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81. Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure. Full Text available with Trip Pro

Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure. Acutely ill adults with hypoxaemic respiratory failure are at risk of life-threatening hypoxia, and thus oxygen is often administered liberally. Excessive oxygen use may, however, increase the number of serious adverse events, including death. Establishing the optimal oxygenation level (...) is important as existing evidence is of low quality. We hypothesise that targeting an arterial partial pressure of oxygen (PaO2 ) of 8 kPa is superior to targeting a PaO2 of 12 kPa in adult intensive care unit (ICU) patients with acute hypoxaemic respiratory failure.The Handling Oxygenation Targets in the ICU (HOT-ICU) trial is an outcome assessment blinded, multicentre, randomised, parallel-group trial targeting PaO2 in acutely ill adults with hypoxaemic respiratory failure within 12 hours after ICU

2019 Acta Anaesthesiologica Scandinavica Controlled trial quality: predicted high

82. The healthcare costs of intoxicated patients who survive ICU admission are higher than non-intoxicated ICU patients: a retrospective study combining healthcare insurance data and data from a Dutch national quality registry. Full Text available with Trip Pro

The healthcare costs of intoxicated patients who survive ICU admission are higher than non-intoxicated ICU patients: a retrospective study combining healthcare insurance data and data from a Dutch national quality registry. The aim of this study was to describe the healthcare costs of intoxicated ICU patients in the year before and the year after ICU admission, and to compare their healthcare costs with non-intoxicated ICU patients and a population based control group.We conducted (...) a retrospective cohort study, combining a national health insurance claims database and a national quality registry database for ICUs. Claims data in the timeframe 2012 until 2014 were combined with the clinical data of patients who had been admitted to an ICU during 2013. Three study populations were compared and matched according to socioeconomic status, type of admission, age and gender: an "ICU population", an "intoxication population" and a "control population" (who had never been on the ICU).2591

2019 BMC Emergency Medicine

83. Candidemia in an Irish intensive care unit (ICU) setting between 2004 and 2018 reflects increased incidence of Candida glabrata. Full Text available with Trip Pro

Candidemia in an Irish intensive care unit (ICU) setting between 2004 and 2018 reflects increased incidence of Candida glabrata. The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher (...) mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.Copyright © 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

2019 Journal of Hospital Infection

84. Serial Daily Organ Failure Assessment Beyond ICU Day 5 Does Not Independently Add Precision to ICU Risk-of-Death Prediction Full Text available with Trip Pro

Serial Daily Organ Failure Assessment Beyond ICU Day 5 Does Not Independently Add Precision to ICU Risk-of-Death Prediction To identify circumstances in which repeated measures of organ failure would improve mortality prediction in ICU patients.Retrospective cohort study, with external validation in a deidentified ICU database.Eleven ICUs in three university hospitals within an academic healthcare system in 2014.Adults (18 yr old or older) who satisfied the following criteria: 1) two of four (...) systemic inflammatory response syndrome criteria plus an ordered blood culture, all within 24 hours of hospital admission; and 2) ICU admission for at least 2 calendar days, within 72 hours of emergency department presentation.NoneMEASUREMENTS AND MAIN RESULTS:: Data were collected until death, ICU discharge, or the seventh ICU day, whichever came first. The highest Sequential Organ Failure Assessment score from the ICU admission day (ICU day 1) was included in a multivariable model controlling

2017 EvidenceUpdates

85. Development and validation of a dynamic delirium prediction rule in patients admitted to the Intensive Care Units (DYNAMIC-ICU): A prospective cohort study. (Abstract)

Development and validation of a dynamic delirium prediction rule in patients admitted to the Intensive Care Units (DYNAMIC-ICU): A prospective cohort study. Delirium is one of the most common cognitive complications among patients admitted to the intensive care units (ICU).To develop and validate a DYNAmic deliriuM predICtion rule for ICU patients (DYNAMIC-ICU) and to stratify patients into different risk levels among patients in various types of ICUs.Prospective cohort study.A total of 560 (...) (median age of 66 years, 62.5% male) consecutively enrolled patients from four ICUs were included in the study. The patients were randomly assigned into either the derivation (n = 336, 60%) or the validation (n = 224, 40%) cohort by stratified randomization based on delirium/non-delirium and types of ICU.The simplified Chinese version of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was used to assess delirium until patients were discharged from the ICUs. Potential predisposing

2019 International journal of nursing studies Controlled trial quality: uncertain

86. Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit

Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

87. Preventing pressure injuries in intubated patients in ICU

Preventing pressure injuries in intubated patients in ICU Preventing pressure injuries in intubated patients 1 Preventing pressure injuries in intubated patients in ICU Citation Garrubba M. 2017. Preventing pressure injuries in intubated patients in ICU: Systematic Review. Centre for Clinical Effectiveness, Monash Innovation and Quality, Monash Health, Melbourne, Australia. Background Monash Health Intensive Care Unit have requested a review of the literature to determine best practice (...) for preventing facial, tongue and oral pressure injuries in intubated patients. Question What is best practice for preventing facial, tongue and oral pressure injuries in intubated patients in the intensive care setting? - What is the incidence of pressure injuries in intubated patients in ICU/PICU? - What is best practice for securing endotracheal tubes (ETT) or nasogastric tubes for airway security, ease of use, infection control and skin integrity? Methods A systematic search of papers in English from

2017 Monash Health Evidence Reviews

88. Is there a difference in PAC versus no-PAC in surgical cardiac and ICU patients?

OR 1-6 8 exp Critical care/ 9 exp Intensive-Care-Units/ 10 critical care unit*.mp. 11 ((intensiv* or critical or post?an?esthesia) adj5 care unit).mp. 12 high dependency unit*.mp. 13 critical care.ti,ab. 14 Exp thoracic surgery/ 15 exp Operating Rooms/ 16 OR 8-15 17 7 AND 16 18 limit 17 to (english language and humans and yr="2012 -Current") *(Similar terms (appropriately translated) were used in other databases.) Table 4. Information sources and search terms Information sources (searches conducted (...) recommendation 7 . Results It should be noted that the high quality review with meta-analysis 6 included in this report only contained one study detailing the outcomes of cardiac surgery patients. As a result, the findings of this paper 6 relate predominantly to general intensive care patients, and this must be kept in mind when interpreting the summary of results. Overall summary of results regarding main outcomes of interest Author Year Mortality Complications Days in ICU Days in hospital Cost Cochrane

2017 Monash Health Evidence Reviews

89. Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Full Text available with Trip Pro

. 5 Ingram School of Nursing, McGill University, Montreal, QC, Canada. 6 Division of Pulmonary and Critical Care Medicine, Department of Physical Medicine and Rehabilitation, School of Medicine, Johns Hopkins University, Baltimore, MD. 7 Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center, Utrecht University, Utrecht, The Netherlands. 8 Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University Medical Center (...) of Surgery, New York University Langone Health, New York, NY. 15 Department of Medicine (Critical Care), McMaster University, Hamilton, ON, Canada. 16 Department of Health Research Methods, Impact and Evidence, McMaster University, Hamilton, ON, Canada. 17 The Ohio State University, College of Nursing, Center of Excellence in Critical and Complex Care, Columbus, OH. 18 The Ohio State University Wexner Medical Center, Columbus, OH. 19 Department of Intensive Care Medicine, Radboud University Medical

2018 Society of Critical Care Medicine

90. Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial

Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

91. Peripherally inserted central catheters are associated with lower risk of bloodstream infection compared with central venous catheters in paediatric intensive care patients: a propensity-adjusted analysis

Peripherally inserted central catheters are associated with lower risk of bloodstream infection compared with central venous catheters in paediatric intensive care patients: a propensity-adjusted analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

92. Delirium and Benzodiazepines Associated With Prolonged ICU Stay in Critically Ill Infants and Young Children

Delirium and Benzodiazepines Associated With Prolonged ICU Stay in Critically Ill Infants and Young Children PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

93. Intensive care for pediatric traumatic brain injury

Intensive care for pediatric traumatic brain injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

94. Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial

Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

95. Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit

Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

96. Single-Dose Etomidate Is Not Associated With Increased Mortality in ICU Patients With Sepsis: Analysis of a Large Electronic ICU Database

Single-Dose Etomidate Is Not Associated With Increased Mortality in ICU Patients With Sepsis: Analysis of a Large Electronic ICU Database PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2013 PedsCCM Evidence-Based Journal Club

97. Early Palliative Care Reduces End‐of‐Life Intensive Care Unit (ICU) Use but Not ICU Course in Patients with Advanced Cancer Full Text available with Trip Pro

Early Palliative Care Reduces End‐of‐Life Intensive Care Unit (ICU) Use but Not ICU Course in Patients with Advanced Cancer Early palliative care for advanced cancer patients improves quality of life and survival, but less is known about its effect on intensive care unit (ICU) use at the end of life. This analysis assessed the effect of a comprehensive early palliative care program on ICU use and other outcomes among patients with advanced cancer.A retrospective cohort of patients (...) location, and outcomes after ICU admission.Early palliative care significantly reduced ICU use at the end of life but did not change ICU events. This study supports early initiation of palliative care for advanced cancer patients before hospitalizations and intensive care. The Oncologist 2017;22:318-323 IMPLICATIONS FOR PRACTICE: Palliative care has shown clear benefit in quality of life and survival in advanced cancer patients, but less is known about its effect on intensive care. This retrospective

2017 The oncologist

98. The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs Full Text available with Trip Pro

The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs Post-intensive care syndrome includes the multiple consequences of an intensive care unit (ICU) stay for patients and families. It has become a new challenge for intensivists. Prevention programs have been disappointing, except for ICU diaries, which report the patient's story in the ICU. However, the effectiveness of ICU diaries for patients (...) and families is still controversial, as the interpretation of the results of previous studies was open to criticism hampering an expanded use of the diary. The primary objective of the study is to evaluate the post-traumatic stress syndrome in patients. The secondary objectives are to evaluate the post-traumatic stress syndrome in families, anxiety and depression symptoms in patients and families, and the recollected memories of patients. Endpoints will be evaluated 3 months after ICU discharge or death.A

2017 Trials Controlled trial quality: uncertain

99. Variation in rates of ICU readmissions and post-ICU in-hospital mortality and their association with ICU discharge practices. Full Text available with Trip Pro

Variation in rates of ICU readmissions and post-ICU in-hospital mortality and their association with ICU discharge practices. Variation in intensive care unit (ICU) readmissions and in-hospital mortality after ICU discharge may indicate potential for improvement and could be explained by ICU discharge practices. Our objective was threefold: (1) describe variation in rates of ICU readmissions within 48 h and post-ICU in-hospital mortality, (2) describe ICU discharge practices in Dutch hospitals (...) , and (3) study the association between rates of ICU readmissions within 48 h and post-ICU in-hospital mortality and ICU discharge practices.We analysed data on 42,040 admissions to 82 (91.1%) Dutch ICUs in 2011 from the Dutch National Intensive Care Evaluation (NICE) registry to describe variation in standardized ICU readmission and post-ICU mortality rates using funnel-plots. We send a questionnaire to all Dutch ICUs. 75 ICUs responded and their questionnaire data could be linked to 38,498 admissions

2017 BMC health services research

100. Nurses and physicians bring different perspectives to end-of-life decisions in intensive care units

-of-life decisions in intensive care units Natalie S McAndrew Correspondence to Dr Natalie S McAndrew, Froedtert and the Medical College of Wisconsin, Froedtert Hospital, Milwaukee, WI 53226, USA; natalie.mcandrew{at}froedtert.com Statistics from Altmetric.com Commentary on : Laurent A, Bonnet M, Capellier G, et al . Emotional impact of end-of-life decisions on professional relationships in the ICU: an obstacle to collegiality? Crit Care Med . 2017;45:2023–30. doi:10.1097/CCM.0000000000002710 (...) for patients, family members, as well as healthcare professionals, and occur frequently in the intensive care unit (ICU) setting. 1–3 It is well documented that communication challenges during decisions about life-sustaining treatments are a source of moral distress. 2 4 Inadequate nurse–physician collaboration … Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get

2018 Evidence-Based Nursing

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