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24 Hour Urine Protein

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1. Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. (PubMed)

Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. Proteinuria monitoring is required in patients receiving lenvatinib, however, current methodology involves burdensome overnight urine collection.To determine whether the simpler urine protein:creatinine ratio (UPCR) calculated from spot urine samples could be accurately used for proteinuria monitoring in patients (...) receiving lenvatinib, we evaluated the correlation between UPCR and 24-hour urine protein results from the phase 3 REFLECT study. Paired data (323 tests, 154 patients) were analysed.Regression analysis showed a statistically significant correlation between UPCR and 24-hour urine protein (R2: 0.75; P < 2 × 10-16). A UPCR cut-off value of 2.4 had 96.9% sensitivity, 82.5% specificity for delineating between grade 2 and 3 proteinuria. Using this UPCR cut-off value to determine the need for further testing

2019 British Journal of Cancer

2. Correction: Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. (PubMed)

Correction: Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma. This article was originally published under a standard license to Publish, but has now been made available under a CC BY license. The PDF and HTML versions of the paper have been modified accordingly.An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2019 British Journal of Cancer

3. Single urine samples are just as good as 24-hour collections for diagnosing pre-eclampsia

a single sample of urine for predicting severe pre-eclampsia with traditional tests on a urine sample taken over 24-hours. The findings suggest that spot albumin-creatinine or protein-creatinine ratios could be used in place of 24-hour urine collection and testing. Each can potentially rule-out women at risk of severe pre-eclampsia while being cheaper, quicker and more acceptable to women. The study supports current NICE recommendations on the use of spot protein-creatinine ratio. Further guideline (...) for around 20% of stillbirths and up to 10% of preterm births. Early detection and active management are therefore essential. Measuring the urine protein excreted over 24 hours is one way of quantifying the proteinuria. However, other tests on single samples, are more convenient and less time-consuming. They could also be a more accurate measure of protein excretion and better tests for ruling out pre-eclampsia. This study aimed to see whether the spot protein-creatinine ratio (SPCR) and spot albumin

2019 NIHR Dissemination Centre

4. Spot urine protein/creatinine ratio as a reliable estimate of 24-hour proteinuria in patients with immunoglobulin A nephropathy, but not membranous nephropathy. (PubMed)

Spot urine protein/creatinine ratio as a reliable estimate of 24-hour proteinuria in patients with immunoglobulin A nephropathy, but not membranous nephropathy. Proteinuria is known to be associated with both kidney function deterioration and cardiovascular diseases. While proteinuria estimation from 24-h urine samples has traditionally been considered as the standard method for assessment of the degree of urinary protein excretion, sample collection is associated with several technical (...) problems such as inaccurate collection and the potential spread of drug-resistant pathogens. Therefore, the spot urine protein/creatinine ratio (PCR) assessment is currently recommended as an alternative. While the utility of PCR has been validated, studies on the association between spot urine PCR and 24-h proteinuria (24HP) in patients with chronic glomerular nephritis (CGN) and nephrotic syndrome (NS) are limited. This study aimed to evaluate whether an estimated result from a spot urine PCR could

2019 BMC Nephrology

5. Serum free light chain measurements to reduce 24-hour urine monitoring in patients with multiple myeloma with measurable urine monoclonal protein. (PubMed)

Serum free light chain measurements to reduce 24-hour urine monitoring in patients with multiple myeloma with measurable urine monoclonal protein. Detection of myeloma progression (PD) relies on serial 24-h urinary M protein measurements in patients without measurable serum M spike. We examined whether serial difference free light chain (dFLC) levels could be used as a surrogate for serial 24-h urine M protein measurements in monitoring for PD in patients with baseline measurable urine M (...) increase of > 10 mg/dL, and 98% had 1 of the 2. We conclude that serial dFLC assessments can be used in place of serial 24-h urine protein assessments during myeloma surveillance to monitor for PD. Once patients have an absolute increase in dFLC of >10 mg/dL from the nadir, a 24-h urine collection can then be assessed to document PD as per the International Myeloma Working Group criteria.© 2018 Wiley Periodicals, Inc.

2018 American journal of hematology

6. Management of Suspected Preeclampsia Based on 6-hour Versus 24-hour Urine Protein Collection

Management of Suspected Preeclampsia Based on 6-hour Versus 24-hour Urine Protein Collection Management of Suspected Preeclampsia Based on 6-hour Versus 24-hour Urine Protein Collection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Management of Suspected Preeclampsia Based on 6-hour Versus 24-hour Urine Protein Collection The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03724786 Recruitment Status : Enrolling by invitation First Posted : October 30, 2018 Last Update Posted : February 1, 2019 Sponsor

2018 Clinical Trials

7. Single urine samples are just as good as 24-hour collections for diagnosing pre-eclampsia

a single sample of urine for predicting severe pre-eclampsia with traditional tests on a urine sample taken over 24-hours. The findings suggest that spot albumin-creatinine or protein-creatinine ratios could be used in place of 24-hour urine collection and testing. Each can potentially rule-out women at risk of severe pre-eclampsia while being cheaper, quicker and more acceptable to women. The study supports current NICE recommendations on the use of spot protein-creatinine ratio. Further guideline (...) for around 20% of stillbirths and up to 10% of preterm births. Early detection and active management are therefore essential. Measuring the urine protein excreted over 24 hours is one way of quantifying the proteinuria. However, other tests on single samples, are more convenient and less time-consuming. They could also be a more accurate measure of protein excretion and better tests for ruling out pre-eclampsia. This study aimed to see whether the spot protein-creatinine ratio (SPCR) and spot albumin

2018 NIHR Dissemination Centre

8. Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH (PubMed)

Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood.We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammonia (NH3) metabolism (15 biological candidates selected a priori, 1 selected from a previous genome-wide association study analysis) to that of 24-hour urine pH in 2493 individuals (...) of European descent across 2 different cohorts using linear regression, adjusting for age, sex, and body mass index.Of 2871 total SNPs in these genes, 13 SNPs in ATP6V0A4 (a4 subunit of hydrogen- adenosine triphosphatase), SLC9A3 (sodium/hydrogen exchanger, isoform 3), and RHCG (Rhesus C glycoprotein), and 12 SNPs from insulin-like growth factor binding protein 7 (IGFBP7) had a meta-analysis P value <0.01 in the joint analysis plus a consistent direction of effect and at a least suggestive association (P

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2017 Kidney international reports

9. Split 24 Hour Urine Protein

Split 24 Hour Urine Protein Split 24 Hour Urine Protein Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Split 24 Hour Urine Protein (...) Split 24 Hour Urine Protein Aka: Split 24 Hour Urine Protein II. Indication Suspected III. Technique See Start collection after first morning void (e.g. 7 am) Bottle 1 Collect daytime urine sample over first 16 hours Void immediately before bedtime Bottle 2 Collect 8 hour overnight (supine) specimen Include first morning void in collection IV. Interpretation Glomerular disease: Bottle 2 with >50 mg Protein : Bottle 2 with <50 mg Protein Images: Related links to external sites (from Bing

2018 FP Notebook

10. 24 Hour Urine Protein

24 Hour Urine Protein 24 Hour Urine Protein Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 24 Hour Urine Protein 24 Hour Urine (...) Protein Aka: 24 Hour Urine Protein , Urine Protein 24 Hour II. Technique See III. Interpretation of 24 Hour Urine Protein Confirm Sample adequacy Calculate expected 24 hour excretion Inadequate sample suggested if discrepancy Findings Normal < 4 mg/m2/hour (<150 mg/day) Abnormal 4-40 mg/m2/hour > 40 mg/m2/hour Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "24 Hour Urine Protein." Click on the image (or right click) to open

2018 FP Notebook

11. The relatively poor correlation between random and 24-hour urine protein excretion in patients with biopsy-proven glomerular diseases. (PubMed)

The relatively poor correlation between random and 24-hour urine protein excretion in patients with biopsy-proven glomerular diseases. Random urine protein creatinine ratios are used to estimate 24-hour urine protein excretion, which is considered a diagnostic gold standard. However, few studies are available of the sensitivity and specificity of this estimation in patients with glomerular proteinuria. To clarify this, we measured the urine protein and creatinine centrally in random and 24-hour (...) urine collections at biopsy and longitudinally every 6 months in individuals participating in the Nephrotic Syndrome Study Network (NEPTUNE) cohort with glomerular disease. In the initial developmental cohort, 302 patients had same day random and 24-hour samples with a total of 827 paired measurements across all visits. The protein excretion (g/day) was higher in adult than pediatric patients. The correlation between the random urine protein creatinine ratio and 24-hour urine protein excretion

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2016 Kidney International

12. Comparison of 12-hour urine protein and protein:creatinine ratio with 24-hour urine protein for the diagnosis of preeclampsia (PubMed)

Comparison of 12-hour urine protein and protein:creatinine ratio with 24-hour urine protein for the diagnosis of preeclampsia The purpose of this study was to evaluate the performance of the 12-hour urine protein >165 mg and protein:creatinine ratio >0.15 for the prediction of 24-hour urine protein of ≥300 mg in patients with suspected preeclampsia.We performed a prospective observational study of 90 women who had been admitted with suspected preeclampsia. Protein:creatinine ratio and 12 (...) - and 24-hour urine specimens were collected for each patient. Test characteristics for the identification of 24-hour urine protein ≥300 mg were calculated.A 12-hour urine protein >165 mg and protein:creatinine ratio of >0.15 correlated significantly with 24-hour urine protein ≥300 mg (r = 0.99; P < .001; and r = 0.54; P < .001, respectively). A 12-hour urine protein >165 mg performed better than protein:creatinine ratio as a predictor of a 24-hour urine protein ≥300 mg (sensitivity, 96% and 89

2012 EvidenceUpdates

13. Efficacy of urine urea nitrogen measurement to assess the compliance with protein restricted diets. (PubMed)

received a diet with the same amount of calories and 0.6 g/kg of proteins. At baseline, seven days and 14 days, 24 h dietary recalls were answered by the participants. They collected 24 hour urine and provided spot urine samples at baseline and at the end of the intervention, to measure creatinine and urea nitrogen. Results: forty-one participants aged 29 ± 5 years completed the follow-up. According to 24h dietary recalls, the group receiving 0.6 g/kg protein reduced significantly the protein intake (...) was observed. No changes were observed in urea nitrogen excretion in spot urine samples. Conclusions: repeated urea nitrogen excretion measured in 24 h urine samples can be a reliable indicator of dietary protein restriction.

2019 Nutricion hospitalaria Controlled trial quality: uncertain

14. Establishing equations to evaluate 24 hour urine protein excretion using routine urinalysis. (PubMed)

Establishing equations to evaluate 24 hour urine protein excretion using routine urinalysis. It is necessary to screen people at high risk for proteinuria with an economical, reliable and convenient method. The aim of this study is to establish a new approach to predict 24 h urine protein (24 h UP) by routine laboratory assays.Five centres were included and a total of 4211 hospitalized patients were enrolled. All samples were assayed for dipstick protein (DSP), specific gravity (SG), 24 h UP (...) and serum albumin (ALB) simultaneously. 4211 patients were randomly divided into two groups for establishing and testing the equations. Equations were built by multiple log-linear regressions.(i) DSP is significantly correlated to 24 h UP in a logarithmic pattern; (ii) SG interprets 24 h UP for specific DSP; (iii) Equation 1 = 0.203 × 10(dummy-variable F)  × [100 (SG-1)](-0.470) ; and (iv) Equation 2 = 13.366 × 10(dummy-variable F)  × [100 (SG-1)](-0.547)  × [ALB (g/L)](-1.130) The dummy-variable F had

2014 Nephrology (Carlton, Vic.) Controlled trial quality: uncertain

15. The Urine Preservative Acetic Acid Degrades Urine Protein: Implications for Urine Biorepositories and the AASK Cohort Study. (PubMed)

samples of 37 patients with AASK-N, with 24-hour protein-to-creatinine ratios (milligrams per milligram) ranging from 0.2 to 1.0, from the National Institute of Diabetes and Digestive Kidney Diseases repository and tested for seven markers of tubular proteinuria. By protocol, each sample had been collected in acetic acid (0.5%; mean final concentration). Compared with samples from patients with lupus nephritis or healthy black controls, AASK-N samples had lower amounts of six markers. Four markers (...) The Urine Preservative Acetic Acid Degrades Urine Protein: Implications for Urine Biorepositories and the AASK Cohort Study. Patients enrolled in the African American Study of Kidney Disease and Hypertension (AASK) Cohort Study who exhibited overt proteinuria have been reported to show high nonalbumin proteinuria (NAP), which is characteristic of a tubulopathy. To determine whether African American Study of Kidney Disease and Hypertension nephropathy (AASK-N) is a tubulopathy, we obtained urine

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2017 Journal of the American Society of Nephrology

16. Predictive value of spot versus 24-hour measures of proteinuria for death, end-stage kidney disease or chronic kidney disease progression. (PubMed)

with 144 proteinuric CKD and kidney transplant recipients attending an outpatient clinic of a tertiary care hospital in Australia. We concurrently collected morning spot urine protein-to-creatinine ratio (UPCR), albumin-to-creatinine ratio (UACR) and 24-h urinary protein excretion (24-UPE) from each participant at baseline. The primary outcome was a composite of death, ESKD or > 30% decline in eGFR over 5-years. Secondary outcomes were each component of the composite outcome. For each proteinuria (...) Predictive value of spot versus 24-hour measures of proteinuria for death, end-stage kidney disease or chronic kidney disease progression. Proteinuria is well recognised as a marker of chronic kidney disease (CKD), as a risk factor for progression of CKD among those with known CKD, and as a risk factor for cardiovascular events and death among both the general and CKD populations. Which measure of proteinuria is most predictive of renal events remains uncertain.We conducted a prospective study

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2018 BMC Nephrology

17. Effect of common storage temperatures and container types on urine protein : creatinine ratios in urine samples of proteinuric dogs (PubMed)

in HP, PC, and glass containers at 24°C for 4 hours, 4°C for 12 hours, and -20°C for 72 hours. The UPC of each was measured after storage and compared with baseline.Statistically significant but clinically irrelevant differences were found in phase 1. In phase 2, storage conditions did not affect urinary protein or creatinine concentrations or UPC.Collection and storage of canine urine samples in clean HP, PC, or glass containers at 24°C for 4 hours, 4°C for 12 hours, or -20°C for 72 hours (...) after storage in glass, PC, or HP containers using common storage times and temperatures.Twelve client-owned dogs with proteinuria.Prospective, nonmasked study, divided into 2 phases. The first phase was a pilot study involving multiple (n = 5) measurements at each storage condition using 24-hours urine samples from 2 dogs with persistent renal proteinuria of different magnitude. The second phase used urine samples from 10 dogs with proteinuria of variable magnitude. Sample aliquots were stored

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2018 Journal of Veterinary Internal Medicine

18. Limited Reliability of the Spot Urine Protein/Creatinine Ratio in the Longitudinal Evaluation of Patients With Lupus Nephritis (PubMed)

Limited Reliability of the Spot Urine Protein/Creatinine Ratio in the Longitudinal Evaluation of Patients With Lupus Nephritis Cross-sectional studies document that the spot protein/creatinine ratio (PCR) is often an inaccurate estimate of proteinuria magnitude compared with the 24-hour PCR, which is the gold standard. However, the extent to which the inaccuracy of the spot PCR varies over time and between individuals has not previously been reported. We address these crucial questions using (...) a unique database, an National Institutes of Health trial in which lupus nephritis (LN) patients (N = 103) provided spot PCR testing each month and 24-hour PCR testing every 3 months for up to 15 months after induction therapy.A gold standard proteinuria trend line was constructed for each patient by joining the points that represented the serial 24-hour PCR values of the patient. The spot PCR values of the patient were then plotted in relationship to the 24-hour PCR trend line. Using our previous work

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2018 Kidney international reports

19. Relative Validity of Nutrient Intakes Assessed by Questionnaire, 24-Hour Recalls, and Diet Records Compared With Urinary Recovery and Plasma Concentration Biomarkers: Findings for Women. (PubMed)

Study (United States, 2010-2012). Two paper SFFQs, 1 Web-based SFFQ, 4 ASA24s (beta version), 2 7DDRs, 4 24-hour urine samples, 1 doubly labeled water measurement (repeated among 76 participants), and 2 fasting blood samples were collected over a 15-month period. The dietary variables evaluated were energy, energy-adjusted intakes of protein, sodium, potassium, and specific fatty acids, carotenoids, α-tocopherol, retinol, and folate. In general, relative to biomarkers, averaged ASA24s had lower (...) Relative Validity of Nutrient Intakes Assessed by Questionnaire, 24-Hour Recalls, and Diet Records Compared With Urinary Recovery and Plasma Concentration Biomarkers: Findings for Women. We evaluated the performance of a semiquantitative food frequency questionnaire (SFFQ), the Automated Self-Administered 24-Hour Dietary Recall (ASA24), and 7-day dietary records (7DDRs), in comparison with biomarkers, in the estimation of nutrient intakes among 627 women in the Women's Lifestyle Validation

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2017 American Journal of Epidemiology

20. Comparison of Urine Protein/Creatinine Ratio With 24-hour Urine Protein Excretion in Woman With Hypertensive Disorders

Comparison of Urine Protein/Creatinine Ratio With 24-hour Urine Protein Excretion in Woman With Hypertensive Disorders Comparison of Urine Protein/Creatinine Ratio With 24-hour Urine Protein Excretion in Woman With Hypertensive Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Comparison of Urine Protein/Creatinine Ratio With 24-hour Urine Protein Excretion in Woman With Hypertensive Disorders The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01508208 Recruitment Status : Completed First

2012 Clinical Trials

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