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1. COVID-19 (Novel Coronavirus)

COVID-19 (Novel Coronavirus) COVID-19 (Novel Coronavirus) You need to enable JavaScript to run this app. Person Subscribe for unlimited access to DynaMed content, CME/CE & MOC credit, and email alerts on content you follow. Subscribe Already subscribed? Language English Search Cancel Specialties KeyboardArrowDown 0 COVID-19 (Novel Coronavirus) List MoreVert AddCircleOutline Follow Share Share AddCircleOutline Follow Share Share General Information Description acute respiratory disease caused (...) by a novel coronavirus (SARS-CoV-2) first identified in December 2019 in Wuhan, Hubei Province, China and spreading worldwide ( ) PubMed 32123347 Nature microbiology Nat Microbiol 20200302 SARS-CoV-2 is a member of beta genus coronaviruses closely related to SARS-CoV ( ) common signs of COVID-19 include fever, cough, and shortness of breath ( ) there is no specific antiviral treatment for COVID-19, but supportive care may help to relieve symptoms and should include support of vital organ functions

2020 DynaMed Plus

2. Novel coronavirus (COVID-19) guidance for acute care

Novel coronavirus (COVID-19) guidance for acute care 1 | Pa g e Ministry of Health Novel Coronavirus (COVID-19) Guidance for Acute Care Version 2 – February 1 1, 2020 This guidance document provides basic information only. It is not intended to take the place of medical advice, communicable diseases surveillance protocols, diagnosis or treatment. What you need to know Acute care settings should: 1. Undertake active screening (asking questions) and passive screening (signage) of patients (...) to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome (SARS-CoV), and COVID-19. A novel coronavirus is a new strain that has not been previously identified in humans. Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans, likely through bat reservoirs. Several known coronaviruses

2020 CPG Infobase

3. Interim guidance: public health management of cases and contacts associated with novel coronavirus (COVID-19) in the community

for longer in the immunocompromised and pediatric populations. Two negative swabs, collected at least 24 hours apart, AND resolution of acute symptoms are required to rule out communicability and discontinue isolation DIAGNOSTIC TESTING PCR developed at BCCDC PHL Up to date lab testing guidelines can be found on the BCCDC Health Professionals page: http://www.bccdc.ca/health-professionals/clinical-resources/novel-coronavirus-(covid-19) SURVEILLANCE AND REPORTING Case definitions have been developed (...) Interim guidance: public health management of cases and contacts associated with novel coronavirus (COVID-19) in the community Interim Guidance: Public Health Management of cases and contacts associated with novel coronavirus (COVID-19) in the community March 10, 2020 CONTEXT The British Columbia Centre for Disease Control (BCCDC) has adapted the interim guidance from the Public Health Agency of Canada (PHAC) for Regional Health Authorities (RHA) for public health management of human illness

2020 CPG Infobase

4. Infection prevention and control for novel coronavirus (COVID-19): interim guidance for acute healthcare settings

Infection prevention and control for novel coronavirus (COVID-19): interim guidance for acute healthcare settings Infection prevention and control for coronavirus disease (COVID-19): Interim guidance for acute healthcare settings - Canada.ca Language selection Search Search Canada.ca Search Menu Main Menu You are here: Infection prevention and control for coronavirus disease (COVID-19): Interim guidance for acute healthcare settings Table of Contents Introduction The Public Health Agency (...) and Control Measures at a Glance In the absence of effective drugs or vaccines, Infection Prevention and Control (IPC) strategies to prevent or limit transmission of COVID-19 in healthcare facilities include: Prompt identification of individuals with ; Institution of appropriate infection prevention and control (IPC) measures (e.g., contact and droplet precautions, patient isolation); and Determination of the etiologic diagnosis. Early Recognition and Source Control To facilitate early recognition

2020 CPG Infobase

5. Novel coronavirus (COVID-19) Guidance for Primary Care Management of patients presenting to primary care

Novel coronavirus (COVID-19) Guidance for Primary Care Management of patients presenting to primary care Health Protection Scotland This document is uncontrolled when printed. Before use check the HPS COVID-19 page to verify this is the current version Novel coronavirus (COVID-19) Guidance for Primary Care Management of patients presenting to primary care Version 10.4 Publication date 27 March 2020 Health Protection Scotland 1 Version History Version Date Summary of changes V1.0 23/01/20 First (...) equipment 12 11.5. Carpeted flooring and soft furnishings 12 11.6. On leaving the room 13 11.7. Cleaning of communal areas 13 11.8. Attending deaths 13 12. Further information 13 Appendix 1: Contact details for local Health Protection Teams 14 Health Protection Scotland 4 Appendix 2: Putting on and removing Personal Protective Equipment (PPE) 15 Instructional video 16 Health Protection Scotland 5 1. Introduction Novel coronavirus (COVID-19) is a new is a new strain of coronavirus first identified

2020 Covid-19 Ad hoc guidelines

6. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)

A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) POSITION ARTICLE AND GUIDELINE Open Access A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) Ying-Hui Jin 1 , Lin Cai 2 , Zhen-Shun Cheng 3 , Hong Cheng 4 , Tong Deng 1,5 , Yi-Pin Fan 6,7 , Cheng Fang 1 , Di Huang 1 , Lu-Qi Huang 6,7 , Qiao Huang 1 , Yong Han 2 ,BoHu 8 , Fen Hu 8 (...) 1,18* , Yong-Yan Wang 6,7* , Xing-Huan Wang 1,2* , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM) Abstract In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020. For it is a never been

2020 Covid-19 Ad hoc guidelines

7. Novel coronavirus (2019-nCoV): self-isolation for patients undergoing testing

for how patients should self-isolate while awaiting results of laboratory testing for SARS-CoV-2. Published 31 January 2020 Last updated 31 January 2020 — From: Documents HTML HTML HTML Details This guidance provides advice for individuals who are awaiting results from diagnostic testing for COVID-19 and do not require admission to hospital. COVID-19 was previously referred to as Wuhan novel coronavirus. There may be further information specific to each country in the United Kingdom, as this guidance (...) Novel coronavirus (2019-nCoV): self-isolation for patients undergoing testing COVID-19: self-isolation for patients undergoing testing - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search The UK has left the EU Guidance COVID-19: self-isolation for patients undergoing testing Guidance

2020 Public Health England

8. The possibility of using Lopinave/Litonawe (LPV/r) as treatment for novel coronavirus (2019-nCov)pneumonia: a quick systematic review based on earlier coronavirus clinical studies Full Text available with Trip Pro

The possibility of using Lopinave/Litonawe (LPV/r) as treatment for novel coronavirus (2019-nCov)pneumonia: a quick systematic review based on earlier coronavirus clinical studies JCM | Free Full-Text | Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review Next Article in Journal Next Article in Special Issue Previous Article in Journal Previous Article in Special Issue Information Initiatives Notice You can make submissions (...) for a specific problem on the support section of our website. Feedback Please let us know what you think of our products and services. Information Our dedicated information section provides allows you to learn more about MDPI. JSmol Viewer Open Access Review Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review by 1,2,* , 1,2 , 1 , 1 , 1 , 1 , 3 , 1,2 , 1,2 , 1 , 1 , 1 , 1 , 1 , 4 , 1 , 1 and 1 1 Saw Swee Hock School of Public Health, National

2020 Covid-19 Ad hoc papers

9. A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections. Full Text available with Trip Pro

A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections. Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Therefore, early diagnosis of nCoV may be of importance for reducing (...) the spread of disease in public. Methods for nCoV diagnosis involve smear dyeing inspection, culture identification, and real-time PCR detection, all of which are proved highly effective. Here, we performed a meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing nCoV infection. Fifteen articles conformed to the inclusion and exclusion criteria for further meta-analysis on the basis of a wide range of publications searched from databases involving PubMed, EMBASE, Web of Science

2015 Genetics and molecular research : GMR

10. COVID-19: Managing the COVID-19 pandemic in care homes

COVID-19: Managing the COVID-19 pandemic in care homes COVID-19: Managing the COVID-19 pandemic in care homes | British Geriatrics Society Toggle main menu visibility Search Search Search COVID-19: Managing the COVID-19 pandemic in care homes tool to recognise deterioration in residents, measure vital signs and communicate concerns to healthcare professionals. Care homes should have standard operating procedures for isolating residents who ‘walk with purpose’ (often referred to as ‘wandering (...) ’) as a consequence of cognitive impairment. Behavioural interventions may be employed but physical restraint should not be used. Care homes should work with General Practitioners, community healthcare staff and community geriatricians to review Advance Care Plans as a matter of urgency with care home residents. This should include discussions about how COVID-19 may cause residents to become critically unwell, and a clear decision about whether hospital admission would be considered in this circumstance. Care

2020 British Geriatrics Society

11. COVID-19: guidance for sampling and for diagnostic laboratories

COVID-19: guidance for sampling and for diagnostic laboratories Wuhan novel coronavirus: guidance for clinical diagnostic laboratories - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Wuhan novel coronavirus: guidance for clinical diagnostic laboratories Information for clinical (...) diagnostic laboratories on specimens associated with Wuhan novel coronavirus. Published 15 January 2020 Last updated 17 January 2020 — From: Documents HTML HTML If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Details These documents provide guidance to clinical diagnostic laboratories on the handling and processing

2020 Public Health England

12. COVID-19: evaluation of commercially available diagnostic products

COVID-19: evaluation of commercially available diagnostic products Guidance for industry on evaluations of diagnostic products for coronavirus (COVID-19) - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Stay at home Only go outside for food, health reasons or work (but only if you cannot (...) work from home) If you go out, stay 2 metres (6ft) away from other people at all times Wash your hands as soon as you get home Do not meet others, even friends or family. You can spread the virus even if you don’t have symptoms. Guidance Guidance for industry on evaluations of diagnostic products for coronavirus (COVID-19) Updated 27 March 2020 Contents © Crown copyright 2020 This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. To view

2020 Public Health England

13. COVID-19 rapid guideline: dialysis service delivery

and initial clinical management of possible cases. This includes information on testing and isolating patients. 4.2 If COVID-19 is diagnosed in someone not isolated from admission or presentation, follow UK government guidance on actions required when a case was not diagnosed on admission. COVID-19 rapid guideline: dialysis service delivery (NG160) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 8 of 175 5 Healthcare (...) possible, do rapid turnaround testing before dialysis to establish COVID-19 status. Dialysis may be needed before the test results are available. If the cohort status of a patient changes based on the results, manage according to the relevant cohort status. For more information see the UK government guidance on sampling and for diagnostic laboratories. 7.7 In patients suspected of having COVID-19, as a minimum: • swab for COVID-19 • assess for alternative causes of symptoms • assess whether dialysis

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

14. COVID-19 rapid guideline: delivery of systemic anticancer treatments

and offering empiric antibiotic therapy immediately. 4.6 If COVID-19 is later diagnosed in someone not isolated from admission or presentation, follow UK government guidance on actions required when a case was not diagnosed on admission. © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 8 of 135 5 Staff who are self-isolating Staff who are self-isolating 5.1 If a healthcare professional needs to self-isolate, ensure (...) COVID-19 rapid guideline: delivery of systemic anticancer treatments COVID-19 rapid guideline: delivery of systemic anticancer treatments NICE guideline Published: 20 March 2020 www.nice.org.uk/guidance/ng161 © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Your responsibility Your responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

15. COVID-19 rapid guideline: critical care

Scale (CFS) for frailty assessment, available from the NHS Specialised Clinical Frailty Network. • Record the frailty assessment in the patient's medical record. 1.2 When patients with possible COVID-19 have been identified, follow appropriate UK government guidance on infection prevention and control measures. This includes recommendations on: • patient transfers and transport • segregation and cohorting • personal protective equipment • aerosol-generating procedures. 1.3 If COVID-19 is diagnosed (...) in someone not isolated from admission or presentation, follow UK government guidance on actions required when a case was not diagnosed on admission. COVID-19 rapid guideline: critical care (NG159) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 112 2 Admission to critical care Admission to critical care See the critical care admission algorithm. 2.1 Discuss the risks, benefits and possible likely outcomes

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

16. COVID-19 rapid guideline: delivery of radiotherapy

sepsis as an acute medical emergency and offering empiric antibiotic therapy immediately. 4.5 If COVID-19 is later diagnosed in someone not isolated from admission or presentation, follow UK government guidance on actions required when a case was not diagnosed on admission. COVID-19 rapid guideline: delivery of radiotherapy (NG162) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 9 of 155 5 Grouping and separating (...) COVID-19 rapid guideline: delivery of radiotherapy COVID-19 rapid guideline: delivery of radiotherapy NICE guideline Published: 28 March 2020 www.nice.org.uk/guidance/ng162 © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Your responsibility Your responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

17. COVID-19 rapid guideline: haematopoietic stem cell transplantation

neutropenic sepsis immediately for assessment in secondary or tertiary care • treating suspected neutropenic sepsis as an acute medical emergency and offering empiric antibiotic therapy immediately. 2.4 If COVID-19 is later diagnosed in a patient not isolated from admission or presentation, follow UK government guidance for health professionals. 2.5 If a patient not previously known or suspected to have COVID-19 shows new symptoms suggestive of COVID-19, the general advice is to follow UK government (...) to reduce patient exposure to COVID-19 and make best use of resources (workforce, facilities, intensive care, equipment), such as by minimising in-patient and day-case admissions. 8.3 Work within clinical networks to support stem cell processing and harvesting, specialised diagnostics and cryopreservation. 8.4 Make decisions about modifications to usual care at an organisational level according to current quality management systems within the HSCT programme and other JACIE accreditation requirements

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

18. COVID-19

COVID-19 Coronavirus disease 2019 (COVID-19) - Symptoms, diagnosis and treatment | BMJ Best Practice     Search  Search Select language Coronavirus disease 2019 (COVID-19) Last reviewed: February 2020 Last updated: March 2020 Important updates 12 Mar 2020 WHO declares COVID-19 outbreak a pandemic The World Health Organization (WHO) formally declared the COVID-19 outbreak a pandemic on 11 March 2020. "WHO has been assessing this outbreak around the clock and we are deeply concerned both (...) by the alarming levels of spread and severity, and by the alarming levels of inaction," said WHO chief Tedros Adhanom Ghebreyesus during a press briefing. "We have therefore made the assessment that COVID-19 can be characterised as a pandemic. Describing the situation as a pandemic does not change WHO’s assessment of the threat posed by this virus. It doesn’t change what WHO is doing, and it doesn’t change what countries should do," he said. This is the first pandemic to be caused by a coronavirus

2020 BMJ Best Practice

19. Prince Edward Island guidelines for the management and control of COVID-19

. Period of Communicability Unknown. 5. Host Susceptibility Host susceptibility remains somewhat unknown. Information indicates that risk factors for disease include host factors (chronic disease, age) and exposure factors. Occurrence 1. General (6) Novel coronavirus (COVID-19) was first detected in Wuhan City, China in December 2019. Currently thousands of individuals have been diagnosed with the virus with the majority in Hubei Province, China. 2. Canada Updated numbers of COVID-19 in Canada (...) of a Case 7 Treatment of a Case 7 Management of Contacts 7 Preventative Measures 8 Infection Prevention and Control in the Community 8 Infection Prevention and Control in the Healthcare Facility 8 Early Recognition and Source Control 9 Application of Routine Practices and Additional Precautions 9 Infection Prevention and Control Guidelines 10 References 11 Appendix A: Novel Coronavirus (COVID-19) Testing 12 Appendix B- Public Health Follow-up 13 Appendix C: Case Report Form 16 Appendix D: Symptom Diary

2020 CPG Infobase

20. Richard Lehman’s Covid-19 reviews, 23rd March

Richard Lehman’s Covid-19 reviews, 23rd March Richard Lehman's covid-19 reviews—23 March 2020 - The BMJ ---> In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19 Covid contemplated Nobody is an expert on covid-19. It has not been around long enough. The idea that I could be a thought leader in this field should inspire you with feelings of mirth and dread. And this is exactly what I hope to do. Thomas Pueyo runs (...) of quarantine following covid-19 is also a vexed issue. Studies show that viral shedding can continue for up to at least 3 weeks following the onset of infection, but most guidelines give a Get Out of Jail card to convalescents a week sooner. “ I ” asks an article from China and (not surprisingly) answers no. In the course of the discussion, the authors also discuss length of incubation before symptoms, and interestingly conclude that it is probably longest (median 9 days) in those who acquire the virus

2020 Covid-19 Ad hoc papers

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