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1. DASH, the data and specimen hub of the National Institute of Child Health and Human Development (PubMed)

DASH, the data and specimen hub of the National Institute of Child Health and Human Development The benefits of data sharing are well-established and an increasing number of policies require that data be shared upon publication of the main study findings. As data sharing becomes the new norm, there is a heightened need for additional resources to drive efficient data reuse. This article describes the development and implementation of the Data and Specimen Hub (DASH) by the Eunice Kennedy (...) Shriver National Institute of Child Health and Human Development (NICHD) to promote data sharing from NICHD-funded studies and enable researchers to comply with NIH data sharing policies. DASH's flexible architecture is designed to archive diverse data types and formats from NICHD's broad scientific portfolio in a manner that promotes FAIR data sharing principles. Performance of DASH over two years since launch is promising: the number of available studies and data requests are growing; three

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2018 Scientific data

2. Comparison of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards. (PubMed)

Comparison of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards. To compare the ability of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards to identify fetuses at risk of adverse perinatal outcomes.A retrospective analysis was performed among women enrolled in a multicenter randomized controlled trial (Routine Antenatal Diagnostic Imaging with Ultrasound) that was conducted (...) at 28-34 weeks predicted statistically significant relative risk (range 1.5-10.2; P<0.05 for 27/30 relative risk values) and area under the receiver operating characteristic curve (range, 0.50-0.59; P<0.05 for 8/15 curves). Nonetheless, differences in accuracy between standards for predicting adverse perinatal outcomes were subtle (P>0.05 for differences in area under the curve values).Although useful to monitor fetal growth trajectory and the level of risk, all three fetal growth standards provided

2018 International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

3. Association of National Institute of Child Health and Human Development Career Development Awards With Subsequent Research Project Grant Funding. (PubMed)

Association of National Institute of Child Health and Human Development Career Development Awards With Subsequent Research Project Grant Funding. Investing in the next generation of researchers is essential, as recently highlighted in the 21st Century Cures Act. From its inception, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported training and career development to ensure a robust pipeline of investigators who are prepared to lead (...) statistically significantly different whether their career development was supported by individual or institutional awards.Physician-scholars are more likely to apply for and receive a National Institutes of Health research grant if they are trained on an individual career development award, with or without an institutional training award. Based on the data, the NICHD intends to provide a greater proportion of its career development fund allocation to individual awards. The NICHD recognizes the importance

2018 JAMA pediatrics

4. Diagnostic Validity of the Proposed Eunice Kennedy Shriver National Institute of Child Health and Human Development Criteria for Intrauterine Inflammation or Infection. (PubMed)

Diagnostic Validity of the Proposed Eunice Kennedy Shriver National Institute of Child Health and Human Development Criteria for Intrauterine Inflammation or Infection. To investigate the test characteristics of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) criteria for intrauterine inflammation or infection or both (triple I) and rates of adverse outcomes in a cohort of febrile intrapartum women.This retrospective cohort study included women at 24 (...) weeks of gestation or greater from June 2015 to September 2017 at a single tertiary hospital with a temperature 100.4°F or greater (38.0°C) during labor or within 1 hour postpartum, all of whom had blood culture data. Women with a fetal demise, expectantly managed preterm prelabor rupture of membranes, or nonobstetric infections were excluded. Documented fever was defined as a single temperature 102.2°F or greater (39.0°C) or a temperature 100.4°F or greater (38.0°C) but less than 102.2°F (39.0°C

2018 Obstetrics and Gynecology

5. Quality measures in high-risk pregnancies: Executive Summary of a Cooperative Workshop of the Society for Maternal-Fetal Medicine, National Institute of Child Health and Human Development, and the American College of Obstetricians and Gynecologists. (PubMed)

Quality measures in high-risk pregnancies: Executive Summary of a Cooperative Workshop of the Society for Maternal-Fetal Medicine, National Institute of Child Health and Human Development, and the American College of Obstetricians and Gynecologists. Providers perceive current obstetric quality measures as imperfect and insufficient. Our organizations convened a "Quality Measures in High-Risk Pregnancies Workshop." The goals were to (1) review the current landscape regarding quality measures (...) in obstetric conditions with increased risk for adverse maternal or fetal outcomes, (2) evaluate the available evidence for management of common obstetric conditions to identify those that may drive the highest impact on outcomes, quality, and value, (3) propose measures for high-risk obstetric conditions that reflect enhanced quality and efficiency, and (4) identify current research gaps, improve methods of data collection, and recommend means of change.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 American Journal of Obstetrics and Gynecology

6. Heart Disease and Stroke Statistics

(smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure [BP], and glucose control) that contribute to cardiovascular health. The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, healthcare administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions. Cardiovascular disease (CVD) produces immense health and economic burdens in the United (...) States and globally. The Statistical Update also presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease [CHD], heart failure [HF], valvular disease, venous disease, and peripheral arterial disease) and the associated outcomes (including quality of care, procedures, and economic costs). Since 2007, the annual versions of the Statistical Update have

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2019 American Heart Association

7. 2017 AHA/ACC Key Data Elements and Definitions for Ambulatory Electronic Health Records in Pediatric and Congenital Cardiology: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards

. In: Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine . 9th ed. Philadelphia, PA : Elsevier Health Sciences ; 2011 :1468–529. Loeys BL, Dietz HC, Braverman AC, et al. . The revised Ghent nosology for the Marfan syndrome. J Med Genet . 2010 ; 47 :476–85. National Cancer Institute Enterprise Vocabulary Server. Available at: . Accessed May 15, 2016. LOINC Test. Available at: . Accessed December 12, 2014. CDISC Glossary. Available at: . Accessed December 12, 2014. National Institute of Child Health (...) and Human Development (NICHD). Available at: . Accessed May 15, 2016. Appendix 1. Author Relationships With Industry and Other Entities (Relevant)—2017 AHA/ACC Key Data Elements and Definitions for Ambulatory Electronic Health Records in Pediatric and Congenital Cardiology Name Employment Consultant Speaker Ownership/Partnership/Principal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Jeffrey R. Boris, Chair Children’s Hospital of Philadelphia—Clinical Professor

2017 American Heart Association

8. Cutting-Edge Statistical Methods for a Life-Course Approach (PubMed)

of the strategy, offer a step-by-step guide on how to conduct the analysis, and illustrate the technique using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development. In addition, we recommend a set of technical and empirical readings for each technique. Our goal was not to address a substantive question of interest but instead to provide life-course researchers with a useful reference guide to cutting-edge statistical methods. (...) Cutting-Edge Statistical Methods for a Life-Course Approach Advances in research methods, data collection and record keeping, and statistical software have substantially increased our ability to conduct rigorous research across the lifespan. In this article, we review a set of cutting-edge statistical methods that life-course researchers can use to rigorously address their research questions. For each technique, we describe the method, highlight the benefits and unique attributes

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2014 Advances in Nutrition

9. Dysfunctional labor: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data (PubMed)

, Sweden. Adanu Richard M K RMK University of Ghana School of Public Health, Ghana. Reddy Uma U Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA. Waugh Jason J S JJS Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom. Gupta Manish M Barts Health NHS Trust, London, United Kingdom. Kochhar Sonali S Global Healthcare Consulting, India; Erasmus University Medical Center, Rotterdam (...) Dysfunctional labor: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data 29150059 2018 07 17 2018 11 13 1873-2518 35 48 Pt A 2017 12 04 Vaccine Vaccine Dysfunctional labor: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. 6538-6545 S0264-410X(17)30115-9 10.1016/j.vaccine.2017.01.050 Boatin Adeline A AA Department of OB/GYN, Massachusetts General Hospital, Harvard Medical School, Boston

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2017 Vaccine

10. Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. (PubMed)

Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. To investigate the relationship among intercourse compliance, ovulation, and the occurrence of pregnancy in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMNPPCOS) Trial.Post hoc data analysis of subjects in the Reproductive Medicine Network PPCOS Trial.Academic

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2010 Fertility and sterility

11. Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility. (PubMed)

of these proteins in UDT are warranted.The Eunice Kennedy Shriver National Institute for Child Health and Human Development (R01HD060769); National Center for Research Resources (P20RR20173), National Institute of General Medical Sciences (P20GM103464), Nemours Biomedical Research, the Testicular Cancer Consortium (U01CA164947), the Intramural Research Program of the NCI, a support services contract HHSN26120130003C with IMS, Inc., the Abramson Cancer Center at Penn, National Cancer Institute (CA114478 (...) Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility. Can subphenotype analysis of genome-wide association study (GWAS) data from subjects with testicular germ cell tumor (TGCT) provide insight into cryptorchidism (undescended testis, UDT) susceptibility?Suggestive intragenic GWAS signals common to UDT, TGCT case-case and TGCT case-control analyses occur in genes encoding RBFOX RNA-binding

2018 Human Reproduction

12. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data

of Child Health and Human Development; National Institutes of Health; Department of Health and Human Services. Bibliographic details Romero R, Nicolaides K, Conde-Agudelo A, Tabor A, O'Brien JM, Cetingoz E, Da Fonseca E, Creasy GW, Klein K, Rode L, Soma-Pillay P, Fusey S, Cam C, Alfirevic Z, Hassan SS. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual (...) sonographic measurement of cervical length be performed at 19 to 24 weeks of gestation. Vaginal progesterone at a dose of 90mg/d should be considered for use in patients with a short cervix, mainly those with a cervical length between 10 and 20mm, from 20 to 36 weeks of gestation. Research : The authors stated that a properly-designed randomised controlled trial of vaginal progesterone in twin gestations was needed. Funding Intramural Research Program of the Eunice Kennedy Shriver National Institute

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2012 DARE.

13. Population-Based Outcomes Data for Counseling at the Margin of Gestational Viability. (PubMed)

for counseling. The National Institute of Child Health and Human Development Neonatal Research Network Outcomes Data is most commonly used (65%) with institutional databases (14.5%) the second choice. Most participants (89%) reported that these data influence their counseling, but it was less clear whether specific estimates of mortality and morbidity influenced families; 36% of neonatologist felt that these data have little or no impact on families. Seventy-one percent reported that outcomes data estimates (...) Population-Based Outcomes Data for Counseling at the Margin of Gestational Viability. To survey neonatologists as to how many use population-based outcomes data to counsel families before and after the birth of 22- to 25-week preterm infants.An anonymous online survey was distributed to 1022 neonatologists in the US. Questions addressed the use of population-based outcome data in prenatal and postnatal counseling.Ninety-one percent of neonatologists reported using population-based outcomes data

2016 Journal of Pediatrics

14. Reporting of birth defects in SART CORS: time to rely on data linkage (PubMed)

Reporting of birth defects in SART CORS: time to rely on data linkage 27343954 2017 12 06 2018 12 02 1556-5653 106 3 2016 09 01 Fertility and sterility Fertil. Steril. Reporting of birth defects in SART CORS: time to rely on data linkage. 554-5 10.1016/j.fertnstert.2016.06.020 S0015-0282(16)61349-3 Mendola Pauline P Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville

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2016 Fertility and Sterility

15. Stillbirth Classification-Developing an International Consensus for Research: Executive Summary of a National Institute of Child Health and Human Development Workshop. (PubMed)

Stillbirth Classification-Developing an International Consensus for Research: Executive Summary of a National Institute of Child Health and Human Development Workshop. Stillbirth is a major obstetric complication, with 3.2 million stillbirths worldwide and 26,000 stillbirths in the United States every year. The Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop from October 22-24, 2007, to review the pathophysiology of conditions underlying (...) stillbirth to define causes of death. The optimal classification system would identify the pathophysiologic entity initiating the chain of events that irreversibly led to death. Because the integrity of the classification is based on available pathologic, clinical, and diagnostic data, experts emphasized that a complete stillbirth workup should be performed. Experts developed evidence-based characteristics of maternal, fetal, and placental conditions to attribute a condition as a cause of stillbirth

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2009 Obstetrics and Gynecology

16. The relationship between male BMI and waist circumference on semen quality: data from the LIFE study. (PubMed)

) is negatively associated with semen parameters with little influence of physical activity. Our findings are the first showing a relationship between WC and semen parameters in a sample of men without known infertility. Given the worldwide obesity epidemic, further study of the role of weight loss to improve semen parameters is warranted.Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Contracts #N01-HD-3-3355, N01-HD-3-3356 (...) to ascertain demographic, health and reproductive histories followed by anthropometric assessment.We categorized BMI (kg/m(2)) as <25.0 (underweight and normal), 25.0-29.9 (overweight) 30.0-34.9 (obese, class I) and ≥35 (obese, class II) for analysis. Data were available for analysis in 468 men (93% participation), with a mean ± SD age of 31.8 ± 4.8 years, BMI of 29.8 ± 5.6 kg/m(2) and WC of 100.8 ± 14.2 cm. The majority of the cohort (82%) was overweight or obese with 58% reporting physical activity <1

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2013 Human Reproduction

17. Parent-mediated interventions for promoting communication and language development in young children with Down syndrome. (PubMed)

for four home visits. No study measured parental use of the strategies outside of the intervention sessions.A grant from the Hospital for Sick Children Foundation (Toronto, Ontario, Canada) funded one study. Another received partial funding from the National Institute of Child Health and Human Development and the Department of Education in the USA. The remaining study did not specify any funding sources.In light of the serious limitations in methodology, and the small number of studies included, we (...) standard Cochrane methodological procedures for data collection and analysis.We included three studies involving 45 children aged between 29 months and six years with Down syndrome. Two studies compared parent-mediated interventions versus TAU; the third compared a parent-mediated plus clinician-mediated intervention versus a clinician-mediated intervention alone. Treatment duration varied from 12 weeks to six months. One study provided nine group sessions and four individualised home-based sessions

2018 Cochrane

18. Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV

Annex B). The differences were not statistically significant for any other outcomes. The certainty of the evidence was rated as very low because data were extrapolated from adults. ARV drug regimens for people initiating ART18 Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV Despite its overall higher efficacy compared with the standard of care, RAL is known to have a lower genetic barrier (...) . Updated recommendations on fi rst-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV: interim guidelines. Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Geneva: World Health Organization; 2018 (WHO/CDS/HIV/18.51). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. Sales, rights

2019 World Health Organisation HIV Guidelines

19. Medically Indicated Late-Preterm and Early-Term Deliveries

delivery with the risks associated with further continuation of pregnancy. Defer- ring delivery to the 39th week of gestation is not recommended if there is a medical or obstetric indication for earlier delivery. To address the issue of appropriate indications for delivery at less than 39 weeks of gestation, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Society for Table 1. Recommendations for the Timing of Delivery When Conditions Complicate Pregnancy (...) ,BailitJL, GrobmanWA, Wapner RJ, Reddy UM, et al. Neonatal outcomes of elective early-term births after demonstrated fetal lung matu- rity. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Med- icine Units Network. Am J Obstet Gynecol 2018;219: 296.e1–8. 7. Antenatalcorticosteroidtherapyforfetalmaturation.Com- mitteeOpinionNo.713. AmericanCollegeofObstetricians and Gynecologists. Obstet Gynecol 2017;130:e102–9. e154 Committee Opinion Late-Preterm and Early

2019 American College of Obstetricians and Gynecologists

20. Approaches to Limit Intervention During Labor and Birth

- comes. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 2009;201:357.e1–7. 54. Allen VM, Baskett TF, O’Connell CM, McKeen D, Allen AC. Maternal and perinatal outcomes with increasing duration of the second stage of labor. Obstet Gynecol 2009;113:1248–58. 55. Tuuli MG, Frey HA, Odibo AO, Macones GA, Cahill AG. Immediate compared with delayed pushing in the second stage of labor: a systematic review and meta (...) -analysis. Ob- stet Gynecol 2012;120:660–8. 56. Yee LM, Sandoval G, Bailit J, Reddy UM, Wapner RJ, Varner MW, et al. Maternal and neonatal outcomes with early compared with delayed pushing among nulliparous women. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Obstet Gynecol 2016;128:1039–47. 57. Cahill AG, Srinivas SK, Tita ATN, Caughey AB, Richter HE, Gregory WT, et al. Effect of immediate vs delayed pushing

2019 American College of Obstetricians and Gynecologists

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