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Actinic Keratoses

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1. Ingenol mebutate for the treatment of actinic keratoses: a systematic review of randomized controlled trials

Ingenol mebutate for the treatment of actinic keratoses: a systematic review of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

2. Local interventions for the treatment of actinic keratoses located on extremities: a meta-analysis

Local interventions for the treatment of actinic keratoses located on extremities: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

3. Actinic Keratoses

Actinic Keratoses GUIDELINES Evidence-andconsensus-based(S3)Guidelinesforthe TreatmentofActinicKeratosis –InternationalLeagueof DermatologicalSocietiesincooperationwiththeEuropean DermatologyForum –Shortversion R.N.Werner, 1, *E.Stock?eth, 2,22 S.M.Connolly, 3 O.Correia, 4 R.Erdmann, 1 P.Foley, 5,6,7 A.K.Gupta, 8,9 A.Jacobs, 1 H.Kerl, 10 H.W.Lim, 11 G.Martin, 12 M.Paquet, 9 D.M.Pariser, 13 S.Rosumeck, 1 H.-J.R€ owert- Huber, 14 A.Sahota, 15 O.P.Sangueza, 16,17 S.Shumack, 18 B.Sporbeck, 1 (...) ?cation. Br J Dermatol 2007; 156(Suppl. 3): 8– 12. 10 Ackerman AB, Mones JM. Solar(actinic)keratosis is squamous cell carci- noma. Br JDermatol 2006; 155:9–22. 11 Cockerell CJ. Histopathology of incipient intraepidermal squamous cell carcinoma (‘actinic keratosis’). J Am Acad Dermatol 2000; 42(1 Pt2): 11–17. 12 Harvey I, Frankel S, Marks R, Shalom D, Nolan-Farrell M. Non- melanoma skin cancer and solar keratoses. I. Methods and descriptive results of the South Wales Skin Cancer Study. Br J Cancer 1996

2015 European Dermatology Forum

4. Use of 5-Aminolevulinic Acid and Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses. (PubMed)

Use of 5-Aminolevulinic Acid and Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses. Photodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-aminolevulinic acid (ALA).To study the safety and efficacy

2019 Dermatologic Surgery

5. Ingenol mebutate-mediated reduction of p53-positive keratinocytes in skin cancerization field directly correlates with clinical response in patients with multiple actinic keratoses. (PubMed)

Ingenol mebutate-mediated reduction of p53-positive keratinocytes in skin cancerization field directly correlates with clinical response in patients with multiple actinic keratoses. UV radiation represents the main risk factor for Non Melanoma Skin Cancers (NMSC). Chronic UV exposure induces "p53 patches", i.e. clonal outgrowths of keratinocytes with high nuclear expression of mutated p53, which might progress to actinic keratosis (AK) and ultimately squamous cell carcinomas (SCC).Analysis

2019 Journal of the European Academy of Dermatology and Venereology

6. Pulse-Daylight-Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial. (PubMed)

Pulse-Daylight-Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial. 30250962 2019 02 04 1651-2057 99 2 2019 Feb 01 Acta dermato-venereologica Acta Derm. Venereol. Pulse-Daylight-Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial. 242-243 10.2340/00015555-3049 Wiegell Stine R SR Department of Dermatology, Bispebjerg

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2019 Acta Dermato-Venereologica Controlled trial quality: uncertain

7. Evaluation of two histological classifications for actinic keratoses - PRO classification scored highest inter-rater reliability. (PubMed)

Evaluation of two histological classifications for actinic keratoses - PRO classification scored highest inter-rater reliability. Actinic keratoses (AKs) can histologically be classified by the extent of atypical keratinocytes throughout the epidermis or their pattern of basal proliferation. Currently, no data on the inter-rater reliability of both scores is available.To evaluate the inter-rater reliability of the two classification schemes; histological grade (AK I-III) and basal proliferation

2019 Journal of the European Academy of Dermatology and Venereology

8. Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma. (PubMed)

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma. Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive

2019 Journal of the European Academy of Dermatology and Venereology

9. A Randomized, Vehicle-Controlled Phase 3 Study of Aminolevulinic Acid Photodynamic Therapy for the Treatment of Actinic Keratoses on the Upper Extremities. (PubMed)

A Randomized, Vehicle-Controlled Phase 3 Study of Aminolevulinic Acid Photodynamic Therapy for the Treatment of Actinic Keratoses on the Upper Extremities. Blue-light aminolevulinic acid photodynamic therapy (ALA-PDT) after broad-area application and 3-hour incubation is efficacious for actinic keratosis (AK) lesion clearance on upper extremities, with use of occlusive dressing significantly increasing efficacy.To prove the safety and efficacy of ALA-PDT versus vehicle (VEH-PDT) in the spot

2019 Dermatologic Surgery Controlled trial quality: uncertain

10. Peptidase inhibitor 3 and chemokine ligand 27 may serve as biomarkers for actinic keratoses in organ transplant recipients. (PubMed)

Peptidase inhibitor 3 and chemokine ligand 27 may serve as biomarkers for actinic keratoses in organ transplant recipients. Molecular profiling of tissue samples in organ transplant recipients (OTRs) may allow early and minimally invasive identification of actinic keratosis (AK). The aim of this study was to compare mRNA expression profiles of 13 genes, as putative genetic biomarkers of AK, before and after treatment using two different field therapies, and to correlate the results (...) a significant convergence to values observed in healthy skin in both groups after therapy. The pattern and level of specific gene expression in actinic keratoses could serve as a biomarker.

2019 European journal of dermatology : EJD Controlled trial quality: uncertain

11. A regimen to minimize pain during blue light photodynamic therapy of actinic keratoses: Bilaterally controlled, randomized trial of simultaneous versus conventional illumination. (PubMed)

A regimen to minimize pain during blue light photodynamic therapy of actinic keratoses: Bilaterally controlled, randomized trial of simultaneous versus conventional illumination. Blue light photodynamic therapy (PDT) is effective for actinic keratosis (AK), but many patients experience stinging pain during illumination.Compare a conventional regimen (1 h ALA preincubation, followed by blue light), to a new modified regimen in which blue light is started immediately after ALA application.A

2019 Journal of American Academy of Dermatology

12. A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes. (PubMed)

A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes. Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimize the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness.In this prospective, randomized study

2018 Photodermatology, photoimmunology & photomedicine Controlled trial quality: uncertain

13. Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin

Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin "Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged" by Stacy E. Legg < > > > > > Title Author Date of Graduation Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers, PA-C, MS Second Advisor Jennifer Van Atta, PA-C, MS Rights . Abstract Background: Actinic keratoses (AKs) are skin lesions primarily caused (...) : Nicotinamide and actinic keratoses Recommended Citation Legg, Stacy E., "Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin" (2016). School of Physician Assistant Studies . 574. https://commons.pacificu.edu/pa/574 DOWNLOADS Since August 26, 2016 Included in Share COinS Browse Search Enter search terms: Select context to search: Authors Quick Links | | | |

2016 Pacific University EBM Capstone Project

14. Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide (PubMed)

Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide Hydroxycarbamide (HC) is the first-line treatment for certain myeloproliferative neoplasms, such as polycythemia vera and essential thrombocytosis (ET). In a subset of these patients long-term treatment with HC can result in the development of confluent actinic keratoses (AK) followed by invasive keratinocytic carcinomas ("squamous dysplasia"), preferentially on sun-exposed skin. Discontinuation

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2018 Case reports in dermatological medicine

15. Microwave Therapy for Treatment of Precancerous Actinic Keratoses

Microwave Therapy for Treatment of Precancerous Actinic Keratoses Microwave Therapy for Treatment of Precancerous Actinic Keratoses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Microwave Therapy (...) for Treatment of Precancerous Actinic Keratoses (MTAK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03483935 Recruitment Status : Active, not recruiting First Posted : March 30, 2018 Last Update Posted : March 15, 2019 Sponsor: University of Dundee Collaborator: Emblation Limited Information provided

2018 Clinical Trials

16. Efficacy of Ingenol Mebutate in the Treatment of Actinic Keratoses: A Pre- and Posttreatment Dermoscopic Comparative Analysis (PubMed)

Efficacy of Ingenol Mebutate in the Treatment of Actinic Keratoses: A Pre- and Posttreatment Dermoscopic Comparative Analysis Actinic keratosis (AK) is a common skin lesion in adults which usually occurs on chronically photoexposed areas and considered as a precancerous lesion or a superficial squamous-cell carcinoma. Many classifications have been proposed and its diagnosis is generally clinical but, sometimes, its wide variety of presentations can make diagnosis difficult, even among expert

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2018 BioMed research international

17. 5-Fluorouracil enhances Protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses: A mechanism-based clinical trial. (PubMed)

5-Fluorouracil enhances Protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses: A mechanism-based clinical trial. Purpose: Actinic keratoses (AK) are precancerous lesions that can progress to squamous cell carcinoma. Photodynamic therapy (PDT) and topical 5-fluorouracil (5FU) are commonly used agents for AK. Empirical reports suggest that combining them can improve the therapeutic response. However, the optimal combined regimen was not clear

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2018 Clinical Cancer Research Controlled trial quality: uncertain

18. Daylight Photodynamic Therapy for Actinic Keratoses. (PubMed)

Daylight Photodynamic Therapy for Actinic Keratoses. Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT (...) remains established as a therapy for Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas (BCCs), and AKs. The evidence for the use of DL-PDT beyond AK is limited, although has been reported in actinic cheilitis, superficial BCC, and acne and cutaneous leishmaniasis. There is emerging interest in combination therapy for AK, using one or more field therapies such as DL-PDT as an option to complement with localized treatment for residual lesions. We

2018 American journal of clinical dermatology

19. Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment. (PubMed)

Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment. The treatment of actinic keratosis (AK) is a potentially effective strategy for the prevention of cutaneous squamous cell carcinoma (cSCC). However, the patient perspective on potential benefits of AK treatment in terms of skin cancer reduction has received little attention to date.(i) To investigate patient preferences for topical treatments for AK using a discrete-choice experiment (DCE); (ii

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2018 British Journal of Dermatology Controlled trial quality: uncertain

20. Photodynamic Therapy with a 5-ALA-Patch Does Not Increase the Risk of Conversion of Actinic Keratoses into Squamous Cell Carcinoma. (PubMed)

Photodynamic Therapy with a 5-ALA-Patch Does Not Increase the Risk of Conversion of Actinic Keratoses into Squamous Cell Carcinoma. It is important to collect data about the risk of transformation of an actinic keratosis (AK) lesion into squamous cell carcinoma (SCC) after a single photodynamic therapy (PDT) with 5-ALA patch for a longer follow-up period under daily routine.The purpose of this non-interventional study (NIS) was to collect data on the frequency of occurrence of SCCs

2018 Experimental Dermatology

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