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1. Valsartan Effective for Malignant Hypertension after Aortic Dissection with Renal Artery Involvement. (PubMed)

Valsartan Effective for Malignant Hypertension after Aortic Dissection with Renal Artery Involvement. When aortic dissections extend to the renal arteries, reductions in renal blood flow can cause marked increases in renin production. The resultant rise in angiotensin II can lead to difficult-to-control blood pressure, despite normal postdissection antihypertensive agents. We highlight a case of a postdissection patient with malignant hypertension refractory to eight different enteral

2018 Pharmacotherapy

2. A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort

A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A New (...) Breath for Malignant Hypertension: Implementation of the HAMA Cohort (HAMA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03755726 Recruitment Status : Not yet recruiting First Posted : November 28, 2018 Last Update

2018 Clinical Trials

3. Malignant Hypertension in Association with Low Estrogen Dose Oral Contraceptives: Case Report and Review of Literature (PubMed)

Malignant Hypertension in Association with Low Estrogen Dose Oral Contraceptives: Case Report and Review of Literature Malignant hypertension (MH) has been described in association with high-dose (50 - 100 mcg) estrogen oral contraceptive pills (OCPs). Although the rise in blood pressure (BP) is usually mild, some women will have a more significant increase in BP, and hypertensive emergencies may very rarely occur. We present a 21-year-old Caucasian female with a past medical history

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2018 Cureus

4. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats (PubMed)

20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats We hypothesized that vascular actions of 20-hydroxyeicosatetraenoic acid (20-HETE), the product of cytochrome P450 (CYP450)-dependent ω-hydroxylase, potentiate prohypertensive actions of angiotensin II (ANG II) in Cyp1a1-Ren-2 transgenic rats, a model of ANG II-dependent malignant hypertension. Therefore, we evaluated (...) the antihypertensive effectiveness of 20-HETE receptor antagonist (AAA) in this model. Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic. Treatment with AAA was started either simultaneously with induction of hypertension or 10 days later, during established hypertension. Systolic blood pressure (SBP) was monitored by radiotelemetry, indices of renal and cardiac injury, and kidney ANG II levels were determined

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2018 Bioscience reports

5. Malignant hypertension: diagnosis, treatment and prognosis with experience from the Bordeaux cohort. (PubMed)

Malignant hypertension: diagnosis, treatment and prognosis with experience from the Bordeaux cohort. Malignant hypertension, the most severe form of hypertension, is defined by high blood pressure and acute ischemic organ damage. It has a worse prognosis than other forms of hypertension, especially in black patients. New tools to assess organ damage, especially that of the heart and brain, are now available and may contribute to a better evaluation of these patients. This report improves

2018 Journal of Hypertension

6. The case report of capillary leakage syndrome secondary to malignant hypertension. (PubMed)

The case report of capillary leakage syndrome secondary to malignant hypertension. Capillary leak syndrome (CLS) is characterized by hypoproteinemia, diffused pitting edema, noncardiogenic pulmonary edema, and hypotension. By far, there are no related reports of CLS secondary to malignant hypertension (MHT). A 33-year-old male was admitted to our hospital with the diagnosis of CLS on the background of MHT.A 33-year-old male was admitted with a 6-day history of worsening dyspnea, chest distress (...) along with the overall improvement. Finally, the renal biopsy revealed malignant hypertensive glomerulosclerosis. All these clinical manifestations were consistent with CLS caused by MHT.Up to now, there has been no case report of CLS caused by MHT. We should pay more attention to CLS induced by MHT, try to diagnose it as soon as possible, and give prompt treatment to CLS and primary disease.

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2018 Medicine

7. Reversible Loss of Vision in Malignant Hypertension. (PubMed)

Reversible Loss of Vision in Malignant Hypertension. 27050208 2016 04 12 2016 04 07 1533-4406 374 14 2016 Apr 07 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Reversible Loss of Vision in Malignant Hypertension. 1368 10.1056/NEJMicm1508601 Shukla Dhananjay D Ratan Jyoti Netralaya, Gwalior, India daksh66@gmail.com. Virani Asif Y AY Ratan Jyoti Netralaya, Gwalior, India daksh66@gmail.com. eng Journal Article United States N Engl J Med 0255562 0028-4793 AIM IM

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2016 NEJM

8. Predictors of 5-year outcomes in malignant phase hypertension: the West Birmingham Malignant Hypertension Registry. (PubMed)

Predictors of 5-year outcomes in malignant phase hypertension: the West Birmingham Malignant Hypertension Registry. Malignant hypertension represents a high-risk condition and there are scarce data on current clinical patterns of this condition. The aim of the study is to identify the clinical and demographic factors associated with poor outcome.The data collected from 1958 to May 2016 included a total of 351 patients whose 5-year survival status was known: 221 white Caucasians (63%, age 51 (...) endpoint of death or dialysis, all P < 0.01.There has been a major improvement in 5-year survival in patients with malignant hypertension over recent decades. Abnormal renal function at presentation still predicts worse outcome. South Asian ethnicity is also associated with better outcome, although mechanisms involved are yet to be established.

2017 Journal of Hypertension

9. Posterior reversible encephalopathy syndrome in malignant hypertension secondary to focal segmental glomerulosclerosis (PubMed)

Posterior reversible encephalopathy syndrome in malignant hypertension secondary to focal segmental glomerulosclerosis Posterior reversible encephalopathy syndrome (PRES) is a neurological condition that occurs secondary to a variety of causes like autoimmune diseases, uncontrolled hypertension and immunosuppressive agents. We report an unusual association of PRES and malignant hypertension secondary to focal segmental glomerulosclerosis in a young woman, presenting with sudden loss of vision

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2016 BMJ case reports

10. A global amnesia associated with the specific variant of posterior reversible encephalopathy syndrome (PRES) that developed due to severe preeclampsia and malignant hypertension (PubMed)

A global amnesia associated with the specific variant of posterior reversible encephalopathy syndrome (PRES) that developed due to severe preeclampsia and malignant hypertension A case is reported of a 26-year-old primiparous woman in the 32nd week of gestation who presented to the emergency department with the symptoms of a severe headache, nausea and vomiting. The patient was diagnosed with preeclampsia that later progressed to eclampsia. This state was characterized by a sudden onset

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2016 Oxford Medical Case Reports

11. Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion (PubMed)

Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion Purpose. Case report describing an eight-month-old infant presenting with intermittent esotropia and irritability who was found to have malignant (grade 4) hypertensive retinopathy and mid-aortic syndrome. Methods. Visual acuity was 6/140 in the right eye and not recordable in the left eye. Blood pressure was as high as 230/120 mmHg. Fundoscopy revealed bilateral optic disc swelling, macular stars, and serous retinal (...) reported case of malignant hypertensive retinopathy in an infant with concomitant mid-aortic occlusion. The authors emphasize the need for an ophthalmological and pediatric examination in a child presenting with intermittent squint and irritability. The esotropia was found to be a false localizing sign of raised intracranial pressure secondary to the severe mid-aortic syndrome.

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2016 Case reports in ophthalmological medicine

12. Takayasu arteritis presenting with malignant hypertension; a rare manifestation of a rare disease: a case report and review of the literature. (PubMed)

Takayasu arteritis presenting with malignant hypertension; a rare manifestation of a rare disease: a case report and review of the literature. Takayasu arteritis (TA) is a chronic inflammatory and obliterative disease of large vessels, which mainly affects the aorta and its major branches. TA can lead to renal failure and renovascular hypertension in 60% of patients; it is rare in children aged <10 years and, more rarely, it presents with malignant hypertension in the paediatric age group. Here (...) we present a case of 9-year-old boy with TA who presented with malignant hypertension and required surgical intervention to control the blood pressure. Subsequently, his medications were titrated using 24 h ambulatory blood pressure monitoring (ABPM) and is doing well on follow-up.© The Author(s) 2016.

2016 Tropical Doctor

13. An ectopic renin‐secreting adrenal corticoadenoma in a child with malignant hypertension (PubMed)

An ectopic renin‐secreting adrenal corticoadenoma in a child with malignant hypertension A previously healthy 7-year-old male presented with hypertensive emergency, hypokalemia, and elevated plasma renin activity and aldosterone levels. There was no evidence of virilization or cushingoid features. MRI of the abdomen revealed a large (5 × 5 × 3 cm) peripherally enhancing, heterogeneous mass arising from the left adrenal gland. The patient was treated for a suspected pheochromocytoma. However (...) rare adrenal tumor not previously reported in a pediatric patient. Malignant hypertension due to a renin-secreting tumor may need to be distinguished from a pheochromocytoma if alpha-adrenergic blockade is ineffective. © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

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2016 Physiological reports

14. [OP.LB.02.05] A PATIENT WITH MALIGNANT HYPERTENSION SUCCESSFULLY TREATED WITH ECULIZUMAB AND BOSENTAN - SUGGESTIONS OF SIGNIFICANT INTERACTIONS OF COMPLEMENT AND THE ENDOTHELIN SYSTEM IN BLOOD PRESSURE CONTROL. (PubMed)

[OP.LB.02.05] A PATIENT WITH MALIGNANT HYPERTENSION SUCCESSFULLY TREATED WITH ECULIZUMAB AND BOSENTAN - SUGGESTIONS OF SIGNIFICANT INTERACTIONS OF COMPLEMENT AND THE ENDOTHELIN SYSTEM IN BLOOD PRESSURE CONTROL.

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2016 Journal of Hypertension

15. Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. (PubMed)

Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. We evaluated the therapeutic effectiveness of a new, orally active epoxyeicosatrienoic acid analog (EET-A) in rats with angiotensin II (ANG II)-dependent malignant hypertension.Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic (...) injury; indices of RAS activity were not affected.The new, orally active EET-A attenuated the development of experimental ANG II-dependent malignant hypertension, likely via suppression of the hypertensiogenic axis and augmentation of the vasodilatory/natriuretic axis of RAS.

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2016 Journal of Hypertension

16. A case report of malignant hypertension in a young woman. (PubMed)

A case report of malignant hypertension in a young woman. Malignant hypertension is a condition characterized by severe hypertension and multi-organ ischemic complications. Albeit mortality and renal survival have improved with antihypertensive therapy, progression to end-stage renal disease remains a significant cause of morbidity and mortality. The underlying cause of malignant hypertension, which can be primary or secondary hypertension, is often difficult to identify and this can (...) media infusion associated with it), but she continued to be medically treated to achieve a tight blood pressure control. Our conservative approach was successful to induce renal function recovery over 2 years of follow-up.This case highlights the difficulty in differentiating between primary and secondary forms of malignant hypertension, particularly when the patient presents with acute renal failure. Clinicians should consider renal artery ultrasound as a first level diagnostic technique, given

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2016 BMC Nephrology

17. Idiopathic midaortic syndrome with malignant hypertension in 3-year-old boy (PubMed)

Idiopathic midaortic syndrome with malignant hypertension in 3-year-old boy Midaortic syndrome (MAS) is a rare vascular disease that commonly causes renovascular hypertension. The lumen of the abdominal aorta narrows and the ostia of the branches show stenosis. MAS is associated with diminished pulses in the lower extremities compared with the upper extremities, severe hypertension with higher blood pressure in the upper rather than lower extremities, and an abdominal bruit. The clinical

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2016 Korean journal of pediatrics

18. CD4+CD25+ T Cells in primary malignant hypertension related kidney injury (PubMed)

CD4+CD25+ T Cells in primary malignant hypertension related kidney injury CD4(+)CD25(+) T cells are critical for maintenance of immunologic self-tolerance. We measured the number of CD4(+)CD25(+) cells in the patients with primary malignant hypertension related kidney injury, to explore the molecular pathogenesis of this disease. We selected 30 patients with primary malignant hypertension related kidney injury and 30 healthy volunteers. Information on clinical characteristics and laboratory (...) tests was obtained from each subject. The number of CD4(+)CD25(+) cells and glomerular injury were assessed by flow cytometry and histopathology, respectively. Both serum IL-2, IL-4, and IL-6 and endothelial cell markers were analyzed by ELISA. ADAMTS13 antibody was detected by Western blotting. CD4(+)CD25(+) cells were significantly reduced in patients with primary malignant hypertension related kidney injury compared to controls (P < 0.05). The number of CD4(+)CD25(+) cells was negatively related

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2016 Scientific reports

19. Malignant hypertension - new aspects of an old clinical entity. (PubMed)

Malignant hypertension - new aspects of an old clinical entity. Malignant hypertension (MHT), also known as accelerated-malignant hypertension or malignant-phase hypertension, is the most severe form of arterial hypertension. It is defined clinically as high blood pressure (BP) levels associated with lesions of the retinal fundus (flame-shaped hemorrhages, exudates, or cotton wool spots, with or without papilledema). Despite the availability of a vast range of antihypertensive agents, MHT

2015 Polskie Archiwum Medycyny Wewnetrznej

20. Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus (PubMed)

Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus We report one case of malignant hypertensive retinopathy as a presenting sign of fetal death in utero. Ophthalmic examination (including intravenous fluorescein angiography and optical coherence tomography) and obstetric and systemic evaluation were performed, providing a multidisciplinary approach. A 33-year-old overweight woman (body mass index 47 kg/m(2)) with no systemic or ocular known disease was admitted (...) pressure of 220/110 mmHg. Further systemic workup revealed a previously unknown 35-week pregnancy with a dead fetus. An emergency cesarean section was performed. Pre-eclampsia is a life-threatening disorder for both mother and fetus. This case highlights the need to rule out pre-eclampsia in all women of childbearing age presenting with ocular signs of malignant hypertension, even without external signs of pregnancy.

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2015 Clinical ophthalmology (Auckland, N.Z.)

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