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141. Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions Full Text available with Trip Pro

Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions 29049577 2017 10 25 2018 11 13 1538-3598 318 14 2017 10 10 JAMA JAMA Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions. 1391-1392 10.1001/jama.2017.11152 Linder Jeffrey A JA Northwestern University Feinberg School of Medicine, Chicago, Illinois. Meeker Daniella D University of Southern

2017 JAMA Controlled trial quality: uncertain

142. Extended Postoperative Prophylactic Antibiotics with First-Generation Cephalosporin Do Not Reduce the Risk of Periprosthetic Joint Infection following Aseptic Revision Total Knee Arthroplasty. (Abstract)

Extended Postoperative Prophylactic Antibiotics with First-Generation Cephalosporin Do Not Reduce the Risk of Periprosthetic Joint Infection following Aseptic Revision Total Knee Arthroplasty. Postoperative prophylactic antibiotics administered within 24 hours of primary total knee arthroplasty (TKA) have been documented to prevent periprosthetic joint infection (PJI). However, the effectiveness of this regimen is still unclear in aseptic revision TKA. The purpose of this study was to evaluate (...) whether extended postoperative prophylactic antibiotics would reduce the PJI rate compared with the current 24-hour standard postoperative prophylactic antibiotics after aseptic revision TKA. A retrospective review of 236 patients (46 men, 190 women, 252 knees) who underwent aseptic revision TKA between 2005 and 2013 was conducted. Patients who underwent septic revision, had a positive intraoperative culture, or who had less than 2 years of follow-up were excluded. Patients were divided according

2019 The journal of knee surgery Controlled trial quality: uncertain

143. Faecal microbiota transplant for eradication of multidrug-resistant Enterobacteriaceae: a lesson in applying best practice? Re: 'A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enteroba Full Text available with Trip Pro

Faecal microbiota transplant for eradication of multidrug-resistant Enterobacteriaceae: a lesson in applying best practice? Re: 'A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enteroba 30685497 2019 06 14 1469-0691 25 7 2019 Jul Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Clin. Microbiol. Infect. Faecal microbiota transplant (...) for eradication of multidrug-resistant Enterobacteriaceae: a lesson in applying best practice? Re: 'A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A Randomized Clinical Trial'. 912-913 S1198-743X(19)30030-8 10.1016/j.cmi.2019.01.010 Mullish B H BH Division of Integrative Systems Medicine and Digestive Disease, St Mary's Hospital Campus, Imperial College London, London, UK. Ghani R R Division of Integrative Systems

2019 Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Controlled trial quality: uncertain

144. Randomized, controlled, crossover trial of prevention of antibiotic-induced gastrointestinal signs using a synbiotic mixture in healthy research dogs. Full Text available with Trip Pro

Randomized, controlled, crossover trial of prevention of antibiotic-induced gastrointestinal signs using a synbiotic mixture in healthy research dogs. Synbiotics decrease antibiotic-associated gastrointestinal signs (AAGS) in cats, but data supporting synbiotic use to ameliorate AAGS in dogs are lacking.To determine if administration of synbiotics mitigates AAGS in dogs.Twenty-two healthy research dogs.Randomized, double-blinded, placebo-controlled, 2-way, 2-period, crossover study with an 8 (...) /metronidazole administration is associated with a high frequency of AAGS. Synbiotic administration decreases food intake derangements. The presence of milder AAGS in period 2 suggests that clinical effects of synbiotics persist >9 weeks after discontinuation, mitigating AAGS in dogs being treated with antibiotics followed by placebo.© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

2019 Journal of Veterinary Internal Medicine Controlled trial quality: predicted high

145. Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial. Full Text available with Trip Pro

Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial. To ensure patients continue to get early access to antibiotics at admission, while also safely reducing antibiotic use in hospitals, one needs to target the continued need for antibiotics as more diagnostic information becomes available. UK Department of Health guidance promotes an initiative called 'Start Smart then Focus': early effective antibiotics followed by active (...) 'review and revision' 24-72 h later. However in 2017, < 10% of antibiotic prescriptions were discontinued at review, despite studies suggesting that 20-30% of prescriptions could be stopped safely.Antibiotic Review Kit for Hospitals (ARK-Hospital) is a complex 'review and revise' behavioural intervention targeting healthcare professionals involved in antibiotic prescribing or administration in inpatients admitted to acute/general medicine (the largest consumers of non-prophylactic antibiotics

2019 Trials Controlled trial quality: uncertain

146. Endodontic treatment of chronically infected primary teeth using triple antibiotic paste: An Full Text available with Trip Pro

Endodontic treatment of chronically infected primary teeth using triple antibiotic paste: An Maintenance of primary dentition is imperative for the development of arch form, esthetics, function, mastication, and normal eruption of permanent teeth. Premature loss can cause various problems such as ectopic eruption, space loss for the successor permanent teeth, alterations in speech, and impairment of function. Hence, decayed primary teeth should not be extracted and treated whenever possible

2019 Journal of conservative dentistry : JCD Controlled trial quality: uncertain

147. Effect of the administration of a probiotic with a combination of Lactobacillus and Bifidobacterium strains on antibiotic-associated diarrhea. (Abstract)

Effect of the administration of a probiotic with a combination of Lactobacillus and Bifidobacterium strains on antibiotic-associated diarrhea. The aim of this study is to analyze the effect, safety and tolerability of a specific probiotic combination of Lactobacillus and Bifidobacterium strains (Pearls IC©) on antibiotic associated diarrhea due to amoxicillin-clavulanic acid treatment.Pilot, unicentric, randomized, double-blind, parallel group, placebo-controlled study (probiotic vs. placebo (...) of the subjective assessment were in favor of the probiotic with higher rate of like responses than placebo.Pearls IC© demonstrated its beneficial effect on antibiotic associated diarrhea by delaying the onset of diarrhea and showed a tendency to decrease the number of daily stools vs. placebo.©The Author 2019. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org

2019 Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia Controlled trial quality: uncertain

148. A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A Randomized Clinical Trial. Full Text available with Trip Pro

A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A Randomized Clinical Trial. Intestinal carriage with extended spectrum β-lactamase Enterobacteriaceae (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) can persist for months. We aimed to evaluate whether oral antibiotics followed by faecal microbiota transplantation (FMT) can eradicate intestinal carriage with ESBL-E/CPE.Randomized, open-label (...) , superiority trial in four tertiary-care centres (Geneva (G), Paris (P), Utrecht (U), Tel Aviv (T)). Non-immunocompromised adult patients were randomized 1: 1 to either no intervention (control) or a 5-day course of oral antibiotics (colistin sulphate 2 × 106 IU 4×/day; neomycin sulphate 500 mg 4×/day) followed by frozen FMT obtained from unrelated healthy donors. The primary outcome was detectable intestinal carriage of ESBL-E/CPE by stool culture 35-48 days after randomization (V4

2019 Clinical Microbiology and Infection Controlled trial quality: predicted high

149. Answer to the letter to the editor of Svend Lings entitled "antibiotics for low back pain?" concerning "antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial Full Text available with Trip Pro

Answer to the letter to the editor of Svend Lings entitled "antibiotics for low back pain?" concerning "antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial 24057198 2015 01 27 2018 12 03 1432-0932 23 2 2014 Feb European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society Eur (...) Spine J Answer to the letter to the editor of Svend Lings entitled "antibiotics for low back pain?" concerning "antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial of efficacy" by Albert HB et al., Eur Spine J (2013) 22:697-707. 473-6 10.1007/s00586-013-2985-0 Albert Hanne B HB Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark, hanne.albert@galnet.dk

2015 European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society Controlled trial quality: uncertain

150. Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent, in Healthy Chinese Subjects. (Abstract)

Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent, in Healthy Chinese Subjects. This study was designed to evaluate the safety and pharmacokinetic profiles of MRX-I tablet, an oxazolidinone antibacterial agent, in healthy Chinese subjects.The study was composed of 3 sequential periods. Period 1 was a randomized, double-blind, placebo-controlled, sequential ascending dose (50 to 1800 mg) study. Period 2 included one arm as a randomized, open

2018 Clinical therapeutics Controlled trial quality: uncertain

151. Could local antibiotics be included in the treatment of acute anal fissure? Full Text available with Trip Pro

Could local antibiotics be included in the treatment of acute anal fissure? Acute anal fissure is a very common disorder of the anorectal region. Its most widely used treatment method is the medications given in addition to conservative therapies. The objective of the present study was to investigate the effects of local metronidazole use in the treatment of acute anal fissure on the symptoms and remission processes of the patients.This was a prospective, randomized, controlled clinical study (...) Analogue Scale scores, there was a statistically significant difference between the two groups at the end of weeks 2 and 4 (p=0.004 and p<0.001, respectively). In Group 1, 28 (56%) patients recovered, but no recovery was observed in 22 (44%) patients. In Group 2, 43 (86%) patients recovered, whereas 7 (14%) patients had no recovery (p=0.004).The topical antimicrobial treatment with metronidazole as an addition to the classical medical treatments in acute anal fissure is an effective and safe practice

2018 Turkish Journal of Surgery Controlled trial quality: uncertain

152. Comparative evaluation of antibacterial effect of nanoparticles and lasers against Endodontic Microbiota: An in vitro study. Full Text available with Trip Pro

Comparative evaluation of antibacterial effect of nanoparticles and lasers against Endodontic Microbiota: An in vitro study. Present study was conducted with the aim of evaluating antimicrobial efficacy of silver (AgNP) and gold nanoparticles (AuNP) with and without Nd: YAG laser (L) irradiation against experimentally inoculated Enterococcus faecalis in infected human root dentin.120 extracted single rooted human teeth were prepared and inoculated with E. faecalis for 24 hrs. The teeth were

2018 Journal of clinical and experimental dentistry Controlled trial quality: uncertain

153. [Are antibiotics neccessary in a first episode of uncomplicated diverticulitis?] Full Text available with Trip Pro

[Are antibiotics neccessary in a first episode of uncomplicated diverticulitis?] 28357456 2018 09 06 2018 11 13 1433-0385 88 4 2017 Apr Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen Chirurg [Are antibiotics neccessary in a first episode of uncomplicated diverticulitis?] 344 10.1007/s00104-017-0417-0 Schrempf M M Klinik für Allgemein-, Viszeral-, Transplantationschirurgie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland. Anthuber M M Klinik für Allgemein

2018 Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen Controlled trial quality: uncertain

154. Should antibiotics be administered after endoscopic mucosalresection in patients with colon polyps? Full Text available with Trip Pro

Should antibiotics be administered after endoscopic mucosalresection in patients with colon polyps? Endoscopic mucosal resection (EMR) is widely used for treating gastrointestinal polypoid lesions. However, it is currently unclear whether antibiotic administration is necessary after EMR of colon polyps to prevent infection. We aimed to assess whether antibiotic administration is essential in such conditions.In total, 115 patients with colon polyps were randomly assigned to 3 groups based (...) on the treatment given after EMR: Group A, no antibiotics treatment after EMR (n = 38); Group B, administration of levofloxacin after EMR (n = 38); and Group C, administration of ceftazidime after EMR (n = 39).The colon polyps were completely removed by EMR in all cases without any serious complications. Although infection developed in 2 cases in Group A, it was resolved via levofloxacin injection over 3 days; infection did not develop in any cases in Group B and C. The postoperative infection rate

2018 Turkish Journal of Medical Sciences Controlled trial quality: uncertain

155. Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction? (Abstract)

Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction? This double-blind, randomized controlled study was done to assess the necessity of systemic antibiotics in the prevention of wound healing complications after intra-alveolar dental extraction. A consecutive recruitment method was used to allocate participants to two treatment groups. Subjects in group A (antibiotics group, n=75) received amoxicillin and metronidazole for 5 (...) days postoperatively, while those in group B (placebo group, n=75) were given identical-looking placebo drugs in place of the antibiotics. Postoperative socket healing complications, pain, and compliance with postoperative instructions were assessed postoperatively. Healing was uneventful in 129 patients (86%). Twenty-one patients (14%) developed wound healing complications. Dry socket was the most common complication in the antibiotics group (six subjects), while acutely inflamed sockets

2018 International Journal of Oral and Maxillofacial Surgery Controlled trial quality: uncertain

156. Study protocol for a Multi-centre, Investigator-initiated, Randomized Controlled Trial to Compare the Effects of Prehospital Antibiotic Treatment for Sepsis Patients with Usual Care after Training Emergency Medical Services (EMS) Personnel in Early Recogn (Abstract)

Study protocol for a Multi-centre, Investigator-initiated, Randomized Controlled Trial to Compare the Effects of Prehospital Antibiotic Treatment for Sepsis Patients with Usual Care after Training Emergency Medical Services (EMS) Personnel in Early Recogn Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. Sepsis becomes more serious when left untreated with a high mortality rate, exceeding even those of myocardial infarction and stroke. Therefore (...) : The Prehospital Antibiotics against Sepsis (PHANTASi) trial is an investigator- initiated, multicentre, randomized controlled open-label clinical trial nested within a step wedge design. This study compares the effects of usual care to that of training EMS personnel in recognizing and initiating treatment in the prehospital setting together with early administration of antibiotics for patients suspected of (severe) sepsis and septic shock. Primary outcome is 28 day mortality. Secondary outcomes include

2018 Acute medicine Controlled trial quality: uncertain

157. Participant experiences of clean intermittent self-catheterisation, urinary tract infections and antibiotic use on the ANTIC trial - A qualitative study. Full Text available with Trip Pro

Participant experiences of clean intermittent self-catheterisation, urinary tract infections and antibiotic use on the ANTIC trial - A qualitative study. Recurrent urinary tract infections are a commonly reported problem in people who use clean intermittent self-catheterisation. Yet there is a lack of knowledge regarding both the impact on people's lives, the use of prophylactic anti-biotics and perceptions of patients on their use.To explore the views and experiences of adults who use clean (...) intermittent self-catheterisation for long-term bladder conditions, with a focus on urinary tract infection experience and prophylactic antibiotic use.A qualitative descriptive study.Twenty-six semi-structured qualitative interviews were conducted with individuals recruited from the ANTIC Trial (Antibiotic treatment for intermittent bladder catheterisation: A randomised controlled trial of once daily prophylaxis). Participants were intermittent self-catheter users aged 18 years or older. Interviews took

2018 International journal of nursing studies Controlled trial quality: uncertain

158. Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial. (Abstract)

Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial. The study aimed to assess the impact of mouthwashes on antibacterial activity of individuals with fixed orthodontic appliances.A total of 60 individuals were considered in the study. Sixty (20 each group) nonextraction class I individuals were randomly divided into experimental and control groups. Group I: Experimental group [chlorhexidine (CHX) mouthwash], group II (...) among CHX and neem mouthwash groups (p = 0.002, p = 0.032 respectively) were significantly reduced after intervention and also the SM colonies count was reduced in CHX and neem mouthwash groups and there was significant difference between the groups.As both mouthwashes showed significant effectiveness on antibacterial activity in individuals with fixed orthodontic appliances, neem mouthwash can be used as an alternative to CHX.It is better to have a sound knowledge regarding the use of mouthwash

2018 The journal of contemporary dental practice Controlled trial quality: uncertain

159. Antibacterial Effect and Tensile Bond Strength of Self-etching Adhesive Resins with and without Methacryloyloxydodecylpyridinium Bromide: An (Abstract)

Antibacterial Effect and Tensile Bond Strength of Self-etching Adhesive Resins with and without Methacryloyloxydodecylpyridinium Bromide: An Aim: The aim of the present study was to compare the antibacterial activity of a self-etching primer containing antibacterial monomer methacryloyloxydodecylpyridinium bromide (MDPB) (Clearfil protect bond) with a conventional self-etching primer without MDPB (Clearfil SE bond) against Streptococcus mutans and the effect of incorporation of MDPB (...) on the tensile bond strength of the experimental self-etching primer (Clearfil protect bond). Materials and methods: The antibacterial activity of the self-etching primers was assessed using agar disk diffusion method and the diameters of the zones of inhibition were measured and ranked. For tensile bond strength testing, 20 noncarious human molars were selected and randomly divided into two groups comprising 10 teeth in each group. Group I specimens were treated with Clearfil SE bond (without MDPB). Group

2018 The journal of contemporary dental practice Controlled trial quality: uncertain

160. A Trial of Antibiotics for Smaller Skin Abscesses. (Abstract)

A Trial of Antibiotics for Smaller Skin Abscesses. 29282969 2018 01 01 2018 12 02 1533-4406 377 26 2017 12 28 The New England journal of medicine N. Engl. J. Med. A Trial of Antibiotics for Smaller Skin Abscesses. e36 10.1056/NEJMc1711124 Nurjadi Dennis D University Hospitals, Heidelberg, Germany Heeg Klaus K University Hospitals, Heidelberg, Germany Zanger Philipp P University Hospitals, Heidelberg, Germany philipp.zanger@uni-heidelberg.d Staph Trav Network eng Letter Comment United States N

2018 The New England journal of medicine Controlled trial quality: uncertain

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