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21. Interventions for unexplained infertility: a systematic review and network meta-analysis. Full Text available with Trip Pro

Interventions for unexplained infertility: a systematic review and network meta-analysis. Clinical management for unexplained infertility includes expectant management as well as active treatments, including ovarian stimulation (OS), intrauterine insemination (IUI), OS-IUI,  and in vitro fertilisation (IVF) with or without intracytoplasmic sperm injection (ICSI).Existing systematic reviews have conducted head-to-head comparisons of these interventions using pairwise meta-analyses (...) approaches to clinical management (expectant management, OS, IUI, OS-IUI, and IVF/ICSI) in couples with unexplained infertility.We performed a systematic review and network meta-analysis of relevant randomised controlled trials (RCTs). We searched electronic databases including the Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials, the Cochrane Central Register of Studies Online, MEDLINE, Embase, PsycINFO and CINAHL, up to 6 September 2018, as well as reference lists

2019 Cochrane

22. Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies. (Abstract)

Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies. Hodgkin lymphoma (HL) is one of the most common haematological malignancies in young adults and, with cure rates of 90%, has become curable for the majority of individuals. Positron emission tomography (PET) is an imaging tool used to monitor a tumour's metabolic activity, stage and progression. Interim PET during chemotherapy has been posited as a prognostic (...) on the interim PET scan results.We developed a data extraction form according to the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS). Two teams of two review authors independently screened the studies, extracted data on overall survival (OS), progression-free survival (PFS) and PET-associated adverse events (AEs), assessed risk of bias (per outcome) according to the Quality in Prognosis Studies (QUIPS) tool, and assessed the certainty

2019 Cochrane

23. Community-based supplementary feeding for food insecure, vulnerable and malnourished populations - an overview of systematic reviews. Full Text available with Trip Pro

Community-based supplementary feeding for food insecure, vulnerable and malnourished populations - an overview of systematic reviews. Supplementary feeding may help food insecure and vulnerable people by optimising the nutritional value and adequacy of the diet, improving quality of life and improving various health parameters of disadvantaged families. In low- and middle-income countries (LMIC), the problems supplementary feeding aims to address are entangled with poverty and deprivation (...) 'Summary of findings' tables from each review to indicate the certainty of the evidence for the main comparisons. We summarised review findings in the text and reported the data for each outcome in additional tables. We also used forest plots to display results graphically.This overview included eight systematic reviews (with last search dates between May 2006 and February 2016). Seven were Cochrane Reviews evaluating interventions in pregnant women; children (aged from birth to five years) from LMIC

2018 Cochrane

24. Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews. Full Text available with Trip Pro

Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews. Preterm birth (PTB) is a major factor contributing to global rates of neonatal death and to longer-term health problems for surviving infants. Both the World Health Organization and the United Nations consider prevention of PTB as central to improving health care for pregnant women and newborn babies. Current preventative clinical strategies show varied efficacy in different populations (...) of pregnant women, frustrating women and health providers alike, while researchers call for better understanding of the underlying mechanisms that lead to PTB.We aimed to summarise all evidence for interventions relevant to the prevention of PTB as reported in Cochrane systematic reviews (SRs). We intended to highlight promising interventions and to identify SRs in need of an update.We searched the Cochrane Database of Systematic Reviews (2 November 2017) with key words to capture any Cochrane SR

2018 Cochrane

25. Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Full Text available with Trip Pro

Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies.To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of the benefits and harms associated with interventions for treating GDM on women and their babies.We searched the Cochrane Database of Systematic Reviews (5 January 2018 (...) ) for reviews of treatment/management for women with GDM. Reviews of pregnant women with pre-existing diabetes were excluded.Two overview authors independently assessed reviews for inclusion, quality (AMSTAR; ROBIS), quality of evidence (GRADE), and extracted data.We included 14 reviews. Of these, 10 provided relevant high-quality and low-risk of bias data (AMSTAR and ROBIS) from 128 randomised controlled trials (RCTs), 27 comparisons, 17,984 women, 16,305 babies, and 1441 children. Evidence ranged from

2018 Cochrane

26. Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews. Full Text available with Trip Pro

Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews. Cerebral palsy is an umbrella term that encompasses disorders of movement and posture attributed to non-progressive disturbances occurring in the developing foetal or infant brain. As there are diverse risk factors and aetiologies, no one strategy will prevent cerebral palsy. Therefore, there is a need to systematically consider all potentially relevant interventions for prevention.PrimaryTo (...) : low- to very low-quality evidenceReview authors observed no clear differences in cerebral palsy with interventions assessed in five reviews.This overview summarises evidence from Cochrane Systematic Reviews regarding effects of neonatal interventions on cerebral palsy, and can be used by researchers, funding bodies, policy makers, clinicians, and consumers to aid decision-making and evidence translation. To formally assess other benefits and/or harms of included interventions, including impact

2018 Cochrane

27. The effective, safe and appropriate use of anticoagulation medicines: A systematic overview of reviews

The effective, safe and appropriate use of anticoagulation medicines: A systematic overview of reviews anticoagulation medicines 18 March 2019 Links Download reports (pdf) Evidence Summary Evidence Report The effective, safe and appropriate use of anticoagulation medicines: A systematic overview of reviews. What do we want to know? Anticoagulation drugs are used to prevent and treat irregular heartbeat (atrial fibrillation, AF), and clotting of blood in veins (venous thromboembolism, VTE (...) of other factors may also influence treatment and maintenance decisions. This knowledge could help clinicians to determine the level of support and information to provide to patients, including communication of risks, benefits and preferences. How did we get these results? A rapid systematic overview of reviews of oral anticoagulant therapy and patient/clinician experience was undertaken. We searched a broad range of sources, then screened with specific inclusion and exclusions criteria to identify

2019 EPPI Centre

28. Mass deworming for improving health and cognition of children in endemic helminth areas: A systematic review and individual participant data network meta?analysis Full Text available with Trip Pro

Mass deworming for improving health and cognition of children in endemic helminth areas: A systematic review and individual participant data network meta?analysis Mass deworming for improving health and cognition of children in endemic helminth areas: A systematic review and individual participant data network metaanalysis - Welch - 2019 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within (...) Search term Search term SYSTEMATIC REVIEW Open Access Mass deworming for improving health and cognition of children in endemic helminth areas: A systematic review and individual participant data network metaanalysis Corresponding Author E-mail address: Centre for Global Health, Bruyère Research Institute, Ottawa, Ontario, Canada School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada Correspondence Centre for Global Health, Bruyère Research

2019 Campbell Collaboration

29. Mass deworming for soil?transmitted helminths and schistosomiasis among pregnant women: A systematic review and individual participant data meta?analysis Full Text available with Trip Pro

Mass deworming for soil?transmitted helminths and schistosomiasis among pregnant women: A systematic review and individual participant data meta?analysis Mass deworming for soil‐transmitted helminths and schistosomiasis among pregnant women: A systematic review and individual participant data metaanalysis - Salam - 2019 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search (...) term SYSTEMATIC REVIEW Open Access Mass deworming for soil‐transmitted helminths and schistosomiasis among pregnant women: A systematic review and individual participant data metaanalysis Healthy Mother, Babies and Children Theme, South Australian Health and MedicalResearch Institute, Adelaide, Australia Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia Maternal Adolescent Reproductive & Child Health (MARCH) Centre, London School of Hygiene and Tropical Medicine

2019 Campbell Collaboration

30. What works to improve early grade literacy in Latin America and the Caribbean? A systematic review and meta?analysis Full Text available with Trip Pro

What works to improve early grade literacy in Latin America and the Caribbean? A systematic review and meta?analysis What works to improve early grade literacy in Latin America and the Caribbean? A systematic review and metaanalysis - Stone - 2020 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term SYSTEMATIC REVIEW Open Access What works to improve early grade (...) literacy in Latin America and the Caribbean? A systematic review and metaanalysis Corresponding Author E-mail address: American Institutes for Research, Washington, District of Columbia Correspondence Rebecca Stone, American Institutes for Research, 1000 Thomas Jefferson Street NW, Washington, DC 20007. Email: American Institutes for Research, Washington, District of Columbia American Institutes for Research, Washington, District of Columbia American Institutes for Research, Washington, District

2019 Campbell Collaboration

31. Twenty?first century adaptive teaching and individualized learning operationalized as specific blends of student?centered instructional events: A systematic review and meta?analysis Full Text available with Trip Pro

Twenty?first century adaptive teaching and individualized learning operationalized as specific blends of student?centered instructional events: A systematic review and meta?analysis Twenty‐first century adaptive teaching and individualized learning operationalized as specific blends of student‐centered instructional events: A systematic review and metaanalysis - Bernard - 2019 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use (...) of cookies as described in our . Search within Search term Search term SYSTEMATIC REVIEW Open Access Twenty‐first century adaptive teaching and individualized learning operationalized as specific blends of student‐centered instructional events: A systematic review and metaanalysis Corresponding Author E-mail address: Centre for the Study of Learning and Performance, Concordia University, Montreal, Canada Correspondence Robert M. Bernard, Centre for the Study of Learning and Performance, Concordia

2019 Campbell Collaboration

32. The use of 18F-FDG PET in the diagnosis of cardiac sarcoidosis: a systematic review and metaanalysis including the Ontario experience

The use of 18F-FDG PET in the diagnosis of cardiac sarcoidosis: a systematic review and metaanalysis including the Ontario experience Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

33. Association between time of admission to the ICU and mortality: a systematic review and metaanalysis

Association between time of admission to the ICU and mortality: a systematic review and metaanalysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2012 PedsCCM Evidence-Based Journal Club

34. Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis. Full Text available with Trip Pro

Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis. Long-acting bronchodilators such as long-acting β-agonist (LABA), long-acting muscarinic antagonist (LAMA), and LABA/inhaled corticosteroid (ICS) combinations have been used in people with moderate to severe chronic obstructive pulmonary disease (COPD) to control symptoms such as dyspnoea and cough, and prevent exacerbations. A number (...) of LABA/LAMA combinations are now available for clinical use in COPD. However, it is not clear which group of above mentioned inhalers is most effective or if any specific formulation works better than the others within the same group or class.To compare the efficacy and safety of available formulations from four different groups of inhalers (i.e. LABA/LAMA combination, LABA/ICS combination, LAMA and LABA) in people with moderate to severe COPD. The review will update previous systematic reviews

2018 Cochrane

35. Comparative Efficacy of Tumor Necrosis Factor-α Inhibitors in Ankylosing Spondylitis: A Systematic Review and Bayesian Network Metaanalysis. (Abstract)

Comparative Efficacy of Tumor Necrosis Factor-α Inhibitors in Ankylosing Spondylitis: A Systematic Review and Bayesian Network Metaanalysis. To compare the efficacy of 6 tumor necrosis factor-α inhibitors (TNFi) in treatment of ankylosing spondylitis (AS) at 12 weeks and 24 weeks.We performed a systematic literature review of randomized controlled trials of TNFi in patients with active AS. We included trials that reported efficacy at 10 to 14 weeks (12-week analysis) and at 24 to 30 weeks (24 (...) -week analysis). We used Bayesian network metaanalysis (NMA) to compare their relative efficacy to improve the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and C-reactive protein (CRP) level.We included 20 trials of 6 TNFi, with 43 treatment arms and 3220 participants. All TNFi were significantly better than placebo in reducing BASDAI and BASFI at 12 weeks and 24 weeks; all but certolizumab pegol (CZP) were statistically better

2018 Journal of Rheumatology

36. Rheumatoid Arthritis and Risk of Sexual Dysfunction: A Systematic Review and Metaanalysis. (Abstract)

Rheumatoid Arthritis and Risk of Sexual Dysfunction: A Systematic Review and Metaanalysis. It has been reported that there is an association between rheumatoid arthritis (RA) and increased susceptibility to sexual dysfunction (SD). This systematic review and metaanalysis aimed to investigate whether RA was a risk factor for SD.MEDLINE (PubMed), EMBASE, and the Cochrane Library were systematically searched for all studies assessing sexual function in patients with RA. The association between RA

2018 Journal of Rheumatology

37. Monitoring of Osteonecrosis in Systemic Lupus Erythematosus Patients: A Systematic Review and Metaanalysis. Full Text available with Trip Pro

Monitoring of Osteonecrosis in Systemic Lupus Erythematosus Patients: A Systematic Review and Metaanalysis. Nontraumatic osteonecrosis (ON) is a well-recognized complication causing disability and affecting quality of life in patients with systemic lupus erythematosus (SLE). The aim of this study was to identify the risk factors for ON, and to identify the minimal investigation(s) needed to optimally monitor the risk of ON in patients with SLE.A systematic review was conducted using MEDLINE (...) with SLE. Results of this review were considered in the development of recommendations for the diagnosis and monitoring of patients with SLE in Canada and will guide clinicians in their assessment of these patients.

2018 Journal of Rheumatology

38. A Systematic Review and Metaanalysis of Antirheumatic Drugs and Vaccine Immunogenicity in Rheumatoid Arthritis. Full Text available with Trip Pro

A Systematic Review and Metaanalysis of Antirheumatic Drugs and Vaccine Immunogenicity in Rheumatoid Arthritis. Vaccination is a key strategy to reduce infection risk in patients with rheumatoid arthritis (RA) and is advocated in internationally recognized rheumatology society guidelines. The aim was to evaluate to the effect of antirheumatic drugs on influenza and pneumococcal vaccine immunogenicity.We conducted a systematic literature review and metaanalysis comparing the humoral response (...) with tocilizumab or tofacitinib was associated with reduced pneumococcal and influenza vaccine responses.Antirheumatic drugs may limit humoral responses to vaccination as evidenced by pneumococcal responses with MTX exposure; however, they are safe and should not preclude immunization against vaccine-preventable disease. Vaccination should be considered in all patients with RA and encouraged as part of routine care. (Systematic review registration number: PROSPERO 2016: CRD42016048093.).

2018 Journal of Rheumatology

39. Low Risk of Primary Clostridium difficile Infection With Tetracyclines: A Systematic Review and Metaanalysis. Full Text available with Trip Pro

Low Risk of Primary Clostridium difficile Infection With Tetracyclines: A Systematic Review and Metaanalysis. The choice of antibiotics for systemic infections in patients with a high risk of Clostridium difficile infection (CDI) remains a clinical practice dilemma. Although some studies suggest that tetracyclines may be associated with a lower risk of CDI than other antibiotics, other results are conflicting. We conducted a systematic review and metaanalysis of studies that assessed the risk (...) of CDI with tetracyclines compared to other antibiotics.We conducted a systematic search of Medline, Embase, and Web of Science from January 1978 through December 2016 to include studies that assessed the association between tetracycline use and risk of CDI. Weighted summary estimates were calculated using generalized inverse variance with a random-effects model using RevMan 5.3. Study quality was assessed using the Newcastle-Ottawa scale.Six studies (4 case control, 2 cohort) with patient

2018 Clinical Infectious Diseases

40. Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis. (Abstract)

Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis. We performed a systematic review and metaanalysis to assess rheumatoid arthritis (RA) disease activity during pregnancy using objective disease activity scoring systems.A systematic review of PubMed, EMBASE/Medline, Cochrane, and LactMed databases was performed. Our inclusion criteria for analysis were prospective studies, more than 5 patients per study, and data on RA using an objective scoring

2018 Journal of Rheumatology

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