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Actinic Keratoses

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1. Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin

Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin "Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged" by Stacy E. Legg < > > > > > Title Author Date of Graduation Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers, PA-C, MS Second Advisor Jennifer Van Atta, PA-C, MS Rights . Abstract Background: Actinic keratoses (AKs) are skin lesions primarily caused (...) : Nicotinamide and actinic keratoses Recommended Citation Legg, Stacy E., "Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin" (2016). School of Physician Assistant Studies . 574. https://commons.pacificu.edu/pa/574 DOWNLOADS Since August 26, 2016 Included in Share COinS Browse Search Enter search terms: Select context to search: Authors Quick Links | | | |

2016 Pacific University EBM Capstone Project

2. Ingenol mebutate for the treatment of actinic keratoses: a systematic review of randomized controlled trials

Ingenol mebutate for the treatment of actinic keratoses: a systematic review of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

3. A Randomized, Vehicle-Controlled Phase 3 Study of Aminolevulinic Acid Photodynamic Therapy for the Treatment of Actinic Keratoses on the Upper Extremities. (PubMed)

A Randomized, Vehicle-Controlled Phase 3 Study of Aminolevulinic Acid Photodynamic Therapy for the Treatment of Actinic Keratoses on the Upper Extremities. Blue-light aminolevulinic acid photodynamic therapy (ALA-PDT) after broad-area application and 3-hour incubation is efficacious for actinic keratosis (AK) lesion clearance on upper extremities, with use of occlusive dressing significantly increasing efficacy.To prove the safety and efficacy of ALA-PDT versus vehicle (VEH-PDT) in the spot

2019 Dermatologic Surgery

4. Ingenol mebutate-mediated reduction of p53-positive keratinocytes in skin cancerization field directly correlates with clinical response in patients with multiple actinic keratoses. (PubMed)

Ingenol mebutate-mediated reduction of p53-positive keratinocytes in skin cancerization field directly correlates with clinical response in patients with multiple actinic keratoses. UV radiation represents the main risk factor for Non Melanoma Skin Cancers (NMSC). Chronic UV exposure induces "p53 patches", i.e. clonal outgrowths of keratinocytes with high nuclear expression of mutated p53, which might progress to actinic keratosis (AK) and ultimately squamous cell carcinomas (SCC).Analysis

2019 Journal of the European Academy of Dermatology and Venereology

5. Use of 5-Aminolevulinic Acid and Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses. (PubMed)

Use of 5-Aminolevulinic Acid and Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses. Photodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-aminolevulinic acid (ALA).To study the safety and efficacy

2019 Dermatologic Surgery

6. Pulse-Daylight-Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial. (PubMed)

Pulse-Daylight-Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial. 30250962 2019 02 04 1651-2057 99 2 2019 Feb 01 Acta dermato-venereologica Acta Derm. Venereol. Pulse-Daylight-Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial. 242-243 10.2340/00015555-3049 Wiegell Stine R SR Department of Dermatology, Bispebjerg

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2019 Acta Dermato-Venereologica

7. Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma. (PubMed)

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma. Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive

2019 Journal of the European Academy of Dermatology and Venereology

8. A regimen to minimize pain during blue light photodynamic therapy of actinic keratoses: Bilaterally controlled, randomized trial of simultaneous versus conventional illumination. (PubMed)

A regimen to minimize pain during blue light photodynamic therapy of actinic keratoses: Bilaterally controlled, randomized trial of simultaneous versus conventional illumination. Blue light photodynamic therapy (PDT) is effective for actinic keratosis (AK), but many patients experience stinging pain during illumination.Compare a conventional regimen (1 h ALA preincubation, followed by blue light), to a new modified regimen in which blue light is started immediately after ALA application.A

2019 Journal of American Academy of Dermatology

9. Thermal Photodynamic Therapy for Actinic Keratoses on Facial Skin: A Proof-of-Concept Study. (PubMed)

Thermal Photodynamic Therapy for Actinic Keratoses on Facial Skin: A Proof-of-Concept Study. Warming the skin during the incubation of 5-aminolevulinic acid (ALA) has the potential to improve the efficacy and efficiency of cutaneous photodynamic therapy (PDT) through multiple mechanisms. The aim of this proof-of-concept study is to investigate the efficacy and tolerability of thermal PDT on facial skin and evaluate porphyrin production objectively during the warming period.Facial skin of 10 (...) subjects was heated during a 20-minute incubation with ALA followed by 10 J/cm blue light illumination. Lesion counts were performed at baseline and 2 months. Porphyrin images were captured and the intensity of fluorescence was measured. The mean intensity of fluorescence after incubation with ALA was compared with baseline.Ten subjects with 363 actinic keratoses completed the study. The average temperature during incubation with the warming mask was 38 to 42°C. Porphyrin intensity increased

2018 Dermatologic Surgery

10. A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes. (PubMed)

A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes. Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimize the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness.In this prospective, randomized study

2018 Photodermatology, photoimmunology & photomedicine

11. Randomized and controlled pilot study of the pragmatic use of mobile phone based follow up of actinic keratoses treated with topical 5-fluorouracil. (PubMed)

Randomized and controlled pilot study of the pragmatic use of mobile phone based follow up of actinic keratoses treated with topical 5-fluorouracil. Store-and-forward teledermatology involves transmission of a patient's images to a healthcare provider and subsequent response from the provider about the diagnosis or management. Furthermore, teledermatology in which mobile phones (e.g. smartphones) are utilized for communication between the patient and their provider is referred to as mobile (...) -teledermatology. In this study, we investigate the use of mobile-teledermatology in the management of actinic keratoses. We demonstrate that mobile-teledermatology may enhance communication between the patient and their provider when managing cutaneous disease and that even individuals in older age groups are highly satisfied with this type of follow up.

2018 Dermatology Online Journal

12. Improvement of Actinic Keratoses Using Topical DNA Repair Enzymes: A Randomized Placebo-Controlled Trial. (PubMed)

Improvement of Actinic Keratoses Using Topical DNA Repair Enzymes: A Randomized Placebo-Controlled Trial. Actinic keratoses (AKs) are proliferations of abnormal keratinocytes, which may progress into non-melanoma skin cancers. Although multiple treatment modalities exist for AKs, their incidence continues to rise, making new methods of both prevention and treatment necessary. DNA repair enzymes have been shown to reverse sun-damage, resulting in reduced rates of AKs and non-melanoma skin cancer

2018 Journal of drugs in dermatology : JDD

13. Photodynamic Therapy with a 5-ALA-Patch Does Not Increase the Risk of Conversion of Actinic Keratoses into Squamous Cell Carcinoma. (PubMed)

Photodynamic Therapy with a 5-ALA-Patch Does Not Increase the Risk of Conversion of Actinic Keratoses into Squamous Cell Carcinoma. It is important to collect data about the risk of transformation of an actinic keratosis (AK) lesion into squamous cell carcinoma (SCC) after a single photodynamic therapy (PDT) with 5-ALA patch for a longer follow-up period under daily routine.The purpose of this non-interventional study (NIS) was to collect data on the frequency of occurrence of SCCs

2018 Experimental Dermatology

14. Cutaneous squamous cell carcinomas are associated with basal proliferating actinic keratoses. (PubMed)

Cutaneous squamous cell carcinomas are associated with basal proliferating actinic keratoses. In addition to the extent of atypical keratinocytes throughout the epidermis, actinic keratoses (AKs) are histologically characterized by downward-directed basal-layer expansion. It is not known whether this growth pattern correlates with the risk of developing invasive squamous cell carcinoma (iSCC).To characterize the prevalence of downward-directed basal-layer expansion of AKs adjacent to iSCC.The

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2018 British Journal of Dermatology

15. 5-Fluorouracil enhances Protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses: A mechanism-based clinical trial. (PubMed)

5-Fluorouracil enhances Protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses: A mechanism-based clinical trial. Purpose: Actinic keratoses (AK) are precancerous lesions that can progress to squamous cell carcinoma. Photodynamic therapy (PDT) and topical 5-fluorouracil (5FU) are commonly used agents for AK. Empirical reports suggest that combining them can improve the therapeutic response. However, the optimal combined regimen was not clear

2018 Clinical Cancer Research

16. Microwave Therapy for Treatment of Precancerous Actinic Keratoses

Microwave Therapy for Treatment of Precancerous Actinic Keratoses Microwave Therapy for Treatment of Precancerous Actinic Keratoses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Microwave Therapy (...) for Treatment of Precancerous Actinic Keratoses (MTAK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03483935 Recruitment Status : Active, not recruiting First Posted : March 30, 2018 Last Update Posted : March 15, 2019 Sponsor: University of Dundee Collaborator: Emblation Limited Information provided

2018 Clinical Trials

17. Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide (PubMed)

Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide Hydroxycarbamide (HC) is the first-line treatment for certain myeloproliferative neoplasms, such as polycythemia vera and essential thrombocytosis (ET). In a subset of these patients long-term treatment with HC can result in the development of confluent actinic keratoses (AK) followed by invasive keratinocytic carcinomas ("squamous dysplasia"), preferentially on sun-exposed skin. Discontinuation

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2018 Case reports in dermatological medicine

18. Efficacy of Ingenol Mebutate in the Treatment of Actinic Keratoses: A Pre- and Posttreatment Dermoscopic Comparative Analysis (PubMed)

Efficacy of Ingenol Mebutate in the Treatment of Actinic Keratoses: A Pre- and Posttreatment Dermoscopic Comparative Analysis Actinic keratosis (AK) is a common skin lesion in adults which usually occurs on chronically photoexposed areas and considered as a precancerous lesion or a superficial squamous-cell carcinoma. Many classifications have been proposed and its diagnosis is generally clinical but, sometimes, its wide variety of presentations can make diagnosis difficult, even among expert

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2018 BioMed research international

19. Pathogenic genes related to the progression of actinic keratoses to cutaneous squamous cell carcinoma. (PubMed)

Pathogenic genes related to the progression of actinic keratoses to cutaneous squamous cell carcinoma. Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (cSCC). Understanding the differentially expressed genes between AK and cSCC states would be helpful for the early prevention and treatment of cSCC. Consequently, this study aimed to screen the key genes associated with the progression of AK to cSCC.The microarray dataset GSE45216 was downloaded from the Gene

2018 International Journal of Dermatology

20. The safety and efficacy of daylight photodynamic therapy in the treatment of actinic keratoses: a systematic review and meta-analysis. (PubMed)

The safety and efficacy of daylight photodynamic therapy in the treatment of actinic keratoses: a systematic review and meta-analysis. Daylight photodynamic therapy (DLPDT) is a novel therapeutic approach for actinic keratoses (AKs). This study aimed to evaluate the safety and efficacy of DLPDT in treating patients with AKs as compared to conventional photodynamic therapy (CPDT). PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials were searched for relevant (...) randomized controlled trials (RCTs) published before November 2017, based on the following search terms: "solar keratoses", "actinic keratoses", "photodynamic therapy", "daylight photodynamic therapy", "conventional photodynamic therapy", and "randomized". The complete response rate, patient satisfaction, and patient-reported pain after intervention with DLPDT or CPDT were primarily measured. Sensitivity analysis was conducted to determine the reliability of results. Begg's and Egger's tests were used

2018 International Journal of Dermatology

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