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1. Safety of prolonged-release tacrolimus versus normal-release tacrolimus in adult organ transplantation: a meta-analysis

Safety of prolonged-release tacrolimus versus normal-release tacrolimus in adult organ transplantation: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A metaanalysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If metaanalysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

2. Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis. Full Text available with Trip Pro

Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis. Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rating (...) in 16% (114/698) of patients with chromoendoscopy compared with 6% (62/1069) with WLE (RR, 3.41; 95% CI, 2.13-5.47). Chromoendoscopy (n=58) was more effective than SDWLE (n=141) for identification of dysplasia (RR, 3.52; 95% CI, 1.38-8.99) and chromoendoscopy (n=113) was also more effective than HDWLE (n=257) (RR, 3.15; 95% CI, 1.62-6.13). The quality of the evidence was very low.Based on this meta-analysis, non-RCTs demonstrate a benefit of chromoendoscopy over SDWLE and HDWLE, whereas RCTs only

2019 Gastrointestinal endoscopy

3. Changes in Female Sexual Function After Vaginal Mesh Repair Versus Native Tissue Repair for Pelvic Organ Prolapse: A Meta-Analysis of Randomized Controlled Trials. (Abstract)

Changes in Female Sexual Function After Vaginal Mesh Repair Versus Native Tissue Repair for Pelvic Organ Prolapse: A Meta-Analysis of Randomized Controlled Trials. To evaluate changes in female sexual function after transvaginal mesh (TVM) repair versus native tissue repair for pelvic organ prolapse.Eligible studies, published through November 2017, were retrieved through searches of ClinicalTrials.gov, MEDLINE, Embase, and Cochrane Review databases and associated bibliographies. We included (...) and those who underwent native tissue repair. Liao S-C, Huang W-C, Su T-H, et al. Changes in Female Sexual Function After Vaginal Mesh Repair Versus Native Tissue Repair for Pelvic Organ Prolapse: A Meta-Analysis of Randomized Controlled Trials. J Sex Med 2019;16:633-639.Copyright © 2019 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

2019 Journal Of Sexual Medicine

4. Treatment target (remission or low disease activity) in Psoriatic Arthritis: reporting in clinical studies, definitions, prevalence and validity of remission definitions - a systematic literature review with meta-analysis

Treatment target (remission or low disease activity) in Psoriatic Arthritis: reporting in clinical studies, definitions, prevalence and validity of remission definitions - a systematic literature review with meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate (...) is required. If metaanalysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely

2019 PROSPERO

5. Systematic review and meta-analysis on trimodal therapy versus radical cystectomy for muscle-invasive bladder cancer: Does the current quality of evidence justify definitive conclusions? Full Text available with Trip Pro

Systematic review and meta-analysis on trimodal therapy versus radical cystectomy for muscle-invasive bladder cancer: Does the current quality of evidence justify definitive conclusions? To systematically review and meta-analyze the current literature in a methodologically rigorous and transparent manner for quantitative evidence on survival outcomes among patients diagnosed with muscle-invasive bladder cancer that were treated by either trimodal therapy or radical cystectomy.MEDLINE, EMBASE (...) , CENTRAL were systematically searched for comparative observational studies reporting disease-specific survival and/or overall survival on adult patients diagnosed with localized muscle-invasive bladder cancer that were exposed to either trimodal therapy or radical cystectomy. Studies qualified for meta-analysis (random effects model) if they were not at critical risk of bias (RoB).The literature search identified 12 eligible studies. Three (all rated as "moderate RoB") out of 6 studies reporting

2019 PLoS ONE

6. Guidelines for the surgical management of gastroesophageal reflux disease in children: a systematic review and meta-analysis from the Evidence/Guidelines Committee of the European Paediatric Surgeons' Association (EUPSA)

Guidelines for the surgical management of gastroesophageal reflux disease in children: a systematic review and meta-analysis from the Evidence/Guidelines Committee of the European Paediatric Surgeons' Association (EUPSA) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate (...) is required. If metaanalysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely

2019 PROSPERO

7. Efficacy of High-Flow Nasal Cannula vs Standard Oxygen Therapy or Nasal Continuous Positive Airway Pressure in Children with Respiratory Distress: A Meta-Analysis (Abstract)

Efficacy of High-Flow Nasal Cannula vs Standard Oxygen Therapy or Nasal Continuous Positive Airway Pressure in Children with Respiratory Distress: A Meta-Analysis To evaluate the efficacy of high-flow nasal cannula (HFNC) oxygen therapy in providing respiratory support of children with acute lower respiratory infection (ALRI), hypoxemia, and respiratory distress.We performed a meta-analysis of randomized controlled trials that compared HFNC and standard flow oxygen therapy or nasal continuous (...) positive airway pressure (nCPAP) and reported treatment failure as an outcome. Data were synthesized using Mann-Whitney U test.Compared with standard oxygen therapy, HFNC significantly reduced treatment failure (risk ratio [RR] 0.49, 95% CI 0.40-0.60, P < .001) in children with mild hypoxemia (arterial pulse oximetry [SpO2] >90% on room air). HFNC had an increased risk of treatment failure compared with nCPAP in infants age 1-6 months with severe hypoxemia (SpO2 <90% on room air or SpO2 >90

2019 EvidenceUpdates

8. Colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae in solid organ transplantation: A meta-analysis and review. (Abstract)

Colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae in solid organ transplantation: A meta-analysis and review. Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) may cause severe infections, often preceded by ESBL-E gastrointestinal (GI) colonization.We conducted a review of the literature, investigating the prevalence of ESBL-E GI colonization in solid organ transplant (SOT) patients and the risk for subsequent ESBL-E infection. We searched

2017 Transplant infectious disease : an official journal of the Transplantation Society

9. Associations Across Caregiver and Care Recipient Symptoms: Self-Organizing Map and Meta-analysis. Full Text available with Trip Pro

Associations Across Caregiver and Care Recipient Symptoms: Self-Organizing Map and Meta-analysis. The main objective of this study was to reveal generalizable associations across caregiver burden (CGB), caregiver depression (CGD), care recipient cognitive ability (CRCA), and care recipient behavioral and psychological symptoms of dementia (BPSD).Studies published between 2004 and 2014 and reporting CGB and/or CGD together with CRCA and/or BPSD were included. Only 95 out of 1,955 studies (...) provided enough data for data clustering with the Self-Organizing Map (SOM) and 27 of them for meta-analyses based on correlation coefficients.Caregiver and care recipient symptoms were not tightly associated with each other, except for the CGB-BPSD interaction at the individual level. SOM emphasized the cluster comprising studies reporting low CGB, low CGD, high CRCA, and few BPSD. Meta-analyses indicated high heterogeneity between the original studies.Relationships between caregiver and care

2017 The Gerontologist

10. The effectiveness of cognitive analytic therapy (CAT) for client target problems: a meta-analysis of single-case experiments

The effectiveness of cognitive analytic therapy (CAT) for client target problems: a meta-analysis of single-case experiments Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) . ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A metaanalysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If metaanalysis is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis

2019 PROSPERO

11. Systematic Review and Meta-Analysis on the Efficacy of Chemotherapy with Transurethral Resection of Bladder Tumors as Definitive Therapy for Muscle Invasive Bladder Cancer. Full Text available with Trip Pro

Systematic Review and Meta-Analysis on the Efficacy of Chemotherapy with Transurethral Resection of Bladder Tumors as Definitive Therapy for Muscle Invasive Bladder Cancer. Bladder-sparing treatment of muscle invasive bladder cancer (MIBC) with systemic chemotherapy plus transurethral resection of bladder tumors (TURBT) is increasingly seen in the literature -both in case series and subanalyses of patients who opt out of or are unfit for radical cystectomy (RC). Survival outcomes among (...) these patients are often impressive, but these are typically small retrospective studies from single institutions and therefore of limited clinical value.Our aim is to summarize the literature regarding definitive treatment of MIBC with systemic chemotherapy plus TURBT and provide a meta-analysis of survival outcomes for patients who received this treatment.A systematic literature search was performed consistent with the Prisma statement to identify publications reporting the outcomes of patients treated

2017 Bladder cancer (Amsterdam, Netherlands)

12. Definitions and measurements of polypharmacy in observational studies using administrative databases: a systematic review and meta-analysis

Definitions and measurements of polypharmacy in observational studies using administrative databases: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration (...) . ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size), and that the true effect is the same

2019 PROSPERO

13. A systematic review and meta-analysis of whole grain intake and body weight changes in adults: a focus on whole grain food definitions

A systematic review and meta-analysis of whole grain intake and body weight changes in adults: a focus on whole grain food definitions Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration (...) . ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size), and that the true effect is the same

2019 PROSPERO

14. Comparative evaluation of PSMA-targeted radiotracers versus f-18 fluclicolvine for the detection of prostate cancer biochemical recurrence after definitive therapy: a systematic review and meta-analysis

Comparative evaluation of PSMA-targeted radiotracers versus f-18 fluclicolvine for the detection of prostate cancer biochemical recurrence after definitive therapy: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears (...) is not possible, data will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e

2019 PROSPERO

15. Oncological safety of testosterone replacement therapy in prostate cancer survivors with the history of definitive therapy: systematic literature review and meta-analysis

Oncological safety of testosterone replacement therapy in prostate cancer survivors with the history of definitive therapy: systematic literature review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability (...) will be reported through a descriptive summary. ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size

2019 PROSPERO

16. Is nab-paclitaxel definitely a better choice than conventional paclitaxel for advanced breast cancer? a systemic review and meta-analysis

Is nab-paclitaxel definitely a better choice than conventional paclitaxel for advanced breast cancer? a systemic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) of publication, language, journal. ">Data to be extracted: other as well as a to meta-analysis of pre-clinical studies are available. Example: A metaanalysis will be performed for all outcome measures reported in 10 or more articles. For subgroup analysis a minimum of 8 studies per subgroup is required. If metaanalysis is not possible, data will be reported through a descriptive summary. ">Planned approach Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio

2019 PROSPERO

17. Treatment of Varicocele in Children and Adolescents: A Systematic Review and Meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel (Abstract)

Treatment of Varicocele in Children and Adolescents: A Systematic Review and Meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel The benefits and harms of intervention (surgical or radiological) versus observation in children and adolescents with varicocele are controversial.To systematically evaluate the evidence regarding the short- and long-term outcomes of varicocele treatment in children and adolescents.A systematic review (...) and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. A priori protocol was registered to PROSPERO (CRD42018084871), and a literature search was performed for all relevant publications published from January 1980 until June 2017. Randomized controlled trials (RCTs), nonrandomized comparative studies (NRSs), and single-arm case series including a minimum of 50 participants were eligible for inclusion.Of 1550 articles

2018 EvidenceUpdates

18. Reaching cardiovascular prevention guideline targets with a polypill-based approach: a meta-analysis of randomised clinical trials Full Text available with Trip Pro

Reaching cardiovascular prevention guideline targets with a polypill-based approach: a meta-analysis of randomised clinical trials The aim of this study was to determine the effect of polypill-based care on the achievement of 2016 European Society of Cardiology (ESC) guideline targets for blood pressure (BP), low-density lipoprotein (LDL) cholesterol and antiplatelet therapy.We conducted an individual participant data meta-analysis of three randomised clinical trials that compared a strategy (...) using a polypill containing aspirin, statin and antihypertensive therapy with usual care in patients with a prior cardiovascular disease (CVD) event or who were at high risk of their first event. Overall, the trials included 3140 patients from Australia, England, India, Ireland, the Netherlands and New Zealand (75% male, mean age 62 years and 76% with a prior CVD event). The primary outcome for this study was the proportion of people achieving ESC guideline targets for BP, LDL and antiplatelet

2018 EvidenceUpdates

19. Evidence-Based Best-Practice Guidelines for Preventing Anterior Cruciate Ligament Injuries in Young Female Athletes: A Systematic Review and Meta-analysis Full Text available with Trip Pro

Evidence-Based Best-Practice Guidelines for Preventing Anterior Cruciate Ligament Injuries in Young Female Athletes: A Systematic Review and Meta-analysis Injury prevention neuromuscular training (NMT) programs reduce the risk for anterior cruciate ligament (ACL) injury. However, variation in program characteristics limits the potential to delineate the most effective practices to optimize injury risk reduction.To evaluate the common and effective components included in ACL NMT programs (...) and develop an efficient, user-friendly tool to assess the quality of ACL NMT programs.Systematic review and meta-analysis.Study inclusion required (1) a prospective controlled trial study design, (2) an NMT intervention aimed to reduce incidence of ACL injury, (3) a comparison group, (4) ACL injury incidence, and (5) female participants. The following data were extracted: year of publication, study design, sample size and characteristics, and NMT characteristics including exercise type and number per

2018 EvidenceUpdates

20. Meta-Analysis of Genotype-Guided Versus Standard Dosing of Vitamin K Antagonists (Abstract)

Meta-Analysis of Genotype-Guided Versus Standard Dosing of Vitamin K Antagonists Vitamin K antagonist (VKA) is a commonly prescribed anticoagulant with a narrow therapeutic window. Genetic polymorphisms account for high VKA dosage variability. Hence, we performed an updated meta-analysis of all randomized clinical trials (RCTs) comparing genotype-guided VKA versus standard dosing algorithms. We conducted a systematic search of electronic databases from inception to October 2017 for all RCTs (...) for the genotype-guided group in comparison with the standard group (mean difference 3.41%, 95% confidence interval [CI] 0.71 to 6.10, p = 0.01). In addition, there were significant reductions in major and all bleeding events ((RR 0.35, 95% CI 0.20 to 0.63, p = 0.0004) and (RR 0.79, 95% CI 0.66 to 0.95, p = 0.01), respectively). However, there were no significant differences between the groups for international normalized ratio >4 (RR 0.89, 95% CI 0.80 to 1.00, p = 0.06), thromboembolism (RR 0.81, 95% CI 0.56

2018 EvidenceUpdates

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