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141. Therapeutic Use of the Human Papillomavirus Vaccine on Recurrent Respiratory Papillomatosis: A Systematic Review and Meta-Analysis

Therapeutic Use of the Human Papillomavirus Vaccine on Recurrent Respiratory Papillomatosis: A Systematic Review and Meta-Analysis Recurrent respiratory papillomatosis is a benign condition caused by human papillomavirus (HPV). Surgery is the mainstay of treatment, but numerous adjuvant therapies have been applied to improve surgical outcome. Recently, HPV vaccination has been introduced, but only smaller studies of its effect have been published. The present meta-analysis is intended (...) as a possible substitute for a proposed but not yet realized multicenter randomized controlled trial.A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. PubMed, Embase, and Cochrane were systematically searched. All retrieved studies (n = 593) were reviewed and qualitatively assessed. In addition, 2 previously unpublished data sets were included. The systematic review included 11 studies, comprising 133 patients

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2019 EvidenceUpdates

142. Acupuncture therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials

Acupuncture therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials Fibromyalgia (FM) can cause chronic widespread pain and seriously affect the quality of patient lives. Acupuncture therapy is widely used for pain management. However, the effect of acupuncture on FM is still uncertain. The aim of this review was to determine the effect and safety of acupuncture therapy on the pain intensity and quality of life in patients with FM.We searched PubMed (...) , the Cochrane Library, Embase, the China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, and the Chinese Biomedical Literature Database to collect randomized controlled trials (RCTs) of acupuncture for FM published before May 2018. A meta-analysis was performed according to the Cochrane systematic review method by using RevMan 5.3 software, and GRADE was used to evaluate the quality of the evidence.We identified 12 RCTs that compared acupuncture therapy to sham

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2019 EvidenceUpdates

143. The Effects of Needling Therapies on Muscle Force Production: A Systematic Review and Meta-analysis

The Effects of Needling Therapies on Muscle Force Production: A Systematic Review and Meta-analysis Needling has been shown to decrease pain in the short term; however, its effects on muscle force production are unclear.To evaluate the evidence regarding the comparative effects of needling on muscle force production.In this systematic review, an electronic search was performed using key words related to needling. Methodological quality of articles was appraised and effect sizes were calculated (...) . The strength of evidence was determined, and meta-analysis was performed when similar methods were used in studies for similar conditions.Twenty-one studies were included in this review, of which 9 were deemed to be of high quality (greater than 6/10 on the Physiotherapy Evidence Database [PEDro] scale), 11 of fair quality (5 to 6/10), and 1 of poor quality (less than 5/10). Three meta-analyses were performed. There was moderate strength of evidence and medium effect sizes for needling therapy to enhance

2019 EvidenceUpdates

144. Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis

Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis The clinical impact of anti-drug antibodies (ADAbs) in paediatric patients with JIA remains unknown. This systematic review and meta-analysis aimed to summarize the prevalence of ADAbs in JIA studies; investigate the effect of ADAbs on treatment efficacy and adverse events; and explore the effect of immunosuppressive therapy on antibody formation.PubMed, Embase and the Cochrane Library were (...) systematically searched to identify relevant clinical trials and observational studies that reported prevalence of ADAbs. Studies were systematically reviewed in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses and appropriate proportional and pairwise meta-analyses were performed.A total of 5183 references were screened; 28 articles, involving 26 studies and 2354 JIA patients, met eligibility criteria. Prevalence of ADAbs ranged from 0% to 82% across nine biologic

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2019 EvidenceUpdates

145. Comparative Effectiveness of Injection Therapies in Rotator Cuff Tendinopathy: A Systematic Review, Pairwise and Network Meta-analysis of Randomized Controlled Trials

Comparative Effectiveness of Injection Therapies in Rotator Cuff Tendinopathy: A Systematic Review, Pairwise and Network Meta-analysis of Randomized Controlled Trials To compare the effectiveness of diverse injections in patients with rotator cuff tendinopathy using pairwise and network meta-analysis.PubMed, EMBASE, Scopus, and Cochrane Library were searched for studies published up to September 31, 2017.We included all published or unpublished randomized controlled trials (RCTs) comparing (...) ) was used for pairwise and network meta-analysis. In pairwise meta-analysis, corticosteroid was more effective only in the short term in both pain reduction and functional improvement. Network meta-analysis indicated that prolotherapy significantly reduced pain compared with placebo in the long term (over 24wk; SMD: 2.63; 95% confidence interval [CI], 1.88-3.38); meanwhile PRP significantly improved shoulder function compared with placebo in the long term (over 24wk; SMD: 0.44; 95% CI, 0.05-0.84

2019 EvidenceUpdates

146. Cerclage for women with twin pregnancies: a systematic review and meta-analysis

Cerclage for women with twin pregnancies: a systematic review and meta-analysis This study was conducted to estimate whether cerclage could extend the prolongation of pregnancy, reduce the risk of preterm birth, and improve perinatal outcomes in women with twin pregnancies.We included randomized controlled trials and cohort studies comparing the efficacy of cerclage with no cerclage for women with twin pregnancies.The following databases were searched for all published studies that compared (...) % confidence interval, 0.20-0.85; P=.030; I2=80%), and <24 weeks of gestation (risk ratio, 0.35; 95% confidence interval, 0.18-0.67; P=.001; I2=24%), and improvement of perinatal outcomes compared with those in the control group. However, for twin pregnancies with a normal cervical length (eg, cerclage for an indication for women with a history of preterm birth or twin alone), the efficacy of cerclage placement was less certain because of the limited data.Our metaanalysis indicates that cerclage placement

2019 EvidenceUpdates

147. Robot-assisted therapy for balance function rehabilitation after stroke: A systematic review and meta-analysis

Robot-assisted therapy for balance function rehabilitation after stroke: A systematic review and meta-analysis To identify the rehabilitative effects of robot-assisted therapy on balance function among stroke patients.A systematic review and meta-analysis of randomized controlled trials.Thirteen electronic databases were systematically searched from inception to March 2018: Web of Science, PubMed, EMBase, The Cochrane Library, Science Direct, CINAHL, MEDLINE, AMED, Physiotherapy Evidence (...) size was evaluated by mean difference with corresponding 95% confidence intervals. Methodological quality and risk bias evaluation for each included study followed the quality appraisal criteria for randomized controlled trials that were recommended by Cochrane Handbook. Meta-analysis was conducted by utilizing Review Manager 5.3, a Cochrane Collaboration tool. Data was synthesized with descriptive analysis instead of meta-analysis where comparisons were not possible to be conducted with a meta

2019 EvidenceUpdates

148. Prevalence and main outcomes of placenta accreta spectrum: a systematic review and metaanalysis. (PubMed)

Prevalence and main outcomes of placenta accreta spectrum: a systematic review and metaanalysis. The objective of this study was to evaluate the prevalence of placenta accreta spectrum in general population studies and the main maternal outcomes at delivery.Data sources: We searched PubMed, Google Scholar, clinicalTrials.gov and MEDLINE between 1982 and 2018.Articles providing data on the number of cases of placenta accreta spectrum per pregnancies, births or deliveries in a defined (...) of the diagnosis and differential diagnosis between adherent and invasive accreta placentation.This meta-analysis indicates wide variation between studies for the prevalence rate of placenta accreta spectrum and for the different grades of accreta placentation, highlighting the need for consistency in definitions used to describe placenta accreta spectrum at birth and in reporting on this increasing common obstetric complication.Copyright © 2019. Published by Elsevier Inc.

2019 American Journal of Obstetrics and Gynecology

149. Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review. (PubMed)

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review. Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies

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2019 BMC Nephrology

150. Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis. (PubMed)

Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis. Transgender women are female individuals who were recorded men at birth based on natal sex. Supporting a person's gender identity improves their psychological health, and gender-affirming hormones reduce gender dysphoria and benefit mental health. For transgender women, estrogen administration has clinically significant benefits. Previous reviews have reported conflicting literature (...) on the thrombotic risk of estrogen therapy in transgender women and have highlighted the need for more high-quality research.To help address the gap in understanding thrombotic risk in transgender women receiving estrogen therapy, we performed a systematic literature review and metaanalysis. Two evaluators independently assessed quality using the Ottawa Scale for Cohort Studies. The Poisson normal model was used to estimate the study-specific incidence rates and the pooled incidence rate. Heterogeneity

2019 Clinical Chemistry

151. Systematic review with meta analysis: Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes

Systematic review with meta analysis: Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you (...) Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes Article Text Therapeutics/Prevention Systematic review with meta analysis Erythropoietin corrects anaemia and reduces the risk of blood transfusion in people with chronic kidney disease, but has uncertain effects on other patient-level outcomes David W Johnson Statistics from Altmetric.com Commentary on: Cody JD , Hodson EM . Recombinant

2016 Evidence-Based Medicine (Requires free registration)

152. Systematic review and meta-analysis: Earplugs might reduce intensive care unit delirium but quality of evidence is low

Systematic review and meta-analysis: Earplugs might reduce intensive care unit delirium but quality of evidence is low Earplugs might reduce intensive care unit delirium but quality of evidence is low | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Earplugs might reduce intensive care unit delirium but quality of evidence is low Article Text Therapeutics/Prevention Systematic review and meta-analysis Earplugs might reduce intensive

2016 Evidence-Based Medicine (Requires free registration)

153. Systematic review with meta analysis: Nebulised hypertonic saline may be less effective than previously reported in reducing hospital length of stay and admission rate in acute bronchiolitis

Systematic review with meta analysis: Nebulised hypertonic saline may be less effective than previously reported in reducing hospital length of stay and admission rate in acute bronchiolitis Nebulised hypertonic saline may be less effective than previously reported in reducing hospital length of stay and admission rate in acute bronchiolitis | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings (...) effective than previously reported in reducing hospital length of stay and admission rate in acute bronchiolitis Article Text Therapeutics/Prevention Systematic review with meta analysis Nebulised hypertonic saline may be less effective than previously reported in reducing hospital length of stay and admission rate in acute bronchiolitis Kevin M Overmann 1 , Todd A Florin 1 , 2 Statistics from Altmetric.com Commentary on : Zhang L , Mendoza-Sassi RA , Klassen TP , et al . Nebulized hypertonic saline

2016 Evidence-Based Medicine (Requires free registration)

154. Systematic review with meta analysis: Study finds little impact of hydrolysed formula on risk of allergic disease, but study methods may limit conclusions and generalisability

Systematic review with meta analysis: Study finds little impact of hydrolysed formula on risk of allergic disease, but study methods may limit conclusions and generalisability Study finds little impact of hydrolysed formula on risk of allergic disease, but study methods may limit conclusions and generalisability | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) , but study methods may limit conclusions and generalisability Article Text Aetiology/Harm Systematic review with meta analysis Study finds little impact of hydrolysed formula on risk of allergic disease, but study methods may limit conclusions and generalisability Yvan Vandenplas Statistics from Altmetric.com Commentary on : Boyle RJ , Ierodiakonou D , Khan T , et al . Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis . . Context Several meta-analyses

2016 Evidence-Based Medicine (Requires free registration)

155. Systematic review with meta analysis: Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes

Systematic review with meta analysis: Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see (...) Therapeutics/Prevention Systematic review with meta analysis Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes Rene Rodriguez-Gutierrez 1 , 2 , Victor M Montori 3 Statistics from Altmetric.com Commentary on: Palmer SC , Mavridis D , Nicolucci A , et al . Comparison of clinical outcomes and adverse events associated with glucose-lowering drugs in patients with type 2 diabetes: a meta-analysis . . Context A broad consensus supports the use

2016 Evidence-Based Medicine (Requires free registration)

156. Systematic review with meta-analysis: Most add-on therapies to metformin have similar effects on HbA1c

Systematic review with meta-analysis: Most add-on therapies to metformin have similar effects on HbA1c Most add-on therapies to metformin have similar effects on HbA1c | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Most add-on therapies to metformin have similar effects on HbA1c Article Text Therapeutics/Prevention Systematic review with meta-analysis Most add-on therapies to metformin have similar effects on HbA1c Thomas Karagiannis 1

2016 Evidence-Based Medicine (Requires free registration)

157. Systematic review with meta-analysis: Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department

Systematic review with meta-analysis: Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your (...) perform poorly in the prediction of acute coronary syndromes in the emergency department Article Text Diagnosis Systematic review with meta-analysis Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department Martin Than Statistics from Altmetric.com Commentary on: Fanaroff AC , Rymer JA , Goldstein SA , et al . Does this patient with chest pain have acute coronary syndrome? The rational clinical examination

2016 Evidence-Based Medicine (Requires free registration)

158. Systematic review with meta analysis: Uncertainty in evidence synthesis limits clinical applicability of a clinical and cost-effectiveness analysis of induction of labour methods

Systematic review with meta analysis: Uncertainty in evidence synthesis limits clinical applicability of a clinical and cost-effectiveness analysis of induction of labour methods Uncertainty in evidence synthesis limits clinical applicability of a clinical and cost-effectiveness analysis of induction of labour methods | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any (...) of a clinical and cost-effectiveness analysis of induction of labour methods Article Text Therapeutics/Prevention Systematic review with meta analysis Uncertainty in evidence synthesis limits clinical applicability of a clinical and cost-effectiveness analysis of induction of labour methods Christina Davidson Statistics from Altmetric.com Commentary on: Alfirevic Z , Keeney E , Dowswell T , et al . Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis

2016 Evidence-Based Medicine (Requires free registration)

159. Systematic review with meta analysis: Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding

Systematic review with meta analysis: Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) disease but at a near equivalent risk of increased bleeding Article Text Therapeutics/Prevention Systematic review with meta analysis Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding Michael D Miedema 1 , Salim S Virani 2 Statistics from Altmetric.com Commentary on: Guirguis-Blake JM , Evans CV , Senger CA , et al . Aspirin for the primary prevention of cardiovascular events: a systematic evidence review

2016 Evidence-Based Medicine (Requires free registration)

160. Systematic review with meta-analysis: Moderate drinkers may not have reduced risk of all-cause mortality: a lifecourse perspective

Systematic review with meta-analysis: Moderate drinkers may not have reduced risk of all-cause mortality: a lifecourse perspective Moderate drinkers may not have reduced risk of all-cause mortality: a lifecourse perspective | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Moderate drinkers may not have reduced risk of all-cause mortality: a lifecourse perspective Article Text Aetiology/Harm Systematic review with meta-analysis Moderate

2016 Evidence-Based Medicine (Requires free registration)

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