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189601. Should we apply suction during fine needle cytology of thyroid lesions? A systematic review and meta-analysis. (PubMed)

Should we apply suction during fine needle cytology of thyroid lesions? A systematic review and meta-analysis. Fine needle aspiration cytology (FNAC) is a well-established investigation in thyroid disease. Fine needle sampling without aspiration (FNS) is less commonly used but often easier to perform. Both methods have advantages and disadvantages but, as yet, there is no agreement on which method produces better specimens for cytological diagnosis.We undertook a review of the literature (...) and performed a meta-analysis of the results of four cross-over trials.The resulting odds ratio favoured FNS (OR = 0.99; 95% CI 0.88-1.11) but was not statistically significant. A fifth paper not included in the meta-analysis reported results in favour of FNS (P = 0.003).There is no evidence from the meta-analysis that one method is superior to the other; however, taking into consideration all available evidence, it seems that FNS may be easier to perform and may produce better samples.

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2006 Annals of the Royal College of Surgeons of England

189602. Illness perceptions predict attendance at cardiac rehabilitation following acute myocardial infarction: a systematic review with meta-analysis. (PubMed)

Illness perceptions predict attendance at cardiac rehabilitation following acute myocardial infarction: a systematic review with meta-analysis. Early reports indicated that the illness perceptions of patients following acute myocardial infarction (AMI) predict attendance at cardiac rehabilitation. However, null findings have subsequently been reported, and there is variation between studies in terms of which illness perception constructs predict attendance. The aim of this meta-analysis (...) was to examine whether illness perceptions really predict attendance at cardiac rehabilitation and to examine factors that moderate this relationship.The strategy and procedures recommended by Hunter and Schmidt [Hunter JE, Schmidt FL. Methods of meta-analysis: correcting error and bias in research findings. Thousand Oaks (CA): Sage, 2004] were followed. Based on a systematic literature search, eight studies (N=906 patients) that examined the relationship between illness perceptions and attendance at cardiac

2006 Journal of psychosomatic research

189603. Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. (PubMed)

Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. An understanding of the neurobiological correlates of vulnerability to psychosis is fundamental to research on schizophrenia. We systematically reviewed data from studies published from 1992 to 2006 on the neurocognitive correlates (as measured by fMRI) of increased vulnerability to psychosis. We also conducted a meta-analysis of abnormalities of activation in the prefrontal cortex (PFC) in high

2007 Neuroscience and biobehavioral reviews

189604. Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. (PubMed)

Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Obesity is a risk factor for several hormone-related cancers but evidence for an effect on risk of epithelial ovarian cancer remains inconclusive. Many studies evaluating this association have had insufficient statistical power to detect modest effects, particularly for histological subtypes of ovarian cancer. We have therefore assembled the published evidence on obesity and ovarian cancer in a systematic (...) literature review and meta-analysis. We identified eligible studies using Medline and manual review of retrieved references, and included all population-based studies that assessed the association between overweight, body mass index (BMI25-29.9) and obesity (BMI30) and histologically confirmed ovarian cancer. Meta-analysis was restricted to those studies that expressed effect as an odds ratio (OR), risk ratio, or standardised incidence ratio and 95% confidence interval (CI). We identified 28 eligible

2007 European journal of cancer (Oxford, England : 1990)

189605. Pancreatic cancer in type 1 and young-onset diabetes: systematic review and meta-analysis. (PubMed)

Pancreatic cancer in type 1 and young-onset diabetes: systematic review and meta-analysis. We conducted a systematic review of the risk of pancreatic cancer in people with type I and young-onset diabetes. In three cohort and six case-control studies, the relative risk for pancreatic cancer in people with (vs without) diabetes was 2.00 (95% confidence interval 1.37-3.01) based on 39 cases with diabetes.

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2007 British journal of cancer

189606. Inflammatory bowel disease is not a risk factor for cardiovascular disease mortality: results from a systematic review and meta-analysis. (PubMed)

Inflammatory bowel disease is not a risk factor for cardiovascular disease mortality: results from a systematic review and meta-analysis. Inflammation in general, and C-reactive protein (CRP) in particular, are closely associated with atherosclerosis. Similarly, the risk of cardiovascular (CV) disease is increased in several systemic inflammatory diseases. The purpose of this study was to examine whether inflammatory bowel disease (IBD) increases CV mortality, an indirect surrogate for CV (...) disease incidence.A systematic review of studies on CV mortality rates in patients with IBD published between 1965 and 2006 was performed. Studies were included for analysis if they reported data on CV-disease-specific standardized mortality ratios (SMRs) for Crohn's disease (CD) and/or ulcerative colitis (UC). A meta-analysis of SMRs from included studies was performed.The review ultimately included 11 studies. Overall there were 4,532 patients with CD and 9,533 patients with UC. SMR point estimates

2007 The American journal of gastroenterology

189607. The value of clinical features in the diagnosis of acute pulmonary embolism: systematic review and meta-analysis. (PubMed)

The value of clinical features in the diagnosis of acute pulmonary embolism: systematic review and meta-analysis. Clinical assessment of patients with suspected pulmonary embolus (PE) is used to estimate the probability of PE and determine what (if any) diagnostic testing is required.We aimed to estimate the diagnostic value of individual clinical features used to determine the pre-test probability of acute PE.Systematic review and meta-analysis.We searched electronic databases (1966 to May

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2007 QJM : monthly journal of the Association of Physicians

189608. Cognitive-behavioral interventions to reduce suicide behavior: a systematic review and meta-analysis. (PubMed)

Cognitive-behavioral interventions to reduce suicide behavior: a systematic review and meta-analysis. Suicide behavior is a serious clinical problem worldwide, and understanding ways of reducing it is a priority. A systematic review and meta-analysis were carried out to investigate whether Cognitive-behavioral therapies (CBTs) would reduce suicide behavior. From 123 potential articles, 28 studies met the entry criteria. Overall, there was a highly significant effect for CBT in reducing suicide

2007 Behavior modification

189609. Thrombolysis is not warranted in submassive pulmonary embolism: a systematic review and meta-analysis. (PubMed)

Thrombolysis is not warranted in submassive pulmonary embolism: a systematic review and meta-analysis. Acute pulmonary embolism (PE) is a major cause of morbidity and mortality in hospitalised patients. While the vast majority of patients with PE survive, a subset die, mostly within a few hours of presentation. Anatomically massive pulmonary emboli account for only half these deaths, while submassive or recurrent embolism accounts for the other half. There are increasing reports of patients (...) at the definition and diagnosis of submassive PE, and systematically reviews the role of thrombolytic therapy in this subgroup of patients.

2007 Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

189610. Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. (PubMed)

Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer. Potential underlying mechanisms include variation in amounts of maternal endogenous sex hormones and growth hormones, germ-cell mutations, formation of cancer stem-cells, and other genetic or epigenetic events. We reviewed and summarised quantitatively

2007 The lancet oncology

189611. Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis. (PubMed)

Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis. Among new biological markers that could become useful prognostic factors for lung carcinoma, Ki-67 is a nuclear protein involved in cell proliferation regulation. Some studies have suggested an association between Ki-67 and poor survival in lung cancer patients. In order to clarify this point, we have performed a systematic review of the literature, using the methodology already (...) for survival in 15 studies while it was not in 22. As there was no statistical difference in quality scores between the significant and nonsignificant studies evaluable for the meta-analysis, we were allowed to aggregate the survival results. The combined hazard ratio for NSCLC, calculated using a random-effects model was 1.56 (95% CI: 1.30-1.87), showing a worse survival when Ki-67 expression is increased. In conclusion, our meta-analysis shows that the expression of Ki-67 is a factor of poor prognosis

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2004 British journal of cancer

189612. [Systematic reviews and meta-analysis in laboratory medicine: principles and methods]. (PubMed)

[Systematic reviews and meta-analysis in laboratory medicine: principles and methods]. Systematic reviews and meta-analyses can help health-care professionals to base their decisions on the highest levels of evidence, and are therefore the cornerstone in practicing evidence-based medicine. In the field of diagnosis in general, and in laboratory medicine in particular, systematic reviews are scarcer, and often of lower quality than in other areas of medicine.To summarize the principles (...) and methods that can be advised to perform systematic reviews of good quality in laboratory medicine.A narrative review of the literature and discussions with members of the Committee on Evidence-Based Laboratory Medicine of the International Federation of Clinical Chemistry and Laboratory Medicine, in particular during our last three meetings, enabled us to adapt to laboratory medicine the methods which are currently being advocated to perform systematic reviews of good quality in other medical areas.The

2004 Annales de biologie clinique

189613. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. (PubMed)

Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. A meta-analysis was performed to evaluate the accuracy of determination of procalcitonin (PCT) and C-reactive protein (CRP) levels for the diagnosis of bacterial infection. The analysis included published studies that evaluated these markers for the diagnosis of bacterial infections in hospitalized patients. PCT level was more sensitive (88% [95% confidence interval [CI

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2004 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

189614. Accuracy of a 12-lead electrocardiogram in screening patients with suspected heart failure for open access echocardiography: a systematic review and meta-analysis. (PubMed)

Accuracy of a 12-lead electrocardiogram in screening patients with suspected heart failure for open access echocardiography: a systematic review and meta-analysis. The aim of this study was to examine the usefulness of 12-lead electrocardiogram in screening patients with suspected heart failure for open access echocardiography. We carried out a systematic review and meta-analysis of published observational studies. Published studies were identified in the Medline and Embase databases

2004 European journal of heart failure

189615. Short vs. long bed rest after uncomplicated acute myocardial infarction: a systematic review and meta-analysis. (PubMed)

Short vs. long bed rest after uncomplicated acute myocardial infarction: a systematic review and meta-analysis. 15358406 2004 12 02 2007 11 15 0895-4356 57 7 2004 Jul Journal of clinical epidemiology J Clin Epidemiol Short vs. long bed rest after uncomplicated acute myocardial infarction: a systematic review and meta-analysis. 759; author reply 760 West Robert R eng Comment Letter United States J Clin Epidemiol 8801383 0895-4356 IM J Clin Epidemiol. 2003 Aug;56(8):775-81 12954470 Bed Rest (...) Evidence-Based Medicine Humans Meta-Analysis as Topic Myocardial Infarction rehabilitation Time Factors 2004 9 11 5 0 2004 12 16 9 0 2004 9 11 5 0 ppublish 15358406 10.1016/j.jclinepi.2003.12.003 S0895435603004414

2004 Journal of Clinical Epidemiology

189616. The genetic basis for smoking behavior: a systematic review and meta-analysis. (PubMed)

The genetic basis for smoking behavior: a systematic review and meta-analysis. Considerable evidence indicates that smoking behavior is under a degree of genetic influence. We conducted a systematic review of candidate gene studies of smoking behavior and, where sufficient studies existed, combined reported data using meta-analytic techniques. A total of 41 studies were identified by the search strategy, of which 28 contributed to the meta-analysis. The meta-analysis included data on the DRD2

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2004 Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

189617. A systematic review and meta-analysis of the incidence and severity of postoperative fatigue. (PubMed)

A systematic review and meta-analysis of the incidence and severity of postoperative fatigue. Postoperative fatigue is common following major abdominal surgery. Less is known about its prevalence in other surgical subgroups, and about its long-term prognosis. A systematic review of prospective cohort studies was conducted to clarify these issues.Studies were identified from an extensive literature search. Overall estimates of pre- to postoperative change in fatigue severity and the incidence

2004 Journal of psychosomatic research

189618. Systematic review of endoscopic therapy for ulcers with clots: Can a meta-analysis be misleading? (PubMed)

Systematic review of endoscopic therapy for ulcers with clots: Can a meta-analysis be misleading? 16344090 2006 02 03 2007 11 15 0016-5085 129 6 2005 Dec Gastroenterology Gastroenterology Systematic review of endoscopic therapy for ulcers with clots: Can a meta-analysis be misleading? 2127; author reply 2127-8 Laine Loren L eng Comment Letter United States Gastroenterology 0374630 0016-5085 AIM IM Gastroenterology. 2005 Sep;129(3):855-62 16143125 Hemostasis, Endoscopic Humans Meta-Analysis

2005 Gastroenterology

189619. Fruit and vegetables consumption and gastric cancer: a systematic review and meta-analysis of cohort studies. (PubMed)

Fruit and vegetables consumption and gastric cancer: a systematic review and meta-analysis of cohort studies. Fruit and vegetable intake is widely recognized as protective for gastric cancer occurrence but prospective research challenged this belief. To evaluate the influence of design options in such results we did a meta-analysis of relevant published cohort studies identified from inception to 2004 in PubMed, EMBASE, and LILACS. Random-effects meta-analysis, stratification, and meta (...) % CI = 0.69-1.13) using all incidence studies and 0.71 (95% CI = 0.53-0.94) when considering only those with the longer follow-up. The association observed between vegetable intake and gastric cancer mortality was 1.05 (95% CI = 0.89-1.25). Other study characteristics assessed added no significant contribution to explain heterogeneity. This meta-analysis showed that design options might play a key role in the observed magnitude or the direction of the association between fruit and vegetable intake

2005 Nutrition and cancer

189620. Outcome of isolated antenatal hydronephrosis: a systematic review and meta-analysis. (PubMed)

Outcome of isolated antenatal hydronephrosis: a systematic review and meta-analysis. Idiopathic antenatal hydronephrosis (IAHN), defined as antenatal hydronephrosis not associated with other morphologic renal tract abnormalities, is the most common abnormality detected by antenatal ultrasound. We performed a systematic review and meta-analysis to determine the outcome of IAHN. We screened three databases and bibliographies to identify English-language original peer-reviewed papers that reported (...) . Meta-analysis of data extracted from seven papers showed stabilization of pelviectasis in 98% of patients with grades 1-2 (95% confidence interval [CI] 0.93-1.0; p =0.0008) and in 51% of patients with grades 3-4 (95% CI 0.34-0.68; p <0.00001). Grades 1-2 pelviectasis was five times more likely to stabilize than grades 3-4 pelviectasis (odds ratio [OR] 4.69; 95% CI 1.73-12.76; p =0.002). We conclude that in patients with IAHN and lesser degrees of pelvic dilatation, pelvic diameter decreases

2006 Pediatric nephrology (Berlin, Germany)

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