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1. Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis. (PubMed)

Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis. Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rating (...) in 16% (114/698) of patients with chromoendoscopy compared with 6% (62/1069) with WLE (RR, 3.41; 95% CI, 2.13-5.47). Chromoendoscopy (n=58) was more effective than SDWLE (n=141) for identification of dysplasia (RR, 3.52; 95% CI, 1.38-8.99) and chromoendoscopy (n=113) was also more effective than HDWLE (n=257) (RR, 3.15; 95% CI, 1.62-6.13). The quality of the evidence was very low.Based on this meta-analysis, non-RCTs demonstrate a benefit of chromoendoscopy over SDWLE and HDWLE, whereas RCTs only

2019 Gastrointestinal endoscopy

2. Changes in Female Sexual Function After Vaginal Mesh Repair Versus Native Tissue Repair for Pelvic Organ Prolapse: A Meta-Analysis of Randomized Controlled Trials. (PubMed)

Changes in Female Sexual Function After Vaginal Mesh Repair Versus Native Tissue Repair for Pelvic Organ Prolapse: A Meta-Analysis of Randomized Controlled Trials. To evaluate changes in female sexual function after transvaginal mesh (TVM) repair versus native tissue repair for pelvic organ prolapse.Eligible studies, published through November 2017, were retrieved through searches of ClinicalTrials.gov, MEDLINE, Embase, and Cochrane Review databases and associated bibliographies. We included (...) and those who underwent native tissue repair. Liao S-C, Huang W-C, Su T-H, et al. Changes in Female Sexual Function After Vaginal Mesh Repair Versus Native Tissue Repair for Pelvic Organ Prolapse: A Meta-Analysis of Randomized Controlled Trials. J Sex Med 2019;16:633-639.Copyright © 2019 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

2019 Journal Of Sexual Medicine

3. Prevention of fractures after solid organ transplantation: a meta-analysis

Prevention of fractures after solid organ transplantation: a meta-analysis Prevention of fractures after solid organ transplantation: a meta-analysis Prevention of fractures after solid organ transplantation: a meta-analysis Stein EM, Ortiz D, Jin Z, McMahon DJ, Shane E CRD summary This review concluded that treatment with bisphosphonates or active vitamin D analogues during the first year after solid organ transplantation was associated with a reduction in bone fractures. The authors (...) neck and lumbar spine bone density. CRD commentary This review was based on defined inclusion criteria. Two databases were searched but this was supplemented by a range of other sources. Attempts were made to identify unpublished material and publication bias was tested. Two reviewers appeared to be involved in all the review processes, which helped to minimise reviewer bias and error. Trial quality was assessed, although results of this were not presented in detail. A meta-analysis appeared

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2011 DARE.

4. Colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae in solid organ transplantation: A meta-analysis and review. (PubMed)

Colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae in solid organ transplantation: A meta-analysis and review. Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) may cause severe infections, often preceded by ESBL-E gastrointestinal (GI) colonization.We conducted a review of the literature, investigating the prevalence of ESBL-E GI colonization in solid organ transplant (SOT) patients and the risk for subsequent ESBL-E infection. We searched

2017 Transplant infectious disease : an official journal of the Transplantation Society

5. Associations Across Caregiver and Care Recipient Symptoms: Self-Organizing Map and Meta-analysis. (PubMed)

Associations Across Caregiver and Care Recipient Symptoms: Self-Organizing Map and Meta-analysis. The main objective of this study was to reveal generalizable associations across caregiver burden (CGB), caregiver depression (CGD), care recipient cognitive ability (CRCA), and care recipient behavioral and psychological symptoms of dementia (BPSD).Studies published between 2004 and 2014 and reporting CGB and/or CGD together with CRCA and/or BPSD were included. Only 95 out of 1,955 studies (...) provided enough data for data clustering with the Self-Organizing Map (SOM) and 27 of them for meta-analyses based on correlation coefficients.Caregiver and care recipient symptoms were not tightly associated with each other, except for the CGB-BPSD interaction at the individual level. SOM emphasized the cluster comprising studies reporting low CGB, low CGD, high CRCA, and few BPSD. Meta-analyses indicated high heterogeneity between the original studies.Relationships between caregiver and care

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2017 The Gerontologist

6. Systematic review and meta-analysis on trimodal therapy versus radical cystectomy for muscle-invasive bladder cancer: Does the current quality of evidence justify definitive conclusions? (PubMed)

Systematic review and meta-analysis on trimodal therapy versus radical cystectomy for muscle-invasive bladder cancer: Does the current quality of evidence justify definitive conclusions? To systematically review and meta-analyze the current literature in a methodologically rigorous and transparent manner for quantitative evidence on survival outcomes among patients diagnosed with muscle-invasive bladder cancer that were treated by either trimodal therapy or radical cystectomy.MEDLINE, EMBASE (...) , CENTRAL were systematically searched for comparative observational studies reporting disease-specific survival and/or overall survival on adult patients diagnosed with localized muscle-invasive bladder cancer that were exposed to either trimodal therapy or radical cystectomy. Studies qualified for meta-analysis (random effects model) if they were not at critical risk of bias (RoB).The literature search identified 12 eligible studies. Three (all rated as "moderate RoB") out of 6 studies reporting

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2019 PLoS ONE

7. The effectiveness of cognitive analytic therapy (CAT) for client target problems: a meta-analysis of single-case experiments

The effectiveness of cognitive analytic therapy (CAT) for client target problems: a meta-analysis of single-case experiments Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A metaanalysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If metaanalysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

8. Systematic Review and Meta-Analysis on the Efficacy of Chemotherapy with Transurethral Resection of Bladder Tumors as Definitive Therapy for Muscle Invasive Bladder Cancer. (PubMed)

Systematic Review and Meta-Analysis on the Efficacy of Chemotherapy with Transurethral Resection of Bladder Tumors as Definitive Therapy for Muscle Invasive Bladder Cancer. Bladder-sparing treatment of muscle invasive bladder cancer (MIBC) with systemic chemotherapy plus transurethral resection of bladder tumors (TURBT) is increasingly seen in the literature -both in case series and subanalyses of patients who opt out of or are unfit for radical cystectomy (RC). Survival outcomes among (...) these patients are often impressive, but these are typically small retrospective studies from single institutions and therefore of limited clinical value.Our aim is to summarize the literature regarding definitive treatment of MIBC with systemic chemotherapy plus TURBT and provide a meta-analysis of survival outcomes for patients who received this treatment.A systematic literature search was performed consistent with the Prisma statement to identify publications reporting the outcomes of patients treated

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2017 Bladder cancer (Amsterdam, Netherlands)

9. Comparative evaluation of PSMA-targeted radiotracers versus f-18 fluclicolvine for the detection of prostate cancer biochemical recurrence after definitive therapy: a systematic review and meta-analysis

Comparative evaluation of PSMA-targeted radiotracers versus f-18 fluclicolvine for the detection of prostate cancer biochemical recurrence after definitive therapy: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears (...) is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e

2019 PROSPERO

10. A meta-analysis of randomized controlled trials that compare standard doxorubicin with other first-line chemotherapies for advanced/metastatic soft tissue sarcomas. (PubMed)

A meta-analysis of randomized controlled trials that compare standard doxorubicin with other first-line chemotherapies for advanced/metastatic soft tissue sarcomas. The standard treatment for patients with advanced/metastatic soft tissue sarcomas (ASTS) is systemic chemotherapy with doxorubicin. A previous meta-analysis of 8 randomized controlled trials (RCTs) demonstrated the superiority of single-agent doxorubicin over doxorubicin-based combination chemotherapy for ASTS. However, meta (...) -analyses of all RCTs that compare doxorubicin to other single-agent or combination regimens as first-line treatments for ASTS are lacking. We conducted a systematic review and meta-analysis to evaluate the efficacy and toxicity of current primary treatments for ASTS.Eligible studies were RCTs of first-line chemotherapies for ASTS comparing doxorubicin alone to other single agents or to combination therapies (experimental arm). Data from studies reporting hazard ratios (HR) and 95% confidence intervals

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2019 PLoS ONE

11. Comparing cardiac output monitors and defining agreement: A systematic review and meta-analysis. (PubMed)

Comparing cardiac output monitors and defining agreement: A systematic review and meta-analysis. Measuring cardiac output is common in critical care and perioperative medicine. Different monitoring systems are often judged against others in comparative studies. There is no agreed standard or definition on which to base the conclusions of such studies.To review comparative studies of cardiac output monitors using an agreement:tolerability index (ATI) as a measure of monitor precision. To compare (...) agreement). Thirty-one percent of authors defined their own terms for acceptable agreement. ATI was only moderately correlated with the conclusions of the authors (Spearman rho = 0.47, P < 0.0001).Authors should define what constitutes acceptable agreement a priori when reporting comparative studies of cardiac output monitors. The ATI and the tolerability interval may be a useful basis for helping define acceptable precision.

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2017 Journal of the Intensive Care Society

12. Meta-analysis To Define a Core Microbiota in the Swine Gut. (PubMed)

Meta-analysis To Define a Core Microbiota in the Swine Gut. The swine gut microbiota encompasses a large and diverse population of bacteria that play a significant role in pig health. As such, a number of recent studies have utilized high-throughput sequencing of the 16S rRNA gene to characterize the composition and structure of the swine gut microbiota, often in response to dietary feed additives. It is important to determine which factors shape the composition of the gut microbiota among (...) multiple studies and if certain bacteria are always present in the gut microbiota of swine, independently of study variables such as country of origin and experimental design. Therefore, we performed a meta-analysis using 20 publically available data sets from high-throughput 16S rRNA gene sequence studies of the swine gut microbiota. Next to the "study" itself, the gastrointestinal (GI) tract section that was sampled had the greatest effect on the composition and structure of the swine gut microbiota

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2017 mSystems

13. The Incidence and Definition of Crohn's Disease of the Pouch: A Systematic Review and Meta-analysis. (PubMed)

The Incidence and Definition of Crohn's Disease of the Pouch: A Systematic Review and Meta-analysis. A subset of patients who undergo total proctocolectomy with ileal pouch-anal anastomosis (IPAA) creation for ulcerative colitis (UC) will later develop Crohn's disease (CD) of the pouch, which has been associated with significant morbidity. We aimed to analyze the incidence of CD of the pouch and to review the existing diagnostic criteria utilized.A systematic search performed through March 1 (...) , 2018, identified 12 studies that reported the incidence of CD of the pouch after IPAA for UC or indeterminate colitis (IC). We compiled all diagnostic criteria utilized in these studies and then performed a meta-analysis using random effects modeling to estimate the overall incidence of CD of the pouch in this population.Among 4843 patients with an IPAA for UC or IC, 10.3% of patients were ultimately diagnosed with CD of the pouch (95% confidence interval [CI], 6.1%-15.4%). The most commonly

2019 Inflammatory Bowel Diseases

14. Imaging of PSMA-targeted Radiotracers for the Detection of Prostate Cancer Biochemical Recurrence After Definitive Therapy: A Systematic Review and Meta-analysis. (PubMed)

for prostate cancer using PSMA-targeted radiotracers.Following the Preferred Reporting Items for Systematic reviews and Meta-Analysis Diagnostic Test Accuracy (PRISMA-DTA) guidelines, our systematic review searched for articles in PubMed and EMBASE databases from 2012 to July 2018. Studies evaluating men with prostate cancer biochemical recurrence after definitive therapy, without known metastatic disease, who underwent PSMA PET/CT for detection of recurrent disease were included. The risk of bias (...) Imaging of PSMA-targeted Radiotracers for the Detection of Prostate Cancer Biochemical Recurrence After Definitive Therapy: A Systematic Review and Meta-analysis. Prostate-specific membrane antigen (PSMA)-targeted radiotracers are promising agents for imaging patients with biochemical recurrence of prostate cancer after definitive therapy.To report the results stratified by PSA levels of a systematic review and meta-analysis for detection of biochemical recurrence after definitive therapy

2019 Journal of Urology

15. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis

Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you (...) of Medical Journal Editors (ICMJE) define competing interests as including: financial relationships with industry (for example through employment, consultancies, stock, ownership, honoraria, and expert testimony), either directly or through immediate family; personal relationships; academic competition; and intellectual passion. If yes, please provide details below Enter response title * Enter CAPTCHA What is thirty divided by five? * By submitting your response, you are stating that you agree to the ©

2019 NIHR HTA programme

16. Reaching cardiovascular prevention guideline targets with a polypill-based approach: a meta-analysis of randomised clinical trials

Reaching cardiovascular prevention guideline targets with a polypill-based approach: a meta-analysis of randomised clinical trials The aim of this study was to determine the effect of polypill-based care on the achievement of 2016 European Society of Cardiology (ESC) guideline targets for blood pressure (BP), low-density lipoprotein (LDL) cholesterol and antiplatelet therapy.We conducted an individual participant data meta-analysis of three randomised clinical trials that compared a strategy (...) using a polypill containing aspirin, statin and antihypertensive therapy with usual care in patients with a prior cardiovascular disease (CVD) event or who were at high risk of their first event. Overall, the trials included 3140 patients from Australia, England, India, Ireland, the Netherlands and New Zealand (75% male, mean age 62 years and 76% with a prior CVD event). The primary outcome for this study was the proportion of people achieving ESC guideline targets for BP, LDL and antiplatelet

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2018 EvidenceUpdates

17. Treatment of Varicocele in Children and Adolescents: A Systematic Review and Meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel

Treatment of Varicocele in Children and Adolescents: A Systematic Review and Meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel The benefits and harms of intervention (surgical or radiological) versus observation in children and adolescents with varicocele are controversial.To systematically evaluate the evidence regarding the short- and long-term outcomes of varicocele treatment in children and adolescents.A systematic review (...) and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. A priori protocol was registered to PROSPERO (CRD42018084871), and a literature search was performed for all relevant publications published from January 1980 until June 2017. Randomized controlled trials (RCTs), nonrandomized comparative studies (NRSs), and single-arm case series including a minimum of 50 participants were eligible for inclusion.Of 1550 articles

2018 EvidenceUpdates

18. Evidence-Based Best-Practice Guidelines for Preventing Anterior Cruciate Ligament Injuries in Young Female Athletes: A Systematic Review and Meta-analysis

Evidence-Based Best-Practice Guidelines for Preventing Anterior Cruciate Ligament Injuries in Young Female Athletes: A Systematic Review and Meta-analysis Injury prevention neuromuscular training (NMT) programs reduce the risk for anterior cruciate ligament (ACL) injury. However, variation in program characteristics limits the potential to delineate the most effective practices to optimize injury risk reduction.To evaluate the common and effective components included in ACL NMT programs (...) and develop an efficient, user-friendly tool to assess the quality of ACL NMT programs.Systematic review and meta-analysis.Study inclusion required (1) a prospective controlled trial study design, (2) an NMT intervention aimed to reduce incidence of ACL injury, (3) a comparison group, (4) ACL injury incidence, and (5) female participants. The following data were extracted: year of publication, study design, sample size and characteristics, and NMT characteristics including exercise type and number per

2018 EvidenceUpdates

19. Meta-Analysis of Genotype-Guided Versus Standard Dosing of Vitamin K Antagonists

Meta-Analysis of Genotype-Guided Versus Standard Dosing of Vitamin K Antagonists Vitamin K antagonist (VKA) is a commonly prescribed anticoagulant with a narrow therapeutic window. Genetic polymorphisms account for high VKA dosage variability. Hence, we performed an updated meta-analysis of all randomized clinical trials (RCTs) comparing genotype-guided VKA versus standard dosing algorithms. We conducted a systematic search of electronic databases from inception to October 2017 for all RCTs (...) for the genotype-guided group in comparison with the standard group (mean difference 3.41%, 95% confidence interval [CI] 0.71 to 6.10, p = 0.01). In addition, there were significant reductions in major and all bleeding events ((RR 0.35, 95% CI 0.20 to 0.63, p = 0.0004) and (RR 0.79, 95% CI 0.66 to 0.95, p = 0.01), respectively). However, there were no significant differences between the groups for international normalized ratio >4 (RR 0.89, 95% CI 0.80 to 1.00, p = 0.06), thromboembolism (RR 0.81, 95% CI 0.56

2018 EvidenceUpdates

20. Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis. (PubMed)

Prevalence and discrimination of OMERACT-defined elementary ultrasound lesions of gout in people with asymptomatic hyperuricaemia: A systematic review and meta-analysis. Ultrasound lesions of gout have been described in people with asymptomatic hyperuricemia. However, the anatomical sites and ultrasound lesions most frequently involved in asymptomatic hyperuricemia have not yet been established. This systematic review and meta-analysis aimed to determine the prevalence of the Outcome Measures (...) in Rheumatology (OMERACT) elementary ultrasound lesions of gout (double contour, aggregates, tophus, erosion) at various sites in people with asymptomatic hyperuricemia and to determine which sites and lesions discriminate from people with normouricemia.A systematic search of electronic databases, conference abstracts and reference lists was undertaken. Studies were included if they used ultrasound to image people with asymptomatic hyperuricemia and reported ≥1 OMERACT-defined lesion of gout. Meta-analyses

2019 Seminars in arthritis and rheumatism

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