How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

12,411 results for

antibiotics

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

12341. The ex vivo antimicrobial activity and colonization rate of two antimicrobial-bonded central venous catheters. (Abstract)

with Standard Arrow catheters (5%) and one patient with an ARROWgard catheter (3%) developed catheter-related sepsis. Antibiotic-coated catheters significantly inhibited the growth of all test organisms except C. albicans (p < or = .05). Zones of inhibition were significantly larger for the Bio-Guard compared with the ARROWgard catheter when tested against MRSA, S. epidermidis, and E. faecalis (p < or = .002).The Bio-Guard central venous catheter had greater ex vivo antimicrobial activity against MRSA, S (...) The ex vivo antimicrobial activity and colonization rate of two antimicrobial-bonded central venous catheters. Catheter-related sepsis is an important complication associated with the use of central venous catheters. Recent studies have suggested that antimicrobial-bonded catheters may reduce catheter colonization and catheter-related sepsis. The aim of this study was to determine the relationship between the antimicrobial activity and the colonization rate of two commercially available

1999 Critical care medicine Controlled trial quality: uncertain

12342. Antibiotic residues in milk samples obtained from cows after treatment for papillomatous digital dermatitis. (Abstract)

Antibiotic residues in milk samples obtained from cows after treatment for papillomatous digital dermatitis. To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline.Randomized controlled clinical trial.28 lactating Holstein cows with PDD.Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution (...) treatment group had violative residues of oxytetracycline in milk samples.Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk.

1999 Journal of the American Veterinary Medical Association Controlled trial quality: uncertain

12343. The absent role of prophylactic antibiotics in low-risk patients undergoing laparoscopic cholecystectomy. (Abstract)

The absent role of prophylactic antibiotics in low-risk patients undergoing laparoscopic cholecystectomy. A retrospective chart review was done to determine the infection rate and the use of prophylactic antibiotics in consecutive laparoscopic cholecystectomies done in a single community. Incisional infections were discovered in 11 of 566 cases, 10 of whom had received prophylactic antibiotics. The infected patients were significantly older, had longer procedures, and had more comorbidity than (...) the uninfected patients. They were also more likely to have a palpable mass preoperatively and past biliary surgery. A second, prospective study was done to evaluate the efficacy of the use of antibiotic prophylaxis in low-risk patients. Fifty-three patients were randomized into two double-blinded groups. No incisional infections occurred in either group within 30 days postoperatively. This suggests prophylactic antibiotics are not needed to prevent infections for low-risk patients undergoing laparoscopic

1999 The American surgeon Controlled trial quality: uncertain

12344. Antibiotic prophylaxis in orthognathic surgery: a 1-day versus 5-day regimen. (Abstract)

Antibiotic prophylaxis in orthognathic surgery: a 1-day versus 5-day regimen. The effect on infection rates of 1-day and 5-day administration of prophylactic antibiotics in orthognathic surgical procedures was compared.A prospective, randomized, double-blind clinical trial using placebo was conducted. Thirty patients were distributed equally between two groups. Each group received penicillin G, two million units intravenously, immediately preoperatively, and one million units intravenously (...) in group 1 (6.7%) and 9 of 15 patients (60%) in group 2 became infected. The overall infection rate was 33.3%. There was a statistically significant difference in rates of infection between the two groups (P < .01).Antibiotic prophylaxis for orthognathic surgical procedures should continue beyond the immediate postoperative period. Five days of antibiotic administration appears to provide adequate coverage.

1999 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Controlled trial quality: uncertain

12345. Head-to-head comparison of 1-week triple regimens combining ranitidine or omeprazole with two antibiotics to eradicate Helicobacter pylori. (Abstract)

Head-to-head comparison of 1-week triple regimens combining ranitidine or omeprazole with two antibiotics to eradicate Helicobacter pylori. Triple therapies containing omeprazole and ranitidine have been shown to be equivalent in eradicating H. pylori infection, but have been assessed either separately or head-to-head, only in small trials.To carry out a large randomized controlled study comparing omeprazole and ranitidine combined with two antibiotic combinations for 1 week.Three hundred (...) , there was significant difference between OAM and OAC (P<0.01) and between RAM and RAC (P<0.05). Side-effects occurred in 15%, 10%, 17% and 16% of patients with respect to the above four subgroups.Omeprazole and ranitidine combined with two antibiotics for 1 week are equally effective in the eradication of H. pylori infection, and these results question the role of profound acid suppression in the eradication of the bacterium.

1999 Alimentary pharmacology & therapeutics Controlled trial quality: uncertain

12346. The effect of postsurgical antibiotics and a bioabsorbable membrane on regenerative healing in Class II furcation defects. (Abstract)

The effect of postsurgical antibiotics and a bioabsorbable membrane on regenerative healing in Class II furcation defects. The purpose of this randomized, controlled, blinded, clinical investigation was to determine the effect of postsurgical antibiotics on osseous healing in Class II furcation defects.Twenty-four Class II furcation defects in 24 patients were treated with either a polylactide bioabsorbable membrane, demineralized freeze-dried bone allograft (DFDBA) plus antibiotics (GBA (...) or test group) or with a polylactide membrane and DFDBA alone (GB or control group). Twelve patients were included in each group. The antibiotic regimen consisted of ciprofloxacin 250 mg twice daily and metronidazole 250 mg tid for 1 week followed by a 7-week regimen of doxycycline hyclate 50 mg daily. Treatment was performed on either mandibular buccal or lingual, or maxillary buccal Class II furcation defects. Defects were randomly selected by a coin toss for treatment and all open and closed

1999 Journal of periodontology Controlled trial quality: uncertain

12347. Confidential prescriber feedback and education to improve antibiotic use in primary care: a controlled trial. Full Text available with Trip Pro

Confidential prescriber feedback and education to improve antibiotic use in primary care: a controlled trial. Antibiotics are a medication class for which inappropriate prescribing is frequently described. We sought to assess the effectiveness of a mailed intervention combining confidential prescribing feedback with targeted educational bulletins in increasing the use of less expensive, first-line antibiotics by practising physicians.The participants were 251 randomly selected primary care (...) physicians from southern Ontario who consented to participate (135 in the feedback group and 116 in the control group). Prescribing data were obtained from the claims database of the Ontario Drug Benefit program, which covers all Ontarians over age 65 years for drugs selected from a minimally restrictive formulary. Confidentially prepared profiles of antibiotic prescriptions coupled with guidelines-based educational bulletins were mailed to the intervention group every 2 months for 6 months. The control

1999 Canadian Medical Association Journal Controlled trial quality: uncertain

12348. Comparison of meropenem with amikacin plus ceftazidime in the empirical treatment of febrile neutropenia: a prospective randomised multicentre trial in patients without previous prophylactic antibiotics. Meropenem Study Group of Turkey. (Abstract)

Comparison of meropenem with amikacin plus ceftazidime in the empirical treatment of febrile neutropenia: a prospective randomised multicentre trial in patients without previous prophylactic antibiotics. Meropenem Study Group of Turkey. Eighty three patients with neutropenia and cancer were randomised to receive either 1 g meropenem tds or amikacin 15 mg/kg single dose daily plus ceftazidime 2 g tds. No prophylactic antibiotics were allowed before entry to the trial. Seventy seven patients were

1999 International journal of antimicrobial agents Controlled trial quality: uncertain

12349. Re-evaluation of a randomized controlled trial of antibiotics for minor respiratory illness in general practice. (Abstract)

Re-evaluation of a randomized controlled trial of antibiotics for minor respiratory illness in general practice. A systematic review examining the efficacy of antibiotics in acute respiratory illness concluded that antibiotics are of little benefit. However, that review was based on analysis of only six randomized controlled trials, one of which was excluded because its analysis included patients with multiple episodes of illness; treatment group, either antibiotic or placebo, might have (...) confounded the likelihood of suffering a subsequent episode of illness.This previously excluded randomized controlled trial of 301 patients with symptoms of minor respiratory illness was re-analysed to examine the efficacy of antibiotic versus placebo in terms of resolution of symptoms, most particularly cough.Antibiotic had no impact on the resolution of symptoms of cough at 1 and 2 weeks, respectively; adjusted odds ratio 1.2 [95% confidence interval (CI) 0.7--2.1] and 0.8 (95% CI 0.4--1.6). In those

2001 Family Practice Controlled trial quality: predicted high

12350. Comparative study of ceftriaxone versus cefazolin plus clindamycin as antibiotic prophylaxis in elective colorectal surgery. (Abstract)

Comparative study of ceftriaxone versus cefazolin plus clindamycin as antibiotic prophylaxis in elective colorectal surgery. A comparative study of 103 consecutive patients who required antibiotic prophylaxis for elective colorectal surgery was carried out. All eligible patients received either ceftriaxone (2 g) as a single intravenous dose at anesthetic induction or cefazolin (1 g) plus clindamycin (0.6g) administered intravenously at anesthetic induction and for two more doses at 8-hourly (...) intervals for a total of 3 days. The incidence of postoperative wound infections was 6.9% in the ceftriaxone group and 11.1% in the cefazolin plus clindamycin group. Single-dose ceftriaxone proved to be a safe and cost-effective form of antibiotic prophylaxis for elective colorectal surgery.

2000 Journal of chemotherapy (Florence, Italy) Controlled trial quality: uncertain

12351. Reducing antibiotic use in children: a randomized trial in 12 practices. (Abstract)

Reducing antibiotic use in children: a randomized trial in 12 practices. To test whether an educational outreach intervention for families and physicians, based on the Centers for Disease Control and Prevention (CDC) principles of judicious antibiotic use, decreases antimicrobial drug prescribing for children younger than 6 years old. Setting. Twelve practices affiliated with 2 managed care organizations (MCOs) in eastern Massachusetts and northwest Washington State. Patients. All enrolled (...) children younger than 6 years old.Practices stratified by MCO and size were randomized to intervention or control groups. The intervention included 2 meetings of the practice with a physician peer leader, using CDC-endorsed summaries of judicious prescribing recommendations; feedback on previous prescribing rates were also provided. Parents were mailed a CDC brochure on antibiotic use, and supporting materials were displayed in waiting rooms. Automated enrollment, ambulatory visit, and pharmacy claims

2001 Pediatrics Controlled trial quality: uncertain

12352. [Antibiotic prophylaxis in oncologic pharyngolaryngeal surgery: ceftriaxone versus clindamycin and gentamycin]. (Abstract)

[Antibiotic prophylaxis in oncologic pharyngolaryngeal surgery: ceftriaxone versus clindamycin and gentamycin]. There are many papers comparing two antibiotic protocols for the profilaxis of head and neck infections after laryngeal surgery. We present one prospective and randomised study in 60 patients comparing the efficacy of two protocols. The comparison was between ceftriaxone versus the association of clindamicyn and gentamicyn. In our database we included the risk factors for infection

2001 Acta otorrinolaringológica española Controlled trial quality: uncertain

12353. Pharmacokinetics of antibiotic prophylaxis in major orthopedic surgery and blood-saving techniques. (Abstract)

Pharmacokinetics of antibiotic prophylaxis in major orthopedic surgery and blood-saving techniques. The pharmacokinetics of cefuroxime, cefotiam, cefamandole, and ampicillin/sulbactam were randomly measured in 40 patients undergoing major orthopedic surgery associated with high blood and volume turnover and intraoperative blood salvage. Serum and bone concentrations and the pharmacokinetics occurring in the context of these procedures were measured. No changes in elimination half-life relative (...) to a normal population occurred with cefuroxime, cefotiam, and ampicillin. Serum and tissue concentrations were slightly lower with cefamandole and sulbactam, but reapplication of the initial dose was required with all antibiotics 4 hours after the first application.

2001 Orthopedics Controlled trial quality: uncertain

12354. Effect of an antibacterial varnish on lactic acid production in plaque adjacent to fixed orthodontic appliances. (Abstract)

Effect of an antibacterial varnish on lactic acid production in plaque adjacent to fixed orthodontic appliances. The effect of an antibacterial varnish on lactic acid concentration in suspensions of early supragingival plaque collected adjacent to fixed orthodontic brackets was evaluated in 25 adolescents using a double-blind split-mouth design with a placebo varnish control. The test varnish contained 1% chlorhexidine and 1% thymol as active ingredients. Both varnishes were applied on two

2001 Clinical oral investigations Controlled trial quality: uncertain

12355. Academic detailing to improve use of broad-spectrum antibiotics at an academic medical center. (Abstract)

Academic detailing to improve use of broad-spectrum antibiotics at an academic medical center. Antibiotic misuse is common and costly and may promote antibiotic resistance. We tested the efficacy of a targeted one-on-one educational program ("academic detailing") designed to improve the appropriateness of broad-spectrum antibiotic use.A randomized controlled trial was conducted in a large US teaching hospital. During an 18-week study period, 17 general medical, oncology, and cardiology services (...) either received academic detailing or did not. The intervention was prompted by an order for either levofloxacin or ceftazidime that led to a computer-based review of data for that patient. Orders for the 2 target antibiotics deemed unnecessary by a priori criteria were included in the study. The primary outcome examined was the number of days that unnecessary levofloxacin or ceftazidime was administered in intervention and control groups.Before the trial, intervention and control services had

2001 Archives of internal medicine Controlled trial quality: predicted high

12356. Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis. (Abstract)

Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis. Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root (...) planing in patients with GAgP.After initial therapy and full-mouth scaling and root planing (SRP), 30 patients were randomly assigned to 1 of 2 antibiotic treatment groups. Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded with an automated probe prior to SRP at baseline (BL) and 15, 30, 41, and 54 weeks later. Three months after SRP, the patients were treated with amoxicillin/clavulanic acid (500 mg tid; SRP + AUG group) or with local tetracycline fiber

2001 Journal of periodontology Controlled trial quality: uncertain

12357. Clinical significance of antibiotic therapy in guided tissue regeneration with a resorbable membrane. (Abstract)

Clinical significance of antibiotic therapy in guided tissue regeneration with a resorbable membrane. This study was designed to evaluate the clinical significance of antibiotic therapy combined with guided tissue regeneration (GTR) therapy with a collagen membrane. The subjects were 20 adults diagnosed with periodontitis (20 intrabony periodontal defects). Ten patients were treated with GTR alone (control group) and the other 10 patients were treated with a combination of GTR and antibiotics (...) (antibiotic group). In the antibiotic group, minocycline ointment was applied locally before GTR therapy, and doxycycline and amoxyline were systemically administered after GTR therapy. Clinical manifestations, the presence or absence of exposed membrane, and microbiological findings were assessed 1 month before, immediately after, and 2 weeks, 6 weeks, and 3 months after GTR therapy. The results showed no significant differences in reduction of probing depth, probing attachment gain (PAG), or the ratio

2001 Periodontal clinical investigations : official publication of the Northeastern Society of Periodontists Controlled trial quality: uncertain

12358. Improving parent knowledge about antibiotics: a video intervention. (Abstract)

Improving parent knowledge about antibiotics: a video intervention. To determine whether an educational video could improve parent knowledge, beliefs, and behaviors about the appropriate use of oral antibiotics.A randomized, controlled trial was conducted in an urban primary care clinic and a suburban pediatric practice. Parents were randomly assigned to the intervention or control groups. Parents in the intervention group were asked to view a 20-minute video, specifically developed (...) for this project, over a 2-month period, and given a brochure about antibiotics. Parent knowledge, beliefs, and behaviors were assessed at the time of enrollment and then by telephone 2 months later.A total of 193 (94%) of 206 parents completed the study. The groups were equivalent with respect to all important baseline characteristics. No differences were found for adjusted posttest means between the intervention and control groups for knowledge, beliefs, or behavior. For example, the intervention group

2001 Pediatrics Controlled trial quality: uncertain

12359. Efficacy and tolerability of antibiotics in patients undergoing H. pylori eradication. (Abstract)

Efficacy and tolerability of antibiotics in patients undergoing H. pylori eradication. Helicobacter pylori (H. pylori) infection is one of the most common gastrointestinal diseases. An increasing number of people undergo different treatment options. Unfortunately, H. pylori therapy may be troublesome for drug side effects and inefficacious for resistance to antibiotics.One hundred and ninety-three (193) H. pylori-positive patients were randomly assigned to one of the following 7-day treatments

2001 Hepato-gastroenterology Controlled trial quality: uncertain

12360. Comparison of 2 techniques for regional antibiotic delivery to the equine forelimb: intraosseous perfusion vs. intravenous perfusion. Full Text available with Trip Pro

Comparison of 2 techniques for regional antibiotic delivery to the equine forelimb: intraosseous perfusion vs. intravenous perfusion. The purpose of this study was to compare the synovial fluid concentrations and pharmacokinetics of amikacin in the equine limb distal to the carpus following intraosseous and intravenous regional perfusion. The front limbs of 6 horses were randomly assigned to either intraosseous or intravenous perfusion. A tourniquet was placed distal to each carpus and the limb

2001 The Canadian veterinary journal. La revue vétérinaire canadienne Controlled trial quality: uncertain

Controlled trials

Controlled trials are important tests of an intervention, particularly randomised controlled trials.  See Testing Treatments to understand the reasons why.