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141. Unbiased shRNA screening, using a combination of FACS and high-throughput sequencing, enables identification of novel modifiers of Polycomb silencing (PubMed)

Unbiased shRNA screening, using a combination of FACS and high-throughput sequencing, enables identification of novel modifiers of Polycomb silencing Polycomb silencing is an important and rapidly growing field that is relevant to a broad range of aspects of human health, including cancer and stem cell biology. To date, the regulatory mechanisms for the fine-tuning of Polycomb silencing remain unclear, but it is likely that there is a series of unidentified factors that functionally modify

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2018 Scientific reports

142. Hypomania Symptoms Across Psychiatric Disorders: Screening Use of the Hypomania Check-List 32 at Admission to an Outpatient Psychiatry Clinic (PubMed)

Hypomania Symptoms Across Psychiatric Disorders: Screening Use of the Hypomania Check-List 32 at Admission to an Outpatient Psychiatry Clinic Introduction: Hypomania symptoms are best described as a continuum, ranging beyond Bipolar Spectrum Disorders (BSD). Other nosological entities, such as major depressive disorder, schizoaffective disorder, or borderline personality disorder, may also share symptoms with BSD, raising challenges for differential diagnosis. While the Hypomania Checklist-32

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2018 Frontiers in Psychiatry

143. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration (PubMed)

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are challenging due to confounding factors such as batch effects and variable

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2018 Nature communications

144. Cervical cancer screening using the Cervista high-risk human papillomavirus test: opportunistic screening of a hospital-based population in Fujian province, China (PubMed)

Cervical cancer screening using the Cervista high-risk human papillomavirus test: opportunistic screening of a hospital-based population in Fujian province, China The Cervista® high-risk human papillomavirus (HR-HPV) test was evaluated as a primary screening method for cervical cancer in women aged ≥21 years and was compared with different screening and triage combinations.A nested case-control study within the Fujian provincial Cervical Lesion Screening Cohorts was used to evaluate (...) the Cervista test as the primary cervical screening method in a hospital-based population. Strategy 1 primarily screened using a cytology screen with HR-HPV testing used for triage. Strategy 2 primarily screened using cytology and HR-HPV co-testing. Strategy 3 primarily screened using HR-HPV testing and triaged HPV-positive women based on cytology. Strategy 4 primarily screened using HR-HPV testing and referred A9 pool HPV-positive women to colposcopy directly, whereas non-A9 HPV-positive women were

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2018 Cancer management and research

145. Automated retinopathy of prematurity screening using deep neural networks (PubMed)

Automated retinopathy of prematurity screening using deep neural networks Retinopathy of prematurity (ROP) is the leading cause of childhood blindness worldwide. Automated ROP detection system is urgent and it appears to be a safe, reliable, and cost-effective complement to human experts.An automated ROP detection system called DeepROP was developed by using Deep Neural Networks (DNNs). ROP detection was divided into ROP identification and grading tasks. Two specific DNN models, i.e., Id-Net

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2018 EBioMedicine

146. Colorectal cancer screening use among insured adults: Is out-of-pocket cost a barrier to routine screening? (PubMed)

Colorectal cancer screening use among insured adults: Is out-of-pocket cost a barrier to routine screening? To describe the characteristics of adults who needed to see a doctor in the past year but could not due to the extra cost and assess the impact of limited financial resources on the receipt of routine fecal occult blood test, sigmoidoscopy, or colonoscopy for colon cancer screening among insured patients.Data obtained from the 2012 Behavioral Risk Factor Surveillance System included

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2018 World journal of gastrointestinal pharmacology and therapeutics

147. Reverse Epidemiology: An Experimental Framework to Drive Leishmania Biomarker Discovery in situ by Functional Genetic Screening Using Relevant Animal Models (PubMed)

Reverse Epidemiology: An Experimental Framework to Drive Leishmania Biomarker Discovery in situ by Functional Genetic Screening Using Relevant Animal Models Leishmania biomarker discovery remains an important challenge that needs to be revisited in light of our increasing knowledge on parasite-specific biology, notably its genome instability. In the absence of classical transcriptional regulation in these early-branching eukaryotes, fluctuations in transcript abundance can be generated by gene

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2018 Frontiers in cellular and infection microbiology

148. Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches (PubMed)

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches Dinitroanilines are chemical compounds with high selectivity for plant cell α-tubulin in which they promote microtubule depolymerization. They target α-tubulin regions that have diverged over evolution and show no effect on non-photosynthetic eukaryotes. Hence, they have been used as herbicides over decades. Interestingly, dinitroanilines proved active

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2018 International journal of molecular sciences

149. Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient. (PubMed)

Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient. Fabry disease is an X-linked disease caused by mutations in α-galactosidase A (GLA); these mutations result in the accumulation of its substrates, mainly globotriaosylceramide (Gb3). The accumulation of glycosphingolipids induces pathogenic changes in various organs, including the heart, and Fabry cardiomyopathy is the most frequent cause of death (...) established an algorithm for selecting proper Gb3 staining that could be used for high-content analysis-based drug screening.We generated a Fabry cardiomyopathy model and a drug screening system by using iPS-CMs from a female Fabry patient. Drug screening using our system may help discover new drugs that would improve the prognosis of patients with Fabry cardiomyopathy.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Journal of Molecular and Cellular Cardiology

150. Breast Cancer Screening Using Tomosynthesis or Mammography: A Meta-analysis of Cancer Detection and Recall. (PubMed)

Breast Cancer Screening Using Tomosynthesis or Mammography: A Meta-analysis of Cancer Detection and Recall. Tomosynthesis approximates a 3D mammogram of the breast, reducing parenchymal overlap that masks cancers or creates false "lesions" on 2D mammography, and potentially enabling more accurate detection of breast cancer. We compared breast cancer screening detection and recall in asymptomatic women for tomosynthesis vs 2D mammography.A systematic review and random effects meta-analysis were

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2018 Journal of the National Cancer Institute

151. An Assessment of Public Preferences for Newborn Screening Using Best-Worst Scaling. (PubMed)

An Assessment of Public Preferences for Newborn Screening Using Best-Worst Scaling. To identify and quantify public preferences for attributes of newborn screening conditions.We conducted an online national survey of the public (n = 502) to evaluate preferences for attributes of candidate newborn screening conditions. Respondents were presented with hypothetical condition profiles that were defined using 10 attributes with 2-6 levels per attribute. Participants indicated whether they would

2018 Journal of Pediatrics

152. Maximizing gain in high-throughput screening using conformal prediction (PubMed)

Maximizing gain in high-throughput screening using conformal prediction Iterative screening has emerged as a promising approach to increase the efficiency of screening campaigns compared to traditional high throughput approaches. By learning from a subset of the compound library, inferences on what compounds to screen next can be made by predictive models, resulting in more efficient screening. One way to evaluate screening is to consider the cost of screening compared to the gain associated (...) with finding an active compound. In this work, we introduce a conformal predictor coupled with a gain-cost function with the aim to maximise gain in iterative screening. Using this setup we were able to show that by evaluating the predictions on the training data, very accurate predictions on what settings will produce the highest gain on the test data can be made. We evaluate the approach on 12 bioactivity datasets from PubChem training the models using 20% of the data. Depending on the settings

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2018 Journal of Cheminformatics

153. Pooled extracellular receptor-ligand interaction screening using CRISPR activation (PubMed)

Pooled extracellular receptor-ligand interaction screening using CRISPR activation Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-affinity antibodies and low-affinity ligands can be unambiguously identified when used in pools or as individual

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2018 Genome Biology

154. Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer. (PubMed)

Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer. To determine if a handheld, nanopore-based DNA sequencer can be used for rapid preimplantation genetic screening (PGS).Laboratory study.Academic medical center.Amplified genomic DNA from euploid and aneuploid trophectoderm biopsy samples (n=9) that was also tested using traditional next generation sequencing (NGS).Short-read DNA library preparation and nanopore-based sequencing using a hand-held MinION

2018 Fertility and Sterility

155. Quality improvement programme of ultrasound based fetal anatomy screening using large scale clinical audit. (PubMed)

Quality improvement programme of ultrasound based fetal anatomy screening using large scale clinical audit. Large scale audit and peer review of ultrasound images is advantageous, but is rarely performed consistently as it is time-consuming and expensive. Here we investigate the effect of large scale audit of routine fetal anatomy scans to assess if a full clinical audit cycle could improve clinical image acquisition standards.A large scale, clinical, retrospective audit was conducted

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2018 Ultrasound in Obstetrics and Gynecology

156. A Modified Algorithm for Critical Congenital Heart Disease Screening Using Pulse Oximetry. (PubMed)

A Modified Algorithm for Critical Congenital Heart Disease Screening Using Pulse Oximetry. : media-1vid110.1542/5727212367001PEDS-VA_2017-4065Video Abstract OBJECTIVES: Determine the performance of the American Academy of Pediatrics (AAP) critical congenital heart disease (CCHD) newborn screening algorithm and the impact of an alternative algorithm.Screening was performed on term infants without a known CCHD diagnosis at or near 24 hours of age at a tertiary birth hospital by using the AAP

2018 Pediatrics

157. Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life. (PubMed)

Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life. Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of diabetes, with multiple causative genes. Some MODY subtypes can be treated with sulfonylureas instead of insulin, improving glycemic control, complication rates, quality of life (QoL), and costs

2018 Diabetes Care

158. Automatic screening using word embeddings achieved high sensitivity and workload reduction for updating living network meta-analyses. (PubMed)

Automatic screening using word embeddings achieved high sensitivity and workload reduction for updating living network meta-analyses. We aimed to develop and evaluate an algorithm for automatically screening citations when updating living network meta-analysis (NMA).Our algorithm learns from the initial screening of citations conducted when creating an NMA to automatically identify eligible citations (i.e., needing full-text consideration) when updating the NMA. We evaluated our algorithm

2018 Journal of Clinical Epidemiology

159. Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: Application to a randomized clinical trial in multiple myeloma. (PubMed)

Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: Application to a randomized clinical trial in multiple myeloma. This article proposes an efficient approach to screening genes associated with a phenotypic variable of interest in genomic studies with subgroups. In order to capture and detect various association profiles across subgroups, we flexibly estimate the underlying effect size distribution across subgroups using a semi

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2018 Biometrics

160. Parent-Child Relationship of Pedometer-Assessed Physical Activity and Proxy-Reported Screen Time in Czech Families with Preschoolers (PubMed)

Parent-Child Relationship of Pedometer-Assessed Physical Activity and Proxy-Reported Screen Time in Czech Families with Preschoolers This study focuses on determining the relationship between parents' step count (SC) and screen time (ST) and children's SC and ST on weekdays and at weekends. The participants (278 parents aged 30-45 and their 194 children aged 4-7) were recruited from 10 randomly selected Czech kindergartens. The participants recorded SC and ST duration over a week-long

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2016 International journal of environmental research and public health

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