochondria. Detachment of hexokinase 2 reduces glycolysis and triggers apoptosis in cancer cells (...) in minipigs for 28 days and 13 weeks established no systemic toxicities and minimal dermal reaction for once-daily application of up to 20% and 15% ointment strengths, respectively. Thus, Comp-1 may address a significant unmet medical need for a non-irritating efficacious topical actinic keratosis treatment.Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

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2018 Journal of Investigative Dermatology

23. Daylight Photodynamic Therapy for Actinic Keratoses. (PubMed)

Daylight Photodynamic Therapy for Actinic Keratoses. Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT (...) remains established as a therapy for Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas (BCCs), and AKs. The evidence for the use of DL-PDT beyond AK is limited, although has been reported in actinic cheilitis, superficial BCC, and acne and cutaneous leishmaniasis. There is emerging interest in combination therapy for AK, using one or more field therapies such as DL-PDT as an option to complement with localized treatment for residual lesions. We

2018 American journal of clinical dermatology

24. Long-term Outcome of Daylight Photodynamic Therapy with Amino-5-laevulinate Nanoemulsion vs. Methyl-5-aminolaevulinate for Actinic Keratoses. (PubMed)

Long-term Outcome of Daylight Photodynamic Therapy with Amino-5-laevulinate Nanoemulsion vs. Methyl-5-aminolaevulinate for Actinic Keratoses. 26806126 2017 01 17 2017 05 08 1651-2057 96 5 2016 06 15 Acta dermato-venereologica Acta Derm. Venereol. Long-term Outcome of Daylight Photodynamic Therapy with Amino-5-laevulinate Nanoemulsion vs. Methyl-5-aminolaevulinate for Actinic Keratoses. 712-3 10.2340/00015555-2345 Neittaanmäki-Perttu Noora N Department of Dermatology and Allergology, Helsinki (...) University and Helsinki University Hospital, FIN-00029 Helsinki, Finland. noora.neittaanmaki@fimnet.fi. Grönroos Mari M Tani Taneli T Snellman Erna E eng Journal Article Randomized Controlled Trial Sweden Acta Derm Venereol 0370310 0001-5555 0 Photosensitizing Agents 585NM85KYM methyl 5-aminolevulinate 88755TAZ87 Aminolevulinic Acid IM Aminolevulinic Acid analogs & derivatives therapeutic use Female Head Humans Keratosis, Actinic drug therapy Male Photochemotherapy methods Photosensitizing Agents

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2017 Acta Dermato-Venereologica

25. Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study. (PubMed)

Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study. Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.In this multicenter, prospective, randomized

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2017 BMC Dermatology

26. Switching From Conventional Photodynamic Therapy to Daylight Photodynamic Therapy For Actinic Keratoses: Systematic Review and Meta-analysis. (PubMed)

Switching From Conventional Photodynamic Therapy to Daylight Photodynamic Therapy For Actinic Keratoses: Systematic Review and Meta-analysis. Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook (...) a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization. The conclusion is that the difference in efficacy is clinically negligible (global estimate of the mean response rate difference, -3.69%; 95% CI, -6.54% to -0.84%). The adverse effects of daylight PDT are mild and localized (79% of patients report no discomfort), and patients report

2017 Actas dermo-sifiliograficas

27. Comparison of "Lesion-by-Lesion" and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study. (PubMed)

Comparison of "Lesion-by-Lesion" and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study. Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local

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2017 Dermatology

28. Monitoring Ingenol Mebutate Gel Treatment of Actinic Keratoses by Reflectance Confocal Microscopy. (PubMed)

Monitoring Ingenol Mebutate Gel Treatment of Actinic Keratoses by Reflectance Confocal Microscopy. 28093603 2018 04 17 2018 04 17 1651-2057 97 5 2017 05 08 Acta dermato-venereologica Acta Derm. Venereol. Monitoring Ingenol Mebutate Gel Treatment of Actinic Keratoses by Reflectance Confocal Microscopy. 646-648 10.2340/00015555-2607 López Estebaranz Jose Luis JL Dermatology Service, Hospital Universitario Fundación Alcorcón, 28922 Alcorcón. Madrid, Spain. JLLopez@fhalcorcon.es. Pampín Franco Ana (...) A Gamo Villegas Reyes R Floristán Uxúa U eng Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 3-ingenyl angelate 0 Dermatologic Agents 0 Diterpenes 0 Gels IM Dermatologic Agents therapeutic use Diterpenes therapeutic use Facial Dermatoses diagnostic imaging drug therapy Gels Humans Keratosis, Actinic diagnostic imaging drug therapy Microscopy, Confocal Middle Aged Prospective Studies Scalp Dermatoses diagnostic imaging drug therapy 2017 1 18 6 0 2018 4 18 6 0 2017 1 18 6 0 ppublish

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2017 Acta Dermato-Venereologica

29. Patient and physician satisfaction in an observational study with methyl aminolevulinate daylight-photodynamic therapy in the treatment of multiple actinic keratoses of the face and scalp in 6 European countries. (PubMed)

Patient and physician satisfaction in an observational study with methyl aminolevulinate daylight-photodynamic therapy in the treatment of multiple actinic keratoses of the face and scalp in 6 European countries. Guidelines recommend treating actinic keratoses (AKs) as they are recognized as precursors of invasive squamous cell carcinoma.The objective of this study was to collect real-world clinical data on the use of methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT

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2017 Journal of the European Academy of Dermatology and Venereology

30. Incidence and Regression of Actinic Keratoses in Organ Transplant Recipients. (PubMed)

Incidence and Regression of Actinic Keratoses in Organ Transplant Recipients. Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models were used to estimate

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2017 Acta Dermato-Venereologica

31. Actinic keratoses treated with cold atmospheric plasma. (PubMed)

Actinic keratoses treated with cold atmospheric plasma. 28695987 2018 01 18 1468-3083 32 1 2018 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Actinic keratoses treated with cold atmospheric plasma. e37-e39 10.1111/jdv.14465 Wirtz M M Department of Dermatology, University Hospital Essen, Hufelandstr. 55, 45122, Essen, Germany. German Cancer Consortium (DKTK), Essen, Germany. Stoffels I I Department of Dermatology, University Hospital

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2017 Journal of the European Academy of Dermatology and Venereology

32. Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment. (PubMed)

Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment. Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied.To investigate the extent of atypical keratinocytes throughout the epidermis and variation in basal growth patterns of AK.AK lesions occurring on the head/face from

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2017 Journal of the European Academy of Dermatology and Venereology

33. Effect of Expedited Microneedle-Assisted Photodynamic Therapy for Field Treatment of Actinic Keratoses: A Randomized Clinical Trial. (PubMed)

Effect of Expedited Microneedle-Assisted Photodynamic Therapy for Field Treatment of Actinic Keratoses: A Randomized Clinical Trial. Photodynamic therapy (PDT) is an effective and cosmetically favorable treatment modality for actinic keratoses (AKs). However, prolonged incubation times and pain associated with treatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field therapy for AK.To evaluate efficacy and pain associated with microneedle expedited

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2017 JAMA dermatology (Chicago, Ill.)

35. Treatment of Actinic Keratoses: A Randomized Split-Site Approach Comparison of Sequential 5-Fluorouracil and 5-Aminolevulinic Acid Photodynamic Therapy to 5-Aminolevulinic Acid Photodynamic Monotherapy. (PubMed)

Treatment of Actinic Keratoses: A Randomized Split-Site Approach Comparison of Sequential 5-Fluorouracil and 5-Aminolevulinic Acid Photodynamic Therapy to 5-Aminolevulinic Acid Photodynamic Monotherapy. Actinic keratoses (AKs) are skin lesions resulting from sun exposure and carry a risk of developing into squamous cell carcinoma. Current therapies for AK eradication include topical 5-fluorouracil (5-FU) and photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA). However

2017 Dermatologic Surgery

37. Is cryosurgery less effective that conservative regimens in the treatment of actinic keratoses?

Is cryosurgery less effective that conservative regimens in the treatment of actinic keratoses? 26347483 2017 04 21 2017 04 21 1468-3083 30 10 2016 Oct Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Is cryosurgery less effective that conservative regimens in the treatment of actinic keratoses? e50-e53 10.1111/jdv.13294 Zouboulis C C CC Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany (...) . christos.zouboulis@klinikum-dessau.de. eng Letter Meta-Analysis Review 2015 09 07 England J Eur Acad Dermatol Venereol 9216037 0926-9959 IM Cryosurgery Humans Keratosis, Actinic therapy 2016 10 21 6 0 2017 4 22 6 0 2015 9 9 6 0 ppublish 26347483 10.1111/jdv.13294

2017 Journal of the European Academy of Dermatology and Venereology : JEADV

38. Pharmacoeconomic evaluations in the treatment of actinic keratoses (PubMed)

Pharmacoeconomic evaluations in the treatment of actinic keratoses Actinic keratoses (AKs) develop as a consequence of chronic ultraviolet (UV) exposure and exist on a continuum with squamous cell carcinoma (SCC). As one of the most common conditions treated by dermatologists, AK places a significant burden on patients and the healthcare system. A range of treatments are used, including topical treatments that target the visible and subclinical lesions. The goal of such therapies is to achieve

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2017 International journal of immunopathology and pharmacology

39. Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time (PubMed)

Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time

BACKGROUND: Actinic keratoses (AKs) are dysplastic lesions of the epidermis that have the potential to progress to non-melanoma skin cancers (NMSC). Traditional photodynamic therapy (PDT) requires a pre-illumination incubation time, which adds to overall in-office time and has been linked to pain. Our group has found a novel protocol to effectively treat AKs with PDT that eliminates the pre

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2017 Journal of drugs in dermatology : JDD

40. Community-Based Practice Variations in Topical Treatment of Actinic Keratoses (PubMed)

Community-Based Practice Variations in Topical Treatment of Actinic Keratoses 28384712 2018 10 29 2018 11 13 2168-6084 153 5 2017 05 01 JAMA dermatology JAMA Dermatol Community-Based Practice Variations in Topical Treatment of Actinic Keratoses. 468-470 10.1001/jamadermatol.2016.6251 Storer Molly M Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston. Zhu Zheng Z Division of Research, Kaiser Permanente Northern California, Oakland. Sokil Monika M Division (...) Letter Research Support, N.I.H., Extramural United States JAMA Dermatol 101589530 2168-6068 0 Dermatologic Agents AIM IM Administration, Topical Community Health Services Dermatologic Agents administration & dosage Health Care Surveys Humans Keratosis, Actinic drug therapy United States 2017 4 7 6 0 2018 10 30 6 0 2017 4 7 6 0 ppublish 28384712 2614255 10.1001/jamadermatol.2016.6251 PMC5597245 NIHMS888251 J Dermatolog Treat. 2006;17(3):162-6 16854758 J Am Acad Dermatol. 2006 Sep;55(3):490-500

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2017 JAMA dermatology

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