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Acne Vulgaris Pathophysiology

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1. Acne vulgaris

Acne vulgaris Acne vulgaris - NICE CKS Share Acne vulgaris: Summary Acne vulgaris is a chronic inflammatory skin condition affecting mainly the face, back and chest - it is characterised by blockage and inflammation of the pilosebaceous unit (the hair follicle, hair shaft and sebaceous gland). It presents with lesions which can be non-inflammatory (comedones), inflammatory (papules, pustules and nodules) or a mixture of both. Up to 95% of adolescents in Western industrialized countries (...) , adverse effects and use of comedongenic make up or face creams should be considered before swapping to an alternative product or the next treatment step. Have I got the right topic? Have I got the right topic? From age 12 years onwards. This CKS topic covers the management of acne vulgaris. This CKS topic does not cover the management of acne secondary to drugs or an underlying condition. There is a separate CKS topic on . The target audience for this CKS topic is healthcare professionals working

2018 NICE Clinical Knowledge Summaries

2. Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris. Full Text available with Trip Pro

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris. Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris (...) . The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris.In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour

2019 BMC Psychiatry

3. Acne Vulgaris Pathophysiology

Acne Vulgaris Pathophysiology Acne Vulgaris Pathophysiology Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Acne Vulgaris (...) Pathophysiology Acne Vulgaris Pathophysiology Aka: Acne Vulgaris Pathophysiology From Related Chapters II. Pathophysiology: Overview Progression (4 step process) Androgen Mediated Production Keratinous Obstruction of sebaceous follicle outlet (Results in formation of comedones) l Colonization of trapped sebum (with Propionibacterium acnes) Inflammatory reaction ( s, s and cysts) Images Lewis (1918) Gray's Anatomy 20th ed (in at or ) III. Pathophysiology: Androgen Mediated Sebum Production composition s esters

2018 FP Notebook

4. Calprotectin can play an inflammatory role in acne vulgaris Full Text available with Trip Pro

Calprotectin can play an inflammatory role in acne vulgaris Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit. Although various mechanisms have been indicated in the etiopathogenesis of acne vulgaris, the exact pathophysiology is still unknown.To investigate the level of calprotectin in acne vulgaris and its levels relationship with disease severity.A total of 66 AV patients, who were divided into 33 mild and 33 moderate-severe cases, and 30 healthy controls were (...) enrolled in the study. Disease severity was assessed using the Global Acne Score. According to this scale, patients whose Global Acne Score was 1-18 had mild acne, those with a score of 19-30 had moderate acne, those with a score of 31-38 had severe acne, and those with a score greater than 39 had very severe acne. Serum calprotectin levels of all participants were measured by enzyme-linked immunosorbent assay method.The serum calprotectin levels in the moderate-severe AV group were significantly

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

5. Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris Full Text available with Trip Pro

Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris Acne is one of the most common skin diseases worldwide and results in major health care costs and significant morbidity to severely affected individuals. However, the pathophysiology of this disorder is not well understood. Host-microbiome interactions that affect both innate and adaptive immune homeostasis appear to be a central factor in this disease, with recent observations suggesting (...) that the composition and activities of the microbiota in acne is perturbed. Staphylococcus epidermidis and Cutibacterium acnes (C. acnes; formerly Propionibacterium acnes) are two major inhabitants of the skin that are thought to contribute to the disease but are also known to promote health by inhibiting the growth and invasion of pathogens. Because C. acnes is ubiquitous in sebaceous-rich skin, it is typically labeled as the etiological agent of acne yet it fails to fulfill all of Koch's postulates. The outdated

2018 Microbiome

6. Apelin12 in Acne Vulgaris

are prone to severe cases. The pathogenesis of acne is complex, with strong evidence supporting the involvement of follicular hyperkeratinization, hyperactivity of the sebaceous glands, colonization of Propionibacterium acnes and yeast, and inflammation. Although the importance of androgens in the pathophysiology of acne has been supported by both clinical studies and experimental data, the research evaluating adipokines are very few in patients with acne vulgaris. Condition or disease Acne Vulgaris (...) Apelin12 in Acne Vulgaris Apelin12 in Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Apelin12 in Acne Vulgaris The safety and scientific validity of this study is the responsibility

2018 Clinical Trials

7. Cutaneous JAK in Vitiligo and Acne Vulgaris.

Cutaneous JAK in Vitiligo and Acne Vulgaris. Cutaneous JAK in Vitiligo and Acne Vulgaris. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cutaneous JAK in Vitiligo and Acne Vulgaris. The safety (...) that many pro inflammatory interleukins use JAK/STAT components for signal transduction . Condition or disease Intervention/treatment Vitiligo and Acne Vulgaris Diagnostic Test: skin biopsy Detailed Description: The JAK/STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription. Binding of ligands, such as interferon and interleukins, to their specific transmembrane receptors activate associated JAKs. Phosphorylation of STAT follows

2017 Clinical Trials

8. Acne Vulgaris

Acne Vulgaris Acne Vulgaris Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Acne Vulgaris Acne Vulgaris Aka: Acne Vulgaris , Acne From (...) Related Chapters II. Epidemiology : 75% of teenagers and young adults III. Pathophysiology See Secondary acne causes See See IV. Signs: Lesion Types Obstructive Acne Open Comedones (Black heads) Closed Comedones (White heads) Inflammatory Acne (in order of lesion formation) s s s s Scars V. Signs: Distribution Face Neck Back VI. Types: Severe subtypes Consider in refractory cases Referral usually indicated Conditions Severe, inflammatory acne Onset months after starting oral antibiotics Acne Fulminans

2018 FP Notebook

9. Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris Full Text available with Trip Pro

Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris Acne vulgaris is one of the most common chronic inflammatory skin disorders among adolescents and young adults. It is associated with substantial morbidity and, rarely, with mortality. The exact worldwide incidence and prevalence are currently unknown. Current challenges involve improving understanding of the underlying pathophysiology of acne vulgaris and developing a practical treatment consensus (...) . Expert panel discussions were held in 2013 and 2014 among a group of scientists and clinicians from the Omani and United Arab Emirate Dermatology Societies to ascertain the current optimal management of acne vulgaris, identify clinically relevant end-points and construct suitable methodology for future clinical trial designs. This article reviews the discussions of these sessions and recent literature on this topic.

2016 Sultan Qaboos University medical journal

10. The epidemiology of acne vulgaris in late adolescence Full Text available with Trip Pro

adolescents (15-19-year olds) and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population.Database summary study.Global Burden of Disease Study 2010 database.Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years.Geographic region-level disability-adjusted life year rates (per 100,000 persons) associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability (...) highlight some of the effective and promising treatments currently available and address important factors, such as sex, nationality, genetics, pathophysiology, and diet, as they relate to acne vulgaris in late adolescence.

2016 Adolescent health, medicine and therapeutics

11. Efficacy, tolerability, impact on quality of life and sebostatic activity of three topical preparations for the treatment of mild to moderate facial acne vulgaris. (Abstract)

Efficacy, tolerability, impact on quality of life and sebostatic activity of three topical preparations for the treatment of mild to moderate facial acne vulgaris. Acne is treated according to the clinical observations and pathophysiologically relevant mechanisms, such as hyper-keratinization, seborrhea and bacterial proliferation. In mild and moderate forms of inflammatory acne, topical antimicrobials are recommended as a monotherapy or in combination with topical retinoids. The aim (...) of this study was to compare the clinical effectiveness, tolerability, impact on quality of life and effect on sebum excretion of three antimicrobial preparations: clindamycin phosphate, benzoyl peroxide and a combination of clindamycin phosphate plus benzoyl peroxide.In total, 240 patients were randomized into treatment groups for an 8-week study. Every two weeks the patients were evaluated using the following methods: photography, the Global Acne Grading System, sebumetric evaluation, and the Acne

2016 Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia Controlled trial quality: uncertain

12. Acne Vulgaris Pathophysiology

Acne Vulgaris Pathophysiology Acne Vulgaris Pathophysiology Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Acne Vulgaris (...) Pathophysiology Acne Vulgaris Pathophysiology Aka: Acne Vulgaris Pathophysiology From Related Chapters II. Pathophysiology: Overview Progression (4 step process) Androgen Mediated Production Keratinous Obstruction of sebaceous follicle outlet (Results in formation of comedones) l Colonization of trapped sebum (with Propionibacterium acnes) Inflammatory reaction ( s, s and cysts) Images Lewis (1918) Gray's Anatomy 20th ed (in at or ) III. Pathophysiology: Androgen Mediated Sebum Production composition s esters

2015 FP Notebook

13. Safety and efficacy of two anti-acne/anti-aging treatments in subjects with photodamaged skin and mild to moderate acne vulgaris. (Abstract)

-prescription formulation includes several ingredients shown to target factors underlying the pathogenesis of acne vulgaris while also addressing multiple components in the pathophysiology of skin aging.A blinded, randomized, split-face study was conducted to evaluate and compare the tolerability and efficacy of the novel anti-acne/ anti-aging product in subjects with photodamaged skin and acne vulgaris relative to tretinoin cream 0.025% (Treatment B). All subjects also were given supportive skincare (...) Safety and efficacy of two anti-acne/anti-aging treatments in subjects with photodamaged skin and mild to moderate acne vulgaris. Although reliable prevalence data are not available, adult acne is thought to be somewhat common, and it is not unusual for patients to have acne as well as early signs of skin aging. A novel anti-acne/anti-aging formulation (Treatment A) has been developed for daily use by patients to address both signs of skin aging and facial acne vulgaris. The novel, non

2012 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

14. The relationship between the second to fourth digit ratio and acne vulgaris. (Abstract)

The relationship between the second to fourth digit ratio and acne vulgaris. Although the pathophysiology of acne vulgaris (AV) is not clear, androgens are thought to play an important role in its development through either an increased level of circulating androgens or end-organ sensitivity. The ratio of the length of the second and fourth digit (2D : 4D) has been hypothesized to reflect prenatal androgen exposure and/or an individual's sensitivity to androgens, with a low 2D : 4D ratio (...) suggesting high prenatal androgen exposure. Interestingly, the prenatal androgen peak time period coincides with both the development of the sebaceous gland and digits.To determine the relationship between digit ratio and AV.Vernier caliper was used to take digit measurements of both patients and controls. Acne severity was assessed by using the International Consensus Conference on Acne Classification System.Data of 251 patients with AV (67.7% female) and 120 healthy controls (72.5% female), aged 16-40

2014 Journal of the European Academy of Dermatology and Venereology

15. Acne Vulgaris (Overview)

Acne Vulgaris (Overview) Acne Vulgaris: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTgwNC1vdmVydmlldw== processing > Acne Vulgaris Updated: Mar 26, 2019 (...) I; multiple open comedones. Acne develops from the following four factors: (1) follicular epidermal hyperproliferation with subsequent plugging of the follicle, (2) excess sebum production, (3) the presence and activity of the commensal bacteria Cutibacterium acnes (formerly Propionibacterium acnes ), and (4) inflammation. [ ] In addition, genetics is also a key factor in the pathophysiology of acne. [ ] Signs and symptoms Acne vulgaris is characterized by noninflammatory, open or closed

2014 eMedicine.com

16. Acne Vulgaris (Diagnosis)

Acne Vulgaris (Diagnosis) Acne Vulgaris: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTgwNC1vdmVydmlldw== processing > Acne Vulgaris Updated: Mar 26, 2019 (...) I; multiple open comedones. Acne develops from the following four factors: (1) follicular epidermal hyperproliferation with subsequent plugging of the follicle, (2) excess sebum production, (3) the presence and activity of the commensal bacteria Cutibacterium acnes (formerly Propionibacterium acnes ), and (4) inflammation. [ ] In addition, genetics is also a key factor in the pathophysiology of acne. [ ] Signs and symptoms Acne vulgaris is characterized by noninflammatory, open or closed

2014 eMedicine.com

17. Acne Vulgaris

Acne Vulgaris Acne Vulgaris Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Acne Vulgaris Acne Vulgaris Aka: Acne Vulgaris , Acne From (...) Related Chapters II. Epidemiology : 75% of teenagers and young adults III. Pathophysiology See Secondary acne causes See See IV. Signs: Lesion Types Obstructive Acne Open Comedones (Black heads) Closed Comedones (White heads) Inflammatory Acne (in order of lesion formation) s s s s Scars V. Signs: Distribution Face Neck Back VI. Types: Severe subtypes Consider in refractory cases Referral usually indicated Conditions Severe, inflammatory acne Onset months after starting oral antibiotics Acne Fulminans

2015 FP Notebook

18. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study. Full Text available with Trip Pro

High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study. The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults.A case-control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011 (...) load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris.

2012 BMC Dermatology

19. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of PCOS in Adolescence Full Text available with Trip Pro

and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Appropriate diagnosis of adolescent PCOS should include adequate and careful evaluation of symptoms, such as hirsutism, severe acne (...) An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of PCOS in Adolescence An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence - FullText - Hormone Research in Paediatrics 2017, Vol. 88, No. 6 - Karger Publishers a,b " /> c " /> d " /> e " /> f " /> g " /> h " /> i " /> j " /> k " /> l " /> m " /> n " /> o " /> p " /> q " /> r " /> s " /> t " /> u " /> v " /> w " /> x " /> y " /> z

2019 Pediatric Endocrine Society

20. Acne Vulgaris

Acne Vulgaris Acne Vulgaris - Dermatologic Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge Diagnostic Tests for Skin (...) Disorders Which of the following diagnostic tests is often done to evaluate pigmented lesions? Shaving Deep excision Patch test Scraping NEWS & VIDEOS Tumor Control Durable With Pembrolizumab in Merkel Cell Cancer WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- For patients with advanced Merkel cell carcinoma (aMCC), pembrolizumab is associated with durable tumor control and favorable overall survival, according... SOCIAL MEDIA Add to Any Platform Loading Topic Resources Acne vulgaris is the formation

2013 Merck Manual (19th Edition)

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