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Acne Vulgaris

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1. Trifarotene (Aklief) - acne vulgaris

Trifarotene (Aklief) - acne vulgaris Drug Approval Package: AKLIEF U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: AKLIEF Company: Galderma Research and Development, LLC Application Number: 211527 Approval Date: 10/04/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

2019 FDA - Drug Approval Package

2. Acne vulgaris

Acne vulgaris Acne vulgaris - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acne vulgaris Last reviewed: February 2019 Last updated: June 2018 Summary Acne may affect any age group, but it is most common in adolescents. Lesions consist of non-inflammatory comedones (whiteheads and blackheads) and inflammatory papules, pustules, nodules, and cysts. Systemic effects may be present with acne fulminans, a rare variant (...) of nodulocystic acne. Treatments include topical retinoids, keratolytics, and antibiotics; severe nodulocystic acne may require oral isotretinoin. Definition Acne vulgaris is a skin disease affecting the pilosebaceous unit. It is characterised by comedones, papules, pustules, nodules, cysts, and/or scarring, primarily on the face and trunk. Clinical manifestations range from mild comedonal acne to severe nodulocystic acne, which can be permanently disfiguring. In addition to the physical lesions, acne can

2018 BMJ Best Practice

3. Relationship between acne vulgaris and insulin resistance markers and effect of isotretinoin on insulin resistance markers in patients with acne vulgaris: a systematic review and meta-analysis

Relationship between acne vulgaris and insulin resistance markers and effect of isotretinoin on insulin resistance markers in patients with acne vulgaris: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

4. Prevalence of H.Pylori in Patients With Acne Vulgaris Acne Vulgaris

Prevalence of H.Pylori in Patients With Acne Vulgaris Acne Vulgaris Prevalence of H.Pylori in Patients With Acne Vulgaris Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prevalence of H.Pylori (...) in Patients With Acne Vulgaris Acne Vulgaris The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03411733 Recruitment Status : Completed First Posted : January 26, 2018 Last Update Posted : May 2, 2018 Sponsor: Sohag University Information provided by (Responsible Party): Dina Ali, Sohag University Study

2018 Clinical Trials

5. How Acne Bumps Cause the Blues: The Influence of Acne Vulgaris on Self-Esteem (PubMed)

How Acne Bumps Cause the Blues: The Influence of Acne Vulgaris on Self-Esteem Acne vulgaris is one of the most common dermatologic complaints. Although dermatologists are skilled at treating acne, invisible psychological scars can be left by the disease. We review 13 articles that examined the effect of acne vulgaris on patients' self-esteem. Overall, these studies demonstrated that acne has a negative effect on self-esteem among patients of all age groups. These effects most strongly affect (...) women and those with severe acne (both subjectively and objectively). Despite the impact on self-esteem, only a minority of patients seek medical treatment, and even fewer seek treatment from a dermatologist. As dermatologists, we are trained in managing acne. We can provide early and effective treatment that improves both the physical and psychological effects. It is up to us to bridge the gap between those suffering from acne and their access to medical treatment.

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2017 International journal of women's dermatology

6. Safety and Efficacy of Topically Applied Selected Cutibacterium acnes Strains over Five Weeks in Patients with Acne Vulgaris: An Open-label, Pilot Study. (PubMed)

Safety and Efficacy of Topically Applied Selected Cutibacterium acnes Strains over Five Weeks in Patients with Acne Vulgaris: An Open-label, Pilot Study. Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction in acne. This pilot study evaluates the safety and efficacy of microbiome modulation on acne-prone skin. The study had (...) 2 phases: active induction (5% benzoyl peroxide gel, 7 days) and interventional C. acnes strains treatment (5 weeks). Patients were randomized to either topical skin formulations PT1 (2 strains of C. acnes Single Locus Sequence Typing [SLST] type C3 and K8, 50% each) or PT2 (4 strains of C. acnes SLST type C3 [55%], K8 [5%], A5 [30%] and F4 [10%]). Safety and efficacy was evaluated in 14 patients (PT1=8/14, PT2=6/14). Skin microbiome composition shifted towards study formulations. No untoward

2019 Acta Dermato-Venereologica

7. Inhibitory effects of Cheongsangbangpoong-tang on both inflammatory acne lesion and facial heat in patients with acne vulgaris: A double-blinded randomized controlled trial. (PubMed)

Inhibitory effects of Cheongsangbangpoong-tang on both inflammatory acne lesion and facial heat in patients with acne vulgaris: A double-blinded randomized controlled trial. To investigate the inhibitory effects of an herbal formulation of Cheongsangbangpoong-tang (CBT) on inflammatory acne lesions as the control of the 'Heat' pattern.A single center study. Randomized, placebo-controlled, parallel group, double-blind trial SETTING: Fifty-six subjects, who had more than 10 acne inflammatory (...) is a potential therapeutic agent for the treatment of acne vulgaris, linked to inhibition of inflammatory lesions and facial heat.CRiS (Clinical Research Information Service, Republic of Korea), KCT0001468. Registered 06 May 2015.Copyright © 2019 Elsevier Ltd. All rights reserved.

2019 Complementary Therapies In Medicine Controlled trial quality: predicted high

8. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. (PubMed)

Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. While the commensal bacterium Propionibacterium acnes (P. acnes) is involved in the maintenance of a healthy skin, it can also act as an opportunistic pathogen in acne vulgaris. The latest findings on P. acnes shed light on the critical role of a tight equilibrium between members of its phylotypes and within the skin microbiota in the development of this skin disease. Indeed, contrary to what (...) was previously thought, proliferation of P. acnes is not the trigger of acne as patients with acne do not harbour more P. acnes in follicles than normal individuals. Instead, the loss of the skin microbial diversity together with the activation of the innate immunity might lead to this chronic inflammatory condition. This review provides results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes (C. acnes

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2018 Journal of the European Academy of Dermatology and Venereology

9. Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018 (PubMed)

Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018 Acne vulgaris is a common heath problem affecting adolescents with considerable impact on their quality of life.To determine the prevalence of Acne vulgaris and its psychological impact among female secondary school students.A cross-sectional study was conducted during the period from January to March 2018, among all female secondary school students in 3 randomly (...) selected schools, in Arar city (Saudi Arabia). The participants were clinically examined by a dermatologist to identify acne cases. Dermatological quality of life of acne cases were assessed using an Arabic version of Dermatology Life Quality Index (DLQI). Data collected were analyzed by IBM-SPSS version 20, using Chi-square, Fisher's Exact test, Mann-Whitney U, and Kruskal Wallis test. P-value ≤0.05 was considered statically significant.The overall prevalence of Acne vulgaris was 14.3

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2018 Electronic physician

10. Complementary therapies for acne vulgaris. (PubMed)

Complementary therapies for acne vulgaris. Acne is a chronic skin disease characterised by inflamed spots and blackheads on the face, neck, back, and chest. Cysts and scarring can also occur, especially in more severe disease. People with acne often turn to complementary and alternative medicine (CAM), such as herbal medicine, acupuncture, and dietary modifications, because of their concerns about the adverse effects of conventional medicines. However, evidence for CAM therapies has not been (...) -13.52 to -1.68, 43 participants, 1 trial) and total skin lesion counts (MD -8.10, 95% CI -14.89 to -1.31, 43 participants, 1 trial) for people with acne vulgaris, data regarding inflammatory and total lesion counts from the other study were incomplete and unusable in synthesis.Data from a single trial showed potential benefit of tea tree oil compared with placebo in improving total skin lesion counts (MD -7.53, 95% CI -10.40 to -4.66, 60 participants, 1 trial, low quality of evidence) and acne

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2015 Cochrane

11. Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris (PubMed)

Is IL-1β Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacterium acnes is now also emerging as a potentially new (...) etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1β. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1β in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1β is the key inflammatory mechanism driving

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2018 Frontiers in cellular and infection microbiology

12. A Review of hormone-based therapies to treat adult acne vulgaris in women (PubMed)

A Review of hormone-based therapies to treat adult acne vulgaris in women Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment on their efficacy and safety profiles for clinical practice. A systematic search using the PubMed Database was conducted (...) and spironolactone as adjuvant and monotherapies are safe and effective to treat women with adult acne. However, appropriate clinical examinations, screening, and individual risk assessments particularly for venous thromboembolism risk must be conducted prior to initiating therapy.

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2017 International journal of women's dermatology

13. What are the risk factors for scarring resulting from acne vulgaris?

What are the risk factors for scarring resulting from acne vulgaris? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

14. What skin care advice is appropriate for people with acne vulgaris?

What skin care advice is appropriate for people with acne vulgaris? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2019 PROSPERO

15. Dietary interventions for treatment of acne vulgaris

Dietary interventions for treatment of acne vulgaris Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2019 PROSPERO

16. Information and support for people with acne vulgaris and their parents or carers

Information and support for people with acne vulgaris and their parents or carers Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

17. Acne vulgaris

Acne vulgaris Acne vulgaris - NICE CKS Share Acne vulgaris: Summary Acne vulgaris is a chronic inflammatory skin condition affecting mainly the face, back and chest - it is characterised by blockage and inflammation of the pilosebaceous unit (the hair follicle, hair shaft and sebaceous gland). It presents with lesions which can be non-inflammatory (comedones), inflammatory (papules, pustules and nodules) or a mixture of both. Up to 95% of adolescents in Western industrialized countries (...) , adverse effects and use of comedongenic make up or face creams should be considered before swapping to an alternative product or the next treatment step. Have I got the right topic? Have I got the right topic? From age 12 years onwards. This CKS topic covers the management of acne vulgaris. This CKS topic does not cover the management of acne secondary to drugs or an underlying condition. There is a separate CKS topic on . The target audience for this CKS topic is healthcare professionals working

2018 NICE Clinical Knowledge Summaries

18. Studying the efficacy of a new radical treatment for acne vulgaris using a surgical technique. (PubMed)

Studying the efficacy of a new radical treatment for acne vulgaris using a surgical technique. Despite the numerous treatments available for acne vulgaris, not all are efficacious, and many patients experience psychological distress and various side effects from medications used to treat this condition. The objective of this study was to develop a new surgical technique for the treatment of acne.This surgical technique utilizes tweezers to widen the hair follicle to discharge comedo and pus (...) completely and quickly from the acne.Complete healing of acne was observed. Patients whose acne were cured within the range of 1-10, 1-20, and 1-50 treatments accounted for approximately 85%, 93%, and 99% of the 4566 patients, respectively.This newly developed surgical technique can be used as a basic treatment option for acne vulgaris. The implications of these findings include the prevention of patient psychological distress and avoidance of side effects of medications.

2019 Journal of Dermatological Treatment

19. The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample. (PubMed)

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample. Little is known about the mental health (MH) hospitalization among patients with acne and rosacea.To determine the MH disorders and cost burden associated with acne and rosacea.Data were examined from the 2002-2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions).A diagnosis of ≥ 1 MH disorder was much more (...) common among all inpatients with vs. those without a diagnosis of acne (43.7% vs. 20.0%, respectively) and rosacea (35.1% vs. 20.0%, respectively). In multivariable logistic regression models controlling for sex, age, race/ethnicity and insurance status, acne (adjusted OR = 13.02; 95% CI 11.75-14.42) and rosacea (adjusted OR = 1.70; 95% CI 1.56-1.95) were associated with significantly higher odds of a primary admission for an MH disorder (13 and 8, respectively, of 15 MH disorders examined). Both

2019 Clinical & Experimental Dermatology

20. Minimise the regular laboratory monitoring during the systemic isotretinoin treatment: data of 704 patients with acne vulgaris. (PubMed)

Minimise the regular laboratory monitoring during the systemic isotretinoin treatment: data of 704 patients with acne vulgaris. Backround: Despite extensive usage of systemic isotretinoin in patients with acne for many years, laboratory monitoring protocols for adverse effects depend on the centers and there is no standardized practice for frequency and type of laboratory testing. We aimed to decrease unnecessary monitoring and to standardize our general clinical practice of our department (...) as well as to provide patient comfort and cost saving.The medical charts of 704 acne patients treated with systemic isotretinoin were reviewed retrospectively. The National Cancer Institute common terminology criteria for adverse events v3.0 grading system was used in order to categorize the laboratory abnormalities of liver functions and lipid levels.All laboratory abnormalities were grade I. Abnormal liver function was seen in 7.2% of the patients (n = 51), maximum values were ALT: 87 IU/L, AST: 97

2019 Journal of Dermatological Treatment

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