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121. Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor (Full text)

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor Structural studies of integral membrane proteins have been limited by the intrinsic conformational flexibility and the need to stabilize the proteins in solution. Stabilization by mutagenesis was very successful for structural biology of G protein-coupled receptors (GPCRs). However, it requires heavy protein engineering and may introduce structural deviations. Here we describe the use (...) of specific calixarenes-based detergents for native GPCR stabilization. Wild type, full length human adenosine A2A receptor was used to exemplify the approach. We could stabilize native, glycosylated, non-aggregated and homogenous A2AR that maintained its ligand binding capacity. The benefit of the preparation for fragment screening, using the Saturation-Transfer Difference nuclear magnetic resonance (STD-NMR) experiment is reported. The binding of the agonist adenosine and the antagonist caffeine were

2018 Scientific reports PubMed abstract

122. Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient. (Abstract)

Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient. Fabry disease is an X-linked disease caused by mutations in α-galactosidase A (GLA); these mutations result in the accumulation of its substrates, mainly globotriaosylceramide (Gb3). The accumulation of glycosphingolipids induces pathogenic changes in various organs, including the heart, and Fabry cardiomyopathy is the most frequent cause of death (...) established an algorithm for selecting proper Gb3 staining that could be used for high-content analysis-based drug screening.We generated a Fabry cardiomyopathy model and a drug screening system by using iPS-CMs from a female Fabry patient. Drug screening using our system may help discover new drugs that would improve the prognosis of patients with Fabry cardiomyopathy.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Journal of Molecular and Cellular Cardiology

123. An Assessment of Public Preferences for Newborn Screening Using Best-Worst Scaling. (Abstract)

An Assessment of Public Preferences for Newborn Screening Using Best-Worst Scaling. To identify and quantify public preferences for attributes of newborn screening conditions.We conducted an online national survey of the public (n = 502) to evaluate preferences for attributes of candidate newborn screening conditions. Respondents were presented with hypothetical condition profiles that were defined using 10 attributes with 2-6 levels per attribute. Participants indicated whether they would

2018 Journal of Pediatrics

124. Risk-adjusted colorectal cancer screening using the FIT and routine screening data: development of a risk prediction model. (Full text)

Risk-adjusted colorectal cancer screening using the FIT and routine screening data: development of a risk prediction model. The faecal immunochemical test (FIT) is replacing the guaiac faecal occult blood test in colorectal cancer screening. Increased uptake and FIT positivity will challenge colonoscopy services. We developed a risk prediction model combining routine screening data with FIT concentration to improve the accuracy of screening referrals.Multivariate analysis used complete cases

2018 British Journal of Cancer PubMed abstract

125. Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer. (Full text)

Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer. To determine if a handheld, nanopore-based DNA sequencer can be used for rapid preimplantation genetic screening (PGS).Laboratory study.Academic medical center.Amplified genomic DNA from euploid and aneuploid trophectoderm biopsy samples (n=9) that was also tested using traditional next generation sequencing (NGS).Short-read DNA library preparation and nanopore-based sequencing using a hand-held MinION

2018 Fertility and Sterility PubMed abstract

126. A latent growth curve model to estimate electronic screen use patterns amongst adolescents aged 10 to 17 years. (Full text)

in Grade 5 (n = 636), Grade 7 (n = 672), and Grade 9 (n = 640) for 24 months. At approximately six-month intervals, students reported their total screen time as well as time spent on social networking, passive screen use, gaming, and web use. Patterns of screen use were determined using latent growth curve modelling.In the Grades 7 and 9 cohorts, girls generally reported more screen use than boys (by approximately one hour a day), though all cohorts of boys reported more gaming. The different forms (...) A latent growth curve model to estimate electronic screen use patterns amongst adolescents aged 10 to 17 years. High quality, longitudinal data describing young people's screen use across a number of distinct forms of screen activity is missing from the literature. This study tracked multiple screen use activities (passive screen use, gaming, social networking, web searching) amongst 10- to 17-year-old adolescents across 24 months.This study tracked the screen use of 1948 Australian students

2018 BMC Public Health PubMed abstract

127. Pooled extracellular receptor-ligand interaction screening using CRISPR activation (Full text)

Pooled extracellular receptor-ligand interaction screening using CRISPR activation Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-affinity antibodies and low-affinity ligands can be unambiguously identified when used in pools or as individual

2018 Genome Biology PubMed abstract

128. HCC Screening Using DNA Methylation Changes in ctDNA

HCC Screening Using DNA Methylation Changes in ctDNA HCC Screening Using DNA Methylation Changes in ctDNA - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. HCC Screening Using DNA Methylation Changes in ctDNA

2018 Clinical Trials

129. Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking

Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

130. Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War (Full text)

Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War Clonorchiasis caused by Clonorchis sinensis and opisthorchiasis caused by Opisthorchis viverrini are prevalent in the Far East, including Vietnam. The causal relationship between the 2 liver flukes and cholangiocarcinoma (CCA) has been well documented. Cholangiocarcinoma, a rare tumor of bile ducts, usually occurs in the sixth-seventh decade of life. In the United States, 8000 people are diagnosed with CCA

2018 Infectious Diseases in Clinical Practice (Baltimore, Md.) PubMed abstract

131. Hypomania Symptoms Across Psychiatric Disorders: Screening Use of the Hypomania Check-List 32 at Admission to an Outpatient Psychiatry Clinic (Full text)

Hypomania Symptoms Across Psychiatric Disorders: Screening Use of the Hypomania Check-List 32 at Admission to an Outpatient Psychiatry Clinic Introduction: Hypomania symptoms are best described as a continuum, ranging beyond Bipolar Spectrum Disorders (BSD). Other nosological entities, such as major depressive disorder, schizoaffective disorder, or borderline personality disorder, may also share symptoms with BSD, raising challenges for differential diagnosis. While the Hypomania Checklist-32

2018 Frontiers in Psychiatry PubMed abstract

132. Segmenting women eligible for cervical cancer screening using demographic, behavioural and attitudinal characteristics. (Abstract)

Segmenting women eligible for cervical cancer screening using demographic, behavioural and attitudinal characteristics. The best ways to communicate effectively to under-screened women about cervical cancer screening are unknown. Segmentation techniques create homogeneous segments of women in the population that are different from one another, and help to determine on whom communication efforts should be focused and how messaging should be tailored. We used segmentation techniques to better

2018 Preventive Medicine

133. A Modified Algorithm for Critical Congenital Heart Disease Screening Using Pulse Oximetry. (Full text)

A Modified Algorithm for Critical Congenital Heart Disease Screening Using Pulse Oximetry. : media-1vid110.1542/5727212367001PEDS-VA_2017-4065Video Abstract OBJECTIVES: Determine the performance of the American Academy of Pediatrics (AAP) critical congenital heart disease (CCHD) newborn screening algorithm and the impact of an alternative algorithm.Screening was performed on term infants without a known CCHD diagnosis at or near 24 hours of age at a tertiary birth hospital by using the AAP

2018 Pediatrics PubMed abstract

134. Demand for Colonoscopy in Colorectal Cancer Screening Using a Quantitative Fecal Immunochemical Test and Age-Sex-Specific Thresholds for Test Positivity. (Full text)

Demand for Colonoscopy in Colorectal Cancer Screening Using a Quantitative Fecal Immunochemical Test and Age-Sex-Specific Thresholds for Test Positivity. Background: Despite age and sex differences in fecal hemoglobin (f-Hb) concentrations, most fecal immunochemical test (FIT) screening programs use population-average cut-points for test positivity. The impact of age/sex-specific threshold on FIT accuracy and colonoscopy demand for colorectal cancer screening are unknown.Methods: Using data

2018 Cancer Epidemiology & Biomarkers and Prevention PubMed abstract

135. Cervical cancer screening using the Cervista high-risk human papillomavirus test: opportunistic screening of a hospital-based population in Fujian province, China (Full text)

Cervical cancer screening using the Cervista high-risk human papillomavirus test: opportunistic screening of a hospital-based population in Fujian province, China The Cervista® high-risk human papillomavirus (HR-HPV) test was evaluated as a primary screening method for cervical cancer in women aged ≥21 years and was compared with different screening and triage combinations.A nested case-control study within the Fujian provincial Cervical Lesion Screening Cohorts was used to evaluate (...) the Cervista test as the primary cervical screening method in a hospital-based population. Strategy 1 primarily screened using a cytology screen with HR-HPV testing used for triage. Strategy 2 primarily screened using cytology and HR-HPV co-testing. Strategy 3 primarily screened using HR-HPV testing and triaged HPV-positive women based on cytology. Strategy 4 primarily screened using HR-HPV testing and referred A9 pool HPV-positive women to colposcopy directly, whereas non-A9 HPV-positive women were

2018 Cancer management and research PubMed abstract

136. Colorectal cancer screening use among insured adults: Is out-of-pocket cost a barrier to routine screening? (Full text)

Colorectal cancer screening use among insured adults: Is out-of-pocket cost a barrier to routine screening? To describe the characteristics of adults who needed to see a doctor in the past year but could not due to the extra cost and assess the impact of limited financial resources on the receipt of routine fecal occult blood test, sigmoidoscopy, or colonoscopy for colon cancer screening among insured patients.Data obtained from the 2012 Behavioral Risk Factor Surveillance System included

2018 World journal of gastrointestinal pharmacology and therapeutics PubMed abstract

137. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration (Full text)

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are challenging due to confounding factors such as batch effects and variable

2018 Nature communications PubMed abstract

138. Automatic screening using word embeddings achieved high sensitivity and workload reduction for updating living network meta-analyses. (Abstract)

Automatic screening using word embeddings achieved high sensitivity and workload reduction for updating living network meta-analyses. We aimed to develop and evaluate an algorithm for automatically screening citations when updating living network meta-analysis (NMA).Our algorithm learns from the initial screening of citations conducted when creating an NMA to automatically identify eligible citations (i.e., needing full-text consideration) when updating the NMA. We evaluated our algorithm

2018 Journal of Clinical Epidemiology

139. Breast Cancer Screening Using Tomosynthesis or Mammography: A Meta-analysis of Cancer Detection and Recall. (Full text)

Breast Cancer Screening Using Tomosynthesis or Mammography: A Meta-analysis of Cancer Detection and Recall. Tomosynthesis approximates a 3D mammogram of the breast, reducing parenchymal overlap that masks cancers or creates false "lesions" on 2D mammography, and potentially enabling more accurate detection of breast cancer. We compared breast cancer screening detection and recall in asymptomatic women for tomosynthesis vs 2D mammography.A systematic review and random effects meta-analysis were

2018 Journal of the National Cancer Institute PubMed abstract

140. Effectiveness and safety of colorectal cancer screening using fecal occult blood test for adults aged from 45 to 75 years: a Systematic Review.

Effectiveness and safety of colorectal cancer screening using fecal occult blood test for adults aged from 45 to 75 years: a Systematic Review. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2020 PROSPERO

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