How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

189,729 results for

"metaanalysis" OR "meta analysis" OR "systematic review"〈=en

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

189641. The use of numbers needed to treat derived from systematic reviews and meta-analysis. Caveats and pitfalls. (PubMed)

The use of numbers needed to treat derived from systematic reviews and meta-analysis. Caveats and pitfalls. Numbers needed to treat (NNTs) may be used to present the effects of treatment and are the reciprocal of the absolute difference between treatment and control groups in a randomized controlled trial. NNTs are sensitive to factors that change the baseline risk of trial participants: the outcome considered; characteristics of patients; secular trends in incidence and case-fatality

2001 Evaluation & the health professions

189642. Activity of chemotherapy and immunotherapy on malignant mesothelioma: a systematic review of the literature with meta-analysis. (PubMed)

Activity of chemotherapy and immunotherapy on malignant mesothelioma: a systematic review of the literature with meta-analysis. The role of chemotherapy for unresectable malignant mesothelioma is unclear. The aims of the present study were to evaluate the methodological quality of published papers relative to chemotherapy or immunotherapy in malignant mesothelioma and to aggregate, for trials having a similar methodology, the response rates in order to identify the most active chemotherapeutic (...) arms) were eligible for the systematic review. Fifty-three arms were considered as positive or potentially positive. No statistically significant difference in the methodological quality was observed between negative and positive studies. Studies were aggregated in four groups according to the presence of cisplatin and/or doxorubicin in the treatment regimen. The combination of cisplatin and doxorubicin had the highest response rate (28.5%; P < 0.001). Cisplatin was the most active single-agent

2002 Lung Cancer

189643. Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis. (PubMed)

Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis. Many HIV patients develop weight loss, which increases morbidity and mortality. We aimed to assess the effects of testosterone therapy on lean body mass, total body weight, over-all exercise functional capacity, and perceived quality of life in patients with HIV wasting syndrome and its adverse effects. We systematically reviewed randomised, placebo-controlled trials that compared the effects of testosterone (...) therapy with placebo in HIV patients with wasting. Eight trials met the inclusion criteria and 417 randomised patients were included. Only six trials used lean-body mass, fat-free mass, or body-cell mass as outcome measures. The meta-analysis of the six trials showed a difference in the lean body mass between the testosterone group and placebo group of 1.22 kg (95% CI 0.23-2.22) for the random effect model and 0.51 kg (0.09-0.93) for fixed effect. However, the difference was much greater in the three

2002 Lancet infectious diseases

189644. The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis. (PubMed)

The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis. The prognostic value of epidermal growth factor receptor (EGF-R) for survival of patients with lung cancer remains controversial. The authors performed a systematic review of the literature in order to clarify its impact. Published studies were identified using an electronic search in order to aggregate the available survival results, after a methodological assessment using a scale (...) or not assessable for meta-analysis or between studies with significant and nonsignificant results. One individual trial reported a survival benefit for patients with EGF-R expression, three a survival disadvantage and 12 no statistically significant difference. Eleven studies (2,185 patients) provided sufficient data to allow a meta-analysis of the survival results. EGF-R expression positivity was determined according to the cut-off as determined by the authors. The meta-analysis showed that EGF-R expression

2002 The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology

189645. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. (PubMed)

Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Milk thistle, an herbal compound, is the dietary supplement taken most frequently by patients with chronic liver disease. We performed a systematic review of the literature to determine the efficacy and safety of this herb for the treatment of liver disease.We searched English and non-English reports through July 1999 using thirteen databases and reference lists, and contacting manufacturers and technical

2002 The American journal of medicine

189646. Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming. Systematic review and meta-analysis. (PubMed)

Ventilation tubes after surgery for otitis media with effusion or acute otitis media and swimming. Systematic review and meta-analysis. To determine if the use of ear protection when swimming of children with ventilation tubes modifies the risk of acute otitis media (AOM) compared to not swimming.Systematic review.Search conducted in MEDLINE, EMBASE and The Cochrane Library databases.Prospective cohort studies and controlled clinical trials of children with ventilation tubes, with a minimum

2002 International journal of pediatric otorhinolaryngology

189647. Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. (PubMed)

Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. We performed a systematic review of randomized, controlled trials to determine whether intranasal corticosteroids offered an advantage over topical antihistamines in the treatment of allergic rhinitis.We searched for studies using MEDLINE, Embase, Cinahi, and Cochrane databases, pharmaceutical companies, and references of included trials.Criteria

2002 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

189648. Enabling meta-analysis in systematic reviews on carpal tunnel syndrome. (PubMed)

Enabling meta-analysis in systematic reviews on carpal tunnel syndrome. Possible solutions to the problems of clinical heterogeneity of outcome measures and inadequate reporting of results for randomized controlled trials (RCTs) on carpal tunnel syndrome (CTS) are presented. Meta-analysis was impeded by these problems in 2 systematic reviews concerning conservative and surgical treatment options for CTS. A solution to the problem of inadequate data presentation is to add explicit information (...) of effect in a meta-analysis.

2002 The Journal of hand surgery

189649. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. (PubMed)

Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. To evaluate critically the evidence linking psychotropic drugs with falls in older people.Fixed-effects meta-analysis.English-language articles in MEDLINE (1966 - March 1996) indexed under accidents or accidental falls and aged or age factors; bibliographies of retrieved papers.Systematic evaluation of sedative/hypnotic, antidepressant, or neuroleptic use with falling in people aged 60 and older.Study

1999 Journal of the American Geriatrics Society

189650. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. (PubMed)

Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. To evaluate critically the evidence linking specific classes of cardiac and analgesic drugs to falls in older people.Fixed-effects meta-analysis.English-language articles in MEDLINE (1966 - March 1996) indexed under accidents or accidental falls and aged or age factors; bibliographies of retrieved papers.Systematic evaluation of cardiac or analgesic drug use and any fall in people aged 60

1999 Journal of the American Geriatrics Society

189651. Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea. (PubMed)

Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea. To establish the evidence base for the diagnosis of sleep apnea (SA) in adult patients, a systematic review of the literature from 1980 through November 1, 1997 was performed. Diagnostic studies were included if they reported results of any test to establish or support a diagnosis of SA, in comparison to a diagnosis from a full polysomnogram (PSG). Test results were meta-analyzed using fixed effects

2000 Sleep

189652. Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis. (PubMed)

Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis. To compare luteinizing hormone-releasing hormone (LHRH) agonists with orchiectomy or diethylstilbestrol, and to compare antiandrogens with any of these three alternatives.A search of the MEDLINE, Cancerlit, EMBASE, and Cochrane Library databases from 1966 to March 1998 and Current Contents to 24 August 1998 for articles comparing the outcomes of the specified treatments. The search (...) was limited to studies on prostatic neoplasms in humans. Total yield was 1477 studies.Reports of efficacy outcomes were limited to randomized, controlled trials. Twenty-four trials involving more than 6600 patients, phase II studies that reported on withdrawals from therapy (the most reliable indicator of adverse effects), and all studies reporting on quality of life were abstracted.Two independent reviewers abstracted each article by following a prospectively designed protocol. The meta-analysis combined

2000 Annals of internal medicine

189653. The effect of home visiting programmes on uptake of childhood immunization: a systematic review and meta-analysis. (PubMed)

The effect of home visiting programmes on uptake of childhood immunization: a systematic review and meta-analysis. The aim of the study was to evaluate the effectiveness of home visiting programmes on the uptake of childhood immunization.A systematic review was carried out of the literature of controlled studies evaluating home visiting programmes involving at least one post-natal visit, which included tasks within the remit of British health visiting and reporting outcomes relevant to British (...) health visiting. Eleven studies were considered, nine of which used socio-economically disadvantaged families. The outcome measure was uptake of a range of childhood immunizations.Eleven studies reported uptake of immunization. Effect sizes from nine studies were included in the meta-analysis. Fixed effects models demonstrated a significant effect of home visiting for all studies and also for several subgroups of studies, but with significant heterogeneity of effect sizes. A random effects model

2000 Journal of public health medicine

189654. Does home visiting improve parenting and the quality of the home environment? A systematic review and meta analysis. (PubMed)

Does home visiting improve parenting and the quality of the home environment? A systematic review and meta analysis. To evaluate the effectiveness of home visiting programmes on parenting and quality of the home environment.Systematic review of the literature of randomised controlled trials and quasi-experimental studies evaluating home visiting programmes involving at least one postnatal visit.Thirty four studies reported relevant outcomes; 26 used participants considered to be at risk (...) of adverse maternal or child health outcomes; two used preterm or low birth weight infants; and two used infants with failure to thrive. Only eight used participants not considered to be at risk of adverse child health outcomes.Seventeen studies reported Home Observation for Measurement of the Environment (HOME) scores, 27 reported other measures of parenting, and 10 reported both types of outcome. Twelve studies were entered into the meta analysis. This showed a significant effect of home visiting

Full Text available with Trip Pro

2000 Archives of disease in childhood

189655. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. (PubMed)

A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. The herbal remedy St John's wort is widely used as an antidepressant but its efficacy has not been systematically investigated. Meta-analyses and systematic reviews of published trials strongly suggest St John's wort is more effective than placebo although comparative efficacy to standard antidepressants is less clearly established. We updated and expanded previous meta-analyses of St (...) John's wort, scrutinised the validity of published reports and examined possible mechanisms of action. Twenty-two randomised controlled trials were identified. Meta-analysis showed St John's wort to be significantly more effective than placebo (relative risk (RR) 1.98 (95% CI 1.49-2.62)) but not significantly different in efficacy from active antidepressants (RR 1.0 (0.90-1.11)). A sub-analysis of six placebo-controlled trials and four active comparator trials satisfying stricter methodological

2001 International clinical psychopharmacology

189656. Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis. (PubMed)

Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis. To assess the effects of multiple courses of antenatal corticosteroids on perinatal and neonatal death and neonatal, infant, and maternal disease.MEDLINE and Embase were searched for human studies published in English. Studies that compared multiple courses of antenatal corticosteroids versus a single course were included if they were published in full and were controlled for gestational age at birth. Meta

2001 American journal of obstetrics and gynecology

189657. Discontinuation of antihypertensive drugs due to adverse events: a systematic review and meta-analysis. (PubMed)

Discontinuation of antihypertensive drugs due to adverse events: a systematic review and meta-analysis. We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total of 190 studies met inclusion criteria. The highest frequency (...) of discontinuations due to adverse events (DAEs) occurred with calcium channel blockers (6.7%) and alpha-adrenergic blockers (6.0%); the lowest with diuretics and angiotensin receptor blockers (each 3.1%). Only in calcium channel blocker studies was the frequency of DAEs greater in treated patients than in patients receiving placebo, but the difference was not significant. This systematic review suggests that the frequency of DAEs in monotherapy antihypertensive trials varies across drug classes and should

2001 Pharmacotherapy

189658. Does bed rest after cervical or lumbar puncture prevent headache? A systematic review and meta-analysis. (PubMed)

Does bed rest after cervical or lumbar puncture prevent headache? A systematic review and meta-analysis. Headache after cervical or lumbar puncture has long been attributed to early mobilization; however, there is little evidence for this. We performed a systematic literature review and meta-analysis of randomized controlled trials to assess whether longer bed rest is better than immediate mobilization or short bed rest in preventing headache.We searched EMBASE (1988 to March 2001), MEDLINE

Full Text available with Trip Pro

2001 Canadian Medical Association Journal

189659. [Methods of investigation in clinical cardiology. VIII. Meta-analysis and systematic reviews in cardiology]. (PubMed)

[Methods of investigation in clinical cardiology. VIII. Meta-analysis and systematic reviews in cardiology]. Over the last 20 years, the development of meta-analysis has been aimed at obtaining objective synthesis of the available results on specific research questions. The main achievements of meta-analysis include the application of techniques to perform systematic literature searches and to obtain unbiased selection of studies, data extraction and pooled estimates of effect. This paper (...) discusses the methodologic steps to follow when conducting a meta-analysis, with emphasis on study selections, data collection and statistical methods to combine the results from individual studies. We also present a set of guided questions as an aid to critically evaluate the conclusions of published meta-analyses. The application of meta-analytic techniques to cardiology is illustrated using a meta-analysis of the randomized controlled trials of angioplasty versus bypass surgery in the management

1997 Revista española de cardiología

189660. Systematic reviews of medical evidence: the use of meta-analysis in obstetrics and gynecology. (PubMed)

Systematic reviews of medical evidence: the use of meta-analysis in obstetrics and gynecology. To review the technique of meta-analysis and its uses and limitations in obstetrics and gynecology.We reviewed four major journals in obstetrics and gynecology (American Journal of Obstetrics and Gynecology, Fertility and Sterility, Journal of Reproductive Medicine, and Obstetrics & Gynecology).Journals were reviewed to determine frequency of meta-analysis as a method of systematic review (...) in obstetrics and gynecology. We also summarized objectives and scientific guidelines for performing a meta-analysis.Meta-analysis is used with increased frequency in obstetrics and gynecology as a way of systematically reviewing medical evidence. This technique is an attempt to improve on traditional methods of narrative review by an expert and as a framework for evidence-based medicine and developing practice guidelines. By combining data from replicate studies, a meta-analysis can increase statistical

1997 Obstetrics and Gynecology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>