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ABCD2 Score

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62. Report: Impact of drug combination of clopidogrel and pantoprazole In the prognosis of patients with transient ischemic attack. (Abstract)

% in the control group. The platelet aggregation before and after treatments between the two groups had not significant difference (P>0.05). The incidence of cerebrovascular events within 90 days (11.7% in the treatment group, 9.6% in the control group) between the two groups had not significant difference (P>0.05). Multivariate analysis showed that the incidence of cerebrovascular events within 90 day was associated with hypertension (P=0.008), diabetes (P=0.000), hyperlipidemia (P=0.002) and ABCD2 score >3

2017 Pakistan journal of pharmaceutical sciences Controlled trial quality: uncertain

63. Factors Associated With Focal Computed Tomographic Perfusion Abnormalities in Supratentorial Transient Ischemic Attacks. Full Text available with Trip Pro

with FPA in patients with supratentorial TIAs.We prospectively collected consecutive patients with supratentorial TIAs defined by the traditional time-based definition who underwent CTP within 24 hours of symptom onset. We recorded demographics, risk factors, clinical features, severity, and timing from onset. We documented the Age, Blood Pressure, Clinical Features, Duration, and Diabetes (ABCD2) scores, vascular territories, and presence of relevant arterial pathology. Variables were tested

2017 Stroke

64. When has service provision for transient ischaemic attack improved enough? A discrete event simulation economic modelling study. Full Text available with Trip Pro

and subsequent stroke.Included existing versus previous (less same day clinics) and hypothetical service reconfiguration (7-day service with less availability of clinics per day).The primary outcome of the model was the prevalence of major stroke after TIA. Secondary outcomes included service costs (including those of treating subsequent stroke) and time to treatment and attainment of national targets for service provision (proportion of high-risk patients (according to ABCD2 score) seen within 24 hours

2017 BMJ open

65. THALES

, defined as neurological deficit of acute onset attributed to focal ischaemia of the brain by history or examination with complete resolution of the deficit, and at least one of the following: ABCD2 score ≥6 and TIA symptoms not limited to isolated numbness, isolated visual changes, or isolated dizziness/vertigo Symptomatic intracranial arterial occlusive disease that could account for the clinical presentation, documented by transcranial Doppler or vascular imaging and defined as at least 50 (...) to first subsequent ischaemic stroke [ Time Frame: Day1-Day30 ] To demonstrate superior efficacy of ticagrelor and ASA compared with placebo and ASA in AIS/TIA patients in the prevention of ischaemic stroke at 30 days The modified Rankin Scale (mRS) score >1 at Visit 3 [ Time Frame: Day30 ] To demonstrate superior efficacy of ticagrelor and ASA compared with placebo and ASA in AIS/TIA patients in reducing overall disability at 30 days. The modified Rankin Scale (mRS) is a scale for measuring the degree

2017 Clinical Trials

66. Stroke and Cerebrovascular Diseases Registry

and has better specificity and sensitivity. Acute Brain injury, Transient Ischemic Attack is a special category of a neurological condition wherein there is an impending devastating outcome if workup is not completed in a timely fashion. There is an urgent need to do investigations with high-risk patients to prevent stroke and further mortality and morbidity. The abcd2 score can help us to risk stratify the TIA and to predict the chances of stroke in this specific cohort. However, investigators need (...) better identifiers than already present, to improve the patient changes in secondary prophylaxis of stroke prevention http://www.stroke.org/sites/default/files/resources/tia-abcd2-tool.pdf?docID There is also some correlation of clinical and biochemical predictors in subarachnoid, cerebral venous thrombosis including Hunt and Hess, SAH score, WFNS-SAH grading among others with variable predictive quality. (Rosen et al; Neurocritical Care; April 2005, Volume 2, Issue 2, pp 110-118: Subarachnoid

2017 Clinical Trials

67. Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia

with an ischemic stroke or TIA before admission and the following requirements should be satisfied as well: The occurrence of an ischemic stroke within 30 days and with a baseline modified Rankin Scale (mRS) score≤4. The occurrence of an TIA within 15 days and with a baseline Oxfordshire Community Stroke Project on the basis of age, blood pressure (BP), clinical features, and duration of TIA symptoms (ABCD2) score≥4. 3. Patients with symptomatic intracranial atherosclerotic stenosis (sIAS) that is attributed

2017 Clinical Trials

68. Coated-platelets predict stroke at 30 days following TIA. (Abstract)

Coated-platelets predict stroke at 30 days following TIA. To examine the potential for coated-platelets, a subset of highly procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, for predicting stroke at 30 days in patients with TIA.Consecutive patients with TIA were enrolled and followed up prospectively. ABCD2 scores were obtained for each patient. Coated-platelet levels, reported as percent of cells converted to coated-platelets, were determined at baseline (...) value of 0.16 (95% CI 0.06-0.26), and negative predictive value of 0.98 (95% CI 0.96-1.0). The adjusted hazard ratio of incident stroke in patients with coated-platelet levels ≥51.1% was 10.72 compared to those with levels <51.1%. ROC analysis showed significant improvement in the predictive ability of the coated-platelet model compared to ABCD2 score (AUC 0.78 ± 0.07 vs 0.54 ± 0.07, p = 0.01).These findings suggest a role for coated-platelets in risk stratification for stroke at 30 days after TIA.©

2017 Neurology

69. Differences in Characteristics and Outcomes Between Asian and Non-Asian Patients in the TIAregistry.org. Full Text available with Trip Pro

, 0.79; 95% confidence interval, 0.63-0.98; P=0.03); the difference was primarily driven by a lower rate of TIA in Asians (4.2% versus 8.3%; P<0.001). Moderately severe bleeding was more frequent in Asians (0.8% versus 0.3%; P=0.02). In multivariable analysis, multiple acute infarcts (P=0.005) and alcohol consumption (P=0.02) were independent predictors of stroke recurrence in Asians, whereas intracranial stenosis (P<0.001), ABCD2 score (P<0.001), atrial fibrillation (P=0.008), extracranial stenosis

2017 Stroke

70. MR perfusion lesions after TIA or minor stroke are associated with new infarction at 7 days. (Abstract)

), and underwent DWI/PWI at baseline and fluid-attenuated inversion recovery (FLAIR)/DWI 1 week after symptom onset were enrolled. Investigators blinded to clinical information independently assessed the presence of acute ischemic lesions on baseline DWI/PWI and follow-up DWI and FLAIR. Baseline and follow-up MRIs were then compared to determine the occurrence and location of new infarctions.Sixty-four patients met the inclusion criteria. Median (IQR) ABCD2 score was 4 (3-5). Median delay from onset

2017 Neurology

71. Comparison of prognostic performance of scores to predict risk of stroke in ED patients with transient ischaemic attack. (Abstract)

Comparison of prognostic performance of scores to predict risk of stroke in ED patients with transient ischaemic attack. To compare the performance of three risk scores (ABCD, ABCD2 and California) in identification of short-term stroke risk in patients with emergency department (ED) diagnosis of transient ischaemic attack. In the retrospective cohort study, information collected included features of clinical risk scores, demographic, clinical and outcome data. The outcome of interest was new (...) stroke occurrence at 2, 7 and 30 days. Data underwent receiver operating curve analyses. Of 326 patients, 17 patients experienced a new stroke within 30 days (4.9%, 95% confidence interval: 2.9-8.0%). C-statistic for high-stroke risk was not significantly different between scores at 2, 7 or 30 days. Using cutoffs of defined risk score cutoffs, the negative predictive values for stroke within 30 days were 97.4% (California), 99.1% (ABCD) and 98.9% (ABCD2), respectively. All three risk scores predict

2010 European Journal of Emergency Medicine

72. An institutional study of time delays for symptomatic carotid endarterectomy. Full Text available with Trip Pro

a clinical database and operative records. Covariates of interest were extracted from electronic medical records. Timing and nature of the first cerebrovascular symptoms were also documented. The first medical contact and pathway of referral were also assessed. When possible, the ABCD2 score (age, blood pressure, clinical features, duration of symptoms, and diabetes) was calculated to calculate further risk of stroke. The nonparametric Wilcoxon test was used to assess differences in time intervals (...) , there was no correlation between ABCD2 risk score and waiting time for surgery.The majority of our cohort falls short of the recommended 2-week interval to perform CEA. Factors contributing to reduced CEA delay were presentation to an emergency department, in-patient investigations, and a stroke center where a vascular surgeon is available.Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

2016 Journal of Vascular Surgery

73. Microalbuminuria could improve risk stratification in patients with TIA and minor stroke Full Text available with Trip Pro

Microalbuminuria could improve risk stratification in patients with TIA and minor stroke Transient ischemic attacks (TIA) and minor strokes are important risk factors for recurrent strokes. Current stroke risk prediction scores such as ABCD2, although widely used, lack optimal sensitivity and specificity. Elevated urinary albumin excretion predicts cardiovascular disease, stroke, and mortality. We explored the role of microalbuminuria (using albumin creatinine ratio (ACR)) in predicting

2016 Annals of clinical and translational neurology

74. Sanchitongtshu Plus Asprine for Minor Ischemic Stroke or Transient Ischemic Attack: A Randomized Double-blind Study

. Acute minor stroke was defined by a score of 3 or less at the time of randomization on the National Institutes of Health Stroke Scale(NIHSS). TIA was defined as focal brain ischemia with resolution of symptoms within 24 hours after onset plus a moderate-to-high risk of stroke recurrence(defined as a score≥4 at the time of randomization on the ABCD2). All patients were confirmed by brain CT or MRI. Patients had ability to accept the medicine and rules of the research. Patients had no serious (...) Measures : Percentage of patients with the 180-day new clinical vascular events (ischemic stroke/ hemorrhagic stroke/ TIA/ MI/ vascular death) as a cluster and evaluated individually [ Time Frame: 180 days ] Modified Rankin Scale score changes (continuous) and dichotomized at percentage with score 0-2 vs. 3-6 at 180 days follow-up [ Time Frame: 180 days ] Further efficacy exploratory analysis:Impairment (changes in NIHSS scores at 180 days follow-up) [ Time Frame: 180 days ] Further efficacy

2016 Clinical Trials

75. Analysis of the Impact of the Fragility of the Over 70 Years of TIAprognosis

with the TIA (transient ischemic attack) has however never been studied. A fortiori, the impact of the fragility of the risk of recurrent stroke after TIA is unknown. Several questions need to be asked: Among older patients hospitalized for TIA, what proportion of those completing the criteria of frailty? In this same population, is there a correlation between fragility and scores ABCD2 score itself predictive of the risk of subsequent ischemic stroke? In other words, fragile subjects who have a TIA Have (...) a higher risk of ischemic stroke (which could cause a strengthening of prevention measures)? Condition or disease Intervention/treatment Vascular Stoke Ischemic Transient Ischemic Attack Other: No intervention Detailed Description: Hypotheses : Frailty is common among the elderly patient population who have a TIA. Compared to control groups of literature. Patients with high fragility score ABCD2 also have a high score. Patients with a high score of fragility also have a significant number of vascular

2016 Clinical Trials

76. Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)

with age from 40 to 80 years old. Patients having an ischemic stroke or a TIA prior to randomization. Patient having an ischemic stroke within 30 days with mRS score≤4 at baseline. Patient having a TIA within 15 days with Oxfordshire Community Stroke Project on the basis of age, blood pressure (BP), clinical features, and duration of TIA symptoms (ABCD2) score≥4 at baseline. The entry event is attributed to symptomatic atherosclerotic stenosis (50-99%) in an intracranial qualifying artery (carotid (...) . ] The time from randomization to the first occurrence of each component of the composite of fatal or non-fatal stroke (ischemic and hemorrhagic), fatal or non-fatal myocardial infarction, and TIA. [ Time Frame: During the first 12 months from randomization. ] Time to death from all causes from randomization. [ Time Frame: During the first 12 months from randomization. ] Other Outcome Measures: Scores assessed by National Institutes of Health Stroke Scale(NIHSS) [ Time Frame: During the first 12 months

2015 Clinical Trials

77. Performing a Low-dose, Whole-body Angiography as the First Element of an Imaging Assessment Following Stroke / TIA

the past 10 days, ABCD2 score greater than 3) without haemorrhage Exclusion Criteria: The patient is currently participating in or has participated in another biomedical research study within the past three months or is currently in an exclusion period determined by a previous study. Patient under guardianship or judicial protection Refusal to sign the consent Inability to correctly inform the patient or his/her trusted person about the study The patient is pregnant, parturient, or breastfeeding

2015 Clinical Trials

78. Cerebral Microbleeds and Early Recurrent Stroke After Transient Ischemic Attack: Results from the Korean Transient Ischemic Attack Expression Registry. Full Text available with Trip Pro

Cerebral Microbleeds and Early Recurrent Stroke After Transient Ischemic Attack: Results from the Korean Transient Ischemic Attack Expression Registry. The risk of early recurrent stroke after transient ischemic attack (TIA) may be modifiable by optimal treatment. Although ABCD2 scores, diffusion-weighted imaging lesions, and large artery stenosis are well known to predict early stroke recurrence, other neuroimaging parameters, such as cerebral microbleeds (CMBs), have not been well explored (...) manifestations, neuroimaging findings, and use of antithrombotics or statins also were analyzed.A total of 500 patients (mean age, 64 years; male, 291 [58.2%]; median ABCD2 score, 4) completed 90-day follow-up with guideline-based management: antiplatelets (457 [91.4%]), anticoagulants (74 [14.8%]), and statins (345 [69.0%]). Recurrent stroke occurred in 25 patients (5.0%). Compared with patients without recurrent stroke, those with recurrent stroke were more likely to have crescendo TIA (20 [4.2%] vs 4

2015 JAMA neurology

79. Platelet Reactivity in Acute Non-disabling Cerebrovascular Events

, randomized, multi-centre, open-label, active-controlled, blinded-endpoint trial (a PROBE design concerning clinical trial). A total of approximately 952 patients (40years≤Age<80years) with high-risk TIA (defined as an ABCD2 score ≥ 4 or the stenosis of offending vessel ≥ 50%) or minor ischemic stroke (defined as an NIHSS ≤ 3), who can be treated within 24 hours of symptom onset will be enrolled. Patients fulfilling all of the inclusion criteria and none of the exclusion criteria will be randomized 1:1 (...) with study drug within 24 hours of symptoms onset defined by the"last see normal"principle. TIA (Neurological deficit attributed to focal brain ischemia, with resolution of the deficit within 24 hours of symptom onset), that can be treated with study drug within 24 hours of symptoms onset and with moderate-to-high risk of stroke recurrence (ABCD2 score ≥ 4 at the time of randomization or the stenosis of offending vessel ≥ 50%). Exclusion Criteria: Diagnosis of hemorrhage or other pathology

2015 Clinical Trials

80. Acute Isolated Dysarthria Is Associated with a High Risk of Stroke Full Text available with Trip Pro

, and death. Isolated dysarthria was defined as slurring with imprecise articulation but without evidence of language dysfunction. The overall rate of stroke in this cohort was compared with that predicted by the median ABCD2 score for this group.Between 2006 and 2009, 1,528 patients were enrolled and had a 90-day follow-up. Of these, 43 patients presented with isolated acute-onset dysarthria (2.8%). Recurrent stroke occurred in 6/43 (14.0%) within 90 days of enrollment. The predicted maximal 90-day (...) stroke rate was 9.8% (based on a median ABCD2 score of 5 for the isolated dysarthria cohort). After adjusting for covariates, isolated dysarthria independently predicted stroke within 90 days (aOR: 3.96; 95% CI: 1.3-11.9; p = 0.014).The isolated dysarthria cohort carried a recurrent stroke risk comparable to that predicted by the median ABCD2 scores. Although isolated dysarthria is a nonspecific and uncommon clinical presentation of TIA, these findings support the need to view it first and foremost

2014 Cerebrovascular Diseases Extra

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