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Abdominal Anatomy

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1. Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal Failure. Full Text available with Trip Pro

Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal Failure. Teduglutide reduces or eliminates parenteral support (PS) dependency in patients with short bowel syndrome (SBS). Recent post hoc analyses demonstrated that effects are correlated with baseline PS volume. We assessed the SBS-related quality-of-life (QoL) impact of teduglutide, particularly whether improvements are greater among subgroups achieving more PS volume reduction.Using phase 3 (...) trial data of teduglutide in patients with SBS (NCT00798967), change in Short Bowel Syndrome-Quality of Life (SBS-QoL) scores from baseline were compared between teduglutide vs placebo in the overall population and subgroups classified by baseline PS volume requirement, disease etiology, and bowel anatomy. Generalized estimating equation models were fitted to assess impact of teduglutide on SBS-related QoL using data from all visits, adjusted for baseline characteristics.Of 86 patients, 43 each were

2019 JPEN. Journal of parenteral and enteral nutrition Controlled trial quality: uncertain

2. Factors Associated With Response to Teduglutide in Patients With Short-Bowel Syndrome and Intestinal Failure. Full Text available with Trip Pro

volume, bowel anatomy (group 1, jejunostomy/ileostomy; group 2, ≥50% colon-in-continuity without stoma; and group 3, other colon anatomies), and disease features (with inflammatory bowel disease, mesenteric vascular diseases, or other conditions). Correlation analyses were conducted using simple linear regression models, with unadjusted r2 values reported. Two-sided t tests were used for comparisons between treatment groups.We correlated parenteral support volume reduction with teduglutide treatment (...) with SBS and inflammatory bowel diseases had colon-in-continuity (10.5% [n = 2/19]), whereas most patients with SBS and vascular or other diseases had colon-in-continuity (84.4% [n = 27/32] and 67.6% [n = 23/34], respectively).In a post hoc analysis of data from a phase III study of the effects of teduglutide on patients with SBS, we associated reduced parenteral support volume with baseline parenteral support volume, bowel anatomy, and SBS features. These findings may inform initial parenteral support

2018 Gastroenterology Controlled trial quality: uncertain

3. Single Balloon Enteroscopy System for Obscure GI Bleeding (Small Bowel)

. Lay summary Patients with obscure gastrointestinal (GI) bleeding – that is, bleeding where the cause is not determined from initial medical procedures examining the GI tract – may be further investigated with balloon enteroscopy. A balloon enteroscope allows for a detailed investigation of the small bowel. Currently, MBS items are available for procedures using a double balloon technique. The application requested that a single balloon technique be included on the MBS. The available evidence (...) Single Balloon Enteroscopy System for Obscure GI Bleeding (Small Bowel) A Spons Date o 1. P An appl balloon (GI) ble Decemb SBE ca same pr For SBE the endo bowel w inserted straight the over similar with air Double gastroin of two b the endo (via an then inf balloon further SBE dif balloon DBE . B the addi Applicati sor/Applica of MSAC c Purpose of lication req n enteroscop eeding was ber 2011. an be perform reparation a E, a 200-cen oscope. The wall it ancho d more deep ter, allowing r-tube

2013 Medical Services Advisory Committee

4. Risk factors and outcomes of tapering surgery for small intestinal dilatation in pediatric short bowel syndrome. Full Text available with Trip Pro

Risk factors and outcomes of tapering surgery for small intestinal dilatation in pediatric short bowel syndrome. In remains unclear why in some short bowel syndrome (SBS) patients, the remaining small bowel (SB) dilates excessively leading to requirement of tapering surgery.Among SBS children, we retrospectively analyzed risk factors for tapering surgery with logistic regression and compared the outcome of operated patients (n=16) to those managed conservatively (n=44) with Cox proportional (...) diagnosis were protective of tapering (p=0.027-0.004). Of operated patients, 75% reached enteral autonomy during follow-up and their postoperative adjusted PN weaning rate was similar to nonoperated children (p=0.842).SBS children with short remaining SB, missing ICV, and SBA etiology are more likely while NEC patients are less likely than others to necessitate tapering surgery. Postoperative PN weaning rates were comparable to patients who initially had more favorable intestinal anatomy and adapted

2017 Journal of Pediatric Surgery

5. Use of balloon dilatation for management of postoperative intestinal strictures in children with short bowel syndrome. (Abstract)

Use of balloon dilatation for management of postoperative intestinal strictures in children with short bowel syndrome. Children with short bowel syndrome (SBS) often require numerous operations to optimize intestinal function. Postoperative intestinal strictures are a complication that inhibits enteral feeding advancement and prolongs parenteral nutrition dependency, often requiring reoperation. Our objective was to review our experience with fluoroscopic balloon dilatation to treat intestinal (...) strictures.A retrospective cohort study of intestinal failure patients with SBS was completed. Patients who had radiologically diagnosed intestinal strictures and treated with fluoroscopic guided balloon dilatation were included [n=6]. Data related to demographics, anatomy, surgical procedures, and dilatation procedures were collected. Descriptive summary statistics were employed.98 intestinal failure patients were recruited between 2011 and 2015. Five of 98 patients (5.1%) [2 males; median age 4.4months

2017 Journal of Pediatric Surgery

6. Apo AIV and Citrulline Plasma Concentrations in Short Bowel Syndrome Patients: The Influence of Short Bowel Anatomy. Full Text available with Trip Pro

Apo AIV and Citrulline Plasma Concentrations in Short Bowel Syndrome Patients: The Influence of Short Bowel Anatomy. Parenteral nutrition (PN) dependence in short bowel syndrome (SBS) patients is linked to the functionality of the remnant small bowel (RSB). Patients may wean off PN following a period of intestinal adaptation that restores this functionality. Currently, plasma citrulline is the standard biomarker for monitoring intestinal functionality and adaptation. However, available studies (...) reveal that the relationship the biomarker with the length and function of the RSB is arguable. Thus, having additional biomarkers would improve pointing out PN weaning.By measuring concomitant changes in citrulline and the novel biomarker apolipoprotein AIV (Apo AIV), as well as taking into account the anatomy of the RSB, this exploratory study aims to a better understanding of the intestinal adaptation process and characterization of the SBS patients under PN.Thirty four adult SBS patients were

2016 PLoS ONE

7. A Case of Fatal Colonic Perforation without Abdominal Exam Findings

A Case of Fatal Colonic Perforation without Abdominal Exam Findings Spotlight: A Case of Fatal Colonic Perforation without Abdominal Exam Findings – Clinical Correlations Search Spotlight: A Case of Fatal Colonic Perforation without Abdominal Exam Findings June 14, 2018 6 min read By Christopher Sonne, MD Peer reviewed Learning Objectives: 1. Understand the pathophysiology of peritonitis secondary to bowel perforation. 2. Understand how classic findings of peritonitis can be absent in some (...) cases of bowel perforation. 3. Recognize bowel perforation as a complication requiring emergent surgical intervention. Case: An 89 year-old woman with a history of chronic constipation was admitted for several weeks of severe constipation and abdominal bloating. On initial exam, she exhibited abdominal distention but had minimal abdominal tenderness. Initial CT imaging demonstrated a significant stool burden with prominent colonic distension extending from the cecum to the transverse colon. She had

2018 Clinical Correlations

8. Impaired intestinal barrier function and relapsing digestive disease: lessons from a porcine model of early life stress Full Text available with Trip Pro

Impaired intestinal barrier function and relapsing digestive disease: lessons from a porcine model of early life stress Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction (...) . This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings. Future studies to examine mechanisms underlying this link between early life

2017 Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

9. Laparoscopic revision of Billroth II with Braun anastomosis into Roux-en-Y anatomy in a patient with intestinal malrotation. Full Text available with Trip Pro

Laparoscopic revision of Billroth II with Braun anastomosis into Roux-en-Y anatomy in a patient with intestinal malrotation. Various reconstructions of the gastro-intestinal tract have been described in the past after distal gastrectomy. Among these, a Billroth II (BII) anastomosis can be performed with the addition of the Omega entero-enterostomy that may theoretically reduce the alkaline reflux. Given the significant complications associated with this procedure such as biliary reflux (...) , marginal ulceration, and afferent loop syndrome, a revision into a Roux-en-Y anatomy is generally recommended.A 73-year-old healthy male was referred to our foregut surgery service for treatment of severe biliary gastritis. The patient previously underwent an open distal gastrectomy with a BII reconstruction followed by a Braun-type entero-enterostomy 6 months later. His main complaint was worsening daily biliary reflux with constant regurgitations, which were non-responsive to medical treatment

2017 Surgical endoscopy

10. Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia Full Text available with Trip Pro

. Historically, murine models have been utilized to study intestinal injury. However, a porcine model offers several advantages including similarity of size as well as gastrointestinal anatomy and physiology to that of humans. By utilizing a porcine model, we establish a protocol in which segmental loops of intestinal ischemia can be created within a single animal, enabling the study of differing time points of ischemic injury and repair in vivo. Additionally, we describe a method to isolate and culture (...) for intestinal renewal during homeostasis and following injury. Ex vivo cell culture techniques have allowed for the successful study of epithelial stem cell interactions by establishing culture conditions that support the growth of three-dimensional epithelial organ-like systems (termed "enteroids" and "colonoids" from the small and large intestine, respectively). These enteroids are composed of crypt and villus-like domains and mature to contain all of the cell types found within the epithelium

2018 Journal of visualized experiments : JoVE

11. The role of endoscopy in the management of suspected small-bowel bleeding

Assessment, Development and Evaluation. Adapted from Guyatt et al. 1 The role of endoscopy in the management of suspected small-bowel bleeding www.giejournal.org Volume 85, No. 1 : 2017 GASTROINTESTINAL ENDOSCOPY 23VCE is considered the ?rst diagnostic step in the evalu- ation of small-bowel sources of occult bleeding once the upper GI tract and colon have been satisfactorily cleared as potential sources. A follow-up push enteroscopy or DAE is usually recommended for further management of positive (...) include large hiatal hernias, hematemesis, and a history of NSAID use. 43 Patients with upper GI mucosal lesions also may have other contributing causes of iron de?ciency anemia, such as malabsorption. 44,45 Small-bowel biopsy to evaluate for underlying celiac disease should be considered in patients with iron-de?ciency anemia. 46 In patients with an unrecognized bleeding source, repeat ileocolonoscopy should be considered when clinical suspicion exists for missed colon lesions, although studies have

2017 American Society for Gastrointestinal Endoscopy

12. The Association of Coloproctology of Great Britain and Ireland Consensus Guidelines in Surgery for Inflammatory Bowel Disease Full Text available with Trip Pro

disease is a severe inflammatory condition of the intestine affecting 322 per 100 000 people in Europe and 319 per 100 000 people in North America . It is associated with periods of debilitating symptoms including tiredness, severe abdominal discomfort, weight loss and chronic diarrhoea, often leading to the need for hospitalization and time off work. The disease can affect any part of the gastrointestinal track from the mouth to the anus, but in one‐third of patients it is localized to the ileocaecal (...) The Association of Coloproctology of Great Britain and Ireland Consensus Guidelines in Surgery for Inflammatory Bowel Disease The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease - Brown - 2018 - Colorectal Disease - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted at iucr.org

2018 Association of Coloproctology of Great Britain and Ireland

13. Bowel Anatomy

the process of digestion. The intestine has two parts, the small intestine and the large intestine. Definition (NCI_CDISC) The portion of the gastrointestinal tract between the stomach and the anus. It includes the small intestine and large intestine. (NCI) Definition (NCI) Of, or related to, or referring to the intestines. Definition (CSP) section of the alimentary canal from the stomach to the anus; includes the large and small intestines. Definition (MSH) The section of the alimentary canal from (...) , Intestine II. Components Duodenum Jejunum Ileum Cecum Ascending Colon Transverse Colon Descending Colon Sigmoid Colon Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Bowel Anatomy." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Intestinal Diseases (C0021831) Definition (NCI) A non-neoplastic or neoplastic disorder that affects the small or large

2018 FP Notebook

14. Large Bowel Anatomy

: Large Bowel Anatomy , Large Bowel , Large Intestine II. Components Cecum Ascending Colon Transverse Colon Descending Colon Sigmoid Colon III. Anatomy Lewis (1918) Gray's Anatomy 20th ed (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) Images: Related (...) that is connected to the small intestine at one end and the anus at the other. The large intestine has four parts: cecum, colon, rectum, and anal canal. Partly digested food moves through the cecum into the colon, where water and some nutrients and electrolytes are removed. The remaining material, solid waste called stool, moves through the colon, is stored in the rectum, and leaves the body through the anal canal and anus. Definition (MSH) A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM

2018 FP Notebook

15. Small Bowel Anatomy

proximally with the stomach and distally with the large intestine. Examples: There is only one small intestine. Definition (NCI) The section of the intestines between the pylorus and cecum. The small intestine is approximately 20 feet long and consists of the duodenum, the jejunum, and the ileum. Its main function is to absorb nutrients from food as the food is transported to the large intestine. Definition (NCI_NCI-GLOSS) The part of the digestive tract that is located between the stomach and the large (...) intestine. Definition (NCI_CDISC) The section of the intestines between the pylorus and cecum. The small intestine is approximately 20 feet long and consists of the duodenum, the jejunum, and the ileum. Its main function is to absorb nutrients from food as the food is transported to the large intestine. (NCI) Definition (MSH) The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM

2018 FP Notebook

16. Short Bowel Syndrome and Intestinal Failure in Crohn's Disease. Full Text available with Trip Pro

Short Bowel Syndrome and Intestinal Failure in Crohn's Disease. Crohn's disease is a chronic and progressive inflammatory disorder of the gastrointestinal tract. Despite the availability of powerful immunosuppressants, many patients with Crohn's disease still require one or more intestinal resections throughout the course of their disease. Multiple resections and a progressive reduction in bowel length can lead to the development of short bowel syndrome, a form of intestinal failure (...) that compromises fluid, electrolyte, and nutrient absorption. The pathophysiology of short bowel syndrome involves a reduction in intestinal surface area, alteration in the enteric hormonal feedback, dysmotility, and related comorbidities. Most patients will initially require parenteral nutrition as a primary or supplemental source of nutrition, although several patients may eventually wean off nutrition support depending on the residual gut anatomy and adherence to medical and nutritional interventions

2016 Inflammatory Bowel Diseases

17. Essential Anatomy of the Anorectum for Colorectal Surgeons Focused on the Gross Anatomy and Histologic Findings Full Text available with Trip Pro

Essential Anatomy of the Anorectum for Colorectal Surgeons Focused on the Gross Anatomy and Histologic Findings The anorectum is a region with a very complex structure, and surgery for benign or malignant disease of the anorectum is impossible without accurate anatomical knowledge. The conjoined longitudinal muscle consists of smooth muscle from the longitudinal muscle of the rectum and the striate muscle from the levator ani and helps maintain continence; the rectourethralis muscle (...) fascial plane. With the development of pelvic structure anatomy, we can understand better how we can remove the tumor and the surrounding metastatic lymph nodes without damaging the neural structure. However, because the anorectal anatomy is not yet fully understood, we hope that additional studies of anatomy will enable anorectal surgery to be performed based on complete anatomical knowledge.

2018 Annals of coloproctology

18. Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity Full Text available with Trip Pro

Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity Despite the fact that the most effective treatment for morbid obesity today is gastric bypass surgery, some patients develop life-threatening nutritional complications associated with their weight loss.Here we examine the influence of the altered anatomy and digestive physiology on pancreatic secretion and fat absorption. Thirteen post Roux-en-Y gastric bypass (RYGB) patients who had lost >100 lbs in the first (...) year following surgery and who gave variable histories of gastrointestinal (GI) dysfunction, were selected for study. Food-stimulated pancreatic enzyme secretion and GI hormone responses were measured during 2 h perfusions of the Roux limb with a standard polymeric liquid formula diet and polyethylene glycol marker, with collections of secretions from the common channel distal to the anastomosis and blood testing. Fat absorption was then measured during a 72 h balance study when a normal diet

2017 Clinical and translational gastroenterology

19. Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster Full Text available with Trip Pro

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster The gastrointestinal tract has recently come to the forefront of multiple research fields. It is now recognized as a major source of signals modulating food intake, insulin secretion and energy balance. It is also a key player in immunity and, through its interaction with microbiota, can shape our physiology and behavior in complex and sometimes unexpected ways. The insect intestine had remained, by comparison, relatively (...) been shown to be more widely applicable to other gastrointestinal systems, and may therefore become relevant in the context of human pathologies such as gastrointestinal cancers, aging, or obesity. This review summarizes our current knowledge of both the formation and function of the Drosophila melanogaster digestive tract, with a major focus on its main digestive/absorptive portion: the strikingly adaptable adult midgut.Copyright © 2018 Miguel-Aliaga et al.

2018 Genetics

20. Recurrent gastric ulcer and cholangitis caused by ectopic drainage of the bile duct into the stomach Full Text available with Trip Pro

Recurrent gastric ulcer and cholangitis caused by ectopic drainage of the bile duct into the stomach We report a case of recurrent gastritis with pyloric stenosis and cholangitis due to a rare variation in bile duct anatomy. A 72-year-old female patient showed recurrent gastral ulcers and biliary colic with cholangitis caused by gallstones in the main bile duct with an ectopic orifice in the prepyloric region and concurrent inflammatory pyloric stenosis. After temporarily successful endoscopic (...) treatment with stenting and pyloric dilatation, the patient suffered from recurrent cholangitis. Finally, the abnormal biliary anatomy required surgical treatment with biliodigestive anastomosis.

2017 GMS Interdisciplinary plastic and reconstructive surgery DGPW

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