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281. Fifty years of preventing and treating childhood behaviour disorders: a systematic review to inform policy and practice Full Text available with Trip Pro

Fifty years of preventing and treating childhood behaviour disorders: a systematic review to inform policy and practice Oppositional defiant and conduct disorders (ODD and CD) start early and persist, incurring high individual and collective costs. To inform policy and practice, we therefore asked: What is the best available research evidence on preventing and treating these disorders?We sought randomised controlled trials (RCTs) evaluating interventions addressing the prevention or treatment

2018 Evidence-Based Mental Health

282. Faecal immunochemical tests to triage patients with lower abdominal symptoms for suspected colorectal cancer referrals in primary care: a systematic review and cost-effectiveness analysis

Faecal immunochemical tests to triage patients with lower abdominal symptoms for suspected colorectal cancer referrals in primary care: a systematic review and cost-effectiveness analysis Faecal immunochemical tests to triage patients with lower abdominal symptoms for suspected colorectal cancer referrals in primary care: a systematic review and cost-effectiveness analysis Faecal immunochemical tests to triage patients with lower abdominal symptoms for suspected colorectal cancer referrals (...) in primary care: a systematic review and cost-effectiveness analysis Westwood M, Corro Ramos I, Lang S, Luyendijk M, Zaim R, Stirk L, Al M, Armstrong N & Kleijnen J Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Westwood M, Corro Ramos I, Lang S, Luyendijk M, Zaim R, Stirk L, Al M, Armstrong N & Kleijnen J. Faecal immunochemical tests to triage

2017 Health Technology Assessment (HTA) Database.

283. Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis

Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review (...) with suspected infectious gastroenteritis: a systematic review and economic analysis. Health Technology Assessment 2017; 21(23) Authors' objectives To systematically review the evidence for GPP tests [xTAG® (Luminex, Toronto, ON, Canada), FilmArray (BioFire Diagnostics, Salt Lake City, UT, USA) and Faecal Pathogens B (AusDiagnostics, Beaconsfield, NSW, Australia)] and to develop a de novo economic model to compare the cost-effectiveness of GPP tests with conventional testing in England and Wales. Authors

2017 Health Technology Assessment (HTA) Database.

284. Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations

Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public (...) , Burke O, Burns A, Clare L, Garrard P, Kehoe P, Passmore P, Holmes C, Maidment I, Murtagh F, Robinson L & Livingston G. Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations. Health Technology Assessment 2017; 21(26) Authors' objectives To agree a set of core outcomes for disease modification trials for mild to moderate dementia with the UK dementia research community

2017 Health Technology Assessment (HTA) Database.

285. A systematic review of network meta-analyses for pharmacological treatment of common mental disorders. (Abstract)

-treatment-comparison and network-meta-analysis studies.Twenty NMAs were eligible for inclusion. The number of randomised controlled trials per NMA ranged from 11 to 234, and included between 801 to more than 26 000 participants. Overall, antidepressants were found to be efficacious and tolerable agents for several disorders based on rankings (45%) or statistical significance (55%). The majority of NMAs in this review adhered to guidelines by including a network diagram (70%), assessing consistency (75 (...) A systematic review of network meta-analyses for pharmacological treatment of common mental disorders. Network meta-analyses (NMAs) of treatment efficacy across different pharmacological treatments help inform clinical decision-making, but their methodological quality may vary a lot depending also on the quality of the included primary studies. We therefore conducted a systematic review of NMAs of pharmacological treatment for common mental disorders in order to assess the methodological

2018 Evidence-Based Mental Health

286. Prostate cancer patient perspectives on the use of information in treatment decision-making: a systematic review and qualitative meta-synthesis

Prostate cancer patient perspectives on the use of information in treatment decision-making: a systematic review and qualitative meta-synthesis Prostate cancer patient perspectives on the use of information in treatment decision-making: a systematic review and qualitative meta-synthesis Prostate cancer patient perspectives on the use of information in treatment decision-making: a systematic review and qualitative meta-synthesis Health Quality Ontario Record Status This is a bibliographic record (...) of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Prostate cancer patient perspectives on the use of information in treatment decision-making: a systematic review and qualitative meta-synthesis. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 17(7). 2017 Authors' conclusions Although each prostate cancer patient is unique, studies suggest

2017 Health Technology Assessment (HTA) Database.

287. Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation

Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation Snowsill T, Coelho H, Huxley N, Jones-Hughes T, Briscoe S, Frayling I M & Hyde C. Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Snowsill T, Coelho H, Huxley N, Jones-Hughes T, Briscoe S, Frayling I M & Hyde C.. Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation. Health Technology Assessment 2017; 21(51) Authors' objectives Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk

2017 Health Technology Assessment (HTA) Database.

288. Effect of early follow-up after hospital discharge on outcomes in patients with heart failure or chronic obstructive pulmonary disease: a systematic review

Effect of early follow-up after hospital discharge on outcomes in patients with heart failure or chronic obstructive pulmonary disease: a systematic review Effect of early follow-up after hospital discharge on outcomes in patients with heart failure or chronic obstructive pulmonary disease: a systematic review Effect of early follow-up after hospital discharge on outcomes in patients with heart failure or chronic obstructive pulmonary disease: a systematic review Health Quality Ontario Record (...) Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Effect of early follow-up after hospital discharge on outcomes in patients with heart failure or chronic obstructive pulmonary disease: a systematic review. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 17(8). 2017 Authors' conclusions Based

2017 Health Technology Assessment (HTA) Database.

289. Clinical and cost-effectiveness of beta interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation

Clinical and cost-effectiveness of beta interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation Clinical and cost-effectiveness of beta interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation Clinical and cost-effectiveness of beta interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation Melendez-Torres G, Auguste P, Armoiry X, Maheswaran (...) -effectiveness of beta interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation. Health Technology Assessment 2017; 21(52) Authors' objectives To undertake (1) systematic reviews of the clinical effectiveness and cost-effectiveness of IFN-β and GA in relapsing–remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and clinically isolated syndrome (CIS) compared with best supportive care (BSC) and each other, investigating

2017 Health Technology Assessment (HTA) Database.

290. Pharmacogenomic testing for psychotropic medication selection: a systematic review of the Assurex GeneSight Psychotropic test

Pharmacogenomic testing for psychotropic medication selection: a systematic review of the Assurex GeneSight Psychotropic test Pharmacogenomic testing for psychotropic medication selection: a systematic review of the Assurex GeneSight Psychotropic test Pharmacogenomic testing for psychotropic medication selection: a systematic review of the Assurex GeneSight Psychotropic test Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from (...) a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Pharmacogenomic testing for psychotropic medication selection: a systematic review of the Assurex GeneSight Psychotropic test. Toronto: Health Quality Ontario (HQO). Ontario Health Technology Assessment Series; 17(4). 2017 Authors' conclusions There is uncertainty about the use of GeneSight Psychotropic pharmacogenomic genetic panel to guide medication selection

2017 Health Technology Assessment (HTA) Database.

291. Patient safety learning systems: a systematic review and qualitative synthesis

Patient safety learning systems: a systematic review and qualitative synthesis Patient safety learning systems: a systematic review and qualitative synthesis Patient safety learning systems: a systematic review and qualitative synthesis Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Patient (...) safety learning systems: a systematic review and qualitative synthesis. Toronto: Health Quality Ontario (HQO). Ontario Health Technology Assessment Series; 17(3). 2017 Authors' conclusions The design of a patient safety learning system can be optimized by an awareness of the barriers to and facilitators of successful adoption and implementation identified by health care professionals. Evaluation of the effectiveness of a patient safety learning system is needed to refine its design. Final publication

2017 Health Technology Assessment (HTA) Database.

292. The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation

The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic (...) D, Bland M, Dunne F, Whitelaw D, Wright J & Sheldon T A. The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation. Health Technology Assessment 2016; 20(86) Authors' objectives Gestational diabetes mellitus (GDM) is associated with a higher risk of important adverse outcomes. Practice varies and the best strategy for identifying and treating GDM is unclear. This study aims

2017 Health Technology Assessment (HTA) Database.

293. Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis

Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid (...) to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis Frampton G K, Jones J, Rose M & Payne L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Frampton G K, Jones J, Rose M & Payne L. Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women

2017 Health Technology Assessment (HTA) Database.

294. Glasgow Coma Scale for field triage of trauma: a systematic review

Glasgow Coma Scale for field triage of trauma: a systematic review Glasgow Coma Scale for field triage of trauma: a systematic review Glasgow Coma Scale for field triage of trauma: a systematic review Chou R, Totten AM, Pappas M, Carney N, Dandy S, Grusing S, Fu R, Wasson N, Newgard C Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Chou R, Totten AM, Pappas M (...) , Carney N, Dandy S, Grusing S, Fu R, Wasson N, Newgard C. Glasgow Coma Scale for field triage of trauma: a systematic review. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 182. 2017 Authors' objectives To assess the predictive utility, reliability, and ease of use of the total Glasgow Coma Scale (tGCS) versus the motor component of the Glasgow Coma Scale (mGCS) for field triage of trauma, and effects on clinical decisionmaking and clinical outcomes

2017 Health Technology Assessment (HTA) Database.

295. First- and second-generation antipsychotics in children and young adults: systematic review update

First- and second-generation antipsychotics in children and young adults: systematic review update First- and second-generation antipsychotics in children and young adults: systematic review update First- and second-generation antipsychotics in children and young adults: systematic review update Pillay J, Boylan K, Carrey N, Newton A, Vandermeer B, Nuspl M, MacGregor T, Ahmed Jafri SH, Featherstone R, Hartling L Record Status This is a bibliographic record of a published health technology (...) assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pillay J, Boylan K, Carrey N, Newton A, Vandermeer B, Nuspl M, MacGregor T, Ahmed Jafri SH, Featherstone R, Hartling L. First- and second-generation antipsychotics in children and young adults: systematic review update. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 184. 2017 Authors' objectives To review the evidence on first- and second-generation

2017 Health Technology Assessment (HTA) Database.

296. Autologous chondrocyte implantation in the knee: systematic review and economic evaluation

Autologous chondrocyte implantation in the knee: systematic review and economic evaluation Autologous chondrocyte implantation in the knee: systematic review and economic evaluation Autologous chondrocyte implantation in the knee: systematic review and economic evaluation Mistry H, Connock M, Pink J, Shyangdan D, Clar C, Royle P, Court R, Biant L C, Metcalfe A & Waugh N Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA (...) . No evaluation of the quality of this assessment has been made for the HTA database. Citation Mistry H, Connock M, Pink J, Shyangdan D, Clar C, Royle P, Court R, Biant L C, Metcalfe A & Waugh N. Autologous chondrocyte implantation in the knee: systematic review and economic evaluation. Health Technology Assessment 2017; 21(6) Authors' objectives To assess the clinical effectiveness and cost-effectiveness of autologous chondrocyte implantation (ACI) in chondral defects in the knee, compared with microfracture

2017 Health Technology Assessment (HTA) Database.

297. A systematic review of the risk factors for suicidal ideation, suicidal attempt and completed suicide among children and adolescents in sub-Saharan Africa between 1986 and 2018: protocol for a systematic review of observational studies. Full Text available with Trip Pro

and burning) used for suicidal attempt, and completed suicide among children and adolescents in SSA; and (c) document the risk factors for suicidal ideation, suicidal attempt and completed suicide among children and adolescents in SSA.The review will be conducted and reported in accordance to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. We will include journal articles that have documented the prevalence and risk factors for suicidal ideation, suicidal attempt (...) A systematic review of the risk factors for suicidal ideation, suicidal attempt and completed suicide among children and adolescents in sub-Saharan Africa between 1986 and 2018: protocol for a systematic review of observational studies. Suicide is one of the leading causes of death among children and adolescents. Most studies about the burden and risk factors for suicide have been conducted in high-income countries. However, there is a dearth in the literature about the burden and risk factors

2018 Systematic reviews

298. Interventions to improve healthcare workers' hand hygiene compliance: A systematic review of systematic reviews. Full Text available with Trip Pro

Interventions to improve healthcare workers' hand hygiene compliance: A systematic review of systematic reviews. To synthesize the existing evidence base of systematic reviews of interventions to improve healthcare worker (HCW) hand hygiene compliance (HHC).PRISMA guidelines were followed, and 10 information sources were searched in September 2017, with no limits to language or date of publication, and papers were screened against inclusion criteria for relevance. Data were extracted and risk (...) of bias was assessed.Overall, 19 systematic reviews (n=20 articles) were included. Only 1 article had a low risk of bias. Moreover, 15 systematic reviews showed positive effects of interventions on HCW HHC, whereas 3 reviews evaluating monitoring technology did not. Findings regarding whether multimodal rather than single interventions are preferable were inconclusive. Targeting social influence, attitude, self-efficacy, and intention were associated with greater effectiveness. No clear link emerged

2018 Infection control and hospital epidemiology

299. Determinants of in-hospital antibiotic prescription behaviour: a systematic review and formation of a comprehensive framework. Category: systematic review. (Abstract)

Determinants of in-hospital antibiotic prescription behaviour: a systematic review and formation of a comprehensive framework. Category: systematic review. Knowledge of determinants that influence antibiotic prescription behaviour (APB) is essential for the successful implementation of antimicrobial stewardship interventions. The theory of planned behaviour (TPB) is an established model that describes how cognitions drive human behaviour.The objective of this study was to identify (...) the sociocultural and behavioural determinants that affect APB and to construct a TPB framework of behavioural intent.The following online databases were searched: PubMed, Medline, Embase, Web of Science, Cochrane Library and Central. Studies published between July 2010 and July 2017 in European countries, the United States, Canada, New Zealand or Australia were included if they identified one or more determinants of physicians' APB. A systematic review was conducted according to the Preferred Reporting Items

2018 Clinical Microbiology and Infection

300. Low-carbohydrate diets for overweight and obesity: a systematic review of the systematic reviews. Full Text available with Trip Pro

Low-carbohydrate diets for overweight and obesity: a systematic review of the systematic reviews. Low-carbohydrate diets are being widely recommended, but with apparently conflicting evidence. We have conducted a formal systematic review of the published systematic reviews of RCTs between low-carbohydrate vs. control (low-fat/energy-restricted) diets in adults with overweight and obesity. In MEDLINE, Embase, Web of Knowledge and Cochrane Database of Systematic Reviews, searched from inception (...) to September 2017, we identified 12 systematic reviews, 10 with meta-analyses. Differences in methods, study quality, weight change and citations of published systematic reviews were assessed by AMSTAR-2. Review methods varied in definitions of low-carbohydrate diet, databases searched and bias assessment. Overall review quality was high in two, moderate in three, critically low in seven. Among meta-analyses, 4/5 with critically low quality showed low-carbohydrate diet superiority for weight loss (0.7-4.0

2018 Obesity Reviews

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