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1. What surface properties of joint arthroplasty implants favor biofilm formation? Does coating implants with antibiotics reduce the rate of surgical site infection or peri-prosthetic joint infection in human subjects? A systematic review of the literature

What surface properties of joint arthroplasty implants favor biofilm formation? Does coating implants with antibiotics reduce the rate of surgical site infection or peri-prosthetic joint infection in human subjects? A systematic review of the literature Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content (...) : Exclusion criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2

2018 PROSPERO

2. Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature. (PubMed)

Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature. Although venous ulcers have a great social and economic impact, there is a lack of evidence from randomised controlled trials (RCTs) to support appropriate management for this disease. Framing the research question using the Population; Intervention; Comparator; Outcome; Time frame (PICOT) format in RCTs can improve the quality (...) of the research design.To evaluate how the PICOT format is used to frame a research question in reports of RCTs of venous ulcer disease and to determine the factors associated with better adherence to the PICOT format in framing the research question.We will conduct a systematic survey of RCTs on venous ulcers published in the National Institute of Health, PubMed database between January 2009 and May 2016. We will include all RCTs addressing therapeutic intervention for venous ulcer disease involving human

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2016 BMJ open

3. Models for the study of nasal and sinus physiology in health and disease: A review of the literature (PubMed)

Models for the study of nasal and sinus physiology in health and disease: A review of the literature Chronic sinusitis is a very common yet poorly understood medical condition with significant morbidity. Hence, it remains an entity that is difficult to treat with unsatisfactory outcomes of current management options. This necessitates research into the etiology and pathophysiology of the condition to enhance our knowledge and the therapeutic options. Unfortunately, this kind of research (...) is not always feasible on human subjects due to practical and ethical limitations. Therefore, an alternative model that simulates the disease had to be found in order to overcome these limitations. These models could either be in vivo or in vitro. The aim of our review is to summarize the research findings and key discoveries of both in vivo and in vitro models of chronic sinusitis that have enhanced our understanding of the condition today and have paved the way for the future research of tomorrow. Data

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2017 Laryngoscope investigative otolaryngology

4. Objective measures of functional impairment for degenerative diseases of the lumbar spine: a systematic review of the literature. (PubMed)

Objective measures of functional impairment for degenerative diseases of the lumbar spine: a systematic review of the literature. The accurate determination of a patient's functional status is necessary for therapeutic decision-making and to critically appraise treatment efficacy. Current subjective patient-reported outcome measure (PROM)-based assessments have limitations and can be complimented by objective measures of function.To systematically review the literature and provide an overview (...) on the available objective measures of function for patients with degenerative diseases of the lumbar spine.Systematic review of the literature.The PRISMA guidelines were followed. Two reviewers independently searched the PubMed, Web of Science, EMBASE and SCOPUS databases for permutations of the words "objective", "assessment", "function", "lumbar" and "spine", including articles on human subjects with degenerative diseases of the lumbar spine that reported on objective measures of function, published until

2019 The Spine Journal

5. Using wearable technology to predict health outcomes: a literature review. (PubMed)

to the research question if they involved human subjects, used wearable technology that tracked a health-related parameter, and incorporated data from wearable technology into a predictive model of mortality, readmission, and/or emergency department (ED) visits.Eight unique studies were directly related to the research question, and all were of at least moderate quality. Six studies developed models for readmission and two for mortality. In each of the eight studies, data obtained from wearable technology (...) Using wearable technology to predict health outcomes: a literature review. To review and analyze the literature to determine whether wearable technologies can predict health outcomes.We queried Ovid Medline 1946 -, Embase 1947 -, Scopus 1823 -, the Cochrane Library, clinicaltrials.gov 1997 - April 17, 2018, and IEEE Xplore Digital Library and Engineering Village through April 18, 2018, for studies utilizing wearable technology in clinical outcome prediction. Studies were deemed relevant

2018 Journal of the American Medical Informatics Association

6. Locomotor Training in the Pediatric Spinal Cord Injury Population: A Systematic Review of the Literature. (PubMed)

to the pediatric SCI population and develop recommendations for pediatric LT. Methods: A thorough search was performed using the following databases: Scopus, CINAHL, PubMed, and Ovid. Studies were selected based on the following inclusion criteria: pediatric SCI population, articles published within last 10 years, human subjects, and LT. Studies looking at other neurological disorders and subjects who were not previously ambulatory were excluded. Five students and one Faculty Research Advisor from (...) Locomotor Training in the Pediatric Spinal Cord Injury Population: A Systematic Review of the Literature. Background: The restoration of walking ability in the spinal cord injury (SCI) population is an increasingly important goal in physical therapy. Locomotor training (LT) is often implemented with the aim to restore ambulation. At this point, there are no guidelines for LT in the pediatric SCI population. Objectives: The aim of this review is to further narrow the effects of LT

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2018 Topics in spinal cord injury rehabilitation

7. Systematic literature review on which maternal alcohol behaviours are related to fetal alcohol spectrum disorders (FASD). (PubMed)

Systematic literature review on which maternal alcohol behaviours are related to fetal alcohol spectrum disorders (FASD). Fetal alcohol spectrum disorders (FASD) is a worldwide problem. Maternal alcohol consumption is an important risk factor for FASD. It remains unknown which alcohol consumption patterns most strongly predict FASD. The objective of this study was to identify these.Systematic literature review.We searched in PubMed, PsychINFO, PsycARTICLES, ERIC, CINAHL, Embase and MEDLINE up (...) to August 2018. The query consisted of keywords and their synonyms related to FASD, pregnancy and behaviour. Studies were excluded when not published in English, were reviews or involved non-human subjects. Substantial heterogeneity precluded aggregation or meta-analysis of the data. Instead, data were qualitatively inspected.In total, 21 studies were eligible for further data analysis. All studies that measured both maternal alcohol drinking behaviours and FASD reported retrospective data on maternal

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2018 BMJ open

8. Participation in research bronchoscopy: a literature review (PubMed)

Participation in research bronchoscopy: a literature review Bronchoscopy is the preferred method for collecting biological samples from the lower airways of subjects in clinical research. However, ensuring participation in clinical research can be challenging when the research includes an invasive procedure. For this report we reviewed the literature to look for information on participation in research bronchoscopy studies to better design our own study, the Bergen COPD Microbiome study (...) (MicroCOPD). We performed a systematic literature search on participation in research bronchoscopy studies in February 2014 using the search engines of PubMed and EMBASE. The literature search resulted in seven relevant papers. Motivation was an end point in six of the seven papers, but reasons for declining participation and recruitment strategies also seemed important. Human subjects participate in research bronchoscopy studies for personal benefit and altruistic reasons. Inconvenience associated

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2016 European clinical respiratory journal

9. Interventions to Improve Veterans' Access to Care: A Systematic Review of the Literature

Interventions to Improve Veterans' Access to Care: A Systematic Review of the Literature Evidence-based Synthesis Program Department of Veterans Affairs Health Services Research & Development Service Evidence-based Synthesis Program Interventions to Improve Veterans’ Access to Care: A Systematic Review of the Literature Department of Veterans Affairs Health Services Research & Development Service January 2011 Investigators: Principal Investigator: Shannon M. Kehle, PhD Co-Investigator: Nancy (...) Specifically, the new conceptualization acknowledges post-access outcomes such as satisfaction, symptom levels, and functioning. As such, we sought to conduct a review of the literature that would clarify the current state of knowledge regarding the link between access to healthcare and system-level (e.g., utilization, satisfaction with care) and patient-level (quality of life, symptoms, mortality) outcomes. Given V A’s continuing commitment to improving access for veterans, 2,3 we also examined

2011 Veterans Affairs Evidence-based Synthesis Program Reports

10. Intra-articular Implantation of Mesenchymal Stem Cells, Part 1: A Review of the Literature for Prevention of Postmeniscectomy Osteoarthritis (PubMed)

have been reported. In human subjects, there are limited data to determine the effect of biological therapies for use in delaying or preventing the onset of OA after a meniscectomy procedure. The purpose of this review is to highlight the findings in the presently available literature on the use of intra-articular implantation of MSCs postmeniscectomy and to offer suggestions for future research with the goal of delaying or treating early OA postmeniscectomy with MSCs. (...) Intra-articular Implantation of Mesenchymal Stem Cells, Part 1: A Review of the Literature for Prevention of Postmeniscectomy Osteoarthritis Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs

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2017 Orthopaedic journal of sports medicine

11. Association of Zika Virus with Myocarditis, Heart Failure, and Arrhythmias: A Literature Review (PubMed)

of the infection. We recognize the limitations of our study owing to the paucity of the sample size of our literature review. However, the significant findings have also proved the dire need to conduct more research to further back the possibility of ZIKV's influence on the cardiac cells. Closely studying these associations can eventually help develop a vaccine for ZIKV in the near future. (...) Association of Zika Virus with Myocarditis, Heart Failure, and Arrhythmias: A Literature Review As the concerns regarding Zika virus (ZIKV) are mostly of neurological disorders, especially in neonates and infants, other possible threats of the virus may have been overlooked. Our study focuses on the potential threat that ZIKV may pose to the heart like that of similar arboviral diseases. We conducted a literature search of multiple terms in March 2017 using the search engines, PubMed, Embase

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2017 Cureus

12. The baby or the bath water? Lessons learned from the National Action Alliance for Suicide Prevention Research Prioritization Task Force literature review. (PubMed)

The baby or the bath water? Lessons learned from the National Action Alliance for Suicide Prevention Research Prioritization Task Force literature review. The Research Prioritization Task Force of the National Action Alliance for Suicide Prevention conducted a comprehensive literature review of suicide prevention/intervention trials to assess the quality of the scientific evidence.A literature "review of reviews" was conducted by searching the most widely used databases for mental health (...) and public health research. The quality of the reviews was evaluated using the Revised Assessment of Multiple Systematic Reviews system; the quality of the scientific evidence for the suicide preventions/interventions was assessed using U.S. Preventive Services Task Force criteria. The reviews were limited to peer-reviewed publications with human subjects published in English.Ninety-eight systematic reviews and 45 primary sources on suicide prevention/interventions published between January 2000

2014 American journal of preventive medicine

13. The olivocochlear system and protection from acoustic trauma: a mini literature review (PubMed)

of the OCS and susceptibility to NIHL was carried out. Animal data consistently show that de-efferented ears exhibit larger temporary threshold shift (TTS) and permanent threshold shift (PTS) than efferented ears. Data from human studies do not consistently show a correlation between the strength of the OCS function and amount of TTS. Further research on human subjects is required to determine how the OCS function could be used to predict susceptibility to NIHL in individual subjects. (...) The olivocochlear system and protection from acoustic trauma: a mini literature review Large intersubject variability in the susceptibility to noise-induced hearing loss (NIHL) is known to occur in both humans and animals. It has been suggested that the olivocochlear system (OCS) plays a significant role in protecting the cochlea from exposure to high levels of noise. A mini literature review about the scientific evidence from animal and human studies about the association between the function

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2015 Frontiers in systems neuroscience

14. Management of Incidental Findings Detected During Research Imaging

Management of Incidental Findings Detected During Research Imaging Management of Incidental Findings Detected During Research Imaging A report by Representatives of Research Imaging Centres, Professional Societies, Regulatory Bodies, Funding Organisations, Royal Colleges involved in research imaging and Patient Organisations, in the UK In collaboration with:Participating Imaging Research Centres n Aberdeen Biomedical Imaging Centre n Aston Brain Centre n Bangor University Imaging Centre n (...) Bristol Oncology Centre n Birmingham University Imaging Centre n Cambridge, Wolfson Brain Imaging Centre and Neurosurgery n Cambridge, University of, Department of Radiology n Cardiff University Brain Imaging Centre n Dundee Research Imaging Centre n University of Edinburgh Research Imaging Centre n Glasgow Clinical Neuroradiology n Glasgow, Centre for Cognitive Neuroimaging n Hull Imaging Centre (Centre for MR Investigations) n Liverpool Magnetic Resonance And Image Analysis Research Centre (MARIARC

2011 Royal College of Radiologists

15. Beware evidence “spin” : an important source of bias in the reporting of clinical research

way than the actual results reflect, or the presence of discrepancies between the abstract and the full text). “Researchers have a duty to make publicly available the results of their research on human subjects and are accountable for the completeness and accuracy of their reports.” So how common is “spin ” in clinical research? An of 72 randomised controlled trials that reported primary outcomes with statistically non-significant results, found that more than 40% of the trials had some form (...) medicine from all over the world, from the fields of research, clinical practice and commissioning. You can follow him on Twitter at Competing interests: I declare no competing interests relevant to this article. Disclaimer: The views expressed are those of the author and not necessarily of any of the institutions or organisations mentioned in the article. Acknowledgements: Thanks to Jeff Aronson, Meena Mahtani and Annette Plüddemann for helpful comments. 02 July 2019 Systematic reviews of qualitative

2016 CEBM blog

16. New frontiers in molecular and imaging research on evaluation and diagnosis of bladder outlet obstruction in women (PubMed)

New frontiers in molecular and imaging research on evaluation and diagnosis of bladder outlet obstruction in women Diagnosis of bladder outlet obstruction (BOO) often presents a challenge in female patients. Traditional diagnostic elements such as symptom history and urodynamic data are rarely clear cut in women. Therefore, we sought to review the current literature on diagnosis of female BOO, focusing on new frontiers in the realm of molecular markers and imaging modalities.In addition (...) to fluoroscopy in the setting of videourodynamics, ultrasound and MRI can augment the diagnosis and aid in therapeutic planning in certain etiologies of female BOO. Furthermore, multiple potential biomarkers (i.e. nerve growth factor, prostaglandins, ATP) that have been studied in correlation to BOO in animal models as well as human subjects hold promise for diagnostic applications.These novel techniques may augment standard clinical and urodynamic evaluation of BOO in females. Future directions include

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2017 Current bladder dysfunction reports

17. Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 (...) March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

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2013 American Heart Association

18. US policies to enhance older driver safety: a systematic review of the literature. (PubMed)

US policies to enhance older driver safety: a systematic review of the literature. The purpose of this study was to conduct a systematic review of the literature related to state policies concerning older drivers and to draw policy conclusions about which policies appear to work to reduce older driver crashes and to identify areas needed for further research. Specific policies examined in this paper concern medical reporting and medical review, license renewal processes, and driver testing (...) . A study was included in the systematic review if it met the following criteria: published in English between 1991and January 2013; included data on human subjects aged 65 and older residing in the United States; included information on at least one policy related to older drivers; and had a transportation-related outcome variable (e.g., crash, fatality, renewal). A total of 29 studies met inclusion criteria. Twenty-two studies investigated license renewal and seven articles examined medical reporting

2013 Journal of aging & social policy

19. Fostering IRB Collaboration for Review of International Research (PubMed)

Fostering IRB Collaboration for Review of International Research This article presents a review of the literature, summarizes current initiatives, and provides a heuristic for assessing the effectiveness of a range of institutional review board (IRB) collaborative strategies that can reduce the regulatory burden of ethics review while ensuring protection of human subjects, with a particular focus on international research. Broad adoption of IRB collaborative strategies will reduce regulatory (...) burdens posed by overlapping oversight mechanisms and has the potential to enhance human subjects protections.

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2014 The American journal of bioethics : AJOB

20. Health Effects for Infants and Young Children Associated with Breastfeeding: A Rapid Review

included 60 papers included: systematic reviews/meta-analyses 13; 41prospective cohort studies; 6 papers reporting on the PROBIT study (cluster-randomized intervention trial) Types of studies included Systematic literature reviews with meta-analysis, prospective cohort Search period Jan 2000 - Jan 2012 Number of databases searched One – PubMed 36 Inclusion and exclusion criteria Inclusion: - Human subjects - English or Nordic language - Study population relevant to Nordic countries - Systematic (...) Health Effects for Infants and Young Children Associated with Breastfeeding: A Rapid Review Health Effects for Infants and Young Children Associated with Breastfeeding A Rapid Review Elizabeth Walker, Analyst, Research and Policy Kate Kerrigan, Public Health Nurse Rita Caprara, Supervisor Judy Buchan, Manager July 30, 2018 i Table of Contents Key Messages 1 Executive Summary 2 1 Issue 5 2 Context 6 3 Conceptual Framework 7 4 Literature Review Question 7 5 Literature Search 8 6 Relevance

2019 Peel Health Library

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