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1. Computed tomography to rule out suspected appendicitis in adults and reduce the negative appendectomy rate

. Publication date: last 5 years. Publication type: comparative study/review/clinical trial (where possible). Date searched 29/03/2016 CT to rule out suspected appendicitis in adults and reduce the negative appendectomy rate: August 2016 18 References 1. National Institute of Biomedical Imaging and Bioengineering (2016). Computed tomography (CT). Available from: https://www.nibib.nih.gov/science- education/science-topics/computed-tomography-ct [Accessed May 3rd 2016]. 2. Lehtimaki, T., Juvonen, P. et al (...) not meet inclusion criteria (CT N = 2; SIP N = 4), withdrew consent (CT N = 1; SIP N = 3) or had missing data (CT N = 4; SIP N = 32). There were no significant differences in the treatment groups with regards to age, sex, diagnoses or surgical operation rate. There was a tendency for a lower proportion of non-specific abdominal pain diagnoses in the CT group at discharge, by final diagnosis this difference had reached statistical significance (p=0.043). The mean total treatment cost per patient who

2016 COAG Health Council - Horizon Scanning Technology Briefs

2. Computational Design, Fabrication, and Evaluation of Optimized Patient-Specific Transtibial Prosthetic Sockets

: NCT03544853 Recruitment Status : Recruiting First Posted : June 4, 2018 Last Update Posted : January 14, 2019 See Sponsor: Massachusetts Institute of Technology Collaborator: National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): Massachusetts Institute of Technology Study Details Study Description Go to Brief Summary: The overall goal of this study is to further develop and clinically assess a computational and data-driven design (...) information United States, Massachusetts Massachusetts Institute of Technology, Media Lab Recruiting Cambridge, Massachusetts, United States, 02142 Contact: Hugh M Herr, PhD 617-253-6780 Contact: Dana Solav, PhD 617 324 8485 Sponsors and Collaborators Massachusetts Institute of Technology National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator: Hugh M Herr, PhD Massachusetts Institute of Technology, Media Lab Study

2018 Clinical Trials

3. Developing Fast Pediatric Imaging

is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03761121 Recruitment Status : Not yet recruiting First Posted : December 3, 2018 Last Update Posted : December 4, 2018 See Sponsor: Dana-Farber Cancer Institute Collaborator: National Institute for Biomedical Imaging and Bioengineering (...) recruiting Boston, Massachusetts, United States, 02215 Contact: Susan N Chi, MD 617-632-3000 Principal Investigator: Susan N Chi, MD Sponsors and Collaborators Dana-Farber Cancer Institute National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator: Kawin Setsompop, PhD Boston Children Hospital/ Massachusetts General Hospital More Information Go to Layout table for additonal information Responsible Party: Kawin

2018 Clinical Trials

4. Cost-effectiveness analysis of Chlamydia trachomatis screening via internet-based self-collected swabs compared with clinic-based sample collection

Supported by grants from the National Institute of Biomedical Imaging and Bioengineering, USA. Bibliographic details Huang W, Gaydos CA, Barnes MR, Jett-Goheen M, Blake DR. Cost-effectiveness analysis of Chlamydia trachomatis screening via internet-based self-collected swabs compared with clinic-based sample collection. Sexually Transmitted Diseases 2011; 38(9): 815-820 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Ambulatory Care Facilities; Chlamydia Infections (...) Chlamydia trachomatis screening. The time horizon was 10 years. The authors reported that the perspective was that of the public health care system. Effectiveness data: The clinical and effectiveness data were from a number of sources, including data collected from July 2004 to June 2010 as part of the evaluation of the self-testing website, and published studies. The relative screening rates were from a study comparing home-based screening to clinic-based screening. A literature search in PubMed

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2012 NHS Economic Evaluation Database.

5. Science News » NIH Names Winners of “Follow that Cell” Phase 2 Competition

that achieve the program’s objectives. It de-risks an inherently risky goal,” said , director of NIH’s Division of Program Coordination, Planning and Strategic Initiatives (DPCPSI), which harbors the NIH Common Fund, whose sponsored the challenge, with additional leadership provided by the National Institute of Mental Health (NIMH) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB). In March of 2015, NIH selection of 16 finalists from Phase 1 of the competition, which sought (...) in the Division of Program Coordination, Planning, and Strategic Initiatives in the NIH Office of the Director in partnership with the NIH Institutes, Centers, and Offices. More information is available at the Common Fund website: . About the National Institute of Mental Health (NIMH): The mission of the . About the National Institute of Biomedical Imaging and Bioengineering (NIBIB): NIBIB’s mission is to support multidisciplinary research and research training at the crossroads of engineering

2017 NIMH blog

6. C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions

: University of Wisconsin, Madison Collaborator: National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): University of Wisconsin, Madison Study Details Study Description Go to Brief Summary: The overarching objective of our proposal is to develop a One-Stop-Shop imaging using the available C-arm Cone-Beam Computed Tomography (CBCT) data acquisition systems currently widely available worldwide in interventional angiography suites to enable acute (...) for location information United States, Wisconsin University of Wisconsin, Madison Recruiting Madison, Wisconsin, United States, 53705 Contact: Gemma Gliori, MS 608-262-7269 Contact: Beverly Aagaard-Kienitz, MD 608-263-8329 Sub-Investigator: Guang-Hong Chen, PhD Sub-Investigator: Charles Strothers, MD Sponsors and Collaborators University of Wisconsin, Madison National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator

2017 Clinical Trials

7. Biokinetics Study for F-18 FDG in Pediatric Molecular Imaging

States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 Sponsors and Collaborators Boston Children’s Hospital National Institute for Biomedical Imaging and Bioengineering (NIBIB) Johns Hopkins University University of Florida Investigators Layout table for investigator information Principal Investigator: Frederic H Fahey, DSc Boston Children’s Hospital More Information Go to Publications of Results: Other Publications: Layout table for additonal information (...) in Pediatric Molecular Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03107325 Recruitment Status : Enrolling by invitation First Posted : April 11, 2017 Last Update Posted : February 12, 2019 Sponsor: Boston Children’s Hospital Collaborators: National Institute for Biomedical Imaging

2017 Clinical Trials

8. Biokinetics Study for Tc-99m MAG3 in Pediatric Molecular Imaging

Children’s Hospital Collaborators: National Institute for Biomedical Imaging and Bioengineering (NIBIB) Johns Hopkins University University of Florida Information provided by (Responsible Party): Frederic Fahey, Boston Children’s Hospital Study Details Study Description Go to Brief Summary: The radiation exposure resulting from medical imaging is a topic of some concern. Nuclear medicine provides potentially life-saving information regarding physiological processes, and is of particular value in children (...) Sponsors and Collaborators Boston Children’s Hospital National Institute for Biomedical Imaging and Bioengineering (NIBIB) Johns Hopkins University University of Florida Investigators Layout table for investigator information Principal Investigator: Frederic H Fahey, DSc Boston Children’s Hospital More Information Go to Publications: Layout table for additonal information Responsible Party: Frederic Fahey, Professor of Radiology, Boston Children’s Hospital ClinicalTrials.gov Identifier: Other Study ID

2017 Clinical Trials

9. Biokinetics Study for Tc-99m MDP in Pediatric Molecular Imaging

or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03107247 Locations Layout table for location information United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 Sponsors and Collaborators Boston Children’s Hospital National Institute for Biomedical Imaging and Bioengineering (NIBIB) Johns Hopkins University University (...) MDP in Pediatric Molecular Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03107247 Recruitment Status : Enrolling by invitation First Posted : April 11, 2017 Last Update Posted : February 12, 2019 Sponsor: Boston Children’s Hospital Collaborators: National Institute for Biomedical Imaging

2017 Clinical Trials

10. Biokinetics Study of Tc-99m DMSA in Pediatric Molecular Imaging

ClinicalTrials.gov identifier (NCT number): NCT03107195 Locations Layout table for location information United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 Sponsors and Collaborators Boston Children’s Hospital National Institute for Biomedical Imaging and Bioengineering (NIBIB) Johns Hopkins University University of Florida Investigators Layout table for investigator information Principal Investigator: Frederic H Fahey, DSc Boston Children’s Hospital More (...) DMSA in Pediatric Molecular Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03107195 Recruitment Status : Enrolling by invitation First Posted : April 11, 2017 Last Update Posted : February 12, 2019 Sponsor: Boston Children’s Hospital Collaborators: National Institute for Biomedical Imaging

2017 Clinical Trials

11. Enhancing Health Care Access With Cellular Technology

Technology The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03180138 Recruitment Status : Completed First Posted : June 8, 2017 Results First Posted : June 25, 2018 Last Update Posted : June 25, 2018 Sponsor: Johns Hopkins University Collaborators: National Institute for Biomedical Imaging (...) Institute for Biomedical Imaging and Bioengineering (NIBIB) Ministry of Science and Technology, India Bal Umang Drishya Sanstha (BUDS), India Royal Datamatics Pvt. Ltd. (RDPL), India St. Louis University Investigators Layout table for investigator information Principal Investigator: Sanjay K Jain, MD Johns Hopkins University Study Documents (Full-Text) Documents provided by Johns Hopkins University: [PDF] December 15, 2016 More Information Go to Layout table for additonal information Responsible Party

2017 Clinical Trials

12. Advanced Perfusion MRI of Treatment Response and Progression in Glioblastoma

, 2018 See Sponsor: University of Wisconsin, Madison Collaborators: National Cancer Institute (NCI) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): University of Wisconsin, Madison Study Details Study Description Go to Brief Summary: The primary aim of this project is to Compare new msCS and standard DSC-PWI methods in GBM patients undergoing post-operative MRI for monitoring of tumor progression. Condition or disease Intervention (...) of Wisconsin, Madison National Cancer Institute (NCI) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator: Alexey Samsonov University of Wisconsin, Madison More Information Go to Additional Information: Layout table for additonal information Responsible Party: University of Wisconsin, Madison ClinicalTrials.gov Identifier: Other Study ID Numbers: UW15098 2016-0007 ( Other Identifier: IRB number ) First Posted

2016 Clinical Trials

13. Ultrasound and Near Infrared Imaging for Predicting and Monitoring Neoadjuvant Treatment

7, 2016 Last Update Posted : February 18, 2019 See Sponsor: Washington University School of Medicine Collaborator: National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): Washington University School of Medicine Study Details Study Description Go to Brief Summary: To determine the accuracy of NIR/US assessment of tumor vasculature and oxygen changes in predicting and monitoring early neoadjuvant treatment response compared to pathological (...) : Haeseong Park, M.D. Sub-Investigator: Antonella Rastelli, M.D. Sub-Investigator: Rama Suresh, M.D. Sub-Investigator: Catherine Young, M.D. Sub-Investigator: Lindsay Peterson, M.D. Sponsors and Collaborators Washington University School of Medicine National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator: Steven Poplack, M.D. Washington University School of Medicine More Information Go to Additional Information

2016 Clinical Trials

14. 18F-FMAU PET/CT in Diagnosing and Characterizing Prostate Cancer

of Southern California Collaborators: National Cancer Institute (NCI) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): University of Southern California Study Details Study Description Go to Brief Summary: This pilot clinical trial studies how well fluorine F 18 d-FMAU (18F-FMAU) positron emission tomography (PET)/computed tomography (CT) works in diagnosing and characterizing prostate cancer. A PET/CT scan is an imaging test that uses (...) table for location information United States, California USC / Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Rosy Diaz 323-442-7469 Principal Investigator: Hossein Jadvar Sponsors and Collaborators University of Southern California National Cancer Institute (NCI) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator: Hossein Jadvar University

2016 Clinical Trials

15. Science News » Worldwide Study Seeks to Unlock the Brain’s Genetic Code

, 2019 March 19, 2019 March 13, 2019 March 11, 2019 February 20, 2019 News by Year News by Topic Disorders Populations Prevention Research Other . “The magnitude of this study is truly remarkable,” said Vinay Pai, Ph.D., director of the Division of Health Informatics Technologies at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the U.S. National Institutes of Health (NIH). “If you want to discover genes that affect the brain, the only way we know how to do (...) connections or its function using other brain imaging modalities such as diffusion tensor imaging or functional MRI. This research was funded in part by NIH grants EB020403 (funding provided by the NIH BD2K program and project managed by NIBIB). ### About the National Institute of Biomedical Imaging and Bioengineering (NIBIB): NIBIB’s mission is to support multidisciplinary research and research training at the crossroads of engineering and the biological and physical sciences. NIBIB supports emerging

2016 NIMH blog

16. Optic Nerve Ultrasound in Severe Traumatic Injury

India Institute of Medical Sciences, New Delhi National Institutes of Health (NIH) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): Venkatakrishna Rajajee, University of Michigan Study Details Study Description Go to Brief Summary: Prospective study of diagnostic accuracy of optic nerve sheath diameter measurement (index study) in traumatic brain injury with simultaneous invasive intracranial pressure monitoring as the reference (...) for location information India All India Institute of Medical Sciences (AIIMS) Recruiting New Delhi, India Contact: Deepak Agrawal, MD +919811282043 Contact: Renu Saini, PhD student 011-4040-1010 Principal Investigator: Deepak Agrawal, MD Sponsors and Collaborators University of Michigan All India Institute of Medical Sciences, New Delhi National Institutes of Health (NIH) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal

2015 Clinical Trials

17. 68Ga-NOTA-Aca-BBN(7-14) PET/CT in Patients With Primary Gliomas

Medical College Hospital Collaborator: National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): Peking Union Medical College Hospital Study Details Study Description Go to Brief Summary: This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-Aca-BBN(7-14) in glioma patients. A single dose of 111-148 Mega-Becquerel (MBq) 68Ga-NOTA-Aca-BBN (...) Beijing, Beijing, China, 100730 Contact: Jingjing Zhang, Dr. +86 15101033017 Principal Investigator: Fang Li, Dr. Sponsors and Collaborators Peking Union Medical College Hospital National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Study Chair: Fang Li, Dr. Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College More Information Go to Layout table for additonal information

2015 Clinical Trials

18. Motion Analysis of Delirium in the ICU

: Azra Bihorac, MD 352-273-8821 Locations Layout table for location information United States, Florida UF Health Recruiting Gainesville, Florida, United States, 32610 Contact: Sandhya A Chheda, JD 352-273-8820 Contact: Azra Bihorac, MD 352-273-8821 Sub-Investigator: Parisa Rashidi, PhD Sponsors and Collaborators University of Florida U.S. National Science Foundation National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal (...) for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still very limited in practice. A common characterization of delirium is changes in activity level, causing patients

2015 Clinical Trials

19. Ultrasound and Biomarker Tests in Predicting Cancer Aggressiveness in Tissue Samples of Patients With Bladder Cancer

. ClinicalTrials.gov Identifier: NCT02494635 Recruitment Status : Recruiting First Posted : July 10, 2015 Last Update Posted : July 2, 2018 See Sponsor: University of Southern California Collaborators: National Cancer Institute (NCI) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): University of Southern California Study Details Study Description Go to Brief Summary: This research trial studies two types of tests, an ultrasound test and a biomarker (...) / Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Andres Weitz 323-865-0648 Principal Investigator: Andres Weitz Sponsors and Collaborators University of Southern California National Cancer Institute (NCI) National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Principal Investigator: Andres Weitz University of Southern California More Information Go to Layout table for additonal

2015 Clinical Trials

20. Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB

Sponsor: Peking Union Medical College Hospital Collaborator: National Institute for Biomedical Imaging and Bioengineering (NIBIB) Information provided by (Responsible Party): Peking Union Medical College Hospital Study Details Study Description Go to Brief Summary: This is an open-label whole-body PET/CT study for investigation of radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and diagnostic performance of 68Ga-NEB in healthy volunteers and patients with suspected infection (...) PET centre Recruiting Beijing, Beijing, China, 100730 Contact: Jingjing Zhang, Dr. +86 15101033017 Principal Investigator: Fang Li, Dr. Sponsors and Collaborators Peking Union Medical College Hospital National Institute for Biomedical Imaging and Bioengineering (NIBIB) Investigators Layout table for investigator information Study Chair: Fang Li, Dr. Peking Union Medical College Hospital More Information Go to Layout table for additonal information Responsible Party: Peking Union Medical College

2015 Clinical Trials

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