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("chocolate addiction" OR addiction to chocolate") AND obesity

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1. Effect of Exercise on Chocolate Addiction

: The study will use stress inducing tasks to determine if there are significant improvements in mood, chocolate cravings, and attentional bias to chocolate in overweight/obese chocolate abusers following rest and a bout of high intensity interval exercise. Condition or disease Intervention/treatment Phase Acute Exercise and Addictive Behavior Behavioral: Exercise Not Applicable Detailed Description: The purpose of this research study is to investigate whether a single high intensity interval exercise (...) or not on addictive behaviors to chocolate. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 12 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: The Effect of a High Intensity Interval Exercise Bout on Addictive Behaviors in Overweight/Obese Adults Actual Study Start Date : January 8, 2018 Actual Primary Completion Date : September 15, 2018 Actual

2017 Clinical Trials

2. Junk food diet-induced obesity increases D2 receptor autoinhibition in the ventral tegmental area and reduces ethanol drinking. (PubMed)

of bacon, potato chips, cheesecake, cookies, breakfast cereals, marshmallows, and chocolate candies to male Wistar rats for 3-4 weeks, producing an obese phenotype. Prior cafeteria diet feeding reduced homecage ethanol drinking over 2 weeks of testing, and transiently reduced sucrose and chow intake. Importantly, cafeteria diet had no effect on ethanol metabolism rate or blood ethanol concentrations following 2g/kg ethanol administration. In midbrain slices, we showed that cafeteria diet feeding (...) Junk food diet-induced obesity increases D2 receptor autoinhibition in the ventral tegmental area and reduces ethanol drinking. Similar to drugs of abuse, the hedonic value of food is mediated, at least in part, by the mesostriatal dopamine (DA) system. Prolonged intake of either high calorie diets or drugs of abuse both lead to a blunting of the DA system. Most studies have focused on DAergic alterations in the striatum, but little is known about the effects of high calorie diets on ventral

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2017 PLoS ONE

3. Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-like Behavior. (PubMed)

Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-like Behavior. An increasing perspective conceptualizes obesity and overeating as disorders related to addictive-like processes that could share common neurobiological mechanisms. In the present study, we aimed at validating an animal model of eating addictive-like behavior in mice, based on the DSM-5 substance use disorder criteria, using operant conditioning maintained by highly palatable chocolate-flavored pellets (...) . For this purpose, we evaluated persistence of food-seeking during a period of non-availability of food, motivation for food, and perseverance of responding when the reward was associated with a punishment. This model has allowed identifying extreme subpopulations of mice related to addictive-like behavior. We investigated in these subpopulations the epigenetic and proteomic changes. A significant decrease in DNA methylation of CNR1 gene promoter was revealed in the prefrontal cortex of addict-like mice, which

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2015 Neuropsychopharmacology

4. Study to Determine the Safety, Tolerability, Pharmacokinetics, Food Effect and Pharmacodynamics of Single and Multiple Ascending Doses of P7435 in Healthy, Overweight or Obese Subjects

Study to Determine the Safety, Tolerability, Pharmacokinetics, Food Effect and Pharmacodynamics of Single and Multiple Ascending Doses of P7435 in Healthy, Overweight or Obese Subjects Study to Determine the Safety, Tolerability, Pharmacokinetics, Food Effect and Pharmacodynamics of Single and Multiple Ascending Doses of P7435 in Healthy, Overweight or Obese Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration (...) or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Determine the Safety, Tolerability, Pharmacokinetics, Food Effect and Pharmacodynamics of Single and Multiple Ascending Doses of P7435 in Healthy, Overweight or Obese Subjects The safety and scientific validity of this study is the responsibility of the study sponsor

2013 Clinical Trials

5. Health and early years, children and young people

(e.g. housing, unemployment, debt, relationships, addictions) and provided a crucial role in referring parents to other agencies and services to provide support. Image of Fair Isle Primary School’s Opportunities for All project taken from “Assets in Action: illustrating asset-based approaches for health improvement”. GCPH; 2012.16 • Templehall Dad’s Group – The project was part of the Cottage Family Centre in Kircaldy which provides a range of services responding to the needs of families

2016 Glasgow Centre for Population Health

6. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications

obesity, or other conditions, then TEE should be performed as soon as possible after TTE. When TTE is negative and clinical suspicion remains low, then other clinical entities should be considered. If TTE shows vegetations but the likelihood of complications is low, then subsequent TEE is unlikely to alter initial medical management. On the other hand, if clinical suspicion of IE or its complications is high (eg, prosthetic valve or new atrioventricular block), then a negative TTE will not definitely

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2016 Infectious Diseases Society of America

8. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications

obesity, or other conditions, then TEE should be performed as soon as possible after TTE. When TTE is negative and clinical suspicion remains low, then other clinical entities should be considered. If TTE shows vegetations but the likelihood of complications is low, then subsequent TEE is unlikely to alter initial medical management. On the other hand, if clinical suspicion of IE or its complications is high (eg, prosthetic valve or new atrioventricular block), then a negative TTE will not definitely

2015 American Heart Association

9. Electronic Cigarettes

-cigarettes could fuel and promote nicotine addiction, especially in children, and their acceptance has the potential to renormalize smoking behavior. E-cigarette use could also potentially serve as a gateway to other drugs and harmful substances. E-Cigarettes: Design and Operation Since their initial manufacturing in 2003, there has been a rapid growth and evolution in the types, design, and overall engineering characteristics of e-cigarettes. , This has resulted in a large degree of product variability (...) in the future. Finally, among college students, another e-cigarette user group, e-cigarette use may not be motivated by the desire to quit smoking, nor may it lead to quitting. In conclusion, the overall use patterns are unclear and constantly changing, which makes it difficult to draw firm conclusions about the prevalence, preference, and purpose of e-cigarette use. Youth Concerned public health advocates see e-cigarettes as a route to nicotine addiction and possibly as a potential gateway to tobacco use

2014 American Heart Association

10. Neural Basis of Eating Behavior in Abstinent Smokers

Phase Nicotine Use Disorder Other: Practice Quit Attempt Not Applicable Detailed Description: Tobacco use and obesity are the two leading causes of preventable deaths. Because these two behaviors share common brain reward mechanisms, reducing one behavior often leads to increases in the other behavior. Behavioral Economic and Incentive Salience models shed much light on this clinical problem. Smoking cessation produces reward dysregulation that can alter the motivational salience of other (...) they experience severe symptoms) b Notable soy allergy c Peanut allergy d a,b,c Boost® Original Very Vanilla Nutritional Shake: Contains milk and soy ingredients. Suitable for Lactose Intolerance. b,c,d M&M's® (Milk Chocolate): Contains milk and soy ingredients (MAY CONTAIN PEANUTS) Lay's® Classic Potato Chips (Gluten Free): Potatoes, vegetable oil, and salt Psychiatric Current diagnosis of major depression. Subjects with a history of major depression, in remission for 6 months or longer (may be stable

2018 Clinical Trials

11. The computational form of craving is a selective multiplication of economic value (PubMed)

The computational form of craving is a selective multiplication of economic value Craving is thought to be a specific desire state that biases choice toward the desired object, be it chocolate or drugs. A vast majority of people report having experienced craving of some kind. In its pathological form craving contributes to health outcomes in addiction and obesity. Yet despite its ubiquity and clinical relevance we still lack a basic neurocomputational understanding of craving. Here, using

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2018 Proceedings of the National Academy of Sciences of the United States of America

12. A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms

or have an uncontrollable habit of chewing or inhaling nicotine products. Drug addiction in history, or a positive urine test for psychoactive or narcotic substances. Use of caffeine products exceeding 500 mg caffeine daily (5 cups of coffee) and the inability to abstain from caffeine products within 48 hours before dosing and prior to the last blood sample collection of each study period. Use of xanthine containing products (e.g., coffee, tea, chocolate, or cola drink) within 48 hours before dosing (...) Vasoconstrictor Agents Nasal Decongestants Respiratory System Agents Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Protective Agents Expectorants Appetite Depressants Anti-Obesity Agents

2017 Clinical Trials

13. Meet the new NCCIH five year strategic plan, same as the old NCCAM five year strategic plan

or obese, living a sedentary life, smoking or using tobacco products, and the excessive consumption of alcohol, are linked to increased rates of cardiovascular disease, cancer, and diabetes. Preliminary evidence indicates that some complementary health approaches may be useful in encouraging improved self-care, an improved personal sense of well-being, and a greater commitment to a healthy lifestyle. For example, analysis of the 2012 NHIS data indicates that many people who practiced yoga reported (...) important to note that NCCIH is now emphasizing, as its key scientific priority, pain and difficult-to-control symptoms, in particular nonpharmacologic methods of relieving pain. While there is certainly a need for better research into how better to control pain without non-steroidal anti-inflammatory drugs or opioids, both of which have significant side effects and the latter of which is recognized as a significant cause of addiction and premature death, one can't help but note that these are also

2016 Respectful Insolence

14. Coping with Common GI Symptoms in the Community: A Global Perspective on Heartburn, Constipation, Bloating, and Abdominal Pain/Discomfort

, if frequent, can severely limit daily activities, work productivity, sleep, and quality of life. • Proper management and monitoring can control symptoms and avoid complications (such as peptic strictures) in most cases. • “Older” simple remedies may be useful: o Occasional reflux can be treated effectively with antacids. o Patients should avoid foods that trigger symptoms—typically chocolate, coffee, fatty food. o The use of chewing gum increases saliva production and partially neutralizes acid. o (...) • Symptoms or signs of laryngitis: hoarseness, wheezing, coughing, or choking • Unexplained weight loss • Continuous nausea, vomiting, diarrhea WGO Global Guidelines Common GI symptoms (long version) 15 © World Gastroenterology Organisation, 2013 • Symptoms suggestive of cardiac-type chest pain: radiating to shoulder, arm, neck, jaw, and shortness of breath, sweating • Pregnant women or nursing mothers • Children 60 or aged 50–60 and has risk factors for cancer (e.g., tobacco, alcohol, obesity), referral

2013 World Gastroenterology Organisation

15. Plain tobacco packaging: A systematic review

that the cigarettes inside were dangerous. Perceptions of harm also included questions on which packs you would purchase if trying to reduce the risks to health or which were perceived as ‘easier to quit’. From a public health perspective, all conventional cigarettes pose a similar health risk; smokers can alter the way they smoke cigarettes of different tar and/or nicotine machine-measured yields in order to compensate for differences and satisfy their nicotine addiction. In addition there is no evidence (...) right to accurate information about the risks of smoking’ and that a basic requisite for reducing tobacco use is that every person be informed of the health consequences, addictive nature, and potential for disability and premature death posed by tobacco consumption and exposure to tobacco smoke (WHO 2011b, p18). Health warnings on tobacco packages have emerged as an important medium for communicating these health risks. Warnings have very high reach and frequency of exposure among smokers; a 20

2012 Public Health Research Consortium

17. CPG on sleep disorders in childhood and adolescence in primary care

, chocolate, nicotine, alcohol and drugs) and applying rules based on the principles of sleep hygiene practices, mainly, and recommendations to relatives about adequate sleep schedules for their children, depending on the age. To reduce discomfort in legs in class at school, family and school support is recommended, which can translate into strategies such as allowing the child to leave to take a walk during class, some physical activity during breaks or frequently changing positions. D More evidence (...) (keeping the same sleep times every day, getting out of bed until becoming sleepy again, eliminating certain habits that can alter sleep behaviour [such as playing video games], foods/drinks with caffeine, eating chocolate, etc.). It has been 5 years since the publication of this Clinical Practice Guideline and it is subject to updating. It has been 5 years since the publication of this Clinical Practice Guideline and it is subject to updating. CLINICAL PRACTICE GUIDELINE ON SLEEP DISORDERS

2011 GuiaSalud

18. Appetitive vs. Aversive conditioning in humans (PubMed)

, although its importance for normal and pathological behaviors (e.g., obesity, addiction) is undeniable. The present study intents to translate animal findings on appetitive conditioning to humans using food as an US. Thirty-three participants were investigated between 8 and 10 am without breakfast in order to assure that they felt hungry. During two acquisition phases, one geometrical shape (avCS+) predicted an aversive US (painful electric shock), another shape (appCS+) predicted an appetitive US (...) (chocolate or salty pretzel according to the participants' preference), and a third shape (CS-) predicted neither US. In a extinction phase, these three shapes plus a novel shape (NEW) were presented again without US delivery. Valence and arousal ratings as well as startle and skin conductance (SCR) responses were collected as learning indices. We found successful aversive and appetitive conditioning. On the one hand, the avCS+ was rated as more negative and more arousing than the CS- and induced startle

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2015 Frontiers in behavioral neuroscience

20. Headache: Pediatric Perspective (Follow-up)

. Individual treatment decisions should be based on the age of the child and receptiveness to behavioral techniques. Behavioral techniques can be highly effective for migraine and tension-type headaches. More focus is also being directed toward the use of complementary/alternative therapies such as acupuncture. Acute tension headaches often respond to symptomatic treatments. Ibuprofen and acetaminophen are recommended to relieve headache pain. Avoid narcotics and other potentially addictive medications (...) . Eliminate identified precipitants; for example, alcohol, drugs, or caffeine may trigger headaches. Encourage appropriate lifestyle changes. Lifestyle changes The role of diet in headaches remains controversial. However, if a given food or beverage is associated with headaches, its avoidance has an obvious and significantly positive impact. A study by Milde-Busch et al linked obesity and physical inactivity to childhood and adolescent headache disorders. [ ] A lifestyle that includes physical exercise

2014 eMedicine.com

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