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1. Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein. Full Text available with Trip Pro

Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein. The year 2020 has seen a major and sustained outbreak of a novel betacoronavirus (severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2) infection that causes fever, severe respiratory illness and pneumonia, a disease called COVID-19. At the time of writing, the death toll was greater than 120 000 worldwide with more than 2 million documented infections. The genome of the CoV encodes a number of structural (...) proteins that facilitate cellular entry and assembly of virions, of which the spike protein S appears to be critical for cellular entry. The spike protein guides the virus to attach to the host cell. The spike protein contains a receptor-binding domain (RBD), a fusion domain and a transmembrane domain. The RBD of spike protein S binds to Angiotensin Converting Enzyme 2 (ACE2) to initiate cellular entry. The spike protein of SARS-CoV-2 shows more than 90% amino acid similarity to the pangolin and bat

2020 Journal of Clinical Pathology

2. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. Full Text available with Trip Pro

Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. To study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019).Retrospective case series.Seven hospitals in Zhejiang province, China.62 patients admitted to hospital with laboratory confirmed SARS (...) time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days.As of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2020 BMJ

3. Covid-19: Immunity after SARS-CoV-2 infection

Covid-19: Immunity after SARS-CoV-2 infection Immunity after SARS-CoV-2 infection - NIPH Search for: Søk Menu To top level Close Infectious diseases & Vaccines Mental & Physical health Environment & Lifestyle Health in Norway Quality & Knowledge Research & Access to data About NIPH Close Immunity after SARS-CoV-2 infection Order Download: Key message The findings in this memo are based on rapid searches in PubMed, EMBASE and two pre-print databases. One researcher went through all search (...) on the severity of SARS-CoV-2 infection? Seroconversion rate and timing do not appear to differ between patients with mild to severe/critical COVID 19 infection. Studies of asymptomatic cases are however lacking. Can antibodies be transmitted from women infected with SARS-CoV-2 to the fetus via placenta and thus confer immunity in the newborn? Results from one small study suggest that antibodies from SARS-CoV-2 infected women may be transmitted to the foetus during pregnancy, but the evidence is uncertain

2020 Norwegian Institute of Public Health

4. COVID-19: Do weather conditions influence the transmission of the coronavirus (SARS-CoV-2)?

and the effect of the weather on the host. The weather effect is minimal, and all estimates are subject to significant biases reinforcing the need for robust public health measures. BACKGROUND Most countries across the globe have now implemented a suite of strategies to reduce transmission of the novel coronavirus (2019-nCoV) and mitigate the effects of the COVID-19. The virus is known to have originated in the port city of Wuhan, in the central Hubei province, China. At the time when the first case (...) COVID-19: Do weather conditions influence the transmission of the coronavirus (SARS-CoV-2)? Do weather conditions influence the transmission of the coronavirus (SARS-CoV-2) - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Do weather conditions influence the transmission of the coronavirus (SARS-CoV-2) Jon Brassey, Carl Heneghan, Kamal R. Mahtani, Jeffrey K. Aronson On behalf of the Oxford COVID-19

2020 Oxford COVID-19 Evidence Service

5. COVID-19: Spreading SARS-CoV-2 through ocular fluids

COVID-19: Spreading SARS-CoV-2 through ocular fluids Maximising mobility in the elderly when isolated with COVID-19 - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Maximising mobility in the elderly when isolated with COVID-19 JAMIE HARTMANN-BOYCE 20/03/2020 On behalf of the Oxford COVID-19 Evidence Service Team Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences

2020 Oxford COVID-19 Evidence Service

6. SARS-CoV-2 viral load and the severity of COVID-19 Full Text available with Trip Pro

SARS-CoV-2 viral load and the severity of COVID-19 SARS-CoV-2 viral load and the severity of COVID-19 - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website SARS-CoV-2 viral load and the severity of COVID-19 March 26, 2020 Carl Heneghan, Jon Brassey, Tom Jefferson Oxford COVID-19 Evidence Service Team Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences University of Oxford (...) The initial dose of virus and the amount of virus an individual has at any one time might worsen the severity of COVID 19 disease. Viral load is a measure of the number of viral particles present in an individual. Higher SARS-CoV-2 viral loads. might worsen outcomes, and data from China suggests the with more severe disease. The amount of virus exposure at the start of infection – the infectious dose – may increase the severity of the illness and is also. linked to a higher viral load Healthcare workers

2020 Oxford COVID-19 Evidence Service

7. Is there any significant difference in sensitivity of COVID-19 virus (SARS-CoV-2) tests based on swabs from oropharyngeal (OP) vs nasopharyngeal (NP) sampling vs both?

recommending collecting only nasopharyngeal swabs (NP), not NP and oropharyngeal swabs (OP). However, OP would be easier to do without training than NP, so one question is whether there is a significant difference in sensitivity between the two methods or using them in combination. SEARCH STRATEGY Search terms: COVID-19, SARS-CoV-2, wuhan coronavirus, 2019-nCoV, 2019nCoV, nasopharyngeal, oropharyngeal, swab, diagnosis, diagnostic, test, sensitivity Databases: PubMed, Embase, Web of Science, Scopus (...) Is there any significant difference in sensitivity of COVID-19 virus (SARS-CoV-2) tests based on swabs from oropharyngeal (OP) vs nasopharyngeal (NP) sampling vs both? Comparative accuracy of oropharyngeal and nasopharyngeal swabs for diagnosis of COVID-19 - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Comparative accuracy of oropharyngeal and nasopharyngeal swabs for diagnosis of COVID-19 March 26

2020 Oxford COVID-19 Evidence Service

8. Current epidemiology and guidance for COVID-19 caused by SARS-CoV-2 virus, in children: March 2020

-CoV-2 virus, in children: March 2020 Posted: Mar 25 2020 The Canadian Paediatric Society gives permission to print single copies of this document from our website. For permission to reprint or reproduce multiple copies, please see our . Principal author(s) Nicole Le Saux, Canadian Paediatric Society, The emergence in December 2019 of COVID-19, caused by a novel coronavirus, and its subsequent spread around the world, led the World Health Organization to declare a pandemic on March 11, 2020 (...) Current epidemiology and guidance for COVID-19 caused by SARS-CoV-2 virus, in children: March 2020 Current epidemiology and guidance for COVID-19 caused by SARS-CoV-2 virus, in children: March 2020Current epidemiology and guidance for COVID-19 caused by SARS-CoV-2 virus, in children: March 2020 | Canadian Paediatric Society A home for paediatricians. A voice for children and youth. Current: Current epidemiology and… Practice Point Current epidemiology and guidance for COVID-19 caused by SARS

2020 Canadian Paediatric Society

9. Covid-19: Contact based transmission of SARS-CoV-2 - a rapid review

. April 2020) Restricted to SARS-CoV-2 and studies published after 1. December 2019. ((((Coronavirus[mh] OR "Coronavirus Infections"[mh] OR "corona virus"[tw] OR coro- navirus*[tw] OR coronovirus*[tw]) AND (novel[tw]OR 2019[tw] OR Wuhan[tw] OR Huanan[tw])) OR "covid-19"[nm] OR "severe acute respiratory syndrome coronavirus 2"[nm] OR "COVID-19"[tw] OR COVID19[tw] OR CORVID-19[tw] OR CORVID19[tw] OR "coronavirus 2"[tw] OR "corona virus 2"[tw] OR nCoV[tw] OR 2019nCoV[tw] OR "SARS-CoV-2"[tw] OR "SARS-CoV2 (...) Covid-19: Contact based transmission of SARS-CoV-2 - a rapid review COVID-19-EPIDEMIC : Contact based transmission of SARS-CoV-2 – a rapid review me moTitle Contact based transmission of SARS-CoV-2 Norwegian title Kontaktsmitte av SARS-CoV-2 Institution Norwegian Institute of Public Health Responsible Camilla Stoltenberg, Director General Authors Brurberg, KG. Department Director, Norwegian Institute of Public Health ISBN 978-82-8406-079-8 Memo April – 2020 Publication type Rapid Review, Covid

2020 Norwegian Institute of Public Health

10. Rapid Expert Consultation on the Possibility of Bioaerosol Spread of SARS-CoV-2 for the COVID-19 Pandemic

Rapid Expert Consultation on the Possibility of Bioaerosol Spread of SARS-CoV-2 for the COVID-19 Pandemic Rapid Expert Consultation on the Possibility of Bioaerosol Spread of SARS-CoV-2 for the COVID-19 Pandemic (April 1, 2020) | The National Academies Press Menu Menu ( 2020 ) View Cover ( 2020 ) × Embed Book Widget Copy the HTML code below to embed this book in your own blog, website, or application. Custom Size: × × Close What is a prepublication? An uncorrected copy, or prepublication (...) , public health, public health preparedness and response, biological sciences, clinical care and crisis standards of care, risk communication, and regulatory issues. This publication responds to questions concerning the possibility that the SARS-Cov-2 virus could be spread by conversation, in addition to sneeze/cough-induced droplets. Suggested Citation National Research Council. 2020. Rapid Expert Consultation on the Possibility of Bioaerosol Spread of SARS-CoV-2 for the COVID-19 Pandemic (April 1

2020 Covid-19 Ad hoc papers

11. Rapid Expert Consultation on SARS-CoV-2 Survival and Incubation for the COVID-19 Pandemic

Rapid Expert Consultation on SARS-CoV-2 Survival and Incubation for the COVID-19 Pandemic Rapid Expert Consultation Update on SARS-CoV-2 Surface Stability and Incubation for the COVID-19 Pandemic (March 27, 2020) | The National Academies Press Menu Menu ( 2020 ) View Cover ( 2020 ) × Embed Book Widget Copy the HTML code below to embed this book in your own blog, website, or application. Custom Size: × × Close What is a prepublication? An uncorrected copy, or prepublication, is an uncorrected (...) Citation National Academies of Sciences, Engineering, and Medicine. 2020. Rapid Expert Consultation Update on SARS-CoV-2 Surface Stability and Incubation for the COVID-19 Pandemic (March 27, 2020) . Washington, DC: The National Academies Press. https://doi.org/10.17226/25763. Import this citation to: Publication Info 10 pages | 8.5 x 11 DOI: Contents Search Inside This Book SEARCH Table of Contents skim chapter 1-10 Rights Copyright Information The National Academies Press and the Transportation

2020 Covid-19 Ad hoc papers

12. Effectiveness of tests to detect the presence of SARS-CoV-2 virus, and antibodies to SARS-CoV-2, to inform COVID-19 diagnosis: a rapid systematic review Full Text available with Trip Pro

Effectiveness of tests to detect the presence of SARS-CoV-2 virus, and antibodies to SARS-CoV-2, to inform COVID-19 diagnosis: a rapid systematic review Effectiveness of tests to detect the presence of SARS-CoV-2 virus, and antibodies to SARS-CoV-2, to inform COVID-19 diagnosis: a rapid systematic review - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: . Get the latest research from NIH: . Find NCBI SARS-CoV-2 literature, sequence, and clinical content: . National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show account info Close Account Logged in as: username (My NCBI) (My Bibliography) Search: Search Save Email Send to Display options Display options Format Save citation

2020 EvidenceUpdates

13. Canadian Thoracic Society recommendations regarding the use of face masks by the public during the SARS-CoV-2 (COVID-19) pandemic

Canadian Thoracic Society recommendations regarding the use of face masks by the public during the SARS-CoV-2 (COVID-19) pandemic 1 ‘In Press’. Submitted for publication in the CJRCCSM on June 2, 2020. Canadian Thoracic Society recommendations regarding the use of face masks by the public during the SARS-CoV-2 (COVID-19) pandemic Mohit Bhutani a , Paul Hernandez b , Connie Yang c , Jean Bourbeau d , Christopher Licskai e , Gail Dechman f , Anne Van Dam g , Samir Gupta h a Department of Medicine (...) is a rapidly evolving situation and recommendations may change as the science informs us. We recommend to routinely visit our COVID-19 website for updates at https://cts-sct.ca/covid-19. 2 ‘In Press’. Submitted for publication in the CJRCCSM on June 2, 2020. Background As Canada begins to relax the measures instituted to limit the spread of the SARS-CoV-2 virus, recommendations by the Public Health Agency of Canada and local public health authorities are simultaneously evolving to assist in this process

2020 Canadian Thoracic Society

14. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)

A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) POSITION ARTICLE AND GUIDELINE Open Access A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) Ying-Hui Jin 1 , Lin Cai 2 , Zhen-Shun Cheng 3 , Hong Cheng 4 , Tong Deng 1,5 , Yi-Pin Fan 6,7 , Cheng Fang 1 , Di Huang 1 , Lu-Qi Huang 6,7 , Qiao Huang 1 , Yong Han 2 ,BoHu 8 , Fen Hu 8 (...) 1,18* , Yong-Yan Wang 6,7* , Xing-Huan Wang 1,2* , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM) Abstract In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020. For it is a never been

2020 Covid-19 Ad hoc guidelines

15. Risk communication and community engagement (RCCE) readiness and response to the 2019 novel coronavirus (??2019-nCoV)??

Risk communication and community engagement (RCCE) readiness and response to the 2019 novel coronavirus (??2019-nCoV)?? Risk communication and community engagement (RCCE) readiness and response to the 2019 novel coronavirus (‎‎2019-nCoV)‎‎ WHO Regional websites / / Risk communication and community engagement (RCCE) readiness and response to the 2019 novel coronavirus (‎‎2019-nCoV)‎‎ © 2020

2020 WHO Coronavirus disease (COVID-19) Pandemic

16. Novel coronavirus (2019-nCoV): guidance to assist professionals in advising the general public

Novel coronavirus (2019-nCoV): guidance to assist professionals in advising the general public COVID-19: guidance to assist professionals in advising the general public - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search The UK has left the EU Guidance COVID-19: guidance to assist (...) professionals in advising the general public Advice on how to prevent spread of the infection, what symptoms to look for and what to do. Published 1 February 2020 Last updated 6 February 2020 — From: Documents HTML Details This guidance will assist professionals in providing advice to the public on how to prevent the spread of COVID-19 infection, what symptoms to look for, and what to do if they become unwell in a variety of settings. There may be further information specific to each country in the United

2020 Public Health England

17. Novel coronavirus (2019-nCoV): self-isolation for patients undergoing testing

for how patients should self-isolate while awaiting results of laboratory testing for SARS-CoV-2. Published 31 January 2020 Last updated 31 January 2020 — From: Documents HTML HTML HTML Details This guidance provides advice for individuals who are awaiting results from diagnostic testing for COVID-19 and do not require admission to hospital. COVID-19 was previously referred to as Wuhan novel coronavirus. There may be further information specific to each country in the United Kingdom, as this guidance (...) Novel coronavirus (2019-nCoV): self-isolation for patients undergoing testing COVID-19: self-isolation for patients undergoing testing - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search The UK has left the EU Guidance COVID-19: self-isolation for patients undergoing testing Guidance

2020 Public Health England

18. Clinical Guidance Summary for Pediatric Patients with MIS-C Associated with SARS-CoV-2 and Hyperinflammation in COVID-19

Clinical Guidance Summary for Pediatric Patients with MIS-C Associated with SARS-CoV-2 and Hyperinflammation in COVID-19 1 Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19 Developed by the ACR MIS-C and COVID-19 Related Hyperinflammation Task Force This draft summary was approved by the ACR Board of Directors on June 17, 2020. A full paper was published on July 23, 2020.* Purpose (...) definition of MIS-C because several already exist. Instead, the Task Force focused on consensus building to identify the most appropriate diagnostic and therapeutic steps that providers should consider at the present time. The Task Force also provided recommendations for children with hyperinflammation during COVID-19, the acute, infectious phase of SARS-CoV-2 infection. Given that our understanding of SARS-CoV-2-related syndromes in the pediatric population continues to evolve, this guidance document

2020 American College of Rheumatology

19. ACR Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID?19. Version 1 Full Text available with Trip Pro

ACR Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID?19. Version 1 American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS‐C) Associated with SARSCoV2 and Hyperinflammation in COVID19. Version 1 - Henderson - - Arthritis & Rheumatology - Wiley Online Library Working off-campus? Learn about our By continuing (...) to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term FULL LENGTH Free Access American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS‐C) Associated with SARSCoV2 and Hyperinflammation in COVID19. Version 1 Corresponding Author E-mail address: Division of Immunology, Boston Children’s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA

2020 American College of Rheumatology

20. Heart Rhythm Journal Review: SARS-CoV-2, COVID-19 & Inherited Arrhythmia Syndromes

Heart Rhythm Journal Review: SARS-CoV-2, COVID-19 & Inherited Arrhythmia Syndromes Heart Rhythm Journal Review: SARS-CoV-2, COVID-19 & Inherited Arrhythmia Syndromes | Heart Rhythm Society Utility Menu Main navigation Search Leave this field blank Main Menu Breadcrumb ,” recently published in Heart Rhythm by Cheng-I. Wu, MD, and colleagues, the authors describe the potential COVID-19 associated risks and therapeutic considerations for patients with distinct inherited arrhythmia syndromes

2020 Heart Rhythm Society

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