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61. Relationship between Physical Activity, Screen Time and Weight Status among Young Adolescents Full Text available with Trip Pro

Relationship between Physical Activity, Screen Time and Weight Status among Young Adolescents It is well established that lack of physical activity and high bouts of sedentary behaviour are now associated with all-cause and cardiovascular mortality. The purpose of this study was to investigate the relationship between physical activity participation, overall screen time and weight status amongst early Irish adolescent youth. Participants were a sample of 169 students: 113 boys (mean age = 12.89 (...) ± 0.34 years) and 56 girls (mean age = 12.87 ± 0.61 years). The data gathered in the present study included physical activity (accelerometry), screen time (self-report) and anthropometric measurements. Overweight and obese participants accumulated significantly more minutes of overall screen time daily compared to their normal-weight counterparts. A correlation between physical activity and daily television viewing was evident among girls. No significant interaction was apparent when examining daily

2018 Sports

62. Screen time and musculoskeletal pain in adolescents: systematic review

Screen time and musculoskeletal pain in adolescents: systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2020 PROSPERO

63. The effectiveness of sedentary behaviour interventions on sitting time and screen time: an umbrella review of systematic reviews

The effectiveness of sedentary behaviour interventions on sitting time and screen time: an umbrella review of systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2020 PROSPERO

64. The association of screen time use with physical activity and sedentary behavior in children and adolescents. A systematic review of observational- and experimental studies.

The association of screen time use with physical activity and sedentary behavior in children and adolescents. A systematic review of observational- and experimental studies. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2020 PROSPERO

65. Effects of Screen Time on Developmental Outcomes of Children Under 8 Years Old: A Systematic Review and Meta-Analysis

Effects of Screen Time on Developmental Outcomes of Children Under 8 Years Old: A Systematic Review and Meta-Analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2020 PROSPERO

66. Correlates of parental support of Canada's 24-hour movement behaviors for children and youth (physical activity, sedentary screen time, and sleep): A systematic review of the literature.

Correlates of parental support of Canada's 24-hour movement behaviors for children and youth (physical activity, sedentary screen time, and sleep): A systematic review of the literature. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2020 PROSPERO

67. Virtual screening using covalent docking to find activators for G245S mutant p53. Full Text available with Trip Pro

Virtual screening using covalent docking to find activators for G245S mutant p53. TP53 is the most mutated gene in all cancers. The mutant protein also accumulates in cells. The high frequency of p53 mutations makes the protein a promising target for anti-cancer therapy. Only a few molecules have been found, using in vitro screening, to reactivate the mutant protein. APR-246 is currently the most successful mutant p53 activator, which reactivates the transcriptional activity of p53 (...) by covalently binding to C124 of the protein. We have recently created in silico models of G245S-mp53 in its apo and DNA-bound forms. In this paper we further report on our in silico screening for potential activators of G245S-mp53. We filtered the ZINC15 database (13 million compounds) to only include drug-like molecules with moderate to standard reactivity. Our filtered database of 130,000 compounds was screened using the DOCKTITE protocol in the Molecular Operating Environment software. We performed

2018 PLoS ONE

68. Feasibility and outcomes of atrial fibrillation screening using intermittent electrocardiography in a primary healthcare setting: A cross-sectional study. Full Text available with Trip Pro

Feasibility and outcomes of atrial fibrillation screening using intermittent electrocardiography in a primary healthcare setting: A cross-sectional study. Atrial fibrillation (AF) is a major risk factor for ischemic stroke unless treated with an anticoagulant. Detecting AF can be difficult because AF is often paroxysmal and asymptomatic. The aims of this study were to develop a screening model to detect AF in a primary healthcare setting and to initiate oral anticoagulant therapy in high-risk

2018 PLoS ONE

69. Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm. Full Text available with Trip Pro

Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm. In the search for novel therapeutic targets, RNA interference screening has become a valuable tool. High-throughput technologies are now broadly accessible but their assay development from baseline remains resource-intensive and challenging. Focusing on this assay development process, we here describe a target discovery screen using pooled shRNA libraries and next

2018 PLoS ONE

70. Cost-effectiveness of breast cancer screening using mammography in Vietnamese women. Full Text available with Trip Pro

Cost-effectiveness of breast cancer screening using mammography in Vietnamese women. The incidence rate of breast cancer is increasing and has become the most common cancer in Vietnamese women while the survival rate is lower than that of developed countries. Early detection to improve breast cancer survival as well as reducing risk factors remains the cornerstone of breast cancer control according to the World Health Organization (WHO). This study aims to evaluate the costs and outcomes

2018 PLoS ONE

71. A user-friendly platform for yeast two-hybrid library screening using next generation sequencing. Full Text available with Trip Pro

A user-friendly platform for yeast two-hybrid library screening using next generation sequencing. Yeast two-hybrid (Y2H) is a well-established genetics-based system that uses yeast to selectively display binary protein-protein interactions (PPIs). To meet the current need to unravel complex PPI networks, several adaptations have been made to establish medium- to high-throughput Y2H screening platforms, with several having successfully incorporated the use of the next-generation sequencing (NGS

2018 PLoS ONE

72. Screen time and social media: Interventions to protect our children’s health

influencers on children’s screen time habits, and it is imperative that they set an example of healthy online behaviours. The UK CMOs commend the work of the Royal College of Paediatrics and Child Health in developing questions and practical tips to support families’ discussion of their screen use . [7] The UK CMOs have also produced advice for parents on how to incorporate screen use into health development. [ 8] To better understand the intersection of screen time and health more comprehensive research (...) Screen time and social media: Interventions to protect our children’s health Screen time and social media: Interventions to protect our children’s health - The BMJ ---> An appropriate mechanism for measuring children’s digital engagement needs to be developed Today’s children have screens integrated into daily life from an early age. There are advantages of having this online world at their fingertips, but the potential threat to their health and development has become of increasing concern

2019 The BMJ Blog

73. Randomised controlled trial: Fifty years of age-based screening: time for a new risk-based screening approach

Randomised controlled trial: Fifty years of age-based screening: time for a new risk-based screening approach Fifty years of age-based screening: time for a new risk-based screening approach | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Fifty years of age-based screening: time for a new risk-based screening approach Article Text Prevention Randomised controlled trial Fifty years of age-based screening: time for a new risk-based

2014 Evidence-Based Medicine

74. Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology: population based study. Full Text available with Trip Pro

Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology: population based study. Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry of histo- and cytopathology

2017 BMJ

75. Mobile Health Technology for Atrial Fibrillation Screening Using Photoplethysmography-Based Smart Devices: The HUAWEI Heart study. (Abstract)

Mobile Health Technology for Atrial Fibrillation Screening Using Photoplethysmography-Based Smart Devices: The HUAWEI Heart study. Low detection and nonadherence are major problems in current management approaches for patients with suspected atrial fibrillation (AF). Mobile health (mHealth) devices may enable earlier AF detection, and improved AF management.To investigate the effectiveness of AF screening in a large population-based cohort using smart device based photoplethysmography (PPG

2019 Journal of the American College of Cardiology

76. Non-invasive screening using ventilatory gas analysis to distinguish between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Full Text available with Trip Pro

Non-invasive screening using ventilatory gas analysis to distinguish between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Clinical presentations associated with chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) at rest are highly similar. Differentiating between CTEPH and PAH using non-invasive techniques remains challenging. Thus, we examined whether analysis of ventilatory gas in response to postural changes

2019 Respirology

77. Does a novel diagnostic pathway including blood-based risk prediction and MRI-targeted biopsies outperform prostate cancer screening using prostate-specific antigen and systematic prostate biopsies? - protocol of the randomised study STHLM3MRI. Full Text available with Trip Pro

Does a novel diagnostic pathway including blood-based risk prediction and MRI-targeted biopsies outperform prostate cancer screening using prostate-specific antigen and systematic prostate biopsies? - protocol of the randomised study STHLM3MRI. Prostate cancer is a leading cause of cancer death among men in the Western world. Early detection of prostate cancer has been shown to decrease mortality, but has limitations with low specificity leading to unnecessary biopsies and overdiagnosis of low

2019 BMJ open Controlled trial quality: uncertain

78. Investigating the feasibility of stratified breast cancer screening using a masking risk predictor. Full Text available with Trip Pro

Investigating the feasibility of stratified breast cancer screening using a masking risk predictor. Women with dense breasts face a double risk for breast cancer; they are at a higher risk for development of breast cancer than those with less dense breasts, and there is a greater chance that mammography will miss detection of a cancer in dense breasts due to the masking effect of surrounding fibroglandular tissue. These women may be candidates for supplemental screening. In this study

2019 Breast cancer research : BCR

79. Feasibility of Automated Cameras to Measure Screen Use in Adolescents. (Abstract)

Feasibility of Automated Cameras to Measure Screen Use in Adolescents. The influence of screens and technology on adolescent well-being is controversial and there is a need to improve methods to measure these behaviors. This study examines the feasibility and acceptability of using automated wearable cameras to measure evening screen use in adolescents.A convenience sample of adolescents (aged 13-17 years, n=15) wore an automated camera for 3 evenings from 5:00pm to bedtime. The camera (Brinno (...) TLC120) captured an image every 15 seconds. Fieldwork was completed between October and December 2017, and data analyzed in 2018. Feasibility was examined by quality of the captured images, wear time, and whether images could be coded in relation to contextual factors (e.g., type of screen and where screen use occurred). Acceptability was examined by participant compliance to the protocol and from an exit interview.Data from 39 evenings were analyzed (41,734 images), with a median of 268 minutes per

2019 American journal of preventive medicine

80. Systematic screening using FRAX<sup>®</sup> leads to increased use of, and adherence to, anti-osteoporosis medications: an analysis of the UK SCOOP trial. (Abstract)

Systematic screening using FRAX® leads to increased use of, and adherence to, anti-osteoporosis medications: an analysis of the UK SCOOP trial. In the large community-based SCOOP trial, systematic fracture risk screening using FRAX® led to greater use of AOM and greater adherence, in women at high fracture risk, compared with usual care.In the SCreening of Older wOmen for Prevention of fracture (SCOOP) trial, we investigated the effect of the screening intervention on subsequent long (...) was associated with poorer adherence (OR per year increase in age 0.96 [95% CI 0.93, 0.99], p = 0.01), whereas history of parental hip fracture was associated with greater rate adherence (OR 1.67 [95% CI 1.23, 2.26], p < 0.01).Systematic fracture risk screening using FRAX® leads to greater use of AOM and greater adherence, in women at high fracture risk, compared with usual care.

2019 Osteoporosis International

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