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201. An analysis of redactions in Canada's Common Drug Review Clinical Review Reports and how they relate to the patients' voice. Full Text available with Trip Pro

An analysis of redactions in Canada's Common Drug Review Clinical Review Reports and how they relate to the patients' voice. Canada's Common Drug Review (CDR) evaluates drug data from published and unpublished research, as well as input from patient groups, to recommend provincial coverage. Currently, the CDR process gives manufacturers the opportunity to redact information in the final publicly available report. Patients often have strong feelings regarding the efficacy, harms, health-related (...) stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

202. How can primary care enhance end-of-life care for liver disease? Qualitative study of general practitioners' perceptions and experiences. Full Text available with Trip Pro

How can primary care enhance end-of-life care for liver disease? Qualitative study of general practitioners' perceptions and experiences. Liver disease is the third most common cause of premature death in the UK. The symptoms of terminal liver disease are often difficult to treat, but very few patients see a palliative care specialist and a high proportion die in hospital. Primary care has been identified as a setting where knowledge and awareness of liver disease is poor. Little is known about (...) general practitioners' (GPs) perceptions of their role in managing end-stage liver disease.To explore GPs' experiences and perceptions of how primary care can enhance end-of-life care for patients with liver disease.Qualitative interview study, thematic analysis.Purposive sample of 25 GPs from five regions of England.GPs expressed a desire to be more closely involved in end-of-life care for patients with liver disease but identified a number of factors that constrained their ability to contribute

2017 BMJ open

203. How does preclinical laboratory training impact physical examination skills during the first clinical year? A retrospective analysis of routinely collected objective structured clinical examination scores among the first two matriculating classes of a ref Full Text available with Trip Pro

How does preclinical laboratory training impact physical examination skills during the first clinical year? A retrospective analysis of routinely collected objective structured clinical examination scores among the first two matriculating classes of a ref As a result of a curriculum reform launched in 2012 at our institution, preclinical training was shortened to 2 years instead of the traditional 3 years, creating additional incentives to optimise teaching methods. In accordance with the new (...) preclinical training.Our results suggest the importance of preclinical training in a CS laboratory to improve students' competence in physical examination at the completion of introductory clinical clerkships during the first clinical year.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

204. How people with dementia and carers understand and react to social functioning changes in mild dementia: a UK-based qualitative study. Full Text available with Trip Pro

How people with dementia and carers understand and react to social functioning changes in mild dementia: a UK-based qualitative study. To analyse people with dementia and their family carers' attribution of social changes in dementia and the consequences of these attributions.Qualitative study, using a semi-structured interview guide. Individual interviews continued to theoretical saturation. Two researchers independently analysed interview transcripts.People with mild dementia and family (...) . Explaining that these may be due to dementia and considering strategies to overcome them may be beneficial.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

205. Exploring how ward staff engage with the implementation of a patient safety intervention: a UK-based qualitative process evaluation. Full Text available with Trip Pro

Exploring how ward staff engage with the implementation of a patient safety intervention: a UK-based qualitative process evaluation. A patient safety intervention was tested in a 33-ward randomised controlled trial. No statistically significant difference between intervention and control wards was found. We conducted a process evaluation of the trial and our aim in this paper is to understand staff engagement across the 17 intervention wards.Large qualitative process evaluation (...) in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

206. How to prepare cytological samples for molecular testing. Full Text available with Trip Pro

How to prepare cytological samples for molecular testing. This review is focused on the challenges in standardising and optimising molecular testing workflow in cytopathology. Although cytological samples yield optimal quality DNA, whose minimal amounts in most cases suffice even for multigene mutational profiling, the success of molecular testing is strongly dependent on standardised preanalytical protocols for maximising DNA yield and quality. Sample cytopreparation influences, even more (...) , underlining the modern role of the cytopathologist, whose continuous education is crucial to meet the opportunities of molecular medicine.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 Journal of Clinical Pathology

207. Autopsy interrogation of emergency medicine dispute cases: how often are clinical diagnoses incorrect? (Abstract)

Autopsy interrogation of emergency medicine dispute cases: how often are clinical diagnoses incorrect? Emergency medicine is a 'high risk' specialty. Some diseases develop suddenly and progress rapidly, and sudden unexpected deaths in the emergency department (ED) may cause medical disputes. We aimed to assess discrepancies between antemortem clinical diagnoses and postmortem autopsy findings concerning emergency medicine dispute cases and to figure out the most common major missed (...) exist in emergency medical disputes cases; acute aortic dissection and myocardial infarction are the most frequently major missed diagnoses that ED clinicians should pay special attention to in practice. This study reaffirmed the necessity and usefulness of autopsy in auditing death in EDs.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 Journal of Clinical Pathology

208. How do trends in mortality inequalities by deprivation and education in Scotland and England & Wales compare? A repeat cross-sectional study. Full Text available with Trip Pro

How do trends in mortality inequalities by deprivation and education in Scotland and England & Wales compare? A repeat cross-sectional study. To compare the trends in mortality inequalities by educational attainment with trends using area deprivation.Scotland and England & Wales (E&W).All people resident in Scotland and E&W between 1981 and 2011 aged 35-79 years.Absolute inequalities (measured using the Slope Index of Inequality (SII)) and relative inequalities (measured using the Relative (...) attainment data in Great Britain prior to 2001 that make these education-based estimates less certain.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

209. Doctors' perception of support and the processes involved in complaints investigations and how these relate to welfare and defensive practice: a cross-sectional survey of the UK physicians. Full Text available with Trip Pro

Doctors' perception of support and the processes involved in complaints investigations and how these relate to welfare and defensive practice: a cross-sectional survey of the UK physicians. How adverse outcomes and complaints are managed may significantly impact on physician well-being and practice. We aimed to investigate how depression, anxiety and defensive medical practice are associated with doctors actual and perceived support, behaviour of colleagues and process issues regarding how (...) otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

210. How effective is community physical activity promotion in areas of deprivation for inactive adults with cardiovascular disease risk and/or mental health concerns? Study protocol for a pragmatic observational evaluation of the 'Active Herts' physical activ Full Text available with Trip Pro

How effective is community physical activity promotion in areas of deprivation for inactive adults with cardiovascular disease risk and/or mental health concerns? Study protocol for a pragmatic observational evaluation of the 'Active Herts' physical activ There is a high prevalence of inactive adults in the UK, and many suffer from conditions such as cardiovascular disease (CVD) or poor mental health. These coexist more frequently in areas of higher socioeconomic deprivation. There is a need (...) programme users in the evaluation. Results will be published in peer-reviewed journals, presented at conferences, and shared through the study website and local community outlets.ClinicalTrials.gov ID number: NCT03153098.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

211. What are older smokers' attitudes to quitting and how are they managed in primary care? An analysis of the cross-sectional English Smoking Toolkit Study. Full Text available with Trip Pro

What are older smokers' attitudes to quitting and how are they managed in primary care? An analysis of the cross-sectional English Smoking Toolkit Study. To investigate whether age is associated with access to smoking cessation services.Data from the Smoking Toolkit Study 2006-2015, a repeated multiwave cross-sectional household survey (n=181 157).England.Past-year smokers who participated in any of the 102 waves stratified into age groups.Amount smoked and nicotine dependency, self-reported (...) support, despite being less addicted to nicotine than younger smokers. It is unclear whether this constitutes inequitable access to services or reflects informed choices by older smokers and their GPs. Future research is needed to understand why older smokers and GPs do not pursue smoking cessation. Service provision should consider how best to reduce these variations, and a stronger effectiveness evidence base is required to support commissioning for this older population so that, where appropriate

2017 BMJ open

212. Primary care management of headaches and how direct-access MRI fits: a qualitative study of UK general practitioners' views. Full Text available with Trip Pro

Primary care management of headaches and how direct-access MRI fits: a qualitative study of UK general practitioners' views. To develop a better understanding of general practitioners' (GPs) views and experiences of the management of patients with headaches and use of direct-access MRI scans, and observe outcomes of an educational session offered by a GP with a special interest (GPwSI) to GPs.A qualitative study using semistructured interviews, analysed using thematic analysis. A GPwSI (...) Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

213. How do women with eating disorders experience a new treatment combining guided physical exercise and dietary therapy? An interview study of women participating in a randomised controlled trial at the Norwegian School of Sport Sciences. Full Text available with Trip Pro

How do women with eating disorders experience a new treatment combining guided physical exercise and dietary therapy? An interview study of women participating in a randomised controlled trial at the Norwegian School of Sport Sciences. To investigate how women with bulimia nervosa (BN) and binge eating disorder (BED) experience participating in a new treatment programme for eating disorders, based on guided physical exercise and dietary therapy.Six women with BN and four with BED were (...) suggested.NCT02079935.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

214. How is defensive medicine understood and experienced in a primary care setting? A qualitative focus group study among Danish general practitioners. Full Text available with Trip Pro

How is defensive medicine understood and experienced in a primary care setting? A qualitative focus group study among Danish general practitioners. Recent years have witnessed a progressive increase in defensive medicine (DM) in several Western welfare countries. In Danish primary and secondary care, documentation on the extent of DM is lacking. Before investigating the extent of DM, we wanted to explore how the phenomenon is understood and experienced in the context of general practice (...) to be carried out as a result of succumbing to various sources of pressure deriving from the system, the patients, the GPs themselves and peers.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

215. How does sevoflurane induction, followed by a ketamine maintenance infusion, affect intraocular pressure? Establishment of an anaesthetic protocol for paediatric glaucoma examinations under anaesthesia. (Abstract)

How does sevoflurane induction, followed by a ketamine maintenance infusion, affect intraocular pressure? Establishment of an anaesthetic protocol for paediatric glaucoma examinations under anaesthesia. Accurate measurement of intraocular pressure (IOP) is essential in paediatric glaucoma management. Children require serial measurements and examination under anaesthesia (EUA). Most anaesthetic agents reduce IOP, and the ideal time to measure IOP under anaesthesia is questionable.To determine (...) in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 British Journal of Ophthalmology

216. How do workplaces, working practices and colleagues affect UK doctors' career decisions? A qualitative study of junior doctors' career decision making in the UK. Full Text available with Trip Pro

and experiences. This paper highlights the importance of understanding how perceptions are formed and preferences are developed, as a basis for generating learning and working environments that nurture students and motivate their professional careers.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. (...) How do workplaces, working practices and colleagues affect UK doctors' career decisions? A qualitative study of junior doctors' career decision making in the UK. This study draws on an in-depth investigation of factors that influenced the career decisions of junior doctors.Junior doctors in the UK can choose to enter specialty training (ST) programmes within 2 years of becoming doctors. Their specialty choices contribute to shaping the balance of the future medical workforce, with views

2017 BMJ open

217. How are clinical commissioning groups managing conflicts of interest under primary care co-commissioning in England? A qualitative analysis. Full Text available with Trip Pro

How are clinical commissioning groups managing conflicts of interest under primary care co-commissioning in England? A qualitative analysis. From April 2015, NHS England (NHSE) started to devolve responsibility for commissioning primary care services to clinical commissioning groups (CCGs). The aim of this paper is to explore how CCGs are managing potential conflicts of interest associated with groups of GPs commissioning themselves or their practices to provide services.We carried out two (...) can properly manage conflicts of interest. Non-clinician members of committees involved in commissioning primary care require training in order to make decisions requiring clinical input in the absence of GPs.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

218. How to adapt existing evidence-based clinical practice guidelines: a case example with smoking cessation guidelines in Canada. Full Text available with Trip Pro

How to adapt existing evidence-based clinical practice guidelines: a case example with smoking cessation guidelines in Canada. To develop and encourage the adoption of clinical practice guidelines (CPGs) for smoking cessation in Canada by engaging stakeholders in the adaptation of existing high-quality CPGs using principles of the ADAPTE framework.An independent expert body in guideline review conducted a review and identified six existing CPGs, which met a priori criteria for quality (...) cessation CPGs to the local context and to facilitate subsequent adoption by various stakeholders.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open

219. How information about overdetection changes breast cancer screening decisions: a mediation analysis within a randomised controlled trial. Full Text available with Trip Pro

How information about overdetection changes breast cancer screening decisions: a mediation analysis within a randomised controlled trial. In a randomised controlled trial, we found that informing women about overdetection changed their breast screening decisions. We now present a mediation analysis exploring the psychological pathways through which study participants who received the intervention processed information about overdetection and how this influenced their decision-making. We (...) to provide good-quality information on screening outcomes and to communicate this information effectively, so that women can make well-informed decisions.This study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12613001035718) on 17 September 2013.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ open Controlled trial quality: uncertain

220. How do general practitioners put preventive care recommendations into practice? A cross-sectional study in Switzerland and France. Full Text available with Trip Pro

How do general practitioners put preventive care recommendations into practice? A cross-sectional study in Switzerland and France. We previously identified that general practitioners (GPs) in French-speaking regions of Europe had a variable uptake of common preventive recommendations. In this study, we describe GPs' reports of how they put different preventive recommendations into practice.Cross-sectional study conducted in 2015 in Switzerland and France. 3400 randomly selected GPs were asked (...) to complete a postal (n=1100) or online (n=2300) questionnaire. GPs who exclusively practiced complementary and alternative medicine were not eligible for the study. 764 GPs (response rate: postal 47%, online 11%) returned the questionnaire (428 in Switzerland and 336 in France).We investigated how the GPs performed five preventive practices (screening for dyslipidaemia, colorectal and prostate cancer, identification of hazardous alcohol consumption and brief intervention), examining which age group

2017 BMJ open

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