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Abdominal Aortic Aneurysm

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121. Additional value of biomechanical indices based on CTa for rupture risk assessment of abdominal aortic aneurysms. Full Text available with Trip Pro

Additional value of biomechanical indices based on CTa for rupture risk assessment of abdominal aortic aneurysms. Biomechanics for rupture risk prediction in abdominal aortic aneurysms (AAA) are gaining popularity. However, their clinical applicability is still doubtful as there is lack of standardization. This study evaluates the added value of biomechanical indices in rupture risk assessment.This study included 175 asymptomatic, 11 sAAA and 45 ruptured aneurysms. 3D-geometries were (...) = 0.001) higher in ruptured. However, after diameter-matching no significant differences were seen. The ROC-curves for the maximum diameter and all biomechanical indices were similar but it slightly increased when diameter and biomechanical indices were combined.This study showed no added value for biomechanical indices in AAA rupture risk assessment. Additionally, the difficulty of such an assessment increases. However, as symptomatic aneurysms show a trend towards higher biomechanical indices

2018 PLoS ONE

122. Hemodynamics and pathology of an enlarging abdominal aortic aneurysm model in rabbits. Full Text available with Trip Pro

Hemodynamics and pathology of an enlarging abdominal aortic aneurysm model in rabbits. Hemodynamics may play an essential role in the initiation and progression of abdominal aortic aneurysm (AAA). We aimed to study the mechanism of self-healing process by the changes of hemodynamics and pathology in an enlarging AAA in rabbits. Seventy-two rabbits were randomly divided into three groups. Rabbits underwent extrinsic coarctation and received a 10-minute elastase incubation in Group A and Group B (...) in Group B, however, high oscillatory shear index had relatively less increase compared with Group A. Aortic diameter reached a plateau at 5 weeks in Group A, which was significantly lower than in week 15 in Group B. Intimal hyperplasia, intima-media thickness increased significantly in Group A at week 5, significantly higher than in week 15 in Group B. Marked destruction of elastin fibers and smooth muscle cells occurred at week 1, and increased significantly at week 15 in Group A. Aneurysm exhibited

2018 PLoS ONE

123. Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study. Full Text available with Trip Pro

Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study. Studies have reported that higher circulating levels of total cholesterol (TC), low-density lipoprotein (LDL) cholesterol and lower of high-density lipoprotein (HDL) cholesterol may be associated with increased risk of abdominal aortic aneurysm (AAA). Whether dyslipidemia causes AAA is still unclear and is potentially testable using a Mendelian randomization (MR) approach. We

2018 PLoS ONE

124. Short- and long-term survival after open versus endovascular repair of abdominal aortic aneurysm-Polish population analysis. Full Text available with Trip Pro

Short- and long-term survival after open versus endovascular repair of abdominal aortic aneurysm-Polish population analysis. The aim of the study was to compare short and long-term mortality and readmissions in patients with non-ruptured abdominal aortic aneurysm (AAA) treated with endovascular aortic repair (EVAR) or open aneurysm repair (OAR).Retrospective survival analysis based on prospectively collected medical records of the national Polish public health insurer.In the National Health

2018 PLoS ONE

125. CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice. Full Text available with Trip Pro

CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice. An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated with an accumulation of inflammatory cells in the aorta including NKT cells. An important factor in promoting the recruitment of these inflammatory cells into tissues and thereby contributing to the development of AAA is angiotensin II (...) , and by cytokine dependently decreasing vSMC viability. Altogether, these data prove that CD1d-dependent NKT cells contribute to AAA development in the Ang II-mediated aneurysm model by enhancing aortic degradation, establishing that therapeutic applications which target NKT cells can be a successful way to prevent AAA development.

2018 PLoS ONE

126. Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study. Full Text available with Trip Pro

Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study. An aortic aneurysm (AA) is a focal dilatation of the aortic wall. Occurrence of AA rupture is an all too common event that is associated with high levels of patient morbidity and mortality. The decision to surgically intervene prior to AA rupture is made with recognition of significant procedural risks, and is primarily based on the maximal diameter and/or growth rate of the AA. Despite (...) and mechanical properties of the aneurysmal tissue. Taken together, our findings encourage an expansion of geometrical parameters considered for rupture risk assessment, and provide perspective on the degree to which tissue mechanical properties may modulate peak stress values within aneurysmal tissue.

2018 PLoS ONE

127. A meta-analysis of monthly variation in occurrence of abdominal aortic aneurysm rupture. (Abstract)

A meta-analysis of monthly variation in occurrence of abdominal aortic aneurysm rupture. We performed a meta-analysis to assess the presence of an annual rhythmic variability of ruptured abdominal aortic aneurysm (RAAA) onset.Eligible studies were observational studies enrolling patients with RAAA and reporting monthly incidence of RAAA. Study-specific estimates, i. e. monthly incidence of RAAA, were combined using the random-effects model. Chronobiological analysis was performed by applying

2017 VASA. Zeitschrift fur Gefasskrankheiten

128. A Case of Superior Mesenteric Artery Aneurysm Mimicking an Abdominal Aortic Aneurysm and Presenting as a Pulsating Abdominal Mass Full Text available with Trip Pro

A Case of Superior Mesenteric Artery Aneurysm Mimicking an Abdominal Aortic Aneurysm and Presenting as a Pulsating Abdominal Mass A 62-year-old male with a smoking history of 30 pack-years presented with a 1-year history of a periumbilical pulsating mass. He had been treated for hypertension for 2 years. Physical examination revealed a huge pulsating mass in the periumbilical abdomen. Femoral and popliteal arterial pulses were palpable. Computed tomography showed arterial dissection (...) in the proximal segment of the superior mesenteric artery, a huge aneurysm (52×50 mm) with mural thrombus and two smaller aneurysms (20×20 mm) in the right ileocolic and ileal branches, along with atherosclerotic changes. Interposition using the great saphenous vein was performed after aneurysmal isolation and ligation of jejunal branches in the sac. Distal flow was reestablished by end-to-end and end-to-side anastomoses of the right ileocolic and ileal branches, respectively. No complications were observed

2016 Vascular specialist international

129. Primary care screening for abdominal aortic aneurysm: a systematic evidence review for the US Preventive Services Task Force

Primary care screening for abdominal aortic aneurysm: a systematic evidence review for the US Preventive Services Task Force Primary care screening for abdominal aortic aneurysm: a systematic evidence review for the US Preventive Services Task Force Primary care screening for abdominal aortic aneurysm: a systematic evidence review for the US Preventive Services Task Force Guirguis-Blake JM, Beil TL, Sun X, Senger CA, Whitlock EP CRD summary This review concluded that one-time invitation (...) for abdominal aortic aneurysm (AAA) screening for men aged 65 years or older was associated with decreased AAA rupture and mortality, but no difference in all-cause mortality. The authors' conclusions largely follow from the presented evidence and appear to be reliable for older Caucasian men. Authors' objectives To assess the benefits and harms of programmes to screen for abdominal aortic aneurysm (AAA) and treat small aneurysms, and to determine the screening yield for population subgroups. Searching

2014 DARE.

130. Stent graft types for endovascular repair of abdominal aortic aneurysms. (Abstract)

Stent graft types for endovascular repair of abdominal aortic aneurysms. The UK prevalence of abdominal aortic aneurysm (AAA) is estimated at 4.9% in over 65-year olds. Progressive and unpredictable enlargement can lead to rupture. Endovascular repair of AAAs involves a stent graft system being introduced via the femoral artery and manipulated within the aorta under radiological guidance. Following endograft deployment, a seal is formed at the proximal and distal landing zones to exclude (...) comparisons of the performance of different stent graft types. Therefore, this review cannot recommend guidance to clinicians in their selection of stent graft types. High quality randomised controlled trials evaluating stent graft types in abdominal endovascular aneurysm repair are required.

2013 Cochrane

131. Limb Remote Ischemic Preconditioning for Intestinal and Pulmonary Protection during Elective Open Infrarenal Abdominal Aortic Aneurysm Repair: A Randomized Controlled Trial: Erratum. (Abstract)

Limb Remote Ischemic Preconditioning for Intestinal and Pulmonary Protection during Elective Open Infrarenal Abdominal Aortic Aneurysm Repair: A Randomized Controlled Trial: Erratum. 31149931 2019 07 23 1528-1175 131 1 2019 07 Anesthesiology Anesthesiology Limb Remote Ischemic Preconditioning for Intestinal and Pulmonary Protection during Elective Open Infrarenal Abdominal Aortic Aneurysm Repair: A Randomized Controlled Trial: Erratum. 222 10.1097/ALN.0000000000002766 eng Journal Article

2019 Anesthesiology Controlled trial quality: predicted high

132. Efficacy of Unibody Bifurcated Endovascular Stent-Graft Repair in the Treatment of Abdominal Aortic Aneurysm. Full Text available with Trip Pro

Efficacy of Unibody Bifurcated Endovascular Stent-Graft Repair in the Treatment of Abdominal Aortic Aneurysm. To compare the clinical efficacy of unibody bifurcated endovascular stent-graft repair versus conventional open surgery for abdominal aortic aneurysm (AAA).Interventional study.Department of Vascular Surgery, Gansu Province People's Hospital, China, from January 2015 to December 2016.A total of 80 patients with AAA were randomly divided into Group A and Group B, with 40 cases in each (...) , respectively). The survival rate of patients in Group B at 6 months, 12 months and 24 months after operation was higher than that of Group A (p=0.002, 0.002 and 0.005, respectively).Unibody bifurcated endovascular stent-graft repair for abdominal aortic aneurysm has advantages of short operation time, little trauma, short recovery time, high safety and efficacy compared with the conventional open surgery.

2019 Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Controlled trial quality: uncertain

133. The effect of ticagrelor on growth of small abdominal aortic aneurysms - a randomized controlled trial. (Abstract)

The effect of ticagrelor on growth of small abdominal aortic aneurysms - a randomized controlled trial. To evaluate if ticagrelor, an effective platelet inhibitor without known non-responders, could inhibit growth of small AAAs.In this multi-center randomized controlled trial, double-blinded for ticagrelor and placebo, acetylic salicylic acid naïve patients with AAA and with a maximum aortic diameter 35-49 mm were included. The primary outcome was mean reduction in log-transformed AAA volume

2019 Cardiovascular Research Controlled trial quality: predicted high

134. Genetic polymorphism of HLA-DRB1 alleles in Mexican mestizo patients with abdominal aortic aneurysms. Full Text available with Trip Pro

Genetic polymorphism of HLA-DRB1 alleles in Mexican mestizo patients with abdominal aortic aneurysms. Multiple factors are implicated in the etiology and pathogenesis of Abdominal Aortic Aneurysms (AAA). Available literature of genetic studies has previously suggested the possible roles of autoimmunity, genetic predisposition and ethnic susceptibility. Due to the association with autoimmune diseases and proven application in population genetics, we aimed to investigate alleles of the Class II (...) Human Leukocyte Antigens (HLA-DRB1) in the Mexican Mestizo population with aortic aneurysms and determine possible associations with susceptibility.We performed a case Control Study; the HLA molecular typing was completed for DRB1 loci by LabType Sequence-Specific Oligonucleotide (SSO) SSO-OneLambda kit (Applied Biosystems; Thermo Fisher Scientific. Inc.) in the studied individuals. Allele frequencies (af) were determined, associations were assessed by chi square or fisher exact tests

2019 BMC Medical Genetics

135. Deletion of interleukin-18 attenuates abdominal aortic aneurysm formation. (Abstract)

Deletion of interleukin-18 attenuates abdominal aortic aneurysm formation. Abdominal aortic aneurysm (AAA) is a common disease; however, its exact pathogenesis remains unknown, and no specific medical therapies are available. Interleukin (IL)-18 plays a crucial role in atherosclerotic plaque destabilization and is a strong predictor of cardiovascular death. Here, we investigated the role of IL-18 in AAA pathogenesis using an experimental mouse model.After infusion of angiotensin II (Ang II (...) into inflammatory M1 phenotype, and matrix metalloproteinase (MMP) activation in abdominal aortas, which is associated with reduced expression of osteopontin (OPN).These findings indicate that IL-18 plays an important role in the development of AAA by enhancing OPN expression, macrophage recruitment, and MMP activation. Moreover, IL-18 represents a previously unrecognized therapeutic target for the prevention of AAA formation.Copyright © 2019 Elsevier B.V. All rights reserved.

2019 Atherosclerosis

136. SGLT-2 (Sodium-Glucose Cotransporter 2) Inhibition Reduces Ang II (Angiotensin II)-Induced Dissecting Abdominal Aortic Aneurysm in ApoE (Apolipoprotein E) Knockout Mice. Full Text available with Trip Pro

SGLT-2 (Sodium-Glucose Cotransporter 2) Inhibition Reduces Ang II (Angiotensin II)-Induced Dissecting Abdominal Aortic Aneurysm in ApoE (Apolipoprotein E) Knockout Mice. Abdominal aortic aneurysm (AAA) is a pathological condition of permanent vessel dilatation that predisposes to the potentially fatal consequence of aortic rupture. SGLT-2 (sodium-glucose cotransporter 2) inhibitors have emerged as powerful pharmacological tools for type 2 diabetes mellitus treatment. Beyond their glucose (...) reduced the Ang II-induced increase in maximal suprarenal aortic diameter in apoE-/- mice independently of blood pressure effects. Immunohistochemistry analysis revealed that empagliflozin diminished Ang II-induced elastin degradation, neovessel formation, and macrophage infiltration at the AAA lesion. Furthermore, Ang II infusion resulted in a marked increase in the expression of chemokines (CCL-2 [chemokine (C-C motif) ligand 2] and CCL-5 [chemokine (C-C motif) ligand 5]), VEGF (vascular endothelial

2019 Thrombosis and Vascular Biology

137. Involvement of macrophage-derived exosomes in abdominal aortic aneurysms development. (Abstract)

Involvement of macrophage-derived exosomes in abdominal aortic aneurysms development. Abdominal aortic aneurysm (AAA) is characterized by infiltration of inflammatory cells, extracellular matrix (ECM) degradation, and dysfunction of vascular smooth muscle cells (VSMCs). Recent studies reported that exosomes mediate intercellular communication and are involved in different diseases. Whether exosomes play a role in AAA is poorly understood. Hence, this study evaluated the function of exosomes (...) were treated with macrophage-derived exosomes, and the expression of matrix metalloproteinase-2 (MMP-2) was evaluated. The activation of mitogen-activated protein kinases (MAPKs) pathways was also investigated in vitro and in vivo.Exosomes were detected in the adventitia of aneurysmal tissues obtained from humans and mice. They were mainly expressed in clusters of macrophages. Intraperitoneal injection of GW4869 for two weeks significantly attenuated the progression of CaPO4-induced AAA, preserved

2019 Atherosclerosis

138. Lack of an effective drug therapy for abdominal aortic aneurysm. Full Text available with Trip Pro

Lack of an effective drug therapy for abdominal aortic aneurysm. Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and human epidemiology, and genetic and observational studies over the last few decades have highlighted the potential of a number of drug therapies, including medications that lower blood pressure, correct dyslipidaemia, or inhibit thrombosis, inflammation or matrix

2019 Journal of internal medicine

139. Response to letter about "Lack of an effective drug for abdominal aortic aneurysm". (Abstract)

Response to letter about "Lack of an effective drug for abdominal aortic aneurysm". We agree there was substantial heterogeneity in the design of the past abdominal aortic aneurysm (AAA) drug trials, particularly those testing antibiotics. While Yu et al. have focused on I2 , it should be noted that this describes the dispersion of effect sizes and does not completely describe the heterogeneity between studies. The included antibiotic trials had many methodological variations, such as different

2019 Journal of internal medicine

140. Nationwide Study of Ruptured Abdominal Aortic Aneurysms During Twenty Years (1994-2013). (Abstract)

Nationwide Study of Ruptured Abdominal Aortic Aneurysms During Twenty Years (1994-2013). To analyze the epidemiology of ruptured abdominal aortic aneurysms (RAAA) in Sweden over 20 years, and assess the effect of endovascular repair (EVAR) on surgical treatment rate and outcome.All Swedish citizens >50 years with RAAA 1994 to 2013 were extracted from 3 national (Cause of Death, Patient, and Vascular Surgical) registries. Incidence, proportion repaired, surgical techniques, and 90-day mortality

2019 Annals of Surgery

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