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259221. Meta-analysis: risk for hypertension in living kidney donors

Meta-analysis: risk for hypertension in living kidney donors Meta-analysis: risk for hypertension in living kidney donors Meta-analysis: risk for hypertension in living kidney donors Boudville N, Ramesh Prasad G V, Knoll G, Muirhead N, Thiessen-Philbrook H, Yang R C, Rosas-Arellano M P, Housawi A, Garg A X CRD summary This review investigated the risk for hypertension after kidney donation and concluded that healthy kidney donors may have a 5-mmHg increase in blood-pressure over that expected (...) calculated for controlled studies. Methods of synthesis How were the studies combined? The study findings were reported in tables and in a narrative synthesis. In addition, studies with a control group and appropriate data were pooled in a meta-analysis using a random-effects model to estimate the weighted mean difference (WMD) and relative risk for the outcomes of interest. How were differences between studies investigated? The Q statistic, using a P-value of less than 0.1 to indicate statistical

2006 DARE.

259222. Meta-analysis: the effect of statins on albuminuria

Meta-analysis: the effect of statins on albuminuria Meta-analysis: the effect of statins on albuminuria Meta-analysis: the effect of statins on albuminuria Douglas K, O'Malley P G, Jackson J L CRD summary This review investigated whether statins affect albuminuria or proteinuria and to what degree they do so. The authors concluded that there may be a beneficial effect of statins on pathologic albuminuria, though larger studies are required to confirm this. It was appropriate that the authors (...) How were the studies combined? The studies were combined in a random-effects meta-analysis to obtain a summary weighted mean difference (WMD) and 95% confidence interval (CI). Publication bias was investigated using a funnel plot and Begg's method. How were differences between studies investigated? Heterogeneity was investigated using the I-squared statistic. Two subgroup analyses were conducted. Studies were stratified according to baseline urinary albumin excretion (30 mg/day nonpathologic level

2006 DARE.

259223. Meta-analysis. Cysticidal drugs for neurocysticercosis: albendazole and praziquantel

Meta-analysis. Cysticidal drugs for neurocysticercosis: albendazole and praziquantel Meta-analysis. Cysticidal drugs for neurocysticercosis: albendazole and praziquantel Meta-analysis. Cysticidal drugs for neurocysticercosis: albendazole and praziquantel Del Brutto O H, Roos K L, Coffey C S, Garcia H H CRD summary The review assessed the effects of cysticidal drugs for neurocysticercosis. The authors concluded that cysticidal drugs result in better resolution of enhancing lesions and cysts (...) , lower risk of recurrence of seizures in patients with enhancing lesions, and a reduction in the rate of generalised seizures in patients with cysts. This was a well-conducted review and the authors' conclusions are likely to be reliable. Authors' objectives To determine the effectiveness of cysticidal drugs on neuroimaging and clinical outcomes of patients with neurocysticercosis. Searching MEDLINE, the Cochrane Database of Systematic Reviews and LILACS were searched from January 1979 to August 2005

2006 DARE.

259224. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths

Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths Salpeter S R, Buckley N S, Ormiston T M, Salpeter E E CRD summary This generally well-conducted review concluded that long-acting beta-agonists increased severe and life (...) How were the studies combined? Pooled Peto odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a fixed-effect meta-analysis. If more than one event occurred in the same patient, only the first event was used in the meta-analysis. Risk differences (RDs) and 95% CIs were calculated for the difference between two independent binomial proportions, and the results were pooled using a fixed-effect meta-analysis. Trials that reported no events were included in the analysis of RDs

2006 DARE.

259225. Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis

Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis Nayak S, Olkin I, Liu H, Grabe M, Gould M K, Allen E, Owens D K, Bravata D M CRD summary This well-conducted and clearly reported review addressed the diagnostic performance of quantitative ultrasound for identifying (...) for osteoporosis. Searching MEDLINE (1966 to October 2005), EMBASE (1993 to May 2004), the Cochrane Controlled Trials Register and Cochrane Database of Systematic Reviews (1952 to March 2004), and the Science Citation Index (1945 to April 2004) were searched for relevant articles in the English language; the search strategies were reported. Reference lists of eligible studies and reviews were also screened. Study selection Study designs of evaluations included in the review Only studies that performed

2006 DARE.

259226. Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency

Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency Lim W, Dentali F, Eikelboom J W, Crowther M A CRD summary This well-conducted review assessed anti-Xa heparin levels and bleeding events in patients with severe renal insufficiency who were (...) to define severe renal failure, where only mean creatinine clearance was reported, or where other relevant data were not reported. For each study, odds ratios (ORs) were calculated for major bleeding events in patients with and without severe renal insufficiency. Methods of synthesis How were the studies combined? The results for anti-Xa levels were presented as a narrative synthesis. ORs for major bleeding events in patients with and without severe renal insufficiency were pooled in a meta-analysis

2006 DARE.

259227. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis

Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis DeZee K J, Shimeall W T, Douglas K M, Shumway N M, O'Malley P G CRD summary This review examined the efficacy of vitamin K in treating excessive anticoagulation. The authors concluded that the limited evidence available suggests that oral (...) research is necessary. However, they also noted that a future placebo-controlled RCT would require at least 1,000 patients to assess whether vitamin K produces a reduction of 3% in the proportion of patients experiencing major bleeding. Bibliographic details DeZee K J, Shimeall W T, Douglas K M, Shumway N M, O'Malley P G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Archives of Internal Medicine 2006; 166(4): 391-397 PubMedID DOI Original Paper URL Indexing

2006 DARE.

259228. Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients

Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients Kalil A C, Levitsky J, Lyden E, Stoner J, Freifeld A G CRD summary This review concluded that universal prophylaxis and pre (...) in preventing organ disease by cytomegalovirus (CMV) infection and other complications in solid organ transplant recipients. Searching MEDLINE and EMBASE (both from inception to May 2005), Evidence-Based Medicine (from 2000 to May 2005), and the Cochrane CENTRAL Register and Cochrane Database of Systematic Reviews (Issue 4, 2004) were searched for English and non-English language studies; the search terms were reported. Relevant pharmaceutical companies were contacted for unpublished studies, and abstracts

2005 DARE.

259229. Androgen treatment and muscle strength in elderly men: a meta-analysis

Androgen treatment and muscle strength in elderly men: a meta-analysis Androgen treatment and muscle strength in elderly men: a meta-analysis Androgen treatment and muscle strength in elderly men: a meta-analysis Ottenbacher K J, Ottenbacher M E, Ottenbacher A J, Acha A A, Ostir G V CRD summary The authors concluded that testosterone moderately increased muscle strength in the older men included in the studies, but the results were influenced by one study. The authors' conclusion appears (...) of study quality on treatment effects was examined. Little information was provided about the participants, making it difficult to determine to what population these results may be applicable. The studies were pooled using meta-analysis and statistical heterogeneity was assessed, but the results of the assessment were not clearly reported. In the absence of meta-analysis graphs or effect sizes from individual studies it was not possible to determine the extent of the heterogeneity. The authors

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2006 DARE.

259230. Selenium and coronary heart disease: a meta-analysis

Selenium and coronary heart disease: a meta-analysis Selenium and coronary heart disease: a meta-analysis Selenium and coronary heart disease: a meta-analysis Flores-Mateo G, Navas-Acien A, Pastor-Barriuso R, Guallar E CRD summary The authors concluded that selenium supplements cannot currently be recommended for the prevention of cardiovascular disease. Although the authors’ conclusion appears to follow from the results presented, their limited search makes it difficult to confidently assess (...) studies. No language restrictions were applied but there were no attempts to minimise publication bias. Appropriate methods were used to minimise reviewer error and bias during the study selection and data extraction processes. Only RCTs were included, and validity was assessed and some aspects of it reported. The studies were combined using meta-analysis and the influence of individual studies was examined. Although a forest plot showed that none of the studies found any significant difference

2006 DARE.

259231. Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis

Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis Bagshaw S M, Galbraith P D, Mitchell L B, Sauve R, Exner D V, Ghali W A CRD summary This review evaluated the effects of amiodarone in post-operative atrial fibrillation. It concluded (...) . They added that the total dose of 5 to 10 g is likely to be adequate, and that the duration of therapy should be short (less than 2 weeks). Research: The authors stated that further surveillance for the adverse effects of amiodarone is required. Bibliographic details Bagshaw S M, Galbraith P D, Mitchell L B, Sauve R, Exner D V, Ghali W A. Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis. Annals of Thoracic Surgery 2006; 82(5): 1927-1937 PubMedID DOI

2006 DARE.

259232. Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis

Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis Waljee A, Waljee J, Morris A M, Higgins P D CRD summary This review concluded that ileal pouch anal anastomosis (...) disagreements resolved by consensus. Methods of synthesis A fixed-effect meta-analysis was conducted. If heterogeneity was identified, studies having outlying values were excluded one at a time to assess whether they contributed to the heterogeneity observed. A meta-analysis using a random-effects model was also performed to assess the effect on outcome. Publication bias was assessed using a funnel plot and a sensitivity analysis was performed to determine whether a single study unduly influenced

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2006 DARE.

259233. Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis

Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis Reisfield G M, Wallace S K, Munsell M F, Webb F J, Alvarez E R, Wilson G R CRD summary The authors concluded that survival to hospital discharge for cancer patients receiving cardiopulmonary resuscitation (...) not state any implications for practice or further research. Funding Not stated. Bibliographic details Reisfield G M, Wallace S K, Munsell M F, Webb F J, Alvarez E R, Wilson G R. Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation: a meta-analysis. Resuscitation 2006; 71(2): 152-160 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Cardiopulmonary Resuscitation; Heart Arrest /complications /mortality /therapy; Hospital Mortality; Humans; Neoplasm Metastasis

2006 DARE.

259234. A comparison of traditional digital blocks and single subcutaneous palmar injection blocks at the base of the finger and a meta-analysis of the digital block trials

A comparison of traditional digital blocks and single subcutaneous palmar injection blocks at the base of the finger and a meta-analysis of the digital block trials A comparison of traditional digital blocks and single subcutaneous palmar injection blocks at the base of the finger and a meta-analysis of the digital block trials A comparison of traditional digital blocks and single subcutaneous palmar injection blocks at the base of the finger and a meta-analysis of the digital block trials Yin (...) ' objectives To compare the effectiveness of different digital block techniques for the treatment of finger injuries. The meta-analysis was conducted in conjunction with a single randomised controlled trial (RCT) carried out by the authors. This abstract focuses on the meta-analysis. Searching MEDLINE (via PubMed; 1966 to 2006), EMBASE (1988 to 2006), the Cochrane Controlled Trials Register (Issue 1, 2006) and the Chinese Biomedical Database (1978 to 2006) were searched for relevant studies; the search

2006 DARE.

259235. Meta-analysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ

Meta-analysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ Meta-analysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ Meta-analysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ Clayton E S, Connor S, Alexakis N, Leandros E CRD summary The authors found no difference between surgery alone and endoscopy plus surgery (...) Clayton E S, Connor S, Alexakis N, Leandros E. Meta-analysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ. British Journal of Surgery 2006; 93(10): 1185-1191 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Cholecystectomy, Laparoscopic /methods; Choledocholithiasis /surgery; Gallbladder; Humans; Randomized Controlled Trials as Topic; Sphincterotomy, Endoscopic /methods; Treatment Outcome AccessionNumber 12006007636 Date

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2006 DARE.

259236. Relative efficacy of psychotherapy and pharmacotherapy in the treatment of depression: a meta-analysis

Relative efficacy of psychotherapy and pharmacotherapy in the treatment of depression: a meta-analysis Relative efficacy of psychotherapy and pharmacotherapy in the treatment of depression: a meta-analysis Relative efficacy of psychotherapy and pharmacotherapy in the treatment of depression: a meta-analysis De Maat S, Dekker J, Schoevers R, De Jonghe F CRD summary The authors concluded that psychotherapy and pharmacology appear to be equally efficacious for depression in the short-term (...) given. The studies were appropriately pooled using meta-analysis; statistical heterogeneity was assessed and specified subgroup analyses were conducted to examine treatment differences for different populations. In their discussion, the authors advised caution when interpreting the results on relapse in the follow-up period. The follow-up data were generally observational rather than part of RCTs, so this advice seems appropriate. Despite uncertainties surrounding the data extraction

2006 DARE.

259237. Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis

Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis Atashili J, Kalilani L, Adimora A A CRD summary The authors concluded that influenza vaccines are moderately effective in reducing the incidence of influenza in individuals infected (...) resolved by consensus. Assessment of study quality The authors did not state that they assessed validity. Data extraction Data were extracted from each study to calculate the risk difference (RD), number-needed-to-vaccinate, and vaccine efficacy or effectiveness. Trial authors were contacted for missing information on study characteristics. Two authors independently extracted the data, with any disagreements resolved by consensus. Methods of synthesis A meta-analysis examining the pooled RD and 95

2006 DARE.

259238. Comparing the efficacy of medications for ADHD using meta-analysis

Comparing the efficacy of medications for ADHD using meta-analysis Comparing the efficacy of medications for ADHD using meta-analysis Comparing the efficacy of medications for ADHD using meta-analysis Faraone S V, Biederman J, Spencer T J, Aleardi M CRD summary The authors concluded that the greater efficacy found for stimulants compared with nonstimulants in children with attention-deficit/hyperactivity disorder (ADHD) needs to be interpreted with caution in view of the impact of potential (...) conclusions. Implications of the review for practice and research Practice: The authors did not state any implications for practice. Research: The authors stated that future studies should ‘review studies of time course such as the analog school laboratory paradigm’. Funding Part funded by a grant from Shire Pharmaceuticals Inc. Bibliographic details Faraone S V, Biederman J, Spencer T J, Aleardi M. Comparing the efficacy of medications for ADHD using meta-analysis. Medscape General Medicine 2006; 8(4):4

2006 DARE.

259239. Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood: a meta-analysis

Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood: a meta-analysis Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood: a meta-analysis Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood: a meta-analysis Geifman-Holtzman O, Grotegut C A, Gaughan J P CRD summary This review concluded that foetal DNA determination based on maternal peripheral blood is highly accurate, especially in the first trimester. The review suffers from (...) were reported in a table but excluded from the meta-analysis. Individual study estimates of accuracy ranged from 31.8 to 100%. Sixteen of the 37 studies reported 100% accuracy. Overall accuracy was 2,980 samples out of 3,261 (91.4%). After the exclusion of small studies and unsuitable samples, accuracy was 2,919 samples out of 3,078 (94.8%). The pooled sensitivity was 95.4% (95% CI: 90.6, 97.8) and the pooled specificity 98.6% (95% CI: 96.4, 99.5). Accuracy was higher in the first trimester than

2006 DARE.

259240. Surgical management of pseudophakic retinal detachments: a meta-analysis

Surgical management of pseudophakic retinal detachments: a meta-analysis Surgical management of pseudophakic retinal detachments: a meta-analysis Surgical management of pseudophakic retinal detachments: a meta-analysis Arya A V, Emerson J W, Engelbert M, Hagedorn C L, Adelman R A CRD summary This review evaluated the surgical techniques of pars plana vitrectomy (PPV), scleral buckle (SB) and combined PPV and SB in the management of uncomplicated pseudophakic retinal detachments. The authors (...) is needed to compare SB, PPV and the combined procedure for the management of uncomplicated PRDs. Funding Not stated. Bibliographic details Arya A V, Emerson J W, Engelbert M, Hagedorn C L, Adelman R A. Surgical management of pseudophakic retinal detachments: a meta-analysis. Ophthalmology 2006; 113(10): 1724-1733 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Aged; Humans; Lens Implantation, Intraocular /adverse effects; Middle Aged; Prospective Studies; Pseudophakia /etiology

2006 DARE.

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