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Actinic Purpura

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1. Treatment of Actinic Purpura Full Text available with Trip Pro

Treatment of Actinic Purpura Mature skin is prone to bruising, resulting in a condition known as actinic purpura, characterized by unsightly ecchymosis and purple patches. Similar to other skin conditions, the incidence of actinic purpura increases with advancing age and occurs with equal frequency among men and women. The unsightly appearance of actinic purpura may be a source of emotional distress among the elderly. A new product has been formulated specifically for the treatment of actinic (...) purpura. This product contains retinol, α-hydroxy acids, arnica oil, ceramides, niacinamide, and phytonadione, which effectively treat actinic purpura by improving local circulation, thickening the skin, and repairing the skin barrier. The objective of this paper is to review the beneficial properties of these ingredients and their respective roles in the treatment of actinic purpura.

2017 The Journal of clinical and aesthetic dermatology

2. Actinic Purpura

Actinic Purpura Actinic Purpura Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Actinic Purpura Actinic Purpura Aka: Actinic Purpura (...) , Senile Purpura , Solar Purpura , Bateman Disease From Related Chapters II. Epidemiology Occurs equally in men and women Age 60-70 years old: 2% Age 90-100 years old: 25% III. History First described by Bateman in 1818 IV. Pathophysiology Chronic resulting in dermal connective tissue damage Solar Purpura refers to acute after , while actinic and Senile Purpura refer to chronic V. Risk Factors Advancing age , s or use VI. Signs Dark purple patches and on sun exposed skin Distribution (common) Dorsal

2018 FP Notebook

3. Actinic Purpura (Overview)

Actinic Purpura (Overview) Actinic Purpura: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4NzAwOC1vdmVydmlldw== processing > Actinic Purpura Updated: Jun 04, 2018 Author (...) : Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Actinic Purpura Overview Background Actinic purpura is a benign clinical entity resulting from sun-induced damage to the connective tissue of the dermis. Actinic purpura is characterized by ecchymoses on the extensor surfaces of the forearms and the dorsa of the hands that usually last 1-3 weeks. See the image below. Actinic, or senile, purpura. Courtesy of José Reynaldo da Fonseca (own

2014 eMedicine.com

4. Actinic Purpura (Follow-up)

Actinic Purpura (Follow-up) Actinic Purpura Treatment & Management: Medical Care, Surgical Care, Activity Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4NzAwOC10cmVhdG1lbnQ= processing > Actinic Purpura (...) Treatment & Management Updated: Jun 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Actinic Purpura Treatment Medical Care Actinic purpura does not require extensive medical care. To prevent further ultraviolet-induced damage to the skin, sunscreens that provide both UV-A and UV-B protection should be applied daily, especially to areas affected by the purpuric lesions. Patients should also use barrier protection (eg

2014 eMedicine.com

5. Actinic Purpura (Treatment)

Actinic Purpura (Treatment) Actinic Purpura Treatment & Management: Medical Care, Surgical Care, Activity Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4NzAwOC10cmVhdG1lbnQ= processing > Actinic Purpura (...) Treatment & Management Updated: Jun 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Actinic Purpura Treatment Medical Care Actinic purpura does not require extensive medical care. To prevent further ultraviolet-induced damage to the skin, sunscreens that provide both UV-A and UV-B protection should be applied daily, especially to areas affected by the purpuric lesions. Patients should also use barrier protection (eg

2014 eMedicine.com

6. Actinic Purpura (Diagnosis)

Actinic Purpura (Diagnosis) Actinic Purpura: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4NzAwOC1vdmVydmlldw== processing > Actinic Purpura Updated: Jun 04, 2018 Author (...) : Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Actinic Purpura Overview Background Actinic purpura is a benign clinical entity resulting from sun-induced damage to the connective tissue of the dermis. Actinic purpura is characterized by ecchymoses on the extensor surfaces of the forearms and the dorsa of the hands that usually last 1-3 weeks. See the image below. Actinic, or senile, purpura. Courtesy of José Reynaldo da Fonseca (own

2014 eMedicine.com

7. Mechanisms of smooth muscle antibody production: a clinical study in children with infections, haemolytic syndromes, and idiopathic thrombocytopenic purpura. Full Text available with Trip Pro

Mechanisms of smooth muscle antibody production: a clinical study in children with infections, haemolytic syndromes, and idiopathic thrombocytopenic purpura. Sera from 530 children suffering from various diseases and from 64 controls were tested for smooth muscle autoantibodies (SMA) by indirect immunofluorescence. A high incidence of SMA (51-86%) was found in patients with viral and bacterial infections (viral hepatitis, infectious mononucleosis, measles, mumps, chickenpox, typhoid fever (...) , and brucellosis), independently of liver invovlvement, and in patients with acute haemolytic anaemia due to G-6-PD deficiency (48%). By contrast, the incidence of SMA from patients with beta-thalassaemia major and idiopathic thrombocytopenic purpura was no higher than in the controls. The discrepancy in incidence in haemolytic anaemias due to different causes may reflect the effect of endogenous and extrinsic agents. In the viral infections, SMA were mainly of the IgM class and gave an 'SMA-V' staining

1979 Journal of Clinical Pathology

8. Actinic elastosis

Actinic elastosis Actinic elastosis - Wikipedia Actinic elastosis From Wikipedia, the free encyclopedia Actinic elastosis Other names Solar elastosis showing solar elastosis - grey, jumbled spaghetti-like material on bottom of image. . Actinic elastosis , also known as solar elastosis , is an accumulation of abnormal (elastic tissue) in the of the , or in the of the , which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as . Contents Signs (...) and symptoms [ ] Actinic elastosis usually appears as thickened, dry, wrinkled skin. Several clinical variants have been recorded. One of the most readily identifiable is the thickened, deeply fissured skin seen on the back of the chronically sun-exposed neck, known as . These features are a part of the constellation of changes that are seen in photoaged skin. Causes [ ] The origin of the elastotic material in the dermis remains a subject of debate. Theories on the formation of the elastotic material

2012 Wikipedia

10. Lichen Planus

host disease Lichen striatus, Linear epidermal nevus, Nevus unius lateralis • Eczema, Lichen simplex chronicus, Prurigo nodularis 9 • Pityriasis rosea, Guttate Psoriasis, Psoriasis vulgaris, Ekzematid-like Purpura • Drug eruption, Syphilis, Tinea corporis, Papular acrodermatitis of childhood • Granuloma annulare, Lichen amyloidosus, Pityriasis lichenoides, Kaposi sarcoma Table 1. Differential diagnosis of site-specific LP Nail Psoriasis, onychomycosis, alopecia areata, atopic dermatitis Genital (...) pigmentosus (ashy dermatosis or erythema dyschromicum perstans) or Actinic LP (LP subtropicus, LP tropicus, summertime actinic lichenoid eruption, LP actinicus, LP atrophicus annularis and lichenoid melanodermatosis). The authors believe that these variants belong to the same entity, representing an overlap in the phenotypic spectrum of lichenoid inflammation in darkly pigmented skin. Patients with darker skin are primarily affected, whereas ethnic and genetic factors may influence the expression

2018 European Dermatology Forum

11. Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock Full Text available with Trip Pro

% in previously healthy children; 9% in chronically ill children). This outcome matched the “best practice outcomes” targeted by the 2002 guidelines ( ). Similar to the experience of St. Mary’s Hospital before 2002 ( ), Sophia Children’s Hospital in Rotterdam also reported a reduction in mortality rate from purpura and severe sepsis from 20% to 1% after implementation of 2002 guideline-based therapy in the referral center, transport system, and tertiary care settings ( ). Both of these centers also used high

2017 Society of Critical Care Medicine

12. Injectafer (VIT-45, ferric carboxymaltose injection; FCM)

-Hodgkin’s lymphoma, post-actinic cardiomyopathy, and other illnesses who experienced Grade IV hypersensitivity reaction and anaphylactic shock with dyspnea, hypotension, and bradycardia beginning 3 minutes after start of Ferinject infusion (received about 36 mg iron in 30 mL saline) and died. Pregnancy-related cases of serious unlisted events including fetal deaths are described in Dr. Min Lu’s Medical Officer Review (July 9, 2013). There were 7 pregnancy-related serious unlisted event cases and 6 fetal (...) in utero to be possibly related to Ferinject. Reference ID: 3337357 (b) (6)NDA 203565, Resubmission Page 11 of 14 Case 2 (Mfr Report 1256-232): On 29-Apr-2013, the sponsor received this report from Vifor International Inc. This initial report was received from a physician in Finland. This report concerns a baby, born on . The mother was a 20-year old female with a medical history of Henoch-Schonlein purpura in 2011, migraine and had no symptoms of Henoch-Schonlein after the 1st trimester. The mother

2013 FDA - Drug Approval Package

15. Mechanisms of skin aging induced by EGFR inhibitors Full Text available with Trip Pro

expression was compared in young (<25 years old) vs. old (> 65 years old) skin. In addition, the regulation of extracellular matrix, senescence-associated genes, and cell cycle status was measured in primary human keratinocytes treated with erlotinib in vitro.There were progressive signs of skin aging, including xerosis cutis, atrophy, rhytide formation, and/or actinic purpura in 12 patients. Keratinocytes treated with erlotinib in vitro showed a significant down-modulation of hyaluronan synthases (HAS2

2016 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

16. Laser Revision of Scars (Overview)

with special attention to operative technique (ie, avoiding overlapping pulses). Postoperative purpura following treatment with the PDL usually resolves within 7-10 days. [ ] During the healing process, the patient should avoid extraneous manipulation of the treatment area. Showers are permitted, but care should be taken to lightly pat lasered areas dry. Gentle cleansing of the treatment area with water and a mild soap followed by application of a topical ointment can be used to keep the area clean (...) , corticosteroid injection, and interferon. [ ] Treatment of striae distensae The 585- or 595-nm PDL can be used in the treatment of striae distensae, which respond best to lower energy densities (3 J/cm 2 ). [ ] Adjacent nonoverlapping laser pulses are delivered such that each individual stria distensae is covered. Irradiated striae distensae do not typically exhibit the characteristic purpura observed with the treatment of hypertrophic scars and keloids. Because of lower fluences, striae usually appear

2014 eMedicine.com

17. Acute Renal Failure (Overview)

molecules. Signs and symptoms Skin Skin examination may reveal the following in patients with AKI: Livedo reticularis, digital ischemia, butterfly rash Palpable purpura: systemic vasculitis Maculopapular rash: Allergic interstitial nephritis Track marks (ie, intravenous drug abuse): Endocarditis Eyes Eye examination may reveal the following: Keratitis, iritis, uveitis, dry conjunctivae: Autoimmune vasculitis Jaundice: Liver diseases Band keratopathy (ie, hypercalcemia): Multiple myeloma Signs (...) of urea, such as volume contraction (this suggests prerenal AKI) Complete blood count (can indicate infection; acute blood loss or chronic anemia; thrombotic microangiopathy) Peripheral smear (eg, schistocytes such as hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura) Serologic tests: These may show evidence of conditions associated with AKI, such as in lupus nephritis, ANCA vasculitis or anti-GBM disease or syndrome Complement testing: Pattern may indicate AKI related to endocartis

2014 eMedicine.com

18. Laser Treatment of Acquired and Congenital Vascular Lesions (Overview)

excellent clinical improvement with a low risk of adverse sequelae. Transient purpura is the most common adverse effect of PDL treatment. Current technologic improvements include dynamic surface cooling and extended pulse duration, which enhance clinical results and minimize adverse effects. Next: Classification of Cutaneous Vascular Lesions Cutaneous vascular lesions are categorized according to pathology and age of onset. Congenital lesions begin in infancy and include port-wine stains, hemangiomas (...) veins. PDL and intense pulsed light have been used for facial telangiectasia. PDL has a superior clearance rate compared with other lasers but posttreatment purpura is cosmetically unacceptable. To minimize post treatment purpura, long-pulse PDL has shown good efficacy. The 1064-nm Nd:YAG laser has been shown to successfully improve lower extremity leg veins, especially blue venulectasia and reticular veins up to 4 mm in diameter. In one study, nearly two thirds of the patients achieved 75-100

2014 eMedicine.com

19. Factor XIII (Overview)

has a variety of uses, potential and confirmed. Plasma levels of FXIII were found to be decreased in children with Henoch-Schönlein purpura having severe abdominal symptoms. Thus, it has been suggested that measurement of FXIII level may be of value to detect the vasculitic process of Henoch-Schönlein purpura before the rash occurs or long after it has disappeared in patients with isolated abdominal or scrotal problems. [ , ] Immunohistochemistry studies have shown that FXIIIa-positive dermal (...) fiber size, density, and strength of the clot. FXIIIa also cross-links actin to fibrin and actin to myosin. Cross-linking of intracellular structural proteins is involved in clot retraction and cell migration. This complex gel network created by the actions of FXIII plays an important role in wound healing, cell adhesion, and cell migration. All of these cross-linking reactions impart increased mechanical strength to the clot, contributing to clot retraction and resistance of the clot to degradation

2014 eMedicine.com

20. Shigellosis (Overview)

and then anuric). These patients may be considered to have thrombotic thrombocytopenic purpura (TTP) if fever and transient neurologic symptoms are also present. Seizures occur in approximately 10% of affected patients, and stroke or cerebral edema occur in 5%. The pathogenesis of HUS or TTP involves cytotoxic damage to the vascular endothelium. In most studies, Shiga toxin production by type 1 S dysenteriae is thought to be directly involved. Other manifestations can also occur. In young girls, Shigella can (...) . 14(3):143-51. . Piro AS, Hernandez D, Luoma S, et al. Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility. MBio . 2017 Dec 12. 8(6): . . Pinaud L, Ferrari ML, Friedman R, et al. Identification of novel substrates of Shigella T3SA through analysis of its virulence plasmid-encoded secretome. PLoS One . 2017. 12(10):e0186920. . Brown JD, Willcox SJ, Franklin N, et al. Shigella species epidemiology and antimicrobial susceptibility

2014 eMedicine.com

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