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166881. A systematic review and economic evaluation of pegylated liposomal doxorubicin hydrochloride for ovarian cancer

ratios (HRs) and 95% confidence intervals (CIs) were extracted, or calculated, where possible. Methods of synthesis How were the studies combined? The studies were combined in a narrative. How were differences between studies investigated? As the studies were not combined in a meta-analysis, heterogeneity was not investigated statistically. Differences between the studies were discussed in the text. Results of the review Ten studies were included in the review. Two of these were RCTs, although one (...) to locate published and unpublished data. Each stage of the review was carried out in duplicate (although this is less clear for the screening of full articles), thus minimising the potential of error or bias. Full details of the studies and an appropriate quality assessment were presented. The main analysis and evaluation were based on a single RCT. Data from the uncontrolled trials were described in a narrative. The decision not to pool the studies in a meta-analysis seemed appropriate. Overall

2002 DARE.

166882. A systematic review of controlled trials of the effectiveness and cost-effectiveness of brief psychological treatments for depression

A systematic review of controlled trials of the effectiveness and cost-effectiveness of brief psychological treatments for depression A systematic review of controlled trials of the effectiveness and cost-effectiveness of brief psychological treatments for depression A systematic review of controlled trials of the effectiveness and cost-effectiveness of brief psychological treatments for depression Churchill R, Hunot V, Corney R, Knapp M, McGuire H, Tylee A, Wessely S Authors' objectives (...) . A systematic review of controlled trials of the effectiveness and cost-effectiveness of brief psychological treatments for depression. Health Technology Assessment 2001; 5(35): 1-173 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Controlled Clinical Trials as Topic; Cost-Benefit Analysis; Depressive Disorder /economics /therapy; Female; Health Care Costs; Humans; Male; Mental Disorders /economics /therapy; Prognosis; Psychotherapy /economics /methods; Severity of Illness

2001 DARE.

166883. Physical restraint in acute and residential care: a systematic review

Physical restraint in acute and residential care: a systematic review Physical restraint in acute and residential care: a systematic review Physical restraint in acute and residential care: a systematic review Evans D, Wood J, Lambert L, Fitzgerald M Authors' objectives To investigate the effectiveness of physical-restraint minimisation (defined as any coordinated effort to minimise the use of physical restraint) in acute and residential care settings, and to investigate physical restraint (...) be investigated as a priority. Bibliographic details Evans D, Wood J, Lambert L, Fitzgerald M. Physical restraint in acute and residential care: a systematic review. Adelaide, S. Australia, Australia: Joanna Briggs Institute for Evidence Based Nursing and Midwifery. Systematic Review; 22. 2002 Other publications of related interest 1. Evans D, Wood J, Lambert L. A review of physical restraint minimization in the acute and residential care settings. J Adv Nurs 2002;40:616-25. 2. Evans D, Wood J, Lambert L

2002 DARE.

166884. Ayurvedic interventions for diabetes mellitus: a systematic review

Ayurvedic interventions for diabetes mellitus: a systematic review Ayurvedic interventions for diabetes mellitus: a systematic review Ayurvedic interventions for diabetes mellitus: a systematic review Hardy M, Coulter I, Venturupalli S, Roth E A, Favreau J, Morton S C, Shekelle P Authors' objectives The overall objective of the project was to assess the use of Ayurvedic medicine for the treatment of health conditions and to select a condition for a comprehensive review. This abstract is based (...) on the systematic review of the efficacy of Ayurvedic medicine or therapies for the treatment of diabetes. Searching MEDLINE (1966 to 1999), HealthSTAR (1975 to 1999), EMBASE (1974 to 1999), AMED (1984 to 1999), MANTIS (1880 to 1999), CAB Health (1983 to 1999), BIOSIS Previews (1993 to 1999) and CINAHL (1982 to 2000) were searched. An extensive search of the Indian literature was also conducted; this included contact with experts, searching of journals not indexed in Western databases, pertinent thesis work

2001 DARE.

166885. Albumin administration: what is the evidence of clinical benefit? A systematic review of randomized controlled trials

to the category of clinical indication and summarised in a narrative. The authors stated that a quantitative meta-analysis was not attempted in view of the diversity of the end points addressed. How were differences between studies investigated? Heterogeneity was not formally assessed. Results of the review Seventy-nine RCTs with a total of 4,755 participants were included in the review. In 14 of the 79 included trials there were potential confounding factors, such as the administration of concomitant albumin (...) Albumin administration: what is the evidence of clinical benefit? A systematic review of randomized controlled trials Albumin administration: what is the evidence of clinical benefit? A systematic review of randomized controlled trials Albumin administration: what is the evidence of clinical benefit? A systematic review of randomized controlled trials Haynes G R, Navickis R J, Wilkes M M CRD summary This review assessed whether albumin confers significant clinical benefit in acute illness

2003 DARE.

166886. Conservative management, gamma-knife radiosurgery, and microsurgery for acoustic neurinomas: a systematic review of outcome and risk of three therapeutic options

Conservative management, gamma-knife radiosurgery, and microsurgery for acoustic neurinomas: a systematic review of outcome and risk of three therapeutic options Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

166887. Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation

Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation Meads C, Salas C, Roberts T, Moore D, Fry-Smith (...) : a systematic review and economic evaluation. Health Technology Assessment 2003; 7(9): 1-98 Original Paper URL Other publications of related interest Meads C, Hyde C Photodynamic therapy with verteporfin is effective, but how big is its effect? Results of a systematic review. Br J Ophthalmol 2004;88:212-7. Indexing Status Subject indexing assigned by NLM MeSH Aged; Cost-Benefit Analysis; Evidence-Based Medicine; Macular Degeneration /drug therapy /physiopathology; Middle Aged; Photochemotherapy /economics

2003 DARE.

166888. Pediatric smoking prevention interventions delivered by care providers: a systematic review

was performed. Data extraction The authors did not state how the data were extracted for the review, or how many reviewers performed the data extraction. Methods of synthesis How were the studies combined? The authors of the review presented a narrative summary of each trial. They stated that the clinical heterogeneity of the included trials precluded a meta-analysis. How were differences between studies investigated? Differences between the studies were commented on within the report. Results of the review (...) Pediatric smoking prevention interventions delivered by care providers: a systematic review Pediatric smoking prevention interventions delivered by care providers: a systematic review Pediatric smoking prevention interventions delivered by care providers: a systematic review Christakis D A, Garrison M M, Ebel B E, Wiehe S E, Rivara F P CRD summary This review found little evidence to support the efficacy of interventions delivered by health care professionals to prevent the uptake of smoking

2003 DARE.

166889. Smoking cessation interventions for adolescents: a systematic review

Smoking cessation interventions for adolescents: a systematic review Smoking cessation interventions for adolescents: a systematic review Smoking cessation interventions for adolescents: a systematic review Garrison MM, Christakis DA, Ebel BE, Wiehe SE, Rivara FP CRD summary The authors found little evidence to support the effectiveness of smoking cessation interventions in adolescents. None of the available evidence was long term. The poor reporting of review methods mean that the authors (...) . Strategies effective in adults should be tested among adolescents. Results should be stratified by variables such as gender, nicotine addition and level of motivation. Funding The Robert Wood Johnson Foundation. Bibliographic details Garrison MM, Christakis DA, Ebel BE, Wiehe SE, Rivara FP. Smoking cessation interventions for adolescents: a systematic review. American Journal of Preventive Medicine 2003; 25(4): 363-367 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH

2003 DARE.

166890. Treatment of established osteoporosis: a systematic review and cost-utility analysis

in the intervention group developing a new fracture(s) compared to those in the control group were combined in a fixed-effect model. The authors assessed publication bias for interventions for which at least 5 trials were included in a meta-analysis. How were differences between studies investigated? Differences between the included studies were discussed within the text of the review. In addition, the authors carried out two sensitivity analyses. The first excluded studies in which fracture was not a primary end (...) and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis (Cochrane review). In: The Cochrane Library, Issue 1, 1999. Oxford: Update Software. 2. Prendiville W, Elbourne D, Chalmers I. The effects of routine oxytocic administration in the management of the third stage of labour: an overview of the evidence from controlled trials. Br J Obset Gynaecol 1988;95:3-16. 3. Brazier JE, Green C, Kanis JA. A systematic review of health state utility values

2002 DARE.

166891. The effectiveness and cost-effectiveness of imatinib in chronic myeloid leukaemia: a systematic review

The effectiveness and cost-effectiveness of imatinib in chronic myeloid leukaemia: a systematic review The effectiveness and cost-effectiveness of imatinib in chronic myeloid leukaemia: a systematic review The effectiveness and cost-effectiveness of imatinib in chronic myeloid leukaemia: a systematic review Garside R, Round A, Dalziel K, Stein K, Royle P Authors' objectives To assess the efficacy and cost-effectiveness of imatinib, compared with existing drug treatments, for the treatment (...) and other chemotherapy drugs; elucidate the relationship between response rates and long-term survival with different treatments; and investigate adverse effects and long-term imatinib use. Funding NHS R&D Health Technology Assessment (HTA) Programme, project number 01/26/01. Bibliographic details Garside R, Round A, Dalziel K, Stein K, Royle P. The effectiveness and cost-effectiveness of imatinib in chronic myeloid leukaemia: a systematic review. Health Technology Assessment 2002; 6(33): 1-162 PubMedID

2002 DARE.

166892. A systematic review of autologous fat transfer for breast augmentation

A systematic review of autologous fat transfer for breast augmentation A systematic review of autologous fat transfer for breast augmentation A systematic review of autologous fat transfer for breast augmentation Chapman A E, Cockburn W, Morrison W, Maddern G J, Moore C, Watters D, Henderson M Authors' objectives To assess the literature on the procedure of autologous fat transfer (AFT) for breast augmentation, and to make recommendations on the safety and efficacy of the technique compared (...) for the review, or how many reviewers performed the data extraction. Methods of synthesis How were the studies combined? The results of the studies were tabulated and synthesised narratively in the text. How were differences between studies investigated? Differences between the study results were highlighted in the text, but they do not seem to have been investigated systematically. Results of the review Sixteen studies, providing data from at least 6,775 patients (one study did not report the number

2002 DARE.

166893. A systematic review of intraoperative radiotherapy in early stage breast cancer

A systematic review of intraoperative radiotherapy in early stage breast cancer A systematic review of intraoperative radiotherapy in early stage breast cancer A systematic review of intraoperative radiotherapy in early stage breast cancer Cuncins-Hearn A, Saunders C, Walsh D, Borg M, Buckingham J, Frizelle F, Maddern G Authors' objectives To evaluate the efficacy and safety of intraoperative radiotherapy (IORT), compared with breast conserving therapy (BCT) with adjuvant post-operative (...) radiotherapy, in patients with early-stage breast cancer. Searching PREMEDLINE, MEDLINE, Current Contents, the Cochrane CENTRAL Register, the Cochrane Database of Systematic Reviews, DARE, NHS EED, EMBASE, PubMed, the National Research Register, ClinicalTrials.gov and HTA were searched for studies in any language; the search terms used and the dates searched were provided. Additional articles were searched for in the proceedings of international and national breast cancer conferences, in the websites

2002 DARE.

166894. A systematic review of radiofrequency ablation for the treatment of liver tumours

A systematic review of radiofrequency ablation for the treatment of liver tumours A systematic review of radiofrequency ablation for the treatment of liver tumours A systematic review of radiofrequency ablation for the treatment of liver tumours Sutherland L M, Williams J A, Padbury R T, Gotley D G, Stokes B, Maddern G J CRD summary This well-conducted review compared the safety and efficacy of radiofrequency ablation with other techniques for the treatment of liver tumours. The authors were (...) recruit adequate numbers of patients and standardise outcome measures. Other areas for consideration are comparison of the percutaneous approach with other access methods, the role of RFA as an adjunct to resection, and the possibility of resectable lesions undergoing RFA. Bibliographic details Sutherland L M, Williams J A, Padbury R T, Gotley D G, Stokes B, Maddern G J. A systematic review of radiofrequency ablation for the treatment of liver tumours. North Adelaide, S. Australia, Australia: Royal

2002 DARE.

166895. A systematic review of stapled haemorrhoidectomy

A systematic review of stapled haemorrhoidectomy A systematic review of stapled haemorrhoidectomy A systematic review of stapled haemorrhoidectomy Sutherland L M, Sweeney J L, Bokey E L, Childs R A, Waxman B P, Roberts A K, Maddern G J Authors' objectives To compare the safety and efficacy of circular stapled haemorrhoidectomy against conventional haemorrhoidectomy. Searching MEDLINE, Current Contents, EMBASE, HealthSTAR, the Cochrane Library (Issue 2, 2001) and the National Research Register (...) details Sutherland L M, Sweeney J L, Bokey E L, Childs R A, Waxman B P, Roberts A K, Maddern G J. A systematic review of stapled haemorrhoidectomy. North Adelaide, S. Australia, Australia: Royal Australasian College of Surgeons, Australian Safety and Efficacy Register of New Interventional Procedures (ASERNIP) - Surgical. ASERNIP-S Report; 24. 2002 Original Paper URL emplate=/TaggedPage/TaggedPageDisplay.cfm&TPLID=17&ContentID=3297 Other publications of related interest Sutherland L, Burchard

2002 DARE.

166896. Screening for hepatitis C among injecting drug users and in genitourinary medicine clinics: systematic reviews of effectiveness, modelling study and national survey of current practice

Screening for hepatitis C among injecting drug users and in genitourinary medicine clinics: systematic reviews of effectiveness, modelling study and national survey of current practice Screening for hepatitis C among injecting drug users and in genitourinary medicine clinics: systematic reviews of effectiveness, modelling study and national survey of current practice Screening for hepatitis C among injecting drug users and in genitourinary medicine clinics: systematic reviews of effectiveness (...) . Methodological quality was not systematically assessed. However, given the small number of poor-quality studies that were anticipated, based on preliminary searches, the assessment of study design in a hierarchy was adequate; the findings were also discussed in the context of study quality. The narrative synthesis was appropriate and relevant details from individual studies were presented. The authors' conclusions are appropriate. Implications of the review for practice and research Practice: The authors

2002 DARE.

166897. A systematic review of the methods used to establish laparoscopic pneumoperitoneum

A systematic review of the methods used to establish laparoscopic pneumoperitoneum A systematic review of the methods used to establish laparoscopic pneumoperitoneum A systematic review of the methods used to establish laparoscopic pneumoperitoneum Merlin T, Jamieson G, Brown A, Maddern G, Hiller J, Kolbe A Authors' objectives The objective was to determine which of the various peritoneal access methods used to establish pneumoperitoneum in laparoscopy was the safest and most effective (...) in full if they were RCTs. Excluded Non-English language studies that had data on relevant outcomes were summarised (based on the abstract) and tabulated. Study selection Study designs of evaluations included in the review Systematic reviews of randomised controlled trials (RCTs), randomised, quasi-randomised and non-randomised trials, or cohort studies (prospective or retrospective) were considered for inclusion. Case series and audit studies with a minimum of 1,000 patients were also considered

2001 DARE.

166898. The clinical effectiveness and cost-effectiveness of vinorelbine for breast cancer: a systematic review and economic evaluation

The clinical effectiveness and cost-effectiveness of vinorelbine for breast cancer: a systematic review and economic evaluation The clinical effectiveness and cost-effectiveness of vinorelbine for breast cancer: a systematic review and economic evaluation The clinical effectiveness and cost-effectiveness of vinorelbine for breast cancer: a systematic review and economic evaluation Lewis R, Bagnall A M, King S, Woolacott N, Forbes C, Shirran L, Duffy S, Kleijnen J, ter Riet G, Riemsma R Authors (...) combined? The studies were grouped according to the type of therapy (first- or second-line) and intervention (monotherapy or combination therapy). The studies were combined narratively and, where no significant diversity or statistical heterogeneity was detected, were pooled using meta-analysis. Publication bias was assessed in relation to the observational studies. How were differences between studies investigated? Both clinical diversity and statistical heterogeneity were investigated. Results

2002 DARE.

166899. Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review

Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

166900. A systematic review update of the clinical effectiveness and cost-effectiveness of glycoprotein IIb/IIIa antagonists

A systematic review update of the clinical effectiveness and cost-effectiveness of glycoprotein IIb/IIIa antagonists A systematic review update of the clinical effectiveness and cost-effectiveness of glycoprotein IIb/IIIa antagonists A systematic review update of the clinical effectiveness and cost-effectiveness of glycoprotein IIb/IIIa antagonists Robinson M, Ginnelly L, Sculpher M, Jones L, Riemsma R, Palmer S, Philips Z, Glanville J Authors' objectives To determine the clinical and cost (...) . A systematic review update of the clinical effectiveness and cost-effectiveness of glycoprotein IIb/IIIa antagonists. Health Technology Assessment 2002; 6(25): 1-160 PubMedID Original Paper URL Other publications of related interest 1. McDonagh MS, Bachmann LM, Golder S, Kleijnen J, ter Riet G. A rapid and systematic review of the clinical effectiveness and cost-effectiveness of glycoprotein IIb/IIIa antagonists in the medical management of unstable angina. Health Technology Assessment 2000;4(30):1-95. 2

2002 DARE.

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